Incidental Mutation 'R4595:Or4a15'
ID 344304
Institutional Source Beutler Lab
Gene Symbol Or4a15
Ensembl Gene ENSMUSG00000075090
Gene Name olfactory receptor family 4 subfamily A member 15
Synonyms Olfr1234, MOR231-2, GA_x6K02T2Q125-50805620-50804676
MMRRC Submission 041811-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R4595 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 89190357-89195209 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 89193669 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 35 (V35M)
Ref Sequence ENSEMBL: ENSMUSP00000149303 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099783] [ENSMUST00000111543] [ENSMUST00000137692]
AlphaFold A2AVK5
Predicted Effect probably damaging
Transcript: ENSMUST00000099783
AA Change: V35M

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000097371
Gene: ENSMUSG00000075090
AA Change: V35M

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 5.9e-32 PFAM
Pfam:7tm_4 137 278 1.5e-37 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000111543
AA Change: V35M

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000107168
Gene: ENSMUSG00000075090
AA Change: V35M

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 3.2e-46 PFAM
Pfam:7tm_1 39 285 7.2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000137692
AA Change: V35M

PolyPhen 2 Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 94% (62/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
4921536K21Rik A G 11: 3,840,052 (GRCm39) I115T probably benign Het
Acads A T 5: 115,251,123 (GRCm39) N120K probably damaging Het
Aco1 T A 4: 40,167,139 (GRCm39) C118S probably benign Het
Alpk2 T C 18: 65,422,819 (GRCm39) T1493A probably damaging Het
AU018091 A G 7: 3,208,268 (GRCm39) Y480H possibly damaging Het
Brd4 A T 17: 32,417,896 (GRCm39) I86N probably damaging Het
Ccdc180 A G 4: 45,945,023 (GRCm39) E1477G probably damaging Het
Ccne2 A G 4: 11,202,986 (GRCm39) N368S probably benign Het
Cenpp A T 13: 49,794,710 (GRCm39) F152L probably benign Het
Cfap46 T A 7: 139,232,320 (GRCm39) D881V possibly damaging Het
Chmp7 A G 14: 69,958,678 (GRCm39) V212A probably damaging Het
Col9a2 A T 4: 120,902,352 (GRCm39) K196N probably benign Het
Copg2 T C 6: 30,749,449 (GRCm39) D814G probably damaging Het
Dcaf13 G A 15: 38,982,288 (GRCm39) G85R probably damaging Het
Dnah9 A G 11: 66,058,978 (GRCm39) S106P probably benign Het
Dpp8 A G 9: 64,983,085 (GRCm39) D739G probably damaging Het
Drd2 T A 9: 49,316,089 (GRCm39) M283K probably benign Het
Espl1 A G 15: 102,207,159 (GRCm39) T208A probably benign Het
Glul G A 1: 153,778,796 (GRCm39) G35D possibly damaging Het
Gm14412 T C 2: 177,007,005 (GRCm39) K297E unknown Het
Gm21976 A T 13: 98,442,318 (GRCm39) R120W probably damaging Het
Hipk3 T A 2: 104,271,622 (GRCm39) T437S probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Lipn T G 19: 34,058,750 (GRCm39) Y321D probably damaging Het
Lrwd1 A G 5: 136,152,810 (GRCm39) V484A probably benign Het
Madd T C 2: 90,998,009 (GRCm39) D673G possibly damaging Het
Marveld1 T A 19: 42,136,203 (GRCm39) L39Q probably damaging Het
Mfsd2b T C 12: 4,915,807 (GRCm39) T299A possibly damaging Het
Micu3 T C 8: 40,812,438 (GRCm39) probably benign Het
Mmp7 T C 9: 7,697,667 (GRCm39) V234A probably damaging Het
Nhsl1 T A 10: 18,403,357 (GRCm39) D1329E probably benign Het
Or4f14b T C 2: 111,774,997 (GRCm39) D268G possibly damaging Het
Or52a33 A G 7: 103,289,308 (GRCm39) F13S probably damaging Het
Pcdhb21 T A 18: 37,647,568 (GRCm39) D232E probably damaging Het
Pebp1 G T 5: 117,421,475 (GRCm39) D156E probably benign Het
Pik3cb A G 9: 98,937,459 (GRCm39) Y745H possibly damaging Het
Pld2 T C 11: 70,432,846 (GRCm39) L170P probably damaging Het
Ptch1 T C 13: 63,691,422 (GRCm39) D277G possibly damaging Het
Rab11fip1 A T 8: 27,644,603 (GRCm39) M394K probably damaging Het
Rhoq T C 17: 87,271,754 (GRCm39) Y57H probably benign Het
Setbp1 T C 18: 78,900,731 (GRCm39) I979V probably benign Het
Slc6a4 A G 11: 76,910,689 (GRCm39) I447V probably benign Het
Sos2 T C 12: 69,663,663 (GRCm39) K607R probably damaging Het
Stt3a T C 9: 36,646,808 (GRCm39) I602V probably damaging Het
Syne2 A T 12: 76,013,845 (GRCm39) Q3012L possibly damaging Het
Taf1b T A 12: 24,550,441 (GRCm39) F9I possibly damaging Het
Tex35 T A 1: 156,926,909 (GRCm39) Y195F probably benign Het
Tnc T C 4: 63,913,982 (GRCm39) T1277A probably damaging Het
Tnfsf15 G T 4: 63,648,180 (GRCm39) Y153* probably null Het
Trim5 C A 7: 103,914,639 (GRCm39) V477F probably damaging Het
Trp73 A G 4: 154,148,874 (GRCm39) I245T probably damaging Het
Zbtb16 C T 9: 48,743,380 (GRCm39) E311K possibly damaging Het
Zmynd19 A G 2: 24,849,000 (GRCm39) D165G probably damaging Het
Other mutations in Or4a15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02134:Or4a15 APN 2 89,193,172 (GRCm39) missense probably damaging 0.97
R0945:Or4a15 UTSW 2 89,193,599 (GRCm39) missense probably damaging 0.98
R1018:Or4a15 UTSW 2 89,193,523 (GRCm39) missense possibly damaging 0.95
R1419:Or4a15 UTSW 2 89,193,666 (GRCm39) missense probably damaging 1.00
R1872:Or4a15 UTSW 2 89,192,933 (GRCm39) missense probably damaging 1.00
R1929:Or4a15 UTSW 2 89,193,353 (GRCm39) missense probably benign 0.01
R2143:Or4a15 UTSW 2 89,193,447 (GRCm39) missense probably damaging 1.00
R3499:Or4a15 UTSW 2 89,193,294 (GRCm39) missense probably benign 0.07
R3776:Or4a15 UTSW 2 89,193,108 (GRCm39) missense possibly damaging 0.69
R6287:Or4a15 UTSW 2 89,193,363 (GRCm39) nonsense probably null
R7256:Or4a15 UTSW 2 89,192,838 (GRCm39) missense probably benign 0.21
R7516:Or4a15 UTSW 2 89,193,719 (GRCm39) missense probably benign 0.01
R7636:Or4a15 UTSW 2 89,193,583 (GRCm39) nonsense probably null
R7975:Or4a15 UTSW 2 89,193,413 (GRCm39) missense probably benign 0.23
R8240:Or4a15 UTSW 2 89,192,896 (GRCm39) missense probably benign 0.01
R8514:Or4a15 UTSW 2 89,193,573 (GRCm39) missense probably benign 0.06
R8680:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably benign 0.00
R8780:Or4a15 UTSW 2 89,193,652 (GRCm39) missense probably damaging 1.00
R8898:Or4a15 UTSW 2 89,192,957 (GRCm39) missense possibly damaging 0.56
R9402:Or4a15 UTSW 2 89,193,123 (GRCm39) nonsense probably null
R9434:Or4a15 UTSW 2 89,193,692 (GRCm39) missense probably benign 0.02
R9451:Or4a15 UTSW 2 89,193,243 (GRCm39) missense probably damaging 1.00
R9632:Or4a15 UTSW 2 89,193,065 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GGTCATAGGCCATCACCACC -3'
(R):5'- TTCAAAATCAACTGCTCTGTCTG -3'

Sequencing Primer
(F):5'- TTGAGTCATACAAGCCCGG -3'
(R):5'- TGCAGGCTCTGACATCTAAG -3'
Posted On 2015-09-25