Incidental Mutation 'R4560:Tsga10'
ID 343017
Institutional Source Beutler Lab
Gene Symbol Tsga10
Ensembl Gene ENSMUSG00000060771
Gene Name testis specific 10
Synonyms Mtsga10, 4933432N21Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R4560 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 37793857-37905510 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37846163 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 321 (M321T)
Ref Sequence ENSEMBL: ENSMUSP00000110552 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041815] [ENSMUST00000088072] [ENSMUST00000114902] [ENSMUST00000151735]
AlphaFold Q6NY15
Predicted Effect probably benign
Transcript: ENSMUST00000041815
AA Change: M321T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000048859
Gene: ENSMUSG00000060771
AA Change: M321T

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000088072
AA Change: M321T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000085391
Gene: ENSMUSG00000060771
AA Change: M321T

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000114902
AA Change: M321T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000110552
Gene: ENSMUSG00000060771
AA Change: M321T

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 249 N/A INTRINSIC
Blast:SPEC 294 391 5e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000151735
SMART Domains Protein: ENSMUSP00000120554
Gene: ENSMUSG00000060771

DomainStartEndE-ValueType
low complexity region 5 17 N/A INTRINSIC
coiled coil region 24 85 N/A INTRINSIC
coiled coil region 110 229 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy4 A C 14: 56,016,407 (GRCm39) probably null Het
Atp8b1 A T 18: 64,689,950 (GRCm39) L594* probably null Het
Atp8b1 C T 18: 64,701,318 (GRCm39) V347I probably benign Het
Axin1 A G 17: 26,392,745 (GRCm39) D342G probably damaging Het
Bace2 G A 16: 97,223,180 (GRCm39) R368Q probably damaging Het
Capn10 T C 1: 92,867,084 (GRCm39) Y105H probably damaging Het
Ccdc89 T G 7: 90,076,336 (GRCm39) L182R probably damaging Het
Cdk5rap2 A G 4: 70,233,568 (GRCm39) F537S probably benign Het
Cidec A T 6: 113,405,399 (GRCm39) M118K probably damaging Het
Cog8 A T 8: 107,778,843 (GRCm39) probably null Het
Ctif A T 18: 75,652,952 (GRCm39) L435Q probably damaging Het
Dhx9 A G 1: 153,342,903 (GRCm39) V533A probably damaging Het
Drc1 T A 5: 30,520,441 (GRCm39) M594K probably benign Het
Dthd1 C T 5: 62,984,435 (GRCm39) T380I probably damaging Het
Fat2 A G 11: 55,156,777 (GRCm39) S3475P possibly damaging Het
G6pd2 G A 5: 61,967,686 (GRCm39) R487H possibly damaging Het
Hcrtr2 A G 9: 76,161,970 (GRCm39) V140A probably damaging Het
Ikbke C T 1: 131,199,857 (GRCm39) C243Y probably damaging Het
Il21 C A 3: 37,279,633 (GRCm39) E128* probably null Het
Kdm7a C T 6: 39,129,757 (GRCm39) R473Q probably damaging Het
Me3 G T 7: 89,498,938 (GRCm39) R506L probably benign Het
Mtf2 T A 5: 108,234,855 (GRCm39) probably null Het
Nbas A G 12: 13,633,528 (GRCm39) N2311S probably benign Het
Nomo1 G T 7: 45,690,904 (GRCm39) V97L probably damaging Het
Pcdhb11 G A 18: 37,556,787 (GRCm39) V706I possibly damaging Het
Pkhd1 G A 1: 20,282,082 (GRCm39) R2920C probably damaging Het
Prox2 T C 12: 85,141,817 (GRCm39) T129A probably benign Het
Rgs18 T G 1: 144,631,720 (GRCm39) I131L probably benign Het
Rnf19b G T 4: 128,965,616 (GRCm39) C57F probably damaging Het
Rpl11 T C 4: 135,778,522 (GRCm39) Y122C probably damaging Het
Sarnp A G 10: 128,682,412 (GRCm39) K5R probably damaging Het
Scg2 A T 1: 79,412,898 (GRCm39) H568Q probably damaging Het
Septin10 T C 10: 59,019,417 (GRCm39) Y150C probably damaging Het
Slco1b2 A G 6: 141,616,893 (GRCm39) T409A probably benign Het
Smco2 T A 6: 146,772,674 (GRCm39) V292D possibly damaging Het
Smok3c A G 5: 138,062,746 (GRCm39) M78V probably benign Het
Spag16 C A 1: 69,883,455 (GRCm39) F61L probably benign Het
Spata22 G A 11: 73,236,585 (GRCm39) R297H probably damaging Het
Spata31d1e A G 13: 59,889,571 (GRCm39) S750P probably damaging Het
Syt3 C A 7: 44,045,368 (GRCm39) P536Q probably benign Het
Tmem117 A T 15: 94,992,677 (GRCm39) M446L probably benign Het
Trim9 A C 12: 70,393,892 (GRCm39) Y17* probably null Het
Ttc13 A G 8: 125,402,016 (GRCm39) L657P probably damaging Het
Ubxn1 C T 19: 8,851,588 (GRCm39) T207I probably benign Het
Vmn2r117 A T 17: 23,678,851 (GRCm39) V791D probably damaging Het
Vps54 C G 11: 21,262,260 (GRCm39) C785W possibly damaging Het
Zfp616 A G 11: 73,973,860 (GRCm39) D43G probably benign Het
Zfp952 A G 17: 33,222,928 (GRCm39) H469R probably benign Het
Other mutations in Tsga10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00573:Tsga10 APN 1 37,846,151 (GRCm39) missense probably damaging 0.99
IGL00579:Tsga10 APN 1 37,874,534 (GRCm39) missense probably damaging 1.00
IGL00837:Tsga10 APN 1 37,840,992 (GRCm39) splice site probably benign
IGL01577:Tsga10 APN 1 37,874,538 (GRCm39) missense possibly damaging 0.85
IGL01727:Tsga10 APN 1 37,874,355 (GRCm39) missense probably damaging 1.00
IGL02037:Tsga10 APN 1 37,846,098 (GRCm39) missense probably benign 0.05
IGL02510:Tsga10 APN 1 37,800,066 (GRCm39) missense possibly damaging 0.89
R0346:Tsga10 UTSW 1 37,879,600 (GRCm39) missense possibly damaging 0.65
R0789:Tsga10 UTSW 1 37,840,868 (GRCm39) missense possibly damaging 0.87
R0961:Tsga10 UTSW 1 37,800,509 (GRCm39) critical splice donor site probably null
R1370:Tsga10 UTSW 1 37,874,534 (GRCm39) missense probably damaging 1.00
R1440:Tsga10 UTSW 1 37,858,680 (GRCm39) missense probably damaging 1.00
R1827:Tsga10 UTSW 1 37,874,661 (GRCm39) missense probably damaging 1.00
R2504:Tsga10 UTSW 1 37,854,758 (GRCm39) missense probably damaging 1.00
R3104:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3105:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3106:Tsga10 UTSW 1 37,840,872 (GRCm39) missense probably damaging 1.00
R3824:Tsga10 UTSW 1 37,873,278 (GRCm39) missense possibly damaging 0.73
R3825:Tsga10 UTSW 1 37,873,278 (GRCm39) missense possibly damaging 0.73
R4773:Tsga10 UTSW 1 37,874,606 (GRCm39) missense probably damaging 1.00
R4927:Tsga10 UTSW 1 37,840,931 (GRCm39) missense probably damaging 1.00
R5036:Tsga10 UTSW 1 37,823,049 (GRCm39) missense possibly damaging 0.65
R5326:Tsga10 UTSW 1 37,800,598 (GRCm39) missense probably damaging 1.00
R5345:Tsga10 UTSW 1 37,802,392 (GRCm39) missense probably damaging 1.00
R5503:Tsga10 UTSW 1 37,800,028 (GRCm39) makesense probably null
R5542:Tsga10 UTSW 1 37,800,598 (GRCm39) missense probably damaging 1.00
R5793:Tsga10 UTSW 1 37,874,540 (GRCm39) missense probably damaging 1.00
R6340:Tsga10 UTSW 1 37,874,266 (GRCm39) intron probably benign
R7096:Tsga10 UTSW 1 37,879,695 (GRCm39) missense probably damaging 0.98
R7130:Tsga10 UTSW 1 37,822,965 (GRCm39) missense probably damaging 1.00
R7401:Tsga10 UTSW 1 37,873,268 (GRCm39) missense probably null 1.00
R7609:Tsga10 UTSW 1 37,843,974 (GRCm39) splice site probably null
R7649:Tsga10 UTSW 1 37,874,229 (GRCm39) missense unknown
R7773:Tsga10 UTSW 1 37,874,323 (GRCm39) missense unknown
R8242:Tsga10 UTSW 1 37,846,182 (GRCm39) missense probably benign 0.28
R8379:Tsga10 UTSW 1 37,840,959 (GRCm39) missense probably benign 0.00
R9205:Tsga10 UTSW 1 37,880,359 (GRCm39) start gained probably benign
R9252:Tsga10 UTSW 1 37,873,364 (GRCm39) missense probably benign 0.35
Predicted Primers PCR Primer
(F):5'- ATGAGGGCTCTGCTCAGAAG -3'
(R):5'- CTGAAGTATGCAACTGCCAGAG -3'

Sequencing Primer
(F):5'- GGGCTCTGCTCAGAAGAAATC -3'
(R):5'- CTGCCAGAGATGGAAGTGTC -3'
Posted On 2015-09-24