Incidental Mutation 'R4585:Ralgapa2'
| ID |
343990 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
041806-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.250)
|
| Stock # |
R4585 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 146156944 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 1882
(D1882E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153734
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000109986
AA Change: D1835E
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: D1835E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000131824
AA Change: D1797E
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: D1797E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000146307
AA Change: M830K
|
| SMART Domains |
Protein: ENSMUSP00000114547
Gene: ENSMUSG00000037110
AA Change: M830K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
285 |
290 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
690 |
830 |
4.9e-39 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000149499
AA Change: D1467E
|
| SMART Domains |
Protein: ENSMUSP00000122017
Gene: ENSMUSG00000037110
AA Change: D1467E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
650 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
934 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1334 |
1511 |
2.4e-48 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000228797
AA Change: D1882E
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| Meta Mutation Damage Score |
0.1884 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
99% (90/91) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akap9 |
T |
C |
5: 4,026,151 (GRCm39) |
S1269P |
probably benign |
Het |
| Akr7a5 |
G |
T |
4: 139,038,238 (GRCm39) |
R58L |
probably benign |
Het |
| Art2a |
A |
T |
7: 101,203,956 (GRCm39) |
L194* |
probably null |
Het |
| Aurkaip1 |
C |
A |
4: 155,917,091 (GRCm39) |
A113D |
possibly damaging |
Het |
| Bsn |
T |
C |
9: 107,987,662 (GRCm39) |
|
probably benign |
Het |
| Ccdc175 |
T |
G |
12: 72,221,953 (GRCm39) |
D123A |
possibly damaging |
Het |
| Ccdc7b |
A |
G |
8: 129,837,401 (GRCm39) |
T131A |
probably benign |
Het |
| Ccnt2 |
T |
C |
1: 127,730,766 (GRCm39) |
S548P |
probably damaging |
Het |
| Cep126 |
T |
C |
9: 8,103,338 (GRCm39) |
Q224R |
probably damaging |
Het |
| Cic |
A |
T |
7: 24,972,203 (GRCm39) |
I645L |
probably benign |
Het |
| Cngb1 |
C |
T |
8: 96,023,756 (GRCm39) |
|
probably null |
Het |
| Col13a1 |
T |
C |
10: 61,723,024 (GRCm39) |
|
probably null |
Het |
| Corin |
A |
T |
5: 72,487,042 (GRCm39) |
V706D |
probably damaging |
Het |
| Crebrf |
A |
G |
17: 26,981,229 (GRCm39) |
K535R |
probably damaging |
Het |
| Cuzd1 |
G |
A |
7: 130,916,529 (GRCm39) |
P310L |
probably damaging |
Het |
| Cxcr5 |
T |
A |
9: 44,425,442 (GRCm39) |
I72F |
probably benign |
Het |
| Dapp1 |
T |
C |
3: 137,644,932 (GRCm39) |
Q148R |
probably benign |
Het |
| Dcaf17 |
T |
A |
2: 70,918,924 (GRCm39) |
S499R |
probably benign |
Het |
| Defb3 |
A |
T |
8: 19,345,172 (GRCm39) |
I43F |
possibly damaging |
Het |
| Dlgap2 |
G |
A |
8: 14,777,999 (GRCm39) |
|
probably null |
Het |
| Dnah8 |
A |
G |
17: 30,970,541 (GRCm39) |
D2684G |
probably benign |
Het |
| Dnajc10 |
T |
G |
2: 80,178,122 (GRCm39) |
F710V |
probably damaging |
Het |
| Ep400 |
G |
A |
5: 110,901,725 (GRCm39) |
T464I |
probably damaging |
Het |
| Epc1 |
G |
A |
18: 6,441,157 (GRCm39) |
Q14* |
probably null |
Het |
| Eral1 |
A |
T |
11: 77,969,130 (GRCm39) |
N123K |
probably damaging |
Het |
| Ercc5 |
G |
A |
1: 44,198,017 (GRCm39) |
V145I |
probably benign |
Het |
| Evc |
A |
G |
5: 37,481,057 (GRCm39) |
S263P |
probably damaging |
Het |
| Fancc |
A |
T |
13: 63,495,378 (GRCm39) |
M182K |
probably benign |
Het |
| Fbxl3 |
G |
T |
14: 103,320,526 (GRCm39) |
A355E |
probably damaging |
Het |
| Glra3 |
C |
A |
8: 56,542,028 (GRCm39) |
T257K |
probably damaging |
Het |
| Gm12789 |
A |
G |
4: 101,847,159 (GRCm39) |
Y148C |
possibly damaging |
Het |
| Gm14393 |
C |
A |
2: 174,904,497 (GRCm39) |
|
probably benign |
Het |
| Gm19965 |
T |
A |
1: 116,749,508 (GRCm39) |
N396K |
probably benign |
Het |
| Gm27013 |
A |
T |
6: 130,498,003 (GRCm39) |
|
noncoding transcript |
Het |
| Gmcl1 |
A |
G |
6: 86,699,605 (GRCm39) |
S141P |
probably damaging |
Het |
| Gsdmd |
T |
A |
15: 75,737,600 (GRCm39) |
|
probably null |
Het |
| Gtf2a1 |
C |
T |
12: 91,529,700 (GRCm39) |
V338I |
possibly damaging |
Het |
| H2ac15 |
T |
C |
13: 21,937,882 (GRCm39) |
N39S |
possibly damaging |
Het |
| Hap1 |
G |
A |
11: 100,245,550 (GRCm39) |
T138M |
probably benign |
Het |
| Ints2 |
G |
T |
11: 86,140,101 (GRCm39) |
R244S |
probably damaging |
Het |
| Itgb4 |
T |
C |
11: 115,884,151 (GRCm39) |
V945A |
probably damaging |
Het |
| Itih2 |
C |
T |
2: 10,115,211 (GRCm39) |
S387N |
probably benign |
Het |
| Klra2 |
T |
A |
6: 131,207,120 (GRCm39) |
D163V |
probably benign |
Het |
| Lctl |
T |
C |
9: 64,038,882 (GRCm39) |
S324P |
probably damaging |
Het |
| Lrrc24 |
C |
A |
15: 76,607,889 (GRCm39) |
R43L |
probably damaging |
Het |
| Mogs |
G |
T |
6: 83,095,619 (GRCm39) |
R812L |
possibly damaging |
Het |
| Mroh5 |
T |
A |
15: 73,661,120 (GRCm39) |
T467S |
probably benign |
Het |
| Mtap |
G |
A |
4: 89,090,511 (GRCm39) |
V194I |
probably benign |
Het |
| Myoz1 |
A |
G |
14: 20,700,663 (GRCm39) |
W185R |
probably damaging |
Het |
| Nufip2 |
T |
C |
11: 77,632,554 (GRCm39) |
V690A |
unknown |
Het |
| Obox1 |
A |
T |
7: 15,290,152 (GRCm39) |
N165I |
possibly damaging |
Het |
| Or1j1 |
C |
T |
2: 36,702,537 (GRCm39) |
C189Y |
probably damaging |
Het |
| Or4b1d |
T |
A |
2: 89,968,558 (GRCm39) |
E308D |
probably benign |
Het |
| Or4c113 |
T |
G |
2: 88,885,498 (GRCm39) |
I91L |
possibly damaging |
Het |
| Or6c35 |
A |
G |
10: 129,169,142 (GRCm39) |
T131A |
probably benign |
Het |
| Pabpc6 |
A |
G |
17: 9,888,002 (GRCm39) |
L183P |
probably damaging |
Het |
| Pcdh15 |
C |
T |
10: 74,460,116 (GRCm39) |
R1355W |
probably damaging |
Het |
| Pcdhgb8 |
C |
A |
18: 37,895,413 (GRCm39) |
A161E |
probably benign |
Het |
| Pex1 |
A |
G |
5: 3,683,885 (GRCm39) |
Y1127C |
probably damaging |
Het |
| Phc2 |
A |
T |
4: 128,637,303 (GRCm39) |
H563L |
probably damaging |
Het |
| Plekha2 |
C |
A |
8: 25,533,685 (GRCm39) |
E291* |
probably null |
Het |
| Qser1 |
C |
A |
2: 104,617,138 (GRCm39) |
V1225L |
probably benign |
Het |
| Rgs17 |
T |
C |
10: 5,792,596 (GRCm39) |
D70G |
probably benign |
Het |
| Runx1t1 |
A |
T |
4: 13,889,864 (GRCm39) |
T598S |
unknown |
Het |
| Scn2a |
T |
A |
2: 65,573,395 (GRCm39) |
|
probably null |
Het |
| Serpinb10 |
T |
A |
1: 107,474,779 (GRCm39) |
C314S |
probably benign |
Het |
| Setbp1 |
A |
C |
18: 79,130,164 (GRCm39) |
S23A |
probably benign |
Het |
| Sh3pxd2b |
A |
G |
11: 32,346,479 (GRCm39) |
D116G |
possibly damaging |
Het |
| Slc4a1 |
G |
T |
11: 102,252,245 (GRCm39) |
|
probably benign |
Het |
| Snx19 |
T |
C |
9: 30,351,491 (GRCm39) |
L155P |
probably damaging |
Het |
| Sox2 |
A |
G |
3: 34,705,193 (GRCm39) |
N210S |
probably benign |
Het |
| Spag6 |
T |
C |
2: 18,736,958 (GRCm39) |
|
probably null |
Het |
| Speer4b |
A |
T |
5: 27,703,036 (GRCm39) |
L154Q |
probably null |
Het |
| Strn3 |
T |
A |
12: 51,696,953 (GRCm39) |
E259D |
probably benign |
Het |
| Tenm1 |
G |
A |
X: 41,626,856 (GRCm39) |
Q1931* |
probably null |
Het |
| Trp53bp1 |
C |
G |
2: 121,038,432 (GRCm39) |
G1469R |
probably damaging |
Het |
| Ttc8 |
C |
A |
12: 98,948,789 (GRCm39) |
Q492K |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,798,747 (GRCm39) |
H509R |
probably benign |
Het |
| Utrn |
T |
A |
10: 12,564,050 (GRCm39) |
H1270L |
probably benign |
Het |
| Vopp1 |
G |
A |
6: 57,731,533 (GRCm39) |
P153S |
probably damaging |
Het |
| Wdfy4 |
T |
A |
14: 32,809,912 (GRCm39) |
I1770F |
possibly damaging |
Het |
| Zfp14 |
G |
T |
7: 29,738,341 (GRCm39) |
Q215K |
probably damaging |
Het |
| Zfp473 |
A |
T |
7: 44,382,376 (GRCm39) |
Y651* |
probably null |
Het |
| Zfp735 |
G |
T |
11: 73,580,550 (GRCm39) |
E16D |
possibly damaging |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1905:Ralgapa2
|
UTSW |
2 |
146,229,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1956:Ralgapa2
|
UTSW |
2 |
146,302,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4627:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4760:Ralgapa2
|
UTSW |
2 |
146,188,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7371:Ralgapa2
|
UTSW |
2 |
146,189,046 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAAACAGTACTGCAGCCTGG -3'
(R):5'- TGCTCTTTGACTTGAAAGCCC -3'
Sequencing Primer
(F):5'- GCCCACTTACCTCTCCTGAAAG -3'
(R):5'- TGACTTGAAAGCCCTCAACTTG -3'
|
| Posted On |
2015-09-24 |
Incidental Mutation