Incidental Mutation 'R4583:Chd6'
| ID |
343789 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Chd6
|
| Ensembl Gene |
ENSMUSG00000057133 |
| Gene Name |
chromodomain helicase DNA binding protein 6 |
| Synonyms |
6330406J24Rik, 5430439G14Rik |
| MMRRC Submission |
041804-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.755)
|
| Stock # |
R4583 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
160946978-161109075 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 161014194 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 715
(E715G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000042291
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039782]
[ENSMUST00000134178]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000039782
AA Change: E715G
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000042291
Gene: ENSMUSG00000057133
AA Change: E715G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
214 |
229 |
N/A |
INTRINSIC |
|
CHROMO
|
289 |
355 |
1.35e-4 |
SMART |
|
CHROMO
|
372 |
430 |
3.48e-7 |
SMART |
|
DEXDc
|
456 |
658 |
1.73e-39 |
SMART |
|
HELICc
|
812 |
896 |
3.84e-23 |
SMART |
|
low complexity region
|
1080 |
1094 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1108 |
1153 |
4e-23 |
BLAST |
|
SANT
|
1445 |
1504 |
1.51e0 |
SMART |
|
low complexity region
|
1866 |
1875 |
N/A |
INTRINSIC |
|
low complexity region
|
2048 |
2057 |
N/A |
INTRINSIC |
|
low complexity region
|
2130 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2277 |
2290 |
N/A |
INTRINSIC |
|
low complexity region
|
2333 |
2349 |
N/A |
INTRINSIC |
|
low complexity region
|
2437 |
2446 |
N/A |
INTRINSIC |
|
low complexity region
|
2539 |
2563 |
N/A |
INTRINSIC |
|
low complexity region
|
2652 |
2659 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000134178
AA Change: E714G
PolyPhen 2
Score 0.616 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000123240
Gene: ENSMUSG00000057133
AA Change: E714G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
86 |
106 |
N/A |
INTRINSIC |
|
low complexity region
|
113 |
143 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
228 |
N/A |
INTRINSIC |
|
CHROMO
|
288 |
354 |
1.35e-4 |
SMART |
|
CHROMO
|
371 |
429 |
3.48e-7 |
SMART |
|
DEXDc
|
455 |
657 |
1.73e-39 |
SMART |
|
HELICc
|
811 |
895 |
3.84e-23 |
SMART |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
1107 |
1152 |
4e-23 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137831
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138078
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a member of the chromodomain/helicase/DNA-binding domain family of chromatin remodeling enzymes. This protein has been found to be specifically involved in transcription initiation and elongation. Homozygous knockout mice exhibit impaired motor coordination. A pseudogene has been identified on chromosome 8. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygous null mice display impaired coordination that is not due to muscle weakness or bradykinesia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 119 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
T |
C |
7: 27,574,592 (GRCm38) |
L86P |
unknown |
Het |
| Aimp1 |
C |
T |
3: 132,677,047 (GRCm38) |
E23K |
probably damaging |
Het |
| Ap2b1 |
A |
T |
11: 83,397,779 (GRCm38) |
N884I |
probably benign |
Het |
| Apoe |
G |
T |
7: 19,697,498 (GRCm38) |
Q65K |
possibly damaging |
Het |
| Arhgef1 |
T |
A |
7: 24,912,571 (GRCm38) |
D93E |
probably benign |
Het |
| Arhgef12 |
G |
T |
9: 42,977,662 (GRCm38) |
T1085K |
probably damaging |
Het |
| Arid5a |
T |
C |
1: 36,317,664 (GRCm38) |
|
probably null |
Het |
| Atp9a |
A |
T |
2: 168,689,360 (GRCm38) |
|
probably null |
Het |
| Baz1a |
T |
C |
12: 54,922,540 (GRCm38) |
I635V |
probably damaging |
Het |
| Bbs10 |
A |
G |
10: 111,301,134 (GRCm38) |
K703E |
probably benign |
Het |
| Cckar |
T |
A |
5: 53,699,782 (GRCm38) |
M429L |
probably benign |
Het |
| Ccl3 |
A |
T |
11: 83,648,338 (GRCm38) |
L65Q |
probably benign |
Het |
| Ccr3 |
A |
G |
9: 124,029,440 (GRCm38) |
T271A |
probably benign |
Het |
| Cd8b1 |
T |
A |
6: 71,326,097 (GRCm38) |
I52N |
probably damaging |
Het |
| Cdh15 |
G |
A |
8: 122,865,028 (GRCm38) |
E551K |
probably damaging |
Het |
| Cdh17 |
A |
G |
4: 11,810,466 (GRCm38) |
K719R |
probably benign |
Het |
| Cfap43 |
T |
C |
19: 47,837,216 (GRCm38) |
R38G |
probably null |
Het |
| Cldn34b2 |
T |
A |
X: 155,125,629 (GRCm38) |
R68* |
probably null |
Het |
| Col19a1 |
T |
G |
1: 24,561,329 (GRCm38) |
D44A |
unknown |
Het |
| Colgalt2 |
C |
T |
1: 152,506,876 (GRCm38) |
S493F |
probably damaging |
Het |
| Cr1l |
T |
C |
1: 195,129,831 (GRCm38) |
I99M |
probably damaging |
Het |
| Crybg1 |
T |
C |
10: 43,997,620 (GRCm38) |
E1164G |
probably damaging |
Het |
| Cym |
G |
T |
3: 107,211,402 (GRCm38) |
D367E |
probably damaging |
Het |
| Dennd2a |
G |
T |
6: 39,522,842 (GRCm38) |
T263K |
probably damaging |
Het |
| Dhx9 |
T |
A |
1: 153,460,303 (GRCm38) |
M869L |
probably damaging |
Het |
| Dnm2 |
A |
G |
9: 21,504,446 (GRCm38) |
H692R |
probably damaging |
Het |
| Ern1 |
A |
T |
11: 106,407,205 (GRCm38) |
S697T |
probably damaging |
Het |
| F12 |
G |
A |
13: 55,421,130 (GRCm38) |
T273I |
probably benign |
Het |
| Fam151b |
A |
T |
13: 92,468,109 (GRCm38) |
L124Q |
probably damaging |
Het |
| Fancg |
A |
G |
4: 43,002,991 (GRCm38) |
V622A |
probably benign |
Het |
| Fbxo2 |
T |
A |
4: 148,164,899 (GRCm38) |
N159K |
possibly damaging |
Het |
| Fgd2 |
C |
A |
17: 29,367,078 (GRCm38) |
T212K |
possibly damaging |
Het |
| Fhl3 |
T |
A |
4: 124,707,549 (GRCm38) |
D178E |
probably benign |
Het |
| Filip1 |
G |
T |
9: 79,815,809 (GRCm38) |
A1176D |
possibly damaging |
Het |
| Fndc1 |
T |
C |
17: 7,739,249 (GRCm38) |
Y1722C |
probably damaging |
Het |
| Frem3 |
T |
C |
8: 80,613,514 (GRCm38) |
V812A |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,978,673 (GRCm38) |
I1779V |
probably benign |
Het |
| Gli2 |
C |
T |
1: 118,842,068 (GRCm38) |
V585I |
probably benign |
Het |
| Gm15056 |
C |
G |
8: 20,900,681 (GRCm38) |
S80T |
probably benign |
Het |
| Gm4951 |
T |
C |
18: 60,246,080 (GRCm38) |
I229T |
possibly damaging |
Het |
| Gm5145 |
A |
G |
17: 20,570,453 (GRCm38) |
E31G |
probably benign |
Het |
| Gmfg |
A |
G |
7: 28,445,944 (GRCm38) |
Y71C |
probably damaging |
Het |
| Grk1 |
A |
G |
8: 13,409,322 (GRCm38) |
E291G |
probably damaging |
Het |
| Gtpbp1 |
A |
G |
15: 79,715,951 (GRCm38) |
E393G |
possibly damaging |
Het |
| Gtpbp2 |
A |
G |
17: 46,161,145 (GRCm38) |
D2G |
probably damaging |
Het |
| Hc |
A |
T |
2: 35,028,177 (GRCm38) |
V698E |
probably benign |
Het |
| Helz |
G |
A |
11: 107,646,069 (GRCm38) |
R249H |
probably damaging |
Het |
| Hmcn2 |
A |
G |
2: 31,413,265 (GRCm38) |
I2973V |
possibly damaging |
Het |
| Hnrnpa3 |
A |
G |
2: 75,663,606 (GRCm38) |
R286G |
probably benign |
Het |
| Hus1b |
A |
T |
13: 30,947,518 (GRCm38) |
W53R |
probably damaging |
Het |
| Hydin |
C |
T |
8: 110,595,225 (GRCm38) |
T4503I |
probably benign |
Het |
| Ighmbp2 |
G |
C |
19: 3,265,324 (GRCm38) |
P699A |
probably benign |
Het |
| Igkv1-122 |
A |
T |
6: 68,017,458 (GRCm38) |
Y110F |
probably benign |
Het |
| Igkv8-28 |
T |
C |
6: 70,143,620 (GRCm38) |
Y113C |
probably damaging |
Het |
| Il16 |
A |
G |
7: 83,682,899 (GRCm38) |
S158P |
probably damaging |
Het |
| Kalrn |
T |
A |
16: 34,235,267 (GRCm38) |
H876L |
probably damaging |
Het |
| Kdm5d |
T |
A |
Y: 914,134 (GRCm38) |
L357H |
probably damaging |
Het |
| Krt78 |
T |
C |
15: 101,946,620 (GRCm38) |
T919A |
possibly damaging |
Het |
| L3mbtl2 |
T |
C |
15: 81,684,906 (GRCm38) |
C594R |
probably damaging |
Het |
| Lcorl |
A |
T |
5: 45,733,589 (GRCm38) |
L474* |
probably null |
Het |
| Lgals3 |
A |
T |
14: 47,381,687 (GRCm38) |
|
probably null |
Het |
| Lnx1 |
C |
T |
5: 74,610,796 (GRCm38) |
V350I |
probably benign |
Het |
| Lpcat3 |
T |
G |
6: 124,703,323 (GRCm38) |
W429G |
possibly damaging |
Het |
| Lrp1 |
T |
C |
10: 127,541,372 (GRCm38) |
T4149A |
probably benign |
Het |
| Memo1 |
G |
A |
17: 74,258,461 (GRCm38) |
Q36* |
probably null |
Het |
| Micalcl |
A |
G |
7: 112,412,947 (GRCm38) |
N668S |
probably benign |
Het |
| Ms4a10 |
A |
T |
19: 10,968,189 (GRCm38) |
I76N |
possibly damaging |
Het |
| Mthfr |
T |
G |
4: 148,051,872 (GRCm38) |
L362V |
possibly damaging |
Het |
| Myh3 |
T |
A |
11: 67,096,453 (GRCm38) |
Y1376* |
probably null |
Het |
| Mymk |
C |
A |
2: 27,062,280 (GRCm38) |
V192F |
probably benign |
Het |
| Myo1c |
A |
G |
11: 75,671,862 (GRCm38) |
D966G |
possibly damaging |
Het |
| Ncam2 |
A |
G |
16: 81,517,557 (GRCm38) |
N474D |
probably damaging |
Het |
| Nmnat1 |
T |
C |
4: 149,469,151 (GRCm38) |
N168S |
possibly damaging |
Het |
| Nmur1 |
C |
T |
1: 86,386,645 (GRCm38) |
V323M |
possibly damaging |
Het |
| Npr2 |
C |
A |
4: 43,633,522 (GRCm38) |
|
probably null |
Het |
| Nsd3 |
T |
A |
8: 25,710,676 (GRCm38) |
M1265K |
probably benign |
Het |
| Olfr1206 |
G |
T |
2: 88,865,494 (GRCm38) |
M296I |
probably benign |
Het |
| Olfr1212 |
T |
A |
2: 88,959,212 (GRCm38) |
F249I |
probably damaging |
Het |
| Olfr1462 |
T |
A |
19: 13,190,698 (GRCm38) |
F10L |
probably damaging |
Het |
| Olfr152 |
T |
C |
2: 87,783,221 (GRCm38) |
V227A |
possibly damaging |
Het |
| Olfr155 |
A |
G |
4: 43,855,262 (GRCm38) |
T318A |
probably benign |
Het |
| Olfr345 |
A |
C |
2: 36,640,614 (GRCm38) |
T192P |
probably damaging |
Het |
| Olfr394 |
T |
C |
11: 73,887,803 (GRCm38) |
T190A |
probably damaging |
Het |
| Olfr812 |
T |
C |
10: 129,842,475 (GRCm38) |
D189G |
probably damaging |
Het |
| Otub1 |
G |
A |
19: 7,204,436 (GRCm38) |
A25V |
possibly damaging |
Het |
| Paqr3 |
T |
A |
5: 97,108,210 (GRCm38) |
R102* |
probably null |
Het |
| Patl2 |
A |
G |
2: 122,126,745 (GRCm38) |
S103P |
probably benign |
Het |
| Pcdhb15 |
A |
T |
18: 37,475,575 (GRCm38) |
H620L |
possibly damaging |
Het |
| Pdgfc |
A |
T |
3: 81,141,528 (GRCm38) |
D81V |
possibly damaging |
Het |
| Pdia2 |
T |
C |
17: 26,196,502 (GRCm38) |
D447G |
probably damaging |
Het |
| Pold1 |
C |
A |
7: 44,538,913 (GRCm38) |
A514S |
probably damaging |
Het |
| Pomgnt1 |
C |
T |
4: 116,158,494 (GRCm38) |
T552I |
probably benign |
Het |
| Ppl |
T |
C |
16: 5,104,536 (GRCm38) |
E294G |
probably benign |
Het |
| Pramef8 |
A |
G |
4: 143,416,754 (GRCm38) |
Y30C |
probably damaging |
Het |
| Prkcb |
A |
G |
7: 122,457,224 (GRCm38) |
S100G |
probably benign |
Het |
| Psg16 |
T |
G |
7: 17,095,172 (GRCm38) |
I227S |
probably benign |
Het |
| Rbbp6 |
AAAGAAGAAGAAGAAGAAG |
AAAGAAGAAGAAGAAG |
7: 123,001,952 (GRCm38) |
|
probably benign |
Het |
| Reck |
T |
C |
4: 43,931,062 (GRCm38) |
|
probably null |
Het |
| Rrbp1 |
C |
T |
2: 143,988,751 (GRCm38) |
G499S |
probably benign |
Het |
| Sema6d |
G |
T |
2: 124,664,162 (GRCm38) |
R630L |
probably damaging |
Het |
| Slc29a1 |
A |
G |
17: 45,589,956 (GRCm38) |
V94A |
possibly damaging |
Het |
| Slc35a1 |
T |
A |
4: 34,664,146 (GRCm38) |
Q324L |
probably benign |
Het |
| Slc35c1 |
A |
T |
2: 92,458,921 (GRCm38) |
L80Q |
probably damaging |
Het |
| Slc7a10 |
G |
T |
7: 35,197,952 (GRCm38) |
|
probably null |
Het |
| Srrm2 |
C |
T |
17: 23,819,619 (GRCm38) |
|
probably benign |
Het |
| Stk38 |
T |
G |
17: 28,982,156 (GRCm38) |
D182A |
probably damaging |
Het |
| Tas2r104 |
C |
T |
6: 131,685,435 (GRCm38) |
G104S |
probably benign |
Het |
| Tmem121b |
T |
C |
6: 120,492,094 (GRCm38) |
E554G |
probably damaging |
Het |
| Tor1aip2 |
A |
G |
1: 156,065,142 (GRCm38) |
H398R |
probably benign |
Het |
| Tram2 |
C |
T |
1: 21,013,449 (GRCm38) |
V83I |
probably benign |
Het |
| Ube3a |
C |
T |
7: 59,286,063 (GRCm38) |
T565I |
probably damaging |
Het |
| Ubr4 |
T |
C |
4: 139,380,853 (GRCm38) |
V56A |
possibly damaging |
Het |
| Vmn1r128 |
T |
C |
7: 21,349,719 (GRCm38) |
V116A |
possibly damaging |
Het |
| Vmn1r170 |
C |
T |
7: 23,606,662 (GRCm38) |
T163I |
probably benign |
Het |
| Vmn2r75 |
T |
A |
7: 86,164,082 (GRCm38) |
D504V |
possibly damaging |
Het |
| Vps36 |
G |
A |
8: 22,218,420 (GRCm38) |
M363I |
probably benign |
Het |
| Wdsub1 |
A |
G |
2: 59,878,317 (GRCm38) |
S71P |
probably damaging |
Het |
| Zdhhc12 |
A |
G |
2: 30,091,484 (GRCm38) |
F189L |
probably benign |
Het |
| Zfp521 |
T |
C |
18: 13,844,330 (GRCm38) |
M1009V |
probably benign |
Het |
|
| Other mutations in Chd6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00837:Chd6
|
APN |
2 |
161,042,079 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL00899:Chd6
|
APN |
2 |
161,029,298 (GRCm38) |
splice site |
probably benign |
|
|
IGL01104:Chd6
|
APN |
2 |
160,961,927 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01295:Chd6
|
APN |
2 |
160,988,370 (GRCm38) |
splice site |
probably benign |
|
|
IGL01717:Chd6
|
APN |
2 |
160,965,259 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL01795:Chd6
|
APN |
2 |
160,961,374 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01814:Chd6
|
APN |
2 |
161,059,929 (GRCm38) |
missense |
probably benign |
0.25 |
|
IGL02016:Chd6
|
APN |
2 |
160,983,678 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02104:Chd6
|
APN |
2 |
160,977,512 (GRCm38) |
missense |
probably benign |
|
|
IGL02158:Chd6
|
APN |
2 |
161,026,292 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL02313:Chd6
|
APN |
2 |
160,965,675 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02472:Chd6
|
APN |
2 |
160,984,452 (GRCm38) |
splice site |
probably benign |
|
|
IGL02522:Chd6
|
APN |
2 |
160,965,796 (GRCm38) |
missense |
probably benign |
0.30 |
|
IGL02626:Chd6
|
APN |
2 |
161,039,350 (GRCm38) |
splice site |
probably benign |
|
|
IGL02727:Chd6
|
APN |
2 |
160,969,463 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02738:Chd6
|
APN |
2 |
160,965,698 (GRCm38) |
missense |
probably benign |
0.45 |
|
IGL02743:Chd6
|
APN |
2 |
160,960,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02800:Chd6
|
APN |
2 |
160,984,632 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02811:Chd6
|
APN |
2 |
160,990,301 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02850:Chd6
|
APN |
2 |
161,019,616 (GRCm38) |
nonsense |
probably null |
|
|
IGL02979:Chd6
|
APN |
2 |
160,966,170 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02993:Chd6
|
APN |
2 |
161,052,384 (GRCm38) |
splice site |
probably benign |
|
|
IGL03277:Chd6
|
APN |
2 |
160,983,061 (GRCm38) |
missense |
probably null |
1.00 |
|
IGL03346:Chd6
|
APN |
2 |
160,960,362 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03357:Chd6
|
APN |
2 |
161,018,016 (GRCm38) |
splice site |
probably benign |
|
|
IGL03134:Chd6
|
UTSW |
2 |
160,965,483 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R0106:Chd6
|
UTSW |
2 |
160,967,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0106:Chd6
|
UTSW |
2 |
160,967,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0212:Chd6
|
UTSW |
2 |
161,052,847 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0363:Chd6
|
UTSW |
2 |
161,014,324 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0399:Chd6
|
UTSW |
2 |
161,052,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0511:Chd6
|
UTSW |
2 |
160,992,191 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0771:Chd6
|
UTSW |
2 |
161,019,580 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,990,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1147:Chd6
|
UTSW |
2 |
160,990,271 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1184:Chd6
|
UTSW |
2 |
161,030,802 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1277:Chd6
|
UTSW |
2 |
160,967,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1396:Chd6
|
UTSW |
2 |
160,983,103 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1647:Chd6
|
UTSW |
2 |
161,042,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1648:Chd6
|
UTSW |
2 |
161,042,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1745:Chd6
|
UTSW |
2 |
160,981,667 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1766:Chd6
|
UTSW |
2 |
160,966,639 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1871:Chd6
|
UTSW |
2 |
160,990,256 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1928:Chd6
|
UTSW |
2 |
160,968,000 (GRCm38) |
splice site |
probably benign |
|
|
R1973:Chd6
|
UTSW |
2 |
160,966,387 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2200:Chd6
|
UTSW |
2 |
160,983,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2340:Chd6
|
UTSW |
2 |
160,965,759 (GRCm38) |
frame shift |
probably null |
|
|
R2341:Chd6
|
UTSW |
2 |
160,965,759 (GRCm38) |
frame shift |
probably null |
|
|
R2519:Chd6
|
UTSW |
2 |
161,029,876 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R2919:Chd6
|
UTSW |
2 |
160,967,880 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R3025:Chd6
|
UTSW |
2 |
160,966,552 (GRCm38) |
small deletion |
probably benign |
|
|
R3426:Chd6
|
UTSW |
2 |
160,990,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3427:Chd6
|
UTSW |
2 |
160,990,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4042:Chd6
|
UTSW |
2 |
160,988,333 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4273:Chd6
|
UTSW |
2 |
160,961,291 (GRCm38) |
missense |
probably benign |
0.04 |
|
R4360:Chd6
|
UTSW |
2 |
160,949,856 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R4399:Chd6
|
UTSW |
2 |
160,965,318 (GRCm38) |
missense |
probably benign |
|
|
R4458:Chd6
|
UTSW |
2 |
161,029,876 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
R4625:Chd6
|
UTSW |
2 |
160,969,492 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4740:Chd6
|
UTSW |
2 |
160,970,183 (GRCm38) |
missense |
probably benign |
|
|
R4765:Chd6
|
UTSW |
2 |
160,966,244 (GRCm38) |
nonsense |
probably null |
|
|
R4779:Chd6
|
UTSW |
2 |
160,949,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4877:Chd6
|
UTSW |
2 |
161,029,299 (GRCm38) |
splice site |
probably benign |
|
|
R5068:Chd6
|
UTSW |
2 |
160,966,369 (GRCm38) |
missense |
possibly damaging |
0.54 |
|
R5215:Chd6
|
UTSW |
2 |
160,949,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5275:Chd6
|
UTSW |
2 |
160,969,363 (GRCm38) |
missense |
probably benign |
|
|
R5405:Chd6
|
UTSW |
2 |
160,965,390 (GRCm38) |
missense |
probably benign |
|
|
R5598:Chd6
|
UTSW |
2 |
161,014,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5693:Chd6
|
UTSW |
2 |
160,965,265 (GRCm38) |
missense |
probably benign |
|
|
R5697:Chd6
|
UTSW |
2 |
161,018,051 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5715:Chd6
|
UTSW |
2 |
160,949,878 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5759:Chd6
|
UTSW |
2 |
160,983,762 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R5761:Chd6
|
UTSW |
2 |
160,957,079 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5761:Chd6
|
UTSW |
2 |
160,957,078 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5954:Chd6
|
UTSW |
2 |
160,965,827 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6025:Chd6
|
UTSW |
2 |
160,965,582 (GRCm38) |
missense |
probably benign |
|
|
R6104:Chd6
|
UTSW |
2 |
161,014,132 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6247:Chd6
|
UTSW |
2 |
160,950,048 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6393:Chd6
|
UTSW |
2 |
160,979,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6452:Chd6
|
UTSW |
2 |
160,965,498 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R6468:Chd6
|
UTSW |
2 |
161,013,067 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6784:Chd6
|
UTSW |
2 |
160,966,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6803:Chd6
|
UTSW |
2 |
160,960,359 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
R6869:Chd6
|
UTSW |
2 |
160,965,730 (GRCm38) |
missense |
probably benign |
|
|
R6895:Chd6
|
UTSW |
2 |
160,988,340 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6925:Chd6
|
UTSW |
2 |
161,013,127 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7061:Chd6
|
UTSW |
2 |
161,025,965 (GRCm38) |
nonsense |
probably null |
|
|
R7064:Chd6
|
UTSW |
2 |
160,950,063 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7248:Chd6
|
UTSW |
2 |
160,961,279 (GRCm38) |
nonsense |
probably null |
|
|
R7287:Chd6
|
UTSW |
2 |
161,008,392 (GRCm38) |
missense |
probably benign |
0.07 |
|
R7431:Chd6
|
UTSW |
2 |
161,026,328 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7486:Chd6
|
UTSW |
2 |
160,950,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7509:Chd6
|
UTSW |
2 |
161,013,154 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7699:Chd6
|
UTSW |
2 |
161,025,943 (GRCm38) |
missense |
probably benign |
0.13 |
|
R7748:Chd6
|
UTSW |
2 |
160,966,619 (GRCm38) |
missense |
probably benign |
0.37 |
|
R7785:Chd6
|
UTSW |
2 |
160,970,175 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R8002:Chd6
|
UTSW |
2 |
160,990,321 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8261:Chd6
|
UTSW |
2 |
160,957,082 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8317:Chd6
|
UTSW |
2 |
160,990,321 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8388:Chd6
|
UTSW |
2 |
161,019,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8865:Chd6
|
UTSW |
2 |
161,021,069 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8867:Chd6
|
UTSW |
2 |
161,021,069 (GRCm38) |
missense |
probably benign |
0.10 |
|
R8996:Chd6
|
UTSW |
2 |
160,981,623 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9091:Chd6
|
UTSW |
2 |
161,029,873 (GRCm38) |
nonsense |
probably null |
|
|
R9270:Chd6
|
UTSW |
2 |
161,029,873 (GRCm38) |
nonsense |
probably null |
|
|
R9310:Chd6
|
UTSW |
2 |
161,039,261 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9367:Chd6
|
UTSW |
2 |
161,029,864 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9438:Chd6
|
UTSW |
2 |
160,957,158 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9756:Chd6
|
UTSW |
2 |
160,960,339 (GRCm38) |
missense |
probably benign |
|
|
Z1088:Chd6
|
UTSW |
2 |
160,966,488 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATCAACCTCTCTGAAGCTCTG -3'
(R):5'- TGGGGCAAATAAATGGCTTTCC -3'
Sequencing Primer
(F):5'- GCAAACAGGCCTTTCTTATTACTAGC -3'
(R):5'- GGGGCAAATAAATGGCTTTCCTTTTC -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation