Incidental Mutation 'R4564:Olfml2a'
ID 343223
Institutional Source Beutler Lab
Gene Symbol Olfml2a
Ensembl Gene ENSMUSG00000046618
Gene Name olfactomedin-like 2A
Synonyms photomedin-1, 4932431K08Rik
MMRRC Submission 041789-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.083) question?
Stock # R4564 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 38821992-38850597 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 38850306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 674 (T674I)
Ref Sequence ENSEMBL: ENSMUSP00000058761 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057279]
AlphaFold Q8BHP7
Predicted Effect probably benign
Transcript: ENSMUST00000057279
AA Change: T674I

PolyPhen 2 Score 0.399 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000058761
Gene: ENSMUSG00000046618
AA Change: T674I

DomainStartEndE-ValueType
signal peptide 1 27 N/A INTRINSIC
internal_repeat_1 39 66 2.55e-7 PROSPERO
internal_repeat_1 78 105 2.55e-7 PROSPERO
coiled coil region 168 189 N/A INTRINSIC
low complexity region 212 228 N/A INTRINSIC
low complexity region 252 271 N/A INTRINSIC
low complexity region 302 320 N/A INTRINSIC
low complexity region 367 407 N/A INTRINSIC
OLF 426 681 8.73e-69 SMART
Meta Mutation Damage Score 0.1454 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 97% (58/60)
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atad3a C T 4: 155,831,766 (GRCm39) probably null Het
Bach2 T G 4: 32,563,338 (GRCm39) S602A probably damaging Het
Ccl19 G T 4: 42,756,295 (GRCm39) S12R probably damaging Het
Cfap54 T C 10: 92,675,402 (GRCm39) probably benign Het
Cndp1 T A 18: 84,640,411 (GRCm39) I265F probably damaging Het
Cnot3 G A 7: 3,656,257 (GRCm39) R181H probably damaging Het
Dicer1 T A 12: 104,671,010 (GRCm39) K1011* probably null Het
Dip2b G A 15: 100,055,139 (GRCm39) W99* probably null Het
Fpr-rs6 A T 17: 20,403,168 (GRCm39) Y64* probably null Het
Fubp1 C A 3: 151,928,573 (GRCm39) Y480* probably null Het
Gfra1 T C 19: 58,227,682 (GRCm39) probably null Het
Gm10770 T C 2: 150,020,831 (GRCm39) T229A probably benign Het
Gm826 A C 2: 160,153,913 (GRCm39) probably benign Het
Gpd2 G A 2: 57,197,095 (GRCm39) V217I possibly damaging Het
Hectd4 T C 5: 121,488,494 (GRCm39) I3595T probably benign Het
Lmln A G 16: 32,930,226 (GRCm39) E561G probably benign Het
Lrrc71 T A 3: 87,652,715 (GRCm39) probably benign Het
Man2a2 T A 7: 80,018,586 (GRCm39) Y91F probably benign Het
Map4k4 A G 1: 40,028,135 (GRCm39) T319A probably damaging Het
Mcm6 G T 1: 128,271,196 (GRCm39) H474Q probably damaging Het
Mn1 C G 5: 111,568,533 (GRCm39) N834K possibly damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Niban3 T C 8: 72,057,704 (GRCm39) probably benign Het
Npas2 A G 1: 39,326,647 (GRCm39) D44G probably damaging Het
Npc1 C T 18: 12,324,789 (GRCm39) G1235R probably damaging Het
Or4f58 A G 2: 111,852,112 (GRCm39) L29P possibly damaging Het
Pgap6 A G 17: 26,336,837 (GRCm39) R252G possibly damaging Het
Plxnb1 C T 9: 108,942,488 (GRCm39) A1779V probably benign Het
Ppil3 T A 1: 58,470,481 (GRCm39) D123V probably damaging Het
Prr23a3 A G 9: 98,747,190 (GRCm39) E48G probably damaging Het
Prr5l T C 2: 101,577,094 (GRCm39) E110G probably damaging Het
Ptgir A G 7: 16,640,794 (GRCm39) M29V possibly damaging Het
R3hdm1 C T 1: 128,149,396 (GRCm39) T839M probably benign Het
Rasgrf2 G A 13: 92,033,773 (GRCm39) Q544* probably null Het
Riok3 C A 18: 12,281,936 (GRCm39) R302S probably damaging Het
Rnf145 A G 11: 44,439,635 (GRCm39) K144E probably benign Het
Sin3b A C 8: 73,480,209 (GRCm39) T904P probably damaging Het
Skint4 C T 4: 111,977,066 (GRCm39) T152M probably damaging Het
Slc22a2 A G 17: 12,828,943 (GRCm39) I350V probably benign Het
Slc6a11 G T 6: 114,108,323 (GRCm39) G29V probably benign Het
Speg A C 1: 75,368,478 (GRCm39) H676P probably damaging Het
St6gal2 T A 17: 55,789,648 (GRCm39) H227Q probably damaging Het
Strn3 A G 12: 51,680,404 (GRCm39) S399P probably benign Het
Tbc1d1 A G 5: 64,330,827 (GRCm39) E2G probably damaging Het
Tecpr2 T A 12: 110,921,219 (GRCm39) M1264K probably benign Het
Trpm6 T C 19: 18,809,961 (GRCm39) L1119P possibly damaging Het
Upf2 A C 2: 6,032,123 (GRCm39) T890P unknown Het
Upk1b T A 16: 38,600,469 (GRCm39) K170N probably benign Het
Vmn1r78 A T 7: 11,886,485 (GRCm39) Y32F probably damaging Het
Vps11 A G 9: 44,272,894 (GRCm39) F12S probably damaging Het
Zfp318 T A 17: 46,723,741 (GRCm39) C1915S possibly damaging Het
Zfp346 A C 13: 55,261,520 (GRCm39) R103S probably damaging Het
Other mutations in Olfml2a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Olfml2a APN 2 38,837,226 (GRCm39) critical splice acceptor site probably null
IGL02367:Olfml2a APN 2 38,844,680 (GRCm39) missense probably benign 0.15
IGL03140:Olfml2a APN 2 38,837,303 (GRCm39) missense probably damaging 1.00
R0559:Olfml2a UTSW 2 38,849,832 (GRCm39) missense probably damaging 1.00
R0781:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1110:Olfml2a UTSW 2 38,849,765 (GRCm39) missense probably damaging 0.99
R1187:Olfml2a UTSW 2 38,849,825 (GRCm39) missense probably damaging 1.00
R1626:Olfml2a UTSW 2 38,841,275 (GRCm39) missense probably damaging 1.00
R1634:Olfml2a UTSW 2 38,850,231 (GRCm39) missense probably benign 0.03
R2127:Olfml2a UTSW 2 38,831,699 (GRCm39) missense probably damaging 1.00
R2987:Olfml2a UTSW 2 38,837,306 (GRCm39) missense probably damaging 0.97
R4428:Olfml2a UTSW 2 38,831,755 (GRCm39) missense probably damaging 0.96
R4609:Olfml2a UTSW 2 38,847,733 (GRCm39) missense probably damaging 0.98
R4667:Olfml2a UTSW 2 38,839,022 (GRCm39) missense probably damaging 0.99
R4703:Olfml2a UTSW 2 38,841,250 (GRCm39) missense probably damaging 1.00
R4827:Olfml2a UTSW 2 38,850,033 (GRCm39) missense probably damaging 1.00
R5588:Olfml2a UTSW 2 38,850,047 (GRCm39) missense probably damaging 1.00
R5879:Olfml2a UTSW 2 38,850,242 (GRCm39) missense probably damaging 1.00
R6063:Olfml2a UTSW 2 38,841,155 (GRCm39) missense probably benign 0.03
R6484:Olfml2a UTSW 2 38,849,780 (GRCm39) missense probably damaging 1.00
R6788:Olfml2a UTSW 2 38,850,238 (GRCm39) nonsense probably null
R7345:Olfml2a UTSW 2 38,850,139 (GRCm39) missense probably damaging 1.00
R7474:Olfml2a UTSW 2 38,850,273 (GRCm39) missense probably damaging 0.98
R7971:Olfml2a UTSW 2 38,831,794 (GRCm39) splice site probably null
R8073:Olfml2a UTSW 2 38,847,766 (GRCm39) missense probably damaging 1.00
R8846:Olfml2a UTSW 2 38,850,255 (GRCm39) missense probably damaging 1.00
R9108:Olfml2a UTSW 2 38,831,753 (GRCm39) missense probably benign 0.10
R9425:Olfml2a UTSW 2 38,847,721 (GRCm39) missense probably damaging 1.00
Z1177:Olfml2a UTSW 2 38,850,296 (GRCm39) missense possibly damaging 0.69
Predicted Primers PCR Primer
(F):5'- CCTATGGGAACTGCTTTCTGG -3'
(R):5'- CTGTGGAAGTGTCACCTACTG -3'

Sequencing Primer
(F):5'- GTGTGCGGCATCCTCTACAC -3'
(R):5'- AAGTGTCACCTACTGGGCACTG -3'
Posted On 2015-09-24