Incidental Mutation 'R4594:Or11g25'
ID 344285
Institutional Source Beutler Lab
Gene Symbol Or11g25
Ensembl Gene ENSMUSG00000095765
Gene Name olfactory receptor family 11 subfamily G member 25
Synonyms MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786
MMRRC Submission 041810-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R4594 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50710514-50723852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50723619 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 235 (R235G)
Ref Sequence ENSEMBL: ENSMUSP00000151020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]
AlphaFold L7N1Y5
Predicted Effect probably benign
Transcript: ENSMUST00000071932
AA Change: R235G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: R235G

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.2e-55 PFAM
Pfam:7tm_1 45 294 2.4e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205518
AA Change: R235G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000213903
AA Change: R235G

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A G 5: 3,625,754 (GRCm39) T64A probably damaging Het
4933427I04Rik A T 4: 123,754,331 (GRCm39) T82S possibly damaging Het
Adamts15 A T 9: 30,832,743 (GRCm39) I264N probably damaging Het
Alpk1 G A 3: 127,477,203 (GRCm39) A285V probably damaging Het
Auh T C 13: 53,067,002 (GRCm39) probably benign Het
Cacna2d3 A G 14: 28,704,303 (GRCm39) F826S probably benign Het
Ccdc54 G T 16: 50,410,380 (GRCm39) Y295* probably null Het
Ctnna3 G A 10: 64,421,858 (GRCm39) V551I probably benign Het
Diaph3 C T 14: 87,223,473 (GRCm39) C347Y probably damaging Het
Dnajb5 A G 4: 42,950,842 (GRCm39) probably benign Het
Dscam A T 16: 96,519,196 (GRCm39) I847K possibly damaging Het
Fam8a1 T C 13: 46,824,742 (GRCm39) F243S probably damaging Het
Fat2 T C 11: 55,175,578 (GRCm39) I1712V possibly damaging Het
Fgfr1 T C 8: 26,063,852 (GRCm39) V793A probably damaging Het
Got2 T C 8: 96,598,814 (GRCm39) E196G probably benign Het
Gsk3b G A 16: 37,991,063 (GRCm39) C107Y possibly damaging Het
H2-M5 T C 17: 37,298,697 (GRCm39) T250A possibly damaging Het
Il17f T A 1: 20,848,026 (GRCm39) T151S probably damaging Het
Ints12 A G 3: 132,814,629 (GRCm39) N279D probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Kynu T A 2: 43,569,902 (GRCm39) S395T probably benign Het
Llgl1 C T 11: 60,597,147 (GRCm39) T226I probably benign Het
Mael T A 1: 166,063,056 (GRCm39) Q132L probably damaging Het
Mcpt1 A T 14: 56,256,109 (GRCm39) R49S probably benign Het
Meioc G T 11: 102,564,992 (GRCm39) G203C probably damaging Het
Mfsd4b1 A G 10: 39,883,313 (GRCm39) S46P probably benign Het
Muc6 G T 7: 141,218,685 (GRCm39) T1996N possibly damaging Het
Mx2 C A 16: 97,348,632 (GRCm39) Y268* probably null Het
Myom1 A G 17: 71,407,069 (GRCm39) D1064G possibly damaging Het
Nek11 A G 9: 105,270,046 (GRCm39) probably null Het
Nfe2 A G 15: 103,157,232 (GRCm39) L253S probably damaging Het
Nup205 T C 6: 35,173,424 (GRCm39) I478T probably benign Het
Nxpe2 T C 9: 48,230,782 (GRCm39) D529G probably damaging Het
Oard1 T C 17: 48,722,267 (GRCm39) S88P possibly damaging Het
Or2p2 C T 13: 21,256,692 (GRCm39) V260I probably benign Het
Or4n4 G A 14: 50,519,140 (GRCm39) T190I probably benign Het
Or51k1 T C 7: 103,661,624 (GRCm39) D95G probably benign Het
Or52e5 T C 7: 104,718,797 (GRCm39) V41A probably benign Het
Or6k6 G T 1: 173,944,886 (GRCm39) T232N probably damaging Het
Or8b1 A C 9: 38,400,057 (GRCm39) H244P probably damaging Het
Osgin1 C T 8: 120,171,992 (GRCm39) T262I possibly damaging Het
Plcb4 A T 2: 135,844,519 (GRCm39) M146L probably damaging Het
Prkdc A T 16: 15,585,830 (GRCm39) E2456V possibly damaging Het
Ptk2 G A 15: 73,078,045 (GRCm39) A1004V probably damaging Het
Rab15 G A 12: 76,847,445 (GRCm39) probably benign Het
Rad51ap2 T C 12: 11,507,881 (GRCm39) V601A probably benign Het
Rasef T A 4: 73,698,626 (GRCm39) I12F possibly damaging Het
Rdh14 T A 12: 10,444,567 (GRCm39) N139K probably damaging Het
Rexo2 A T 9: 48,391,717 (GRCm39) V46E probably damaging Het
Rskr T A 11: 78,182,473 (GRCm39) V94D possibly damaging Het
Slmap A T 14: 26,186,772 (GRCm39) L68H probably damaging Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Tmem132e T C 11: 82,325,894 (GRCm39) I206T possibly damaging Het
Trappc8 A T 18: 20,970,005 (GRCm39) V995E probably benign Het
Vmn2r12 A C 5: 109,234,301 (GRCm39) I637S probably damaging Het
Vmn2r124 T C 17: 18,294,231 (GRCm39) F773L probably damaging Het
Vmn2r99 A T 17: 19,613,924 (GRCm39) D548V probably damaging Het
Wdr81 T C 11: 75,336,620 (GRCm39) N1590D probably benign Het
Zbtb6 A T 2: 37,319,054 (GRCm39) N291K possibly damaging Het
Zfp119a G A 17: 56,173,325 (GRCm39) R173C probably benign Het
Zmynd15 T C 11: 70,355,008 (GRCm39) L335P probably damaging Het
Other mutations in Or11g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Or11g25 APN 14 50,723,230 (GRCm39) missense probably damaging 0.98
IGL01796:Or11g25 APN 14 50,722,998 (GRCm39) missense probably benign 0.28
IGL01916:Or11g25 APN 14 50,722,950 (GRCm39) missense probably benign 0.01
IGL02686:Or11g25 APN 14 50,723,426 (GRCm39) missense probably benign 0.01
IGL02874:Or11g25 APN 14 50,723,686 (GRCm39) missense possibly damaging 0.57
IGL02898:Or11g25 APN 14 50,723,643 (GRCm39) missense probably damaging 1.00
PIT4515001:Or11g25 UTSW 14 50,723,536 (GRCm39) missense probably benign 0.03
R0085:Or11g25 UTSW 14 50,723,791 (GRCm39) missense probably benign 0.16
R1777:Or11g25 UTSW 14 50,723,757 (GRCm39) missense probably benign 0.08
R1850:Or11g25 UTSW 14 50,723,055 (GRCm39) missense probably benign
R2270:Or11g25 UTSW 14 50,723,494 (GRCm39) missense probably damaging 1.00
R2338:Or11g25 UTSW 14 50,723,097 (GRCm39) missense possibly damaging 0.47
R2971:Or11g25 UTSW 14 50,723,065 (GRCm39) missense probably damaging 0.99
R5383:Or11g25 UTSW 14 50,723,509 (GRCm39) nonsense probably null
R5708:Or11g25 UTSW 14 50,723,452 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R7116:Or11g25 UTSW 14 50,723,025 (GRCm39) missense probably benign 0.00
R7702:Or11g25 UTSW 14 50,723,751 (GRCm39) missense possibly damaging 0.79
R8169:Or11g25 UTSW 14 50,723,692 (GRCm39) missense probably benign 0.13
R9040:Or11g25 UTSW 14 50,722,995 (GRCm39) missense probably benign 0.00
R9139:Or11g25 UTSW 14 50,723,707 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TAGACCACTTCCTGTGTGACCC -3'
(R):5'- GTTCTCAAAATCTTCTGTAGGGC -3'

Sequencing Primer
(F):5'- GACCCAGGCCCTCTTTTGG -3'
(R):5'- TGTTCCTCAGACTGTATATCATAGG -3'
Posted On 2015-09-25