Incidental Mutation 'R4567:Or2y6'
ID 343362
Institutional Source Beutler Lab
Gene Symbol Or2y6
Ensembl Gene ENSMUSG00000060170
Gene Name olfactory receptor family 2 subfamily Y member 6
Synonyms GA_x6K02T2QP88-3214035-3214970, MOR256-58, Olfr1371
MMRRC Submission 041791-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R4567 (G1)
Quality Score 194
Status Not validated
Chromosome 11
Chromosomal Location 52103879-52104814 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 52104291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 175 (H175R)
Ref Sequence ENSEMBL: ENSMUSP00000075241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075844]
AlphaFold Q7TQT7
Predicted Effect probably damaging
Transcript: ENSMUST00000075844
AA Change: H175R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075241
Gene: ENSMUSG00000060170
AA Change: H175R

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 7.9e-48 PFAM
Pfam:7tm_1 41 289 5.1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181262
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 95% (38/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T A 17: 35,315,499 (GRCm39) L182Q probably damaging Het
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Alg12 T C 15: 88,690,556 (GRCm39) probably benign Het
Asmt A G X: 169,110,261 (GRCm39) probably null Het
Atp10b T C 11: 43,088,384 (GRCm39) I330T probably benign Het
Ceacam23 T C 7: 17,642,891 (GRCm39) S434P probably damaging Het
Dennd5a T C 7: 109,498,942 (GRCm39) M998V probably benign Het
Erbb3 A G 10: 128,414,944 (GRCm39) S401P probably damaging Het
Gm10718 A T 9: 3,023,716 (GRCm39) T56S probably benign Het
Gm1527 A T 3: 28,968,556 (GRCm39) N203Y probably damaging Het
Hsf2bp C T 17: 32,165,708 (GRCm39) V296M probably benign Het
Htr1d T A 4: 136,170,836 (GRCm39) V355E probably benign Het
Ints11 T C 4: 155,970,132 (GRCm39) V203A probably damaging Het
Iqsec3 A G 6: 121,364,721 (GRCm39) V856A probably damaging Het
Nherf4 C A 9: 44,160,323 (GRCm39) V294L possibly damaging Het
Or2ag1b G A 7: 106,288,420 (GRCm39) Q173* probably null Het
Or5t18 A G 2: 86,637,146 (GRCm39) S66P probably damaging Het
Phf11 A T 14: 59,488,627 (GRCm39) Y57N probably damaging Het
Ppfia2 G A 10: 106,701,267 (GRCm39) probably null Het
Prss23 T A 7: 89,160,074 (GRCm39) probably benign Het
Rasl2-9 AGG A 7: 5,128,374 (GRCm39) probably null Het
Rcn2 A T 9: 55,960,266 (GRCm39) I178F probably benign Het
Rtn1 C T 12: 72,259,261 (GRCm39) probably benign Het
Sik2 A G 9: 50,909,876 (GRCm39) V59A probably damaging Het
Slc25a42 A T 8: 70,641,504 (GRCm39) M159K probably damaging Het
Slc9a4 T C 1: 40,619,737 (GRCm39) L21P probably damaging Het
Smap2 A C 4: 120,842,508 (GRCm39) W41G probably damaging Het
Sox6 T C 7: 115,261,557 (GRCm39) I220V probably benign Het
Spata31e2 T C 1: 26,722,198 (GRCm39) D994G probably benign Het
Syt17 A G 7: 118,033,495 (GRCm39) V171A probably benign Het
Tjp1 A G 7: 64,956,249 (GRCm39) F1332S probably damaging Het
Trim3 C T 7: 105,262,623 (GRCm39) V512I possibly damaging Het
Uhmk1 G A 1: 170,032,686 (GRCm39) Q282* probably null Het
Ushbp1 G A 8: 71,838,361 (GRCm39) R648W probably damaging Het
Other mutations in Or2y6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0513:Or2y6 UTSW 11 52,104,576 (GRCm39) missense possibly damaging 0.94
R4462:Or2y6 UTSW 11 52,104,801 (GRCm39) missense probably damaging 1.00
R4621:Or2y6 UTSW 11 52,104,706 (GRCm39) missense probably benign 0.26
R5846:Or2y6 UTSW 11 52,103,881 (GRCm39) makesense probably null
R5873:Or2y6 UTSW 11 52,104,180 (GRCm39) missense probably damaging 1.00
R8181:Or2y6 UTSW 11 52,104,096 (GRCm39) missense probably damaging 1.00
Z1177:Or2y6 UTSW 11 52,104,237 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TCCCAAAAGCCTTTCTGCGAC -3'
(R):5'- TCACTGGGAGGAACTGAGTG -3'

Sequencing Primer
(F):5'- GACCAGCCATTGACCTGATG -3'
(R):5'- TTGGTGGCAATGGCTATAGATC -3'
Posted On 2015-09-24