Incidental Mutation 'R4595:Dcaf13'
ID 344348
Institutional Source Beutler Lab
Gene Symbol Dcaf13
Ensembl Gene ENSMUSG00000022300
Gene Name DDB1 and CUL4 associated factor 13
Synonyms Wdsof1, LOC223499
MMRRC Submission 041811-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.955) question?
Stock # R4595 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 38976300-39010251 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 38982288 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Arginine at position 85 (G85R)
Ref Sequence ENSEMBL: ENSMUSP00000022909 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022909]
AlphaFold Q6PAC3
Predicted Effect probably damaging
Transcript: ENSMUST00000022909
AA Change: G85R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000022909
Gene: ENSMUSG00000022300
AA Change: G85R

DomainStartEndE-ValueType
WD40 55 95 5.77e-5 SMART
WD40 98 137 4.38e-5 SMART
WD40 185 225 5.97e-1 SMART
Blast:WD40 228 267 1e-18 BLAST
WD40 271 310 2.69e-5 SMART
WD40 312 353 2.96e-2 SMART
Pfam:Sof1 354 440 7.2e-38 PFAM
Meta Mutation Damage Score 0.9719 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency 94% (62/66)
Allele List at MGI

All alleles(9) : Targeted, other(2) Gene trapped(7)

Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
4921536K21Rik A G 11: 3,840,052 (GRCm39) I115T probably benign Het
Acads A T 5: 115,251,123 (GRCm39) N120K probably damaging Het
Aco1 T A 4: 40,167,139 (GRCm39) C118S probably benign Het
Alpk2 T C 18: 65,422,819 (GRCm39) T1493A probably damaging Het
AU018091 A G 7: 3,208,268 (GRCm39) Y480H possibly damaging Het
Brd4 A T 17: 32,417,896 (GRCm39) I86N probably damaging Het
Ccdc180 A G 4: 45,945,023 (GRCm39) E1477G probably damaging Het
Ccne2 A G 4: 11,202,986 (GRCm39) N368S probably benign Het
Cenpp A T 13: 49,794,710 (GRCm39) F152L probably benign Het
Cfap46 T A 7: 139,232,320 (GRCm39) D881V possibly damaging Het
Chmp7 A G 14: 69,958,678 (GRCm39) V212A probably damaging Het
Col9a2 A T 4: 120,902,352 (GRCm39) K196N probably benign Het
Copg2 T C 6: 30,749,449 (GRCm39) D814G probably damaging Het
Dnah9 A G 11: 66,058,978 (GRCm39) S106P probably benign Het
Dpp8 A G 9: 64,983,085 (GRCm39) D739G probably damaging Het
Drd2 T A 9: 49,316,089 (GRCm39) M283K probably benign Het
Espl1 A G 15: 102,207,159 (GRCm39) T208A probably benign Het
Glul G A 1: 153,778,796 (GRCm39) G35D possibly damaging Het
Gm14412 T C 2: 177,007,005 (GRCm39) K297E unknown Het
Gm21976 A T 13: 98,442,318 (GRCm39) R120W probably damaging Het
Hipk3 T A 2: 104,271,622 (GRCm39) T437S probably benign Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Lipn T G 19: 34,058,750 (GRCm39) Y321D probably damaging Het
Lrwd1 A G 5: 136,152,810 (GRCm39) V484A probably benign Het
Madd T C 2: 90,998,009 (GRCm39) D673G possibly damaging Het
Marveld1 T A 19: 42,136,203 (GRCm39) L39Q probably damaging Het
Mfsd2b T C 12: 4,915,807 (GRCm39) T299A possibly damaging Het
Micu3 T C 8: 40,812,438 (GRCm39) probably benign Het
Mmp7 T C 9: 7,697,667 (GRCm39) V234A probably damaging Het
Nhsl1 T A 10: 18,403,357 (GRCm39) D1329E probably benign Het
Or4a15 C T 2: 89,193,669 (GRCm39) V35M probably damaging Het
Or4f14b T C 2: 111,774,997 (GRCm39) D268G possibly damaging Het
Or52a33 A G 7: 103,289,308 (GRCm39) F13S probably damaging Het
Pcdhb21 T A 18: 37,647,568 (GRCm39) D232E probably damaging Het
Pebp1 G T 5: 117,421,475 (GRCm39) D156E probably benign Het
Pik3cb A G 9: 98,937,459 (GRCm39) Y745H possibly damaging Het
Pld2 T C 11: 70,432,846 (GRCm39) L170P probably damaging Het
Ptch1 T C 13: 63,691,422 (GRCm39) D277G possibly damaging Het
Rab11fip1 A T 8: 27,644,603 (GRCm39) M394K probably damaging Het
Rhoq T C 17: 87,271,754 (GRCm39) Y57H probably benign Het
Setbp1 T C 18: 78,900,731 (GRCm39) I979V probably benign Het
Slc6a4 A G 11: 76,910,689 (GRCm39) I447V probably benign Het
Sos2 T C 12: 69,663,663 (GRCm39) K607R probably damaging Het
Stt3a T C 9: 36,646,808 (GRCm39) I602V probably damaging Het
Syne2 A T 12: 76,013,845 (GRCm39) Q3012L possibly damaging Het
Taf1b T A 12: 24,550,441 (GRCm39) F9I possibly damaging Het
Tex35 T A 1: 156,926,909 (GRCm39) Y195F probably benign Het
Tnc T C 4: 63,913,982 (GRCm39) T1277A probably damaging Het
Tnfsf15 G T 4: 63,648,180 (GRCm39) Y153* probably null Het
Trim5 C A 7: 103,914,639 (GRCm39) V477F probably damaging Het
Trp73 A G 4: 154,148,874 (GRCm39) I245T probably damaging Het
Zbtb16 C T 9: 48,743,380 (GRCm39) E311K possibly damaging Het
Zmynd19 A G 2: 24,849,000 (GRCm39) D165G probably damaging Het
Other mutations in Dcaf13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00787:Dcaf13 APN 15 39,007,027 (GRCm39) nonsense probably null
IGL01081:Dcaf13 APN 15 38,982,201 (GRCm39) missense probably damaging 1.00
IGL01766:Dcaf13 APN 15 38,982,145 (GRCm39) missense probably benign 0.00
IGL02174:Dcaf13 APN 15 39,001,544 (GRCm39) missense probably damaging 1.00
IGL02262:Dcaf13 APN 15 38,982,102 (GRCm39) splice site probably benign
IGL02740:Dcaf13 APN 15 39,008,495 (GRCm39) nonsense probably null
IGL03092:Dcaf13 APN 15 38,991,371 (GRCm39) splice site probably benign
IGL03374:Dcaf13 APN 15 39,008,543 (GRCm39) nonsense probably null
R0590:Dcaf13 UTSW 15 39,008,480 (GRCm39) splice site probably benign
R0594:Dcaf13 UTSW 15 38,986,663 (GRCm39) missense probably benign 0.00
R0711:Dcaf13 UTSW 15 39,001,484 (GRCm39) missense probably damaging 1.00
R1036:Dcaf13 UTSW 15 39,007,113 (GRCm39) missense probably damaging 1.00
R1770:Dcaf13 UTSW 15 38,993,633 (GRCm39) missense probably damaging 1.00
R1826:Dcaf13 UTSW 15 38,982,294 (GRCm39) missense probably damaging 1.00
R1933:Dcaf13 UTSW 15 39,001,483 (GRCm39) missense probably damaging 0.99
R2508:Dcaf13 UTSW 15 39,008,547 (GRCm39) missense probably benign
R4113:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R4649:Dcaf13 UTSW 15 39,001,637 (GRCm39) missense possibly damaging 0.54
R5431:Dcaf13 UTSW 15 38,986,619 (GRCm39) missense probably benign 0.16
R5454:Dcaf13 UTSW 15 38,987,759 (GRCm39) missense probably benign
R5834:Dcaf13 UTSW 15 39,007,037 (GRCm39) nonsense probably null
R5929:Dcaf13 UTSW 15 39,007,048 (GRCm39) missense possibly damaging 0.89
R5944:Dcaf13 UTSW 15 39,010,072 (GRCm39) missense probably benign
R6319:Dcaf13 UTSW 15 39,007,067 (GRCm39) missense probably benign 0.00
R6394:Dcaf13 UTSW 15 39,007,132 (GRCm39) missense probably benign 0.04
R6664:Dcaf13 UTSW 15 38,982,283 (GRCm39) missense probably damaging 1.00
R6884:Dcaf13 UTSW 15 38,986,635 (GRCm39) missense probably damaging 1.00
R7419:Dcaf13 UTSW 15 38,993,615 (GRCm39) missense probably damaging 0.98
R8750:Dcaf13 UTSW 15 38,982,836 (GRCm39) missense probably damaging 1.00
R8944:Dcaf13 UTSW 15 39,001,612 (GRCm39) missense possibly damaging 0.79
R9294:Dcaf13 UTSW 15 38,993,687 (GRCm39) missense possibly damaging 0.92
R9300:Dcaf13 UTSW 15 39,010,102 (GRCm39) missense probably damaging 1.00
R9663:Dcaf13 UTSW 15 38,982,178 (GRCm39) missense possibly damaging 0.88
R9696:Dcaf13 UTSW 15 39,001,496 (GRCm39) missense possibly damaging 0.80
R9778:Dcaf13 UTSW 15 39,008,586 (GRCm39) missense probably damaging 0.99
Z1088:Dcaf13 UTSW 15 39,008,642 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTTCCACAGGAAGTAGTAAATGTG -3'
(R):5'- ACTGTTAAATGGAACCTTACACCACTG -3'

Sequencing Primer
(F):5'- AGAGCGATTGTTCTTATTTCAGTCC -3'
(R):5'- TGGAACCTTACACCACTGAACTG -3'
Posted On 2015-09-25