Mutagenetix > Incidental Mutation

Incidental Mutation 'R4594:Prkdc'

344290

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DOXNPH, DNA-PKcs, XRCC7, dxnph, DNA-PK, DNAPDcs

MMRRC Submission

041810-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.955) question?

Stock #

R4594 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

15637866-15842235 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 15767966 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Valine at position 2456 (E2456V)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000023352
AA Change: E2456V

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: E2456V

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Meta Mutation Damage Score

0.1166

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.7%

Validation Efficiency

100% (66/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	G	5: 3,575,754 (GRCm38)	T64A	probably damaging	Het
4933427I04Rik	A	T	4: 123,860,538 (GRCm38)	T82S	possibly damaging	Het
Adamts15	A	T	9: 30,921,447 (GRCm38)	I264N	probably damaging	Het
Alpk1	G	A	3: 127,683,554 (GRCm38)	A285V	probably damaging	Het
Auh	T	C	13: 52,912,966 (GRCm38)		probably benign	Het
BC030499	T	A	11: 78,291,647 (GRCm38)	V94D	possibly damaging	Het
Cacna2d3	A	G	14: 28,982,346 (GRCm38)	F826S	probably benign	Het
Ccdc54	G	T	16: 50,590,017 (GRCm38)	Y295*	probably null	Het
Ctnna3	G	A	10: 64,586,079 (GRCm38)	V551I	probably benign	Het
Diaph3	C	T	14: 86,986,037 (GRCm38)	C347Y	probably damaging	Het
Dnajb5	A	G	4: 42,950,842 (GRCm38)		probably benign	Het
Dscam	A	T	16: 96,717,996 (GRCm38)	I847K	possibly damaging	Het
Fam8a1	T	C	13: 46,671,266 (GRCm38)	F243S	probably damaging	Het
Fat2	T	C	11: 55,284,752 (GRCm38)	I1712V	possibly damaging	Het
Fgfr1	T	C	8: 25,573,836 (GRCm38)	V793A	probably damaging	Het
Got2	T	C	8: 95,872,186 (GRCm38)	E196G	probably benign	Het
Gsk3b	G	A	16: 38,170,701 (GRCm38)	C107Y	possibly damaging	Het
H2-M5	T	C	17: 36,987,805 (GRCm38)	T250A	possibly damaging	Het
Il17f	T	A	1: 20,777,802 (GRCm38)	T151S	probably damaging	Het
Ints12	A	G	3: 133,108,868 (GRCm38)	N279D	probably benign	Het
Kcnd3	C	T	3: 105,658,766 (GRCm38)	A421V	probably damaging	Het
Kynu	T	A	2: 43,679,890 (GRCm38)	S395T	probably benign	Het
Llgl1	C	T	11: 60,706,321 (GRCm38)	T226I	probably benign	Het
Mael	T	A	1: 166,235,487 (GRCm38)	Q132L	probably damaging	Het
Mcpt1	A	T	14: 56,018,652 (GRCm38)	R49S	probably benign	Het
Meioc	G	T	11: 102,674,166 (GRCm38)	G203C	probably damaging	Het
Mfsd4b1	A	G	10: 40,007,317 (GRCm38)	S46P	probably benign	Het
Muc6	G	T	7: 141,638,772 (GRCm38)	T1996N	possibly damaging	Het
Mx2	C	A	16: 97,547,432 (GRCm38)	Y268*	probably null	Het
Myom1	A	G	17: 71,100,074 (GRCm38)	D1064G	possibly damaging	Het
Nek11	A	G	9: 105,392,847 (GRCm38)		probably null	Het
Nfe2	A	G	15: 103,248,805 (GRCm38)	L253S	probably damaging	Het
Nup205	T	C	6: 35,196,489 (GRCm38)	I478T	probably benign	Het
Nxpe2	T	C	9: 48,319,482 (GRCm38)	D529G	probably damaging	Het
Oard1	T	C	17: 48,415,239 (GRCm38)	S88P	possibly damaging	Het
Olfr1370	C	T	13: 21,072,522 (GRCm38)	V260I	probably benign	Het
Olfr231	G	T	1: 174,117,320 (GRCm38)	T232N	probably damaging	Het
Olfr639	T	C	7: 104,012,417 (GRCm38)	D95G	probably benign	Het
Olfr678	T	C	7: 105,069,590 (GRCm38)	V41A	probably benign	Het
Olfr732	G	A	14: 50,281,683 (GRCm38)	T190I	probably benign	Het
Olfr741	A	G	14: 50,486,162 (GRCm38)	R235G	probably benign	Het
Olfr906	A	C	9: 38,488,761 (GRCm38)	H244P	probably damaging	Het
Osgin1	C	T	8: 119,445,253 (GRCm38)	T262I	possibly damaging	Het
Plcb4	A	T	2: 136,002,599 (GRCm38)	M146L	probably damaging	Het
Ptk2	G	A	15: 73,206,196 (GRCm38)	A1004V	probably damaging	Het
Rab15	G	A	12: 76,800,671 (GRCm38)		probably benign	Het
Rad51ap2	T	C	12: 11,457,880 (GRCm38)	V601A	probably benign	Het
Rasef	T	A	4: 73,780,389 (GRCm38)	I12F	possibly damaging	Het
Rdh14	T	A	12: 10,394,567 (GRCm38)	N139K	probably damaging	Het
Rexo2	A	T	9: 48,480,417 (GRCm38)	V46E	probably damaging	Het
Slmap	A	T	14: 26,465,617 (GRCm38)	L68H	probably damaging	Het
Speer3	C	G	5: 13,796,380 (GRCm38)	A238G	possibly damaging	Het
Tmem132e	T	C	11: 82,435,068 (GRCm38)	I206T	possibly damaging	Het
Trappc8	A	T	18: 20,836,948 (GRCm38)	V995E	probably benign	Het
Vmn2r12	A	C	5: 109,086,435 (GRCm38)	I637S	probably damaging	Het
Vmn2r124	T	C	17: 18,073,969 (GRCm38)	F773L	probably damaging	Het
Vmn2r99	A	T	17: 19,393,662 (GRCm38)	D548V	probably damaging	Het
Wdr81	T	C	11: 75,445,794 (GRCm38)	N1590D	probably benign	Het
Zbtb6	A	T	2: 37,429,042 (GRCm38)	N291K	possibly damaging	Het
Zfp119a	G	A	17: 55,866,325 (GRCm38)	R173C	probably benign	Het
Zmynd15	T	C	11: 70,464,182 (GRCm38)	L335P	probably damaging	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,697,226 (GRCm38)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,809,644 (GRCm38)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,790,466 (GRCm38)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,775,847 (GRCm38)	splice site	probably null
IGL00489:Prkdc	APN	16	15,799,926 (GRCm38)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,664,239 (GRCm38)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,652,358 (GRCm38)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,736,835 (GRCm38)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,787,158 (GRCm38)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,779,426 (GRCm38)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,816,639 (GRCm38)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,759,754 (GRCm38)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,739,564 (GRCm38)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,702,115 (GRCm38)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,669,321 (GRCm38)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,726,704 (GRCm38)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,829,692 (GRCm38)	missense	probably benign
IGL01335:Prkdc	APN	16	15,816,896 (GRCm38)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,835,166 (GRCm38)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,713,587 (GRCm38)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,652,302 (GRCm38)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,667,745 (GRCm38)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,734,994 (GRCm38)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,698,887 (GRCm38)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,708,779 (GRCm38)	missense	probably benign
IGL02121:Prkdc	APN	16	15,717,184 (GRCm38)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,669,285 (GRCm38)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,809,759 (GRCm38)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,785,979 (GRCm38)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,785,978 (GRCm38)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,816,758 (GRCm38)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,670,535 (GRCm38)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,714,282 (GRCm38)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,726,542 (GRCm38)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,670,601 (GRCm38)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,783,087 (GRCm38)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,769,825 (GRCm38)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,836,043 (GRCm38)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,752,726 (GRCm38)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,833,666 (GRCm38)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,831,327 (GRCm38)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,651,519 (GRCm38)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,800,016 (GRCm38)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,799,984 (GRCm38)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,705,310 (GRCm38)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,713,635 (GRCm38)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,700,744 (GRCm38)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,834,166 (GRCm38)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,769,801 (GRCm38)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,670,626 (GRCm38)	nonsense	probably null
anhimid	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
anhinga	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
Bushtit	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
clover	UTSW	16	15,702,156 (GRCm38)	splice site	probably benign
crackle	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
Daffy	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
darter	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,808,058 (GRCm38)	missense	probably benign	0.01
envenomation	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
hobgoblin	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
Incubus	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
liming	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
newt	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
primitive	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
roadrunner	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
Schreier	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
screamer	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
Screamer10	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
screamer2	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
screamer3	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
screamer4	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
screamer5	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
screamer6	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
screamer7	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
Screamer8	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
Screamer9	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
Tweetie	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
updock	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,667,731 (GRCm38)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,708,701 (GRCm38)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,726,542 (GRCm38)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,726,504 (GRCm38)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,699,007 (GRCm38)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,713,653 (GRCm38)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,740,332 (GRCm38)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,736,799 (GRCm38)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,791,927 (GRCm38)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,833,740 (GRCm38)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,831,282 (GRCm38)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,833,788 (GRCm38)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,808,088 (GRCm38)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,772,057 (GRCm38)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,690,407 (GRCm38)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,810,801 (GRCm38)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,785,971 (GRCm38)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,829,716 (GRCm38)	missense	probably benign
R1027:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,654,749 (GRCm38)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,767,951 (GRCm38)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,752,782 (GRCm38)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,783,079 (GRCm38)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,759,746 (GRCm38)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,690,282 (GRCm38)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,759,723 (GRCm38)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,664,227 (GRCm38)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,667,700 (GRCm38)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,731,566 (GRCm38)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,687,404 (GRCm38)	missense	probably benign
R1531:Prkdc	UTSW	16	15,772,106 (GRCm38)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,675,328 (GRCm38)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,734,058 (GRCm38)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,676,989 (GRCm38)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,795,094 (GRCm38)	missense	probably benign
R1762:Prkdc	UTSW	16	15,637,961 (GRCm38)	missense	probably benign
R1789:Prkdc	UTSW	16	15,739,524 (GRCm38)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,759,605 (GRCm38)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,808,058 (GRCm38)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,829,635 (GRCm38)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,725,436 (GRCm38)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,714,215 (GRCm38)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,714,266 (GRCm38)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R1939:Prkdc	UTSW	16	15,835,913 (GRCm38)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,677,009 (GRCm38)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,687,352 (GRCm38)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,727,605 (GRCm38)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,715,963 (GRCm38)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,687,390 (GRCm38)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,719,433 (GRCm38)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,705,207 (GRCm38)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,734,922 (GRCm38)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,698,824 (GRCm38)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2271:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2272:Prkdc	UTSW	16	15,654,817 (GRCm38)	splice site	probably null
R2356:Prkdc	UTSW	16	15,684,204 (GRCm38)	missense	probably benign
R2852:Prkdc	UTSW	16	15,652,552 (GRCm38)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,664,358 (GRCm38)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,768,025 (GRCm38)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,799,967 (GRCm38)	missense	probably benign
R3834:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,791,946 (GRCm38)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,829,611 (GRCm38)	splice site	probably null
R4151:Prkdc	UTSW	16	15,816,773 (GRCm38)	missense	probably benign
R4233:Prkdc	UTSW	16	15,835,919 (GRCm38)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,806,099 (GRCm38)	splice site	probably null
R4296:Prkdc	UTSW	16	15,737,905 (GRCm38)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,768,022 (GRCm38)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,773,739 (GRCm38)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,700,653 (GRCm38)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,736,870 (GRCm38)	missense	possibly damaging	0.89
R4603:Prkdc	UTSW	16	15,810,824 (GRCm38)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,663,074 (GRCm38)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,816,774 (GRCm38)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,734,052 (GRCm38)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,772,030 (GRCm38)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,702,112 (GRCm38)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,810,837 (GRCm38)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,667,715 (GRCm38)	missense	probably benign
R4785:Prkdc	UTSW	16	15,648,976 (GRCm38)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,650,712 (GRCm38)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,702,075 (GRCm38)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,678,309 (GRCm38)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,673,997 (GRCm38)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,838,018 (GRCm38)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,772,048 (GRCm38)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,790,580 (GRCm38)	missense	probably benign
R5151:Prkdc	UTSW	16	15,716,035 (GRCm38)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,772,121 (GRCm38)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,734,955 (GRCm38)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,714,974 (GRCm38)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,831,312 (GRCm38)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,805,950 (GRCm38)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,795,097 (GRCm38)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,769,875 (GRCm38)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,768,637 (GRCm38)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,678,308 (GRCm38)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,651,469 (GRCm38)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,706,791 (GRCm38)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,809,612 (GRCm38)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,829,769 (GRCm38)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,810,770 (GRCm38)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,664,233 (GRCm38)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,779,388 (GRCm38)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,816,752 (GRCm38)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,737,834 (GRCm38)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,734,098 (GRCm38)	missense	probably benign
R5883:Prkdc	UTSW	16	15,715,914 (GRCm38)	missense	probably benign
R5895:Prkdc	UTSW	16	15,752,829 (GRCm38)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,783,157 (GRCm38)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,829,697 (GRCm38)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,739,471 (GRCm38)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,772,073 (GRCm38)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,790,592 (GRCm38)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,787,155 (GRCm38)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,714,919 (GRCm38)	missense	probably benign
R6376:Prkdc	UTSW	16	15,769,885 (GRCm38)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,698,815 (GRCm38)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,717,801 (GRCm38)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,795,075 (GRCm38)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,752,764 (GRCm38)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,786,050 (GRCm38)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,670,528 (GRCm38)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,725,461 (GRCm38)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,651,538 (GRCm38)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,777,072 (GRCm38)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,808,156 (GRCm38)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,783,263 (GRCm38)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,799,989 (GRCm38)	missense	probably benign
R6950:Prkdc	UTSW	16	15,815,986 (GRCm38)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,769,966 (GRCm38)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,790,453 (GRCm38)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,689,343 (GRCm38)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,698,803 (GRCm38)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,714,263 (GRCm38)	missense	probably benign
R7283:Prkdc	UTSW	16	15,717,764 (GRCm38)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,648,738 (GRCm38)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,672,327 (GRCm38)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,737,943 (GRCm38)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,831,319 (GRCm38)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,806,096 (GRCm38)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,689,277 (GRCm38)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,715,006 (GRCm38)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,708,903 (GRCm38)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,779,451 (GRCm38)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,816,885 (GRCm38)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,664,244 (GRCm38)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,705,253 (GRCm38)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,836,082 (GRCm38)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,714,141 (GRCm38)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,773,613 (GRCm38)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,835,158 (GRCm38)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,790,676 (GRCm38)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,651,536 (GRCm38)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,648,924 (GRCm38)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,664,368 (GRCm38)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,663,035 (GRCm38)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,708,932 (GRCm38)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,808,204 (GRCm38)	missense	probably benign	0.01
R8749:Prkdc	UTSW	16	15,783,165 (GRCm38)	missense	possibly damaging	0.85
R8836:Prkdc	UTSW	16	15,727,659 (GRCm38)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,727,726 (GRCm38)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,673,760 (GRCm38)	intron	probably benign
R8971:Prkdc	UTSW	16	15,675,365 (GRCm38)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,799,862 (GRCm38)	splice site	probably null
R9052:Prkdc	UTSW	16	15,690,296 (GRCm38)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,835,227 (GRCm38)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,705,289 (GRCm38)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,833,887 (GRCm38)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,816,659 (GRCm38)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,708,928 (GRCm38)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,678,272 (GRCm38)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,667,601 (GRCm38)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,839,215 (GRCm38)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,730,471 (GRCm38)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,730,470 (GRCm38)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,730,477 (GRCm38)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,799,954 (GRCm38)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,715,955 (GRCm38)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,839,180 (GRCm38)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,740,278 (GRCm38)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,687,422 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CACTTAAGGCCTCGCAATCC -3'
(R):5'- TCTGATCTTTGTGCAGAGGC -3'

Sequencing Primer
(F):5'- TTGCCCTTCTTATAGAGACACAAC -3'
(R):5'- GGCTAACCTGTAATTGTCATG -3'

Posted On

2015-09-25