Incidental Mutation 'R0064:Fbxw14'
ID 34411
Institutional Source Beutler Lab
Gene Symbol Fbxw14
Ensembl Gene ENSMUSG00000105589
Gene Name F-box and WD-40 domain protein 14
Synonyms Fbxo12, E330009N23Rik, Fbx12
MMRRC Submission 038356-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # R0064 (G1)
Quality Score 174
Status Validated
Chromosome 9
Chromosomal Location 109099858-109116744 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 109116660 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 16 (Y16*)
Ref Sequence ENSEMBL: ENSMUSP00000143404 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112041] [ENSMUST00000198844] [ENSMUST00000198928]
AlphaFold Q8C2Y5
Predicted Effect probably null
Transcript: ENSMUST00000066901
AA Change: Y16*
SMART Domains Protein: ENSMUSP00000066613
Gene: ENSMUSG00000054087
AA Change: Y16*

DomainStartEndE-ValueType
FBOX 5 45 3.13e-6 SMART
SCOP:d1tbga_ 114 249 4e-9 SMART
Blast:WD40 136 175 3e-6 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000112041
AA Change: Y16*
SMART Domains Protein: ENSMUSP00000107672
Gene: ENSMUSG00000105589
AA Change: Y16*

DomainStartEndE-ValueType
FBOX 5 45 3.13e-6 SMART
SCOP:d1tbga_ 114 208 2e-3 SMART
Blast:WD40 136 175 4e-6 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000198844
AA Change: Y16*
SMART Domains Protein: ENSMUSP00000143404
Gene: ENSMUSG00000105589
AA Change: Y16*

DomainStartEndE-ValueType
FBOX 5 45 3.13e-6 SMART
SCOP:d1tbga_ 114 249 4e-9 SMART
Blast:WD40 136 175 3e-6 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000198928
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.0%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 G T 11: 110,035,698 (GRCm39) L641M probably damaging Het
Abca9 A C 11: 110,035,697 (GRCm39) L641R probably damaging Het
Abhd18 A G 3: 40,888,288 (GRCm39) I377M probably benign Het
Arhgef17 C A 7: 100,530,561 (GRCm39) M1408I probably benign Het
Bcl2a1a G C 9: 88,839,516 (GRCm39) G138A probably damaging Het
C4b A G 17: 34,957,830 (GRCm39) L617P probably damaging Het
Ccdc25 T A 14: 66,091,561 (GRCm39) I60K possibly damaging Het
Cdk1 T C 10: 69,180,907 (GRCm39) D101G probably benign Het
Cdon A G 9: 35,400,523 (GRCm39) H1079R probably benign Het
Cep126 A T 9: 8,130,183 (GRCm39) probably benign Het
Cic T A 7: 24,986,565 (GRCm39) S1299T probably damaging Het
Cic C A 7: 24,986,566 (GRCm39) S1299Y probably damaging Het
Clstn1 G A 4: 149,719,253 (GRCm39) V361M probably damaging Het
Crlf3 A G 11: 79,948,728 (GRCm39) I239T possibly damaging Het
Cstf2t T A 19: 31,060,699 (GRCm39) N78K probably damaging Het
Cul1 A G 6: 47,479,349 (GRCm39) probably benign Het
D430041D05Rik T G 2: 104,079,502 (GRCm39) T1194P probably damaging Het
Fbp2 A T 13: 63,001,862 (GRCm39) F118I probably damaging Het
Fgd3 T G 13: 49,449,901 (GRCm39) D116A possibly damaging Het
Gm7168 C T 17: 14,170,121 (GRCm39) T496I probably benign Het
Hsh2d G A 8: 72,954,304 (GRCm39) D229N probably benign Het
Klhl5 T A 5: 65,298,631 (GRCm39) S137T probably benign Het
Knl1 T A 2: 118,906,724 (GRCm39) N1604K probably benign Het
Lpcat1 T A 13: 73,662,585 (GRCm39) N463K probably damaging Het
Lpl A G 8: 69,345,356 (GRCm39) H120R probably damaging Het
Man1a2 A T 3: 100,499,199 (GRCm39) S412T possibly damaging Het
Mcc C G 18: 44,652,583 (GRCm39) probably benign Het
Myo18a G T 11: 77,738,170 (GRCm39) R1704L probably damaging Het
Nlrc3 G T 16: 3,781,951 (GRCm39) T486K possibly damaging Het
Nrip1 T A 16: 76,091,558 (GRCm39) probably benign Het
Nutf2 A G 8: 106,605,441 (GRCm39) D92G probably damaging Het
Obscn A C 11: 58,918,292 (GRCm39) V6260G probably damaging Het
Or10a2 T C 7: 106,673,487 (GRCm39) F151L probably benign Het
Or2ak7 G A 11: 58,575,301 (GRCm39) V201M probably benign Het
Plce1 T C 19: 38,769,228 (GRCm39) probably null Het
Pmpca C A 2: 26,285,519 (GRCm39) D498E probably benign Het
Pnpla7 G T 2: 24,887,239 (GRCm39) E28* probably null Het
Polg C A 7: 79,111,632 (GRCm39) W206C probably damaging Het
Ptprt C T 2: 161,769,711 (GRCm39) probably benign Het
Slc7a14 T C 3: 31,281,209 (GRCm39) D367G probably damaging Het
Spata31 T C 13: 65,069,912 (GRCm39) Y687H probably damaging Het
Sybu T A 15: 44,536,389 (GRCm39) T646S probably benign Het
Thbs1 A T 2: 117,954,395 (GRCm39) probably null Het
Tie1 A G 4: 118,346,898 (GRCm39) V2A possibly damaging Het
Tma16 A T 8: 66,929,457 (GRCm39) I179K possibly damaging Het
Tns3 G A 11: 8,385,856 (GRCm39) Q1381* probably null Het
Trank1 A G 9: 111,172,263 (GRCm39) D84G probably damaging Het
Ttc3 A T 16: 94,223,106 (GRCm39) H197L possibly damaging Het
Urb1 A G 16: 90,576,028 (GRCm39) F843L probably benign Het
Vmn1r24 T G 6: 57,933,003 (GRCm39) I172L probably benign Het
Vmn2r1 T A 3: 64,012,209 (GRCm39) I690N possibly damaging Het
Vmn2r111 T A 17: 22,791,053 (GRCm39) I82L probably benign Het
Zfp287 A T 11: 62,605,764 (GRCm39) L370H possibly damaging Het
Zfp608 A T 18: 55,031,888 (GRCm39) I684N probably benign Het
Other mutations in Fbxw14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01319:Fbxw14 APN 9 109,107,859 (GRCm39) missense probably damaging 1.00
IGL01351:Fbxw14 APN 9 109,103,640 (GRCm39) missense possibly damaging 0.47
IGL01654:Fbxw14 APN 9 109,115,648 (GRCm39) splice site probably benign
K3955:Fbxw14 UTSW 9 109,105,313 (GRCm39) missense possibly damaging 0.87
R0133:Fbxw14 UTSW 9 109,103,647 (GRCm39) missense probably benign 0.02
R0975:Fbxw14 UTSW 9 109,100,307 (GRCm39) missense probably benign 0.00
R1124:Fbxw14 UTSW 9 109,105,236 (GRCm39) missense possibly damaging 0.48
R1782:Fbxw14 UTSW 9 109,107,759 (GRCm39) missense possibly damaging 0.94
R2118:Fbxw14 UTSW 9 109,103,692 (GRCm39) splice site probably benign
R3881:Fbxw14 UTSW 9 109,100,262 (GRCm39) missense possibly damaging 0.95
R4641:Fbxw14 UTSW 9 109,107,750 (GRCm39) critical splice donor site probably null
R4915:Fbxw14 UTSW 9 109,103,592 (GRCm39) missense possibly damaging 0.82
R4952:Fbxw14 UTSW 9 109,105,269 (GRCm39) missense probably benign 0.01
R6137:Fbxw14 UTSW 9 109,105,290 (GRCm39) missense probably damaging 1.00
R6187:Fbxw14 UTSW 9 109,105,332 (GRCm39) missense probably damaging 1.00
R6584:Fbxw14 UTSW 9 109,115,611 (GRCm39) missense possibly damaging 0.85
R7130:Fbxw14 UTSW 9 109,100,350 (GRCm39) missense probably benign 0.02
R7845:Fbxw14 UTSW 9 109,116,671 (GRCm39) missense probably damaging 1.00
R8049:Fbxw14 UTSW 9 109,105,211 (GRCm39) missense probably damaging 0.98
R8169:Fbxw14 UTSW 9 109,106,284 (GRCm39) missense probably benign 0.05
R8815:Fbxw14 UTSW 9 109,105,305 (GRCm39) nonsense probably null
R8816:Fbxw14 UTSW 9 109,105,305 (GRCm39) nonsense probably null
R8818:Fbxw14 UTSW 9 109,116,071 (GRCm39) start gained probably benign
R8958:Fbxw14 UTSW 9 109,107,810 (GRCm39) missense probably damaging 0.99
R8960:Fbxw14 UTSW 9 109,114,367 (GRCm39) missense possibly damaging 0.74
R9093:Fbxw14 UTSW 9 109,105,250 (GRCm39) missense probably benign
R9306:Fbxw14 UTSW 9 109,100,280 (GRCm39) missense probably benign 0.12
R9455:Fbxw14 UTSW 9 109,103,567 (GRCm39) missense probably benign 0.00
R9563:Fbxw14 UTSW 9 109,106,335 (GRCm39) missense probably benign 0.00
X0067:Fbxw14 UTSW 9 109,105,269 (GRCm39) missense probably benign 0.01
Z1177:Fbxw14 UTSW 9 109,105,314 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- TAGCAAGACATCTCCGCAGGGTAG -3'
(R):5'- TGCTCCAACCAAAGGCTGATGG -3'

Sequencing Primer
(F):5'- gggagggaaagaagaaaggaag -3'
(R):5'- CAAAGGCTGATGGCCTGTG -3'
Posted On 2013-05-09