Incidental Mutation 'R4610:Dusp11'
ID 344602
Institutional Source Beutler Lab
Gene Symbol Dusp11
Ensembl Gene ENSMUSG00000030002
Gene Name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
MMRRC Submission 041821-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4610 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 85942268-85961667 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85950055 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 193 (N193Y)
Ref Sequence ENSEMBL: ENSMUSP00000032071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032071]
AlphaFold Q6NXK5
Predicted Effect probably damaging
Transcript: ENSMUST00000032071
AA Change: N193Y

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000032071
Gene: ENSMUSG00000030002
AA Change: N193Y

low complexity region 6 14 N/A INTRINSIC
Pfam:DSPc 74 203 2.5e-18 PFAM
low complexity region 230 243 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137527
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151394
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156821
Predicted Effect unknown
Transcript: ENSMUST00000201530
AA Change: E142V
Meta Mutation Damage Score 0.5546 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 98% (121/124)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Allele List at MGI
Other mutations in this stock
Total: 117 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700029J07Rik A T 8: 45,970,468 (GRCm38) I69N probably damaging Het
Aars2 T A 17: 45,516,921 (GRCm38) D555E probably damaging Het
Adgre1 C A 17: 57,450,073 (GRCm38) Q777K possibly damaging Het
Agpat4 G A 17: 12,210,377 (GRCm38) probably null Het
Ak7 G A 12: 105,713,575 (GRCm38) V123M probably benign Het
Ankle1 AT A 8: 71,407,207 (GRCm38) probably benign Het
Ankrd44 T G 1: 54,766,748 (GRCm38) probably benign Het
Aprt A T 8: 122,575,415 (GRCm38) probably null Het
Aptx T C 4: 40,702,766 (GRCm38) probably null Het
Arsi G A 18: 60,916,651 (GRCm38) G202E probably benign Het
AY358078 T A 14: 51,826,075 (GRCm38) C393S possibly damaging Het
Bbip1 T C 19: 53,932,175 (GRCm38) M1V probably null Het
Cacng7 T A 7: 3,336,691 (GRCm38) M36K probably benign Het
Camta1 A G 4: 151,084,827 (GRCm38) W156R probably damaging Het
Casd1 G A 6: 4,631,165 (GRCm38) probably null Het
Casz1 T A 4: 148,933,267 (GRCm38) Y338N probably damaging Het
Ccdc66 T C 14: 27,500,420 (GRCm38) N122S probably damaging Het
Celf2 G T 2: 6,586,020 (GRCm38) N279K possibly damaging Het
Cit A G 5: 115,994,087 (GRCm38) T1801A probably benign Het
Cnot2 A G 10: 116,499,418 (GRCm38) I275T probably damaging Het
Ddx4 T C 13: 112,612,060 (GRCm38) K435E probably damaging Het
Dnajc6 T C 4: 101,611,264 (GRCm38) F166L probably damaging Het
Dst T C 1: 34,169,856 (GRCm38) L820P probably damaging Het
Eif3m A T 2: 105,013,288 (GRCm38) N116K probably benign Het
Epb41l1 A T 2: 156,509,261 (GRCm38) E418D possibly damaging Het
Esyt2 T G 12: 116,318,890 (GRCm38) N153K probably damaging Het
Exoc6b T G 6: 85,003,159 (GRCm38) probably benign Het
Ezr C T 17: 6,739,722 (GRCm38) E502K possibly damaging Het
Fbxw11 T A 11: 32,711,859 (GRCm38) Y66N possibly damaging Het
Frem2 A G 3: 53,547,807 (GRCm38) L2116S possibly damaging Het
Fry T C 5: 150,386,104 (GRCm38) L671P probably damaging Het
Galnt7 A G 8: 57,545,769 (GRCm38) I262T probably damaging Het
Glp1r T C 17: 30,931,247 (GRCm38) F381S probably benign Het
Gm3867 T C 9: 36,257,271 (GRCm38) noncoding transcript Het
Gm5662 T C 12: 88,271,774 (GRCm38) N72S probably benign Het
Gm8741 G T 17: 35,336,086 (GRCm38) noncoding transcript Het
Golgb1 A G 16: 36,918,625 (GRCm38) D2442G probably damaging Het
Gp1bb A T 16: 18,621,143 (GRCm38) L67Q probably damaging Het
Gstm7 G A 3: 107,926,919 (GRCm38) T206I possibly damaging Het
Hist1h2bf A T 13: 23,574,057 (GRCm38) V45E possibly damaging Het
Hs3st5 A T 10: 36,828,806 (GRCm38) D35V probably benign Het
Hspa13 T C 16: 75,761,302 (GRCm38) H125R probably benign Het
Hspa1a T G 17: 34,971,180 (GRCm38) H249P probably damaging Het
Igkv10-95 A T 6: 68,680,578 (GRCm38) Q6L probably damaging Het
Il1rap T A 16: 26,714,776 (GRCm38) L474H probably benign Het
Ipo11 T A 13: 106,879,737 (GRCm38) Y489F probably benign Het
Itga5 A G 15: 103,350,832 (GRCm38) Y723H probably damaging Het
Itih2 T C 2: 10,105,160 (GRCm38) N594S probably damaging Het
Itk T A 11: 46,336,515 (GRCm38) Q427L probably benign Het
Kif26b A G 1: 178,679,355 (GRCm38) Y332C probably damaging Het
Kmt2c G A 5: 25,354,384 (GRCm38) R1086W probably damaging Het
Ktn1 T A 14: 47,726,179 (GRCm38) probably benign Het
Lars2 T A 9: 123,418,693 (GRCm38) I305N probably damaging Het
Lgmn G T 12: 102,400,124 (GRCm38) probably benign Het
Ltbp4 C T 7: 27,306,700 (GRCm38) E1453K probably damaging Het
Lypd8 G A 11: 58,386,849 (GRCm38) M152I probably benign Het
Man2a1 T A 17: 64,712,459 (GRCm38) S773T probably benign Het
Map2k6 T G 11: 110,499,474 (GRCm38) L278R probably damaging Het
Mbtps1 A T 8: 119,535,347 (GRCm38) D354E probably damaging Het
Mcpt9 C T 14: 56,028,592 (GRCm38) V60M probably damaging Het
Mical3 C A 6: 120,934,838 (GRCm38) E1083* probably null Het
Mms19 A G 19: 41,945,496 (GRCm38) V811A possibly damaging Het
Mrc2 G A 11: 105,348,431 (GRCm38) probably null Het
Mslnl G A 17: 25,742,934 (GRCm38) V128M probably damaging Het
Mtcl1 T A 17: 66,377,887 (GRCm38) H520L probably benign Het
Mymk A T 2: 27,062,707 (GRCm38) F130I probably damaging Het
Myo1f C T 17: 33,582,332 (GRCm38) R333C probably damaging Het
Myo9a T A 9: 59,871,882 (GRCm38) H1640Q probably benign Het
Nav1 A G 1: 135,592,448 (GRCm38) probably benign Het
Ncbp3 G T 11: 73,079,018 (GRCm38) G564C probably damaging Het
Ncoa4 A T 14: 32,176,725 (GRCm38) I501L probably benign Het
Ngp T A 9: 110,420,815 (GRCm38) N60K possibly damaging Het
Npc1l1 G T 11: 6,228,215 (GRCm38) D398E probably damaging Het
Nphs2 T A 1: 156,326,131 (GRCm38) M264K probably damaging Het
Olfr1193 G A 2: 88,677,896 (GRCm38) V14I probably benign Het
Olfr1193 T G 2: 88,678,179 (GRCm38) V101G probably benign Het
Olfr145 T A 9: 37,898,326 (GRCm38) S307R probably benign Het
Olfr58 T A 9: 19,783,146 (GRCm38) Y4* probably null Het
Patz1 A G 11: 3,306,241 (GRCm38) Y509C probably damaging Het
Pax8 G A 2: 24,421,583 (GRCm38) P447S probably damaging Het
Pde11a A G 2: 76,158,333 (GRCm38) V488A probably benign Het
Pex11g C T 8: 3,465,899 (GRCm38) V45M probably benign Het
Pik3ip1 T A 11: 3,333,327 (GRCm38) S142R probably damaging Het
Pitpnm2 C G 5: 124,125,371 (GRCm38) A819P probably damaging Het
Pla2g4e T G 2: 120,186,382 (GRCm38) H226P possibly damaging Het
Plin4 T A 17: 56,105,418 (GRCm38) M538L probably benign Het
Ppp3cb T C 14: 20,520,646 (GRCm38) N339S possibly damaging Het
Rev1 T C 1: 38,053,649 (GRCm38) E1202G probably damaging Het
Rngtt T A 4: 33,339,133 (GRCm38) probably benign Het
Serpinb12 T A 1: 106,949,153 (GRCm38) D66E probably benign Het
Sgsm1 A T 5: 113,255,307 (GRCm38) F958Y probably damaging Het
Slc35e2 T C 4: 155,617,649 (GRCm38) F290S probably benign Het
Sorl1 C T 9: 42,031,914 (GRCm38) V889M possibly damaging Het
Sptlc3 G A 2: 139,636,680 (GRCm38) V520I probably benign Het
Stam A T 2: 14,115,858 (GRCm38) H53L probably damaging Het
Stox2 A G 8: 47,192,935 (GRCm38) S497P probably damaging Het
Tarbp1 A G 8: 126,474,330 (GRCm38) Y246H probably damaging Het
Tbx15 A G 3: 99,352,367 (GRCm38) Y518C probably damaging Het
Tdrd5 T A 1: 156,284,374 (GRCm38) T479S probably benign Het
Tescl T C 7: 24,333,258 (GRCm38) E214G probably damaging Het
Tex10 T C 4: 48,452,946 (GRCm38) D671G probably benign Het
Tmem132d A G 5: 127,984,296 (GRCm38) V414A probably benign Het
Tmem41b T A 7: 109,974,734 (GRCm38) probably benign Het
Tnfrsf18 A G 4: 156,021,880 (GRCm38) probably benign Het
Tulp4 T A 17: 6,198,833 (GRCm38) D42E probably damaging Het
Ubtd1 A G 19: 42,033,664 (GRCm38) N125S probably damaging Het
Ubxn4 T A 1: 128,255,449 (GRCm38) F68I probably benign Het
Urb1 A G 16: 90,776,271 (GRCm38) S958P probably benign Het
Vash2 T C 1: 190,960,301 (GRCm38) S226G probably benign Het
Vmn2r120 C T 17: 57,509,120 (GRCm38) G745E probably damaging Het
Vmn2r58 T A 7: 41,837,693 (GRCm38) I593F probably benign Het
Zfp398 T C 6: 47,840,427 (GRCm38) L67P probably damaging Het
Zfp607b T A 7: 27,703,695 (GRCm38) H525Q probably damaging Het
Zfp629 T C 7: 127,612,320 (GRCm38) T106A probably benign Het
Zfp980 G A 4: 145,702,083 (GRCm38) G461S probably benign Het
Zic5 T A 14: 122,464,800 (GRCm38) D173V probably damaging Het
Zranb2 G A 3: 157,541,884 (GRCm38) probably benign Het
Other mutations in Dusp11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01107:Dusp11 APN 6 85,952,370 (GRCm38) splice site probably benign
IGL01584:Dusp11 APN 6 85,953,394 (GRCm38) missense probably damaging 1.00
IGL02276:Dusp11 APN 6 85,958,617 (GRCm38) missense probably damaging 1.00
IGL02727:Dusp11 APN 6 85,961,492 (GRCm38) missense probably damaging 1.00
R0372:Dusp11 UTSW 6 85,958,730 (GRCm38) splice site probably benign
R0413:Dusp11 UTSW 6 85,952,370 (GRCm38) splice site probably benign
R1669:Dusp11 UTSW 6 85,950,026 (GRCm38) missense probably benign 0.05
R2115:Dusp11 UTSW 6 85,958,669 (GRCm38) missense probably damaging 1.00
R4678:Dusp11 UTSW 6 85,953,381 (GRCm38) missense probably damaging 0.98
R5288:Dusp11 UTSW 6 85,947,605 (GRCm38) makesense probably null
R5386:Dusp11 UTSW 6 85,947,605 (GRCm38) makesense probably null
R5756:Dusp11 UTSW 6 85,952,357 (GRCm38) missense probably damaging 1.00
R5987:Dusp11 UTSW 6 85,959,233 (GRCm38) nonsense probably null
R6591:Dusp11 UTSW 6 85,961,525 (GRCm38) missense possibly damaging 0.53
R6691:Dusp11 UTSW 6 85,961,525 (GRCm38) missense possibly damaging 0.53
R7684:Dusp11 UTSW 6 85,950,560 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-09-25