Incidental Mutation 'R0064:Ttc3'
| ID |
34430 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
2610202A04Rik, D16Ium21, D16Ium21e, TPRD |
| MMRRC Submission |
038356-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.812)
|
| Stock # |
R0064 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94370618-94469343 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 94422247 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 197
(H197L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116896
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000122895]
[ENSMUST00000139513]
[ENSMUST00000141856]
[ENSMUST00000143145]
[ENSMUST00000145883]
[ENSMUST00000147046]
[ENSMUST00000147352]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000153988]
[ENSMUST00000155692]
[ENSMUST00000232395]
[ENSMUST00000232660]
[ENSMUST00000231569]
[ENSMUST00000231850]
[ENSMUST00000231915]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117648
AA Change: H598L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
AA Change: H598L
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000122895
AA Change: H580L
PolyPhen 2
Score 0.197 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
AA Change: H580L
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000139513
|
| SMART Domains |
Protein: ENSMUSP00000117881
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
22 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141176
|
| SMART Domains |
Protein: ENSMUSP00000114483
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
40 |
N/A |
INTRINSIC |
|
coiled coil region
|
72 |
103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000141856
AA Change: H112L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000117369
Gene: ENSMUSG00000040785
AA Change: H112L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TPR_1
|
90 |
121 |
1e-6 |
PFAM |
|
Pfam:TPR_2
|
90 |
121 |
7.9e-6 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145883
|
| SMART Domains |
Protein: ENSMUSP00000123442
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
42 |
64 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000147046
AA Change: H197L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000119265
Gene: ENSMUSG00000040785
AA Change: H197L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
5.3e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147352
AA Change: H580L
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
AA Change: H580L
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150346
AA Change: H197L
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
AA Change: H197L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151770
AA Change: H598L
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
AA Change: H598L
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000152117
AA Change: H197L
PolyPhen 2
Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
AA Change: H197L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000153988
AA Change: H288L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000118763
Gene: ENSMUSG00000040785
AA Change: H288L
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
3e-6 |
BLAST |
|
low complexity region
|
134 |
149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000155692
AA Change: H617L
PolyPhen 2
Score 0.503 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
AA Change: H617L
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000232395
AA Change: H598L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000232660
AA Change: H598L
PolyPhen 2
Score 0.660 (Sensitivity: 0.86; Specificity: 0.91)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231569
AA Change: H243L
PolyPhen 2
Score 0.386 (Sensitivity: 0.90; Specificity: 0.89)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231850
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Meta Mutation Damage Score |
0.3234 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
100% (55/55) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 54 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca9 |
A |
C |
11: 110,144,871 |
L641R |
probably damaging |
Het |
| Abca9 |
G |
T |
11: 110,144,872 |
L641M |
probably damaging |
Het |
| Abhd18 |
A |
G |
3: 40,933,853 |
I377M |
probably benign |
Het |
| Arhgef17 |
C |
A |
7: 100,881,354 |
M1408I |
probably benign |
Het |
| Bcl2a1a |
G |
C |
9: 88,957,463 |
G138A |
probably damaging |
Het |
| C4b |
A |
G |
17: 34,738,856 |
L617P |
probably damaging |
Het |
| Ccdc25 |
T |
A |
14: 65,854,112 |
I60K |
possibly damaging |
Het |
| Cdk1 |
T |
C |
10: 69,345,077 |
D101G |
probably benign |
Het |
| Cdon |
A |
G |
9: 35,489,227 |
H1079R |
probably benign |
Het |
| Cep126 |
A |
T |
9: 8,130,182 |
|
probably benign |
Het |
| Cic |
T |
A |
7: 25,287,140 |
S1299T |
probably damaging |
Het |
| Cic |
C |
A |
7: 25,287,141 |
S1299Y |
probably damaging |
Het |
| Clstn1 |
G |
A |
4: 149,634,796 |
V361M |
probably damaging |
Het |
| Crlf3 |
A |
G |
11: 80,057,902 |
I239T |
possibly damaging |
Het |
| Cstf2t |
T |
A |
19: 31,083,299 |
N78K |
probably damaging |
Het |
| Cul1 |
A |
G |
6: 47,502,415 |
|
probably benign |
Het |
| D430041D05Rik |
T |
G |
2: 104,249,157 |
T1194P |
probably damaging |
Het |
| Fbp2 |
A |
T |
13: 62,854,048 |
F118I |
probably damaging |
Het |
| Fbxw14 |
A |
T |
9: 109,287,592 |
Y16* |
probably null |
Het |
| Fgd3 |
T |
G |
13: 49,296,425 |
D116A |
possibly damaging |
Het |
| Gm7168 |
C |
T |
17: 13,949,859 |
T496I |
probably benign |
Het |
| Hsh2d |
G |
A |
8: 72,200,460 |
D229N |
probably benign |
Het |
| Klhl5 |
T |
A |
5: 65,141,288 |
S137T |
probably benign |
Het |
| Knl1 |
T |
A |
2: 119,076,243 |
N1604K |
probably benign |
Het |
| Lpcat1 |
T |
A |
13: 73,514,466 |
N463K |
probably damaging |
Het |
| Lpl |
A |
G |
8: 68,892,704 |
H120R |
probably damaging |
Het |
| Man1a2 |
A |
T |
3: 100,591,883 |
S412T |
possibly damaging |
Het |
| Mcc |
C |
G |
18: 44,519,516 |
|
probably benign |
Het |
| Myo18a |
G |
T |
11: 77,847,344 |
R1704L |
probably damaging |
Het |
| Nlrc3 |
G |
T |
16: 3,964,087 |
T486K |
possibly damaging |
Het |
| Nrip1 |
T |
A |
16: 76,294,670 |
|
probably benign |
Het |
| Nutf2 |
A |
G |
8: 105,878,809 |
D92G |
probably damaging |
Het |
| Obscn |
A |
C |
11: 59,027,466 |
V6260G |
probably damaging |
Het |
| Olfr320 |
G |
A |
11: 58,684,475 |
V201M |
probably benign |
Het |
| Olfr714 |
T |
C |
7: 107,074,280 |
F151L |
probably benign |
Het |
| Plce1 |
T |
C |
19: 38,780,784 |
|
probably null |
Het |
| Pmpca |
C |
A |
2: 26,395,507 |
D498E |
probably benign |
Het |
| Pnpla7 |
G |
T |
2: 24,997,227 |
E28* |
probably null |
Het |
| Polg |
C |
A |
7: 79,461,884 |
W206C |
probably damaging |
Het |
| Ptprt |
C |
T |
2: 161,927,791 |
|
probably benign |
Het |
| Slc7a14 |
T |
C |
3: 31,227,060 |
D367G |
probably damaging |
Het |
| Spata31 |
T |
C |
13: 64,922,098 |
Y687H |
probably damaging |
Het |
| Sybu |
T |
A |
15: 44,672,993 |
T646S |
probably benign |
Het |
| Thbs1 |
A |
T |
2: 118,123,914 |
|
probably null |
Het |
| Tie1 |
A |
G |
4: 118,489,701 |
V2A |
possibly damaging |
Het |
| Tma16 |
A |
T |
8: 66,476,805 |
I179K |
possibly damaging |
Het |
| Tns3 |
G |
A |
11: 8,435,856 |
Q1381* |
probably null |
Het |
| Trank1 |
A |
G |
9: 111,343,195 |
D84G |
probably damaging |
Het |
| Urb1 |
A |
G |
16: 90,779,140 |
F843L |
probably benign |
Het |
| Vmn1r24 |
T |
G |
6: 57,956,018 |
I172L |
probably benign |
Het |
| Vmn2r1 |
T |
A |
3: 64,104,788 |
I690N |
possibly damaging |
Het |
| Vmn2r111 |
T |
A |
17: 22,572,072 |
I82L |
probably benign |
Het |
| Zfp287 |
A |
T |
11: 62,714,938 |
L370H |
possibly damaging |
Het |
| Zfp608 |
A |
T |
18: 54,898,816 |
I684N |
probably benign |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94426761 |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94456718 |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94390207 |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94409731 |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94385369 |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94442527 |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94409681 |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94418598 |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94448108 |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94467926 |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94419426 |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94410906 |
missense |
probably benign |
0.01 |
|
R0098:Ttc3
|
UTSW |
16 |
94390265 |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94385322 |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94462268 |
missense |
possibly damaging |
0.92 |
|
R0480:Ttc3
|
UTSW |
16 |
94432004 |
nonsense |
probably null |
|
|
R0513:Ttc3
|
UTSW |
16 |
94426212 |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94387330 |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94456785 |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94459880 |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94456789 |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94416268 |
splice site |
probably benign |
|
|
R1355:Ttc3
|
UTSW |
16 |
94418637 |
missense |
possibly damaging |
0.46 |
|
R1370:Ttc3
|
UTSW |
16 |
94418637 |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94448129 |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94422297 |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94443317 |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94442832 |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94459972 |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94431998 |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94442563 |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94422277 |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94466961 |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94410958 |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94466877 |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94442901 |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94388272 |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94442761 |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94439241 |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94390283 |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94454515 |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94419465 |
missense |
probably damaging |
1.00 |
|
R4885:Ttc3
|
UTSW |
16 |
94426831 |
critical splice donor site |
probably null |
|
|
R4899:Ttc3
|
UTSW |
16 |
94429455 |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94452982 |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94429359 |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94466934 |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94448059 |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94459844 |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94384041 |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94429620 |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94459844 |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94457382 |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94439324 |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94442695 |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94457413 |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94418623 |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94422349 |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94442611 |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94443453 |
missense |
probably benign |
|
|
R7331:Ttc3
|
UTSW |
16 |
94394359 |
missense |
probably benign |
0.27 |
|
R7497:Ttc3
|
UTSW |
16 |
94418682 |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94427838 |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94387382 |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94457364 |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94467989 |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94442953 |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94466979 |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94418676 |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94454492 |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94457379 |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94390208 |
missense |
probably damaging |
0.99 |
|
R8826:Ttc3
|
UTSW |
16 |
94431970 |
missense |
possibly damaging |
0.85 |
|
R8868:Ttc3
|
UTSW |
16 |
94451143 |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94442983 |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94429499 |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94427808 |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94403360 |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94392091 |
missense |
probably damaging |
0.98 |
|
R9124:Ttc3
|
UTSW |
16 |
94435530 |
missense |
probably benign |
0.00 |
|
R9129:Ttc3
|
UTSW |
16 |
94384349 |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94467972 |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94429608 |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94444501 |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94448059 |
missense |
probably benign |
0.07 |
|
R9631:Ttc3
|
UTSW |
16 |
94370722 |
intron |
probably benign |
|
|
X0022:Ttc3
|
UTSW |
16 |
94442525 |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94412129 |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGGATCAGGGATGTAGGAGATTCTAGAC -3'
(R):5'- GCACCCAGAGAGGCATACACAG -3'
Sequencing Primer
(F):5'- GAGATTCTAGACAGAAATGTGCTTC -3'
(R):5'- GCATACACAGAGTGCTGCTAC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation