Incidental Mutation 'R4587:Or1e33'
ID 344184
Institutional Source Beutler Lab
Gene Symbol Or1e33
Ensembl Gene ENSMUSG00000094488
Gene Name olfactory receptor family 1 subfamily E member 33
Synonyms MOR135-7, GA_x6K02T2P1NL-4004140-4003208, Olfr393
MMRRC Submission 042006-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R4587 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73738011-73738949 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73738045 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 302 (I302T)
Ref Sequence ENSEMBL: ENSMUSP00000150031 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102523] [ENSMUST00000213365]
AlphaFold Q8VGR6
Predicted Effect probably benign
Transcript: ENSMUST00000102523
AA Change: I302T

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000099582
Gene: ENSMUSG00000094488
AA Change: I302T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.5e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.3e-7 PFAM
Pfam:7tm_1 41 290 4.8e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213365
AA Change: I302T

PolyPhen 2 Score 0.120 (Sensitivity: 0.93; Specificity: 0.86)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency 100% (47/47)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd16a T C 17: 35,320,063 (GRCm39) probably null Het
Adsl T C 15: 80,851,968 (GRCm39) probably null Het
Arhgap32 T C 9: 32,172,241 (GRCm39) S1674P probably benign Het
Cd244a T G 1: 171,405,447 (GRCm39) D277E probably benign Het
Ceacam23 C T 7: 17,620,149 (GRCm39) L18F possibly damaging Het
Ces1a A G 8: 93,751,932 (GRCm39) Y401H probably damaging Het
Chd9 G T 8: 91,763,134 (GRCm39) V2320F possibly damaging Het
Chrd A G 16: 20,557,325 (GRCm39) E670G possibly damaging Het
Ckap2 A G 8: 22,666,992 (GRCm39) S290P probably benign Het
Cluap1 T A 16: 3,751,680 (GRCm39) probably null Het
Col15a1 C T 4: 47,257,184 (GRCm39) T325M probably damaging Het
Cplane1 T C 15: 8,230,636 (GRCm39) I971T possibly damaging Het
Dnah5 T C 15: 28,304,745 (GRCm39) F1652S probably damaging Het
Dok6 T C 18: 89,319,320 (GRCm39) Q312R probably benign Het
Glis1 C A 4: 107,484,740 (GRCm39) H600N possibly damaging Het
Hivep1 A G 13: 42,309,704 (GRCm39) D648G probably benign Het
Kif22 A T 7: 126,632,052 (GRCm39) probably null Het
Lmtk3 A G 7: 45,443,504 (GRCm39) D729G possibly damaging Het
Mapk8ip3 G A 17: 25,123,761 (GRCm39) P587L probably damaging Het
Muc4 G C 16: 32,753,919 (GRCm38) R1265P probably benign Het
Myt1l A G 12: 29,960,800 (GRCm39) K1038E unknown Het
Nf1 T A 11: 79,426,863 (GRCm39) probably null Het
Nom1 T C 5: 29,656,163 (GRCm39) S843P possibly damaging Het
Pex14 A G 4: 149,048,021 (GRCm39) probably benign Het
Ptcd1 T C 5: 145,091,531 (GRCm39) T523A possibly damaging Het
Rasip1 T C 7: 45,282,159 (GRCm39) V554A possibly damaging Het
Ric3 A T 7: 108,653,570 (GRCm39) probably null Het
Skint4 G A 4: 111,944,221 (GRCm39) C11Y probably damaging Het
Smr2 G A 5: 88,256,631 (GRCm39) R103H probably benign Het
Sobp T C 10: 43,034,020 (GRCm39) Y102C probably damaging Het
Taar7f T A 10: 23,926,473 (GRCm39) F356I probably damaging Het
Tbcd T C 11: 121,496,097 (GRCm39) V1044A possibly damaging Het
Tecpr1 C G 5: 144,149,408 (GRCm39) V340L probably damaging Het
Tle3 A G 9: 61,281,295 (GRCm39) I22V probably damaging Het
Trim30a G A 7: 104,084,851 (GRCm39) R120* probably null Het
Trim72 A G 7: 127,607,164 (GRCm39) D231G probably benign Het
Vmn2r59 T A 7: 41,695,648 (GRCm39) N255Y probably benign Het
Vps13a T C 19: 16,617,403 (GRCm39) T3002A probably damaging Het
Wnt7a A T 6: 91,343,324 (GRCm39) probably null Het
Zfp51 C T 17: 21,685,178 (GRCm39) Q598* probably null Het
Zfp617 A T 8: 72,683,003 (GRCm39) N51I probably damaging Het
Zfp977 A T 7: 42,229,614 (GRCm39) C304S probably damaging Het
Zic1 A G 9: 91,246,875 (GRCm39) S66P probably damaging Het
Other mutations in Or1e33
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01485:Or1e33 APN 11 73,738,036 (GRCm39) missense probably benign 0.00
IGL01845:Or1e33 APN 11 73,738,298 (GRCm39) missense probably damaging 1.00
IGL01969:Or1e33 APN 11 73,738,435 (GRCm39) missense possibly damaging 0.56
IGL02288:Or1e33 APN 11 73,738,207 (GRCm39) missense possibly damaging 0.88
IGL02726:Or1e33 APN 11 73,738,691 (GRCm39) missense probably benign 0.02
R0400:Or1e33 UTSW 11 73,738,867 (GRCm39) missense probably benign 0.15
R1672:Or1e33 UTSW 11 73,738,781 (GRCm39) missense probably benign 0.31
R1816:Or1e33 UTSW 11 73,738,025 (GRCm39) missense probably benign 0.00
R2294:Or1e33 UTSW 11 73,738,312 (GRCm39) missense probably damaging 1.00
R4506:Or1e33 UTSW 11 73,738,521 (GRCm39) nonsense probably null
R4593:Or1e33 UTSW 11 73,738,140 (GRCm39) missense probably benign 0.22
R5216:Or1e33 UTSW 11 73,738,262 (GRCm39) missense probably damaging 0.97
R5657:Or1e33 UTSW 11 73,738,366 (GRCm39) missense probably damaging 1.00
R5763:Or1e33 UTSW 11 73,738,693 (GRCm39) missense probably benign 0.01
R5912:Or1e33 UTSW 11 73,738,501 (GRCm39) missense possibly damaging 0.61
R6025:Or1e33 UTSW 11 73,738,745 (GRCm39) missense probably benign 0.23
R6630:Or1e33 UTSW 11 73,738,702 (GRCm39) missense probably benign
R6804:Or1e33 UTSW 11 73,738,240 (GRCm39) missense probably benign 0.00
R7363:Or1e33 UTSW 11 73,738,741 (GRCm39) missense probably damaging 1.00
R7860:Or1e33 UTSW 11 73,738,333 (GRCm39) missense probably benign 0.07
R8103:Or1e33 UTSW 11 73,738,735 (GRCm39) missense probably damaging 1.00
R8158:Or1e33 UTSW 11 73,738,697 (GRCm39) missense probably benign 0.01
R8835:Or1e33 UTSW 11 73,738,702 (GRCm39) missense probably benign
R8925:Or1e33 UTSW 11 73,738,406 (GRCm39) missense probably benign 0.03
R8927:Or1e33 UTSW 11 73,738,406 (GRCm39) missense probably benign 0.03
R8960:Or1e33 UTSW 11 73,738,167 (GRCm39) nonsense probably null
R9221:Or1e33 UTSW 11 73,738,108 (GRCm39) missense probably damaging 1.00
R9355:Or1e33 UTSW 11 73,738,643 (GRCm39) missense probably damaging 0.98
R9502:Or1e33 UTSW 11 73,738,825 (GRCm39) missense probably damaging 1.00
Z1177:Or1e33 UTSW 11 73,738,627 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- ATTATTCCCACATTGACTACTGCAC -3'
(R):5'- CAAGGTATTCTCCACCTGTGG -3'

Sequencing Primer
(F):5'- ACATTGACTACTGCACTAAACTTC -3'
(R):5'- GGTTCCCATCTGTCTGTGGTATC -3'
Posted On 2015-09-24