Incidental Mutation 'R4610:Mrc2'
| ID |
344637 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrc2
|
| Ensembl Gene |
ENSMUSG00000020695 |
| Gene Name |
mannose receptor, C type 2 |
| Synonyms |
Endo180, uPARAP, novel lectin |
| MMRRC Submission |
041821-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4610 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
105183469-105241965 bp(+) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 105239257 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097909
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021038]
[ENSMUST00000100335]
|
| AlphaFold |
Q64449 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000021038
|
| SMART Domains |
Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000100335
|
| SMART Domains |
Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
30 |
N/A |
INTRINSIC |
|
RICIN
|
40 |
160 |
8.49e-12 |
SMART |
|
FN2
|
179 |
227 |
4.83e-27 |
SMART |
|
CLECT
|
234 |
359 |
1.15e-33 |
SMART |
|
CLECT
|
381 |
504 |
1.47e-40 |
SMART |
|
CLECT
|
520 |
644 |
6.82e-27 |
SMART |
|
CLECT
|
668 |
808 |
2.71e-30 |
SMART |
|
CLECT
|
824 |
950 |
6.77e-31 |
SMART |
|
CLECT
|
971 |
1107 |
3.91e-36 |
SMART |
|
CLECT
|
1124 |
1243 |
1.04e-17 |
SMART |
|
CLECT
|
1259 |
1392 |
9.08e-23 |
SMART |
|
transmembrane domain
|
1412 |
1434 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
98% (121/124) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 117 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars2 |
T |
A |
17: 45,827,847 (GRCm39) |
D555E |
probably damaging |
Het |
| Adgre1 |
C |
A |
17: 57,757,073 (GRCm39) |
Q777K |
possibly damaging |
Het |
| Agpat4 |
G |
A |
17: 12,429,264 (GRCm39) |
|
probably null |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Ankle1 |
AT |
A |
8: 71,859,851 (GRCm39) |
|
probably benign |
Het |
| Ankrd44 |
T |
G |
1: 54,805,907 (GRCm39) |
|
probably benign |
Het |
| Aprt |
A |
T |
8: 123,302,154 (GRCm39) |
|
probably null |
Het |
| Aptx |
T |
C |
4: 40,702,766 (GRCm39) |
|
probably null |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Bbip1 |
T |
C |
19: 53,920,606 (GRCm39) |
M1V |
probably null |
Het |
| Cacng7 |
T |
A |
7: 3,385,207 (GRCm39) |
M36K |
probably benign |
Het |
| Camta1 |
A |
G |
4: 151,169,284 (GRCm39) |
W156R |
probably damaging |
Het |
| Casd1 |
G |
A |
6: 4,631,165 (GRCm39) |
|
probably null |
Het |
| Casz1 |
T |
A |
4: 149,017,724 (GRCm39) |
Y338N |
probably damaging |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Celf2 |
G |
T |
2: 6,590,831 (GRCm39) |
N279K |
possibly damaging |
Het |
| Cfap96 |
A |
T |
8: 46,423,505 (GRCm39) |
I69N |
probably damaging |
Het |
| Cit |
A |
G |
5: 116,132,146 (GRCm39) |
T1801A |
probably benign |
Het |
| Cnot2 |
A |
G |
10: 116,335,323 (GRCm39) |
I275T |
probably damaging |
Het |
| Ddx4 |
T |
C |
13: 112,748,594 (GRCm39) |
K435E |
probably damaging |
Het |
| Dnajc6 |
T |
C |
4: 101,468,461 (GRCm39) |
F166L |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,208,937 (GRCm39) |
L820P |
probably damaging |
Het |
| Dusp11 |
T |
A |
6: 85,927,037 (GRCm39) |
N193Y |
probably damaging |
Het |
| Eif1ad7 |
T |
C |
12: 88,238,544 (GRCm39) |
N72S |
probably benign |
Het |
| Eif3m |
A |
T |
2: 104,843,633 (GRCm39) |
N116K |
probably benign |
Het |
| Epb41l1 |
A |
T |
2: 156,351,181 (GRCm39) |
E418D |
possibly damaging |
Het |
| Esyt2 |
T |
G |
12: 116,282,510 (GRCm39) |
N153K |
probably damaging |
Het |
| Exoc6b |
T |
G |
6: 84,980,141 (GRCm39) |
|
probably benign |
Het |
| Ezr |
C |
T |
17: 7,007,121 (GRCm39) |
E502K |
possibly damaging |
Het |
| Fbxw11 |
T |
A |
11: 32,661,859 (GRCm39) |
Y66N |
possibly damaging |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Fry |
T |
C |
5: 150,309,569 (GRCm39) |
L671P |
probably damaging |
Het |
| Galnt7 |
A |
G |
8: 57,998,803 (GRCm39) |
I262T |
probably damaging |
Het |
| Glp1r |
T |
C |
17: 31,150,221 (GRCm39) |
F381S |
probably benign |
Het |
| Gm3867 |
T |
C |
9: 36,168,567 (GRCm39) |
|
noncoding transcript |
Het |
| Gm8741 |
G |
T |
17: 35,555,062 (GRCm39) |
|
noncoding transcript |
Het |
| Golgb1 |
A |
G |
16: 36,738,987 (GRCm39) |
D2442G |
probably damaging |
Het |
| Gp1bb |
A |
T |
16: 18,439,893 (GRCm39) |
L67Q |
probably damaging |
Het |
| Gstm7 |
G |
A |
3: 107,834,235 (GRCm39) |
T206I |
possibly damaging |
Het |
| H2bc7 |
A |
T |
13: 23,758,231 (GRCm39) |
V45E |
possibly damaging |
Het |
| Hs3st5 |
A |
T |
10: 36,704,802 (GRCm39) |
D35V |
probably benign |
Het |
| Hspa13 |
T |
C |
16: 75,558,190 (GRCm39) |
H125R |
probably benign |
Het |
| Hspa1a |
T |
G |
17: 35,190,156 (GRCm39) |
H249P |
probably damaging |
Het |
| Igkv10-95 |
A |
T |
6: 68,657,562 (GRCm39) |
Q6L |
probably damaging |
Het |
| Il1rap |
T |
A |
16: 26,533,526 (GRCm39) |
L474H |
probably benign |
Het |
| Ipo11 |
T |
A |
13: 107,016,245 (GRCm39) |
Y489F |
probably benign |
Het |
| Itga5 |
A |
G |
15: 103,259,259 (GRCm39) |
Y723H |
probably damaging |
Het |
| Itih2 |
T |
C |
2: 10,109,971 (GRCm39) |
N594S |
probably damaging |
Het |
| Itk |
T |
A |
11: 46,227,342 (GRCm39) |
Q427L |
probably benign |
Het |
| Kif26b |
A |
G |
1: 178,506,920 (GRCm39) |
Y332C |
probably damaging |
Het |
| Kmt2c |
G |
A |
5: 25,559,382 (GRCm39) |
R1086W |
probably damaging |
Het |
| Ktn1 |
T |
A |
14: 47,963,636 (GRCm39) |
|
probably benign |
Het |
| Lars2 |
T |
A |
9: 123,247,758 (GRCm39) |
I305N |
probably damaging |
Het |
| Lgmn |
G |
T |
12: 102,366,383 (GRCm39) |
|
probably benign |
Het |
| Ltbp4 |
C |
T |
7: 27,006,125 (GRCm39) |
E1453K |
probably damaging |
Het |
| Lypd8 |
G |
A |
11: 58,277,675 (GRCm39) |
M152I |
probably benign |
Het |
| Man2a1 |
T |
A |
17: 65,019,454 (GRCm39) |
S773T |
probably benign |
Het |
| Map2k6 |
T |
G |
11: 110,390,300 (GRCm39) |
L278R |
probably damaging |
Het |
| Mbtps1 |
A |
T |
8: 120,262,086 (GRCm39) |
D354E |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mical3 |
C |
A |
6: 120,911,799 (GRCm39) |
E1083* |
probably null |
Het |
| Mms19 |
A |
G |
19: 41,933,935 (GRCm39) |
V811A |
possibly damaging |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,684,882 (GRCm39) |
H520L |
probably benign |
Het |
| Mymk |
A |
T |
2: 26,952,719 (GRCm39) |
F130I |
probably damaging |
Het |
| Myo1f |
C |
T |
17: 33,801,306 (GRCm39) |
R333C |
probably damaging |
Het |
| Myo9a |
T |
A |
9: 59,779,165 (GRCm39) |
H1640Q |
probably benign |
Het |
| Nav1 |
A |
G |
1: 135,520,186 (GRCm39) |
|
probably benign |
Het |
| Ncbp3 |
G |
T |
11: 72,969,844 (GRCm39) |
G564C |
probably damaging |
Het |
| Ncoa4 |
A |
T |
14: 31,898,682 (GRCm39) |
I501L |
probably benign |
Het |
| Ngp |
T |
A |
9: 110,249,883 (GRCm39) |
N60K |
possibly damaging |
Het |
| Npc1l1 |
G |
T |
11: 6,178,215 (GRCm39) |
D398E |
probably damaging |
Het |
| Nphs2 |
T |
A |
1: 156,153,701 (GRCm39) |
M264K |
probably damaging |
Het |
| Or4s2b |
G |
A |
2: 88,508,240 (GRCm39) |
V14I |
probably benign |
Het |
| Or4s2b |
T |
G |
2: 88,508,523 (GRCm39) |
V101G |
probably benign |
Het |
| Or7e165 |
T |
A |
9: 19,694,442 (GRCm39) |
Y4* |
probably null |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Patz1 |
A |
G |
11: 3,256,241 (GRCm39) |
Y509C |
probably damaging |
Het |
| Pax8 |
G |
A |
2: 24,311,595 (GRCm39) |
P447S |
probably damaging |
Het |
| Pde11a |
A |
G |
2: 75,988,677 (GRCm39) |
V488A |
probably benign |
Het |
| Pex11g |
C |
T |
8: 3,515,899 (GRCm39) |
V45M |
probably benign |
Het |
| Pik3ip1 |
T |
A |
11: 3,283,327 (GRCm39) |
S142R |
probably damaging |
Het |
| Pitpnm2 |
C |
G |
5: 124,263,434 (GRCm39) |
A819P |
probably damaging |
Het |
| Pla2g4e |
T |
G |
2: 120,016,863 (GRCm39) |
H226P |
possibly damaging |
Het |
| Plin4 |
T |
A |
17: 56,412,418 (GRCm39) |
M538L |
probably benign |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Rev1 |
T |
C |
1: 38,092,730 (GRCm39) |
E1202G |
probably damaging |
Het |
| Rngtt |
T |
A |
4: 33,339,133 (GRCm39) |
|
probably benign |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Sgsm1 |
A |
T |
5: 113,403,173 (GRCm39) |
F958Y |
probably damaging |
Het |
| Slc35e2 |
T |
C |
4: 155,702,106 (GRCm39) |
F290S |
probably benign |
Het |
| Sorl1 |
C |
T |
9: 41,943,210 (GRCm39) |
V889M |
possibly damaging |
Het |
| Sptlc3 |
G |
A |
2: 139,478,600 (GRCm39) |
V520I |
probably benign |
Het |
| Stam |
A |
T |
2: 14,120,669 (GRCm39) |
H53L |
probably damaging |
Het |
| Stox2 |
A |
G |
8: 47,645,970 (GRCm39) |
S497P |
probably damaging |
Het |
| Tarbp1 |
A |
G |
8: 127,201,069 (GRCm39) |
Y246H |
probably damaging |
Het |
| Tbx15 |
A |
G |
3: 99,259,683 (GRCm39) |
Y518C |
probably damaging |
Het |
| Tdrd5 |
T |
A |
1: 156,111,944 (GRCm39) |
T479S |
probably benign |
Het |
| Tescl |
T |
C |
7: 24,032,683 (GRCm39) |
E214G |
probably damaging |
Het |
| Tex10 |
T |
C |
4: 48,452,946 (GRCm39) |
D671G |
probably benign |
Het |
| Tmem132d |
A |
G |
5: 128,061,360 (GRCm39) |
V414A |
probably benign |
Het |
| Tmem41b |
T |
A |
7: 109,573,941 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf18 |
A |
G |
4: 156,106,337 (GRCm39) |
|
probably benign |
Het |
| Tulp4 |
T |
A |
17: 6,249,108 (GRCm39) |
D42E |
probably damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,022,103 (GRCm39) |
N125S |
probably damaging |
Het |
| Ubxn4 |
T |
A |
1: 128,183,186 (GRCm39) |
F68I |
probably benign |
Het |
| Urb1 |
A |
G |
16: 90,573,159 (GRCm39) |
S958P |
probably benign |
Het |
| Vash2 |
T |
C |
1: 190,692,498 (GRCm39) |
S226G |
probably benign |
Het |
| Vmn2r120 |
C |
T |
17: 57,816,120 (GRCm39) |
G745E |
probably damaging |
Het |
| Vmn2r58 |
T |
A |
7: 41,487,117 (GRCm39) |
I593F |
probably benign |
Het |
| Zfp398 |
T |
C |
6: 47,817,361 (GRCm39) |
L67P |
probably damaging |
Het |
| Zfp607b |
T |
A |
7: 27,403,120 (GRCm39) |
H525Q |
probably damaging |
Het |
| Zfp629 |
T |
C |
7: 127,211,492 (GRCm39) |
T106A |
probably benign |
Het |
| Zfp980 |
G |
A |
4: 145,428,653 (GRCm39) |
G461S |
probably benign |
Het |
| Zic5 |
T |
A |
14: 122,702,212 (GRCm39) |
D173V |
probably damaging |
Het |
| Zranb2 |
G |
A |
3: 157,247,521 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Mrc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01105:Mrc2
|
APN |
11 |
105,219,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01374:Mrc2
|
APN |
11 |
105,238,469 (GRCm39) |
nonsense |
probably null |
|
|
IGL01751:Mrc2
|
APN |
11 |
105,216,560 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01780:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01835:Mrc2
|
APN |
11 |
105,227,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02350:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02357:Mrc2
|
APN |
11 |
105,216,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02829:Mrc2
|
APN |
11 |
105,227,533 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02863:Mrc2
|
APN |
11 |
105,224,446 (GRCm39) |
splice site |
probably benign |
|
|
IGL02940:Mrc2
|
APN |
11 |
105,231,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02988:Mrc2
|
UTSW |
11 |
105,216,397 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0254:Mrc2
|
UTSW |
11 |
105,238,692 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0634:Mrc2
|
UTSW |
11 |
105,238,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1102:Mrc2
|
UTSW |
11 |
105,231,647 (GRCm39) |
missense |
probably benign |
|
|
R1233:Mrc2
|
UTSW |
11 |
105,239,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R1458:Mrc2
|
UTSW |
11 |
105,228,598 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1500:Mrc2
|
UTSW |
11 |
105,238,551 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1573:Mrc2
|
UTSW |
11 |
105,227,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1770:Mrc2
|
UTSW |
11 |
105,229,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1842:Mrc2
|
UTSW |
11 |
105,228,546 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2156:Mrc2
|
UTSW |
11 |
105,238,682 (GRCm39) |
splice site |
probably null |
|
|
R2165:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2265:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2266:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2267:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2268:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2269:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2270:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2271:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2272:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2296:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2298:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2300:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2326:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2518:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2519:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2520:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R2895:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3029:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3030:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3079:Mrc2
|
UTSW |
11 |
105,227,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3122:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3149:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3150:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3420:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3422:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3441:Mrc2
|
UTSW |
11 |
105,238,542 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3726:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3731:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3800:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3820:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3821:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3837:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3838:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3849:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3850:Mrc2
|
UTSW |
11 |
105,183,729 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3914:Mrc2
|
UTSW |
11 |
105,238,058 (GRCm39) |
splice site |
probably benign |
|
|
R3932:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3933:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R3971:Mrc2
|
UTSW |
11 |
105,218,857 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4105:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4107:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4113:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4274:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4399:Mrc2
|
UTSW |
11 |
105,227,484 (GRCm39) |
nonsense |
probably null |
|
|
R4477:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4478:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4493:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4494:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4495:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4547:Mrc2
|
UTSW |
11 |
105,227,467 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4600:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4601:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4602:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4603:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4611:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4637:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4672:Mrc2
|
UTSW |
11 |
105,233,923 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4674:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4675:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4693:Mrc2
|
UTSW |
11 |
105,234,528 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4706:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4707:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4791:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4792:Mrc2
|
UTSW |
11 |
105,239,257 (GRCm39) |
splice site |
probably null |
|
|
R4888:Mrc2
|
UTSW |
11 |
105,232,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5523:Mrc2
|
UTSW |
11 |
105,234,408 (GRCm39) |
missense |
probably benign |
|
|
R5600:Mrc2
|
UTSW |
11 |
105,224,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5634:Mrc2
|
UTSW |
11 |
105,227,040 (GRCm39) |
nonsense |
probably null |
|
|
R5692:Mrc2
|
UTSW |
11 |
105,227,468 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5706:Mrc2
|
UTSW |
11 |
105,223,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5775:Mrc2
|
UTSW |
11 |
105,228,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6140:Mrc2
|
UTSW |
11 |
105,237,615 (GRCm39) |
missense |
probably benign |
|
|
R6146:Mrc2
|
UTSW |
11 |
105,216,470 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6225:Mrc2
|
UTSW |
11 |
105,237,646 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6437:Mrc2
|
UTSW |
11 |
105,240,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Mrc2
|
UTSW |
11 |
105,240,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6675:Mrc2
|
UTSW |
11 |
105,233,906 (GRCm39) |
splice site |
probably null |
|
|
R6680:Mrc2
|
UTSW |
11 |
105,216,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6868:Mrc2
|
UTSW |
11 |
105,219,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6979:Mrc2
|
UTSW |
11 |
105,239,461 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7038:Mrc2
|
UTSW |
11 |
105,223,062 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7303:Mrc2
|
UTSW |
11 |
105,216,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7320:Mrc2
|
UTSW |
11 |
105,220,061 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7422:Mrc2
|
UTSW |
11 |
105,183,609 (GRCm39) |
start gained |
probably benign |
|
|
R7537:Mrc2
|
UTSW |
11 |
105,183,623 (GRCm39) |
missense |
probably benign |
|
|
R7640:Mrc2
|
UTSW |
11 |
105,223,121 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7709:Mrc2
|
UTSW |
11 |
105,237,285 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7885:Mrc2
|
UTSW |
11 |
105,223,092 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7976:Mrc2
|
UTSW |
11 |
105,238,829 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8042:Mrc2
|
UTSW |
11 |
105,239,181 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8096:Mrc2
|
UTSW |
11 |
105,234,333 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8353:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8453:Mrc2
|
UTSW |
11 |
105,223,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8519:Mrc2
|
UTSW |
11 |
105,238,132 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R8771:Mrc2
|
UTSW |
11 |
105,240,596 (GRCm39) |
missense |
probably benign |
|
|
R8787:Mrc2
|
UTSW |
11 |
105,238,465 (GRCm39) |
missense |
probably benign |
|
|
R8925:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8927:Mrc2
|
UTSW |
11 |
105,216,334 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8991:Mrc2
|
UTSW |
11 |
105,229,740 (GRCm39) |
missense |
probably benign |
|
|
R9017:Mrc2
|
UTSW |
11 |
105,216,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9096:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9097:Mrc2
|
UTSW |
11 |
105,231,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Mrc2
|
UTSW |
11 |
105,220,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9471:Mrc2
|
UTSW |
11 |
105,234,559 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9531:Mrc2
|
UTSW |
11 |
105,240,731 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
T0970:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0004:Mrc2
|
UTSW |
11 |
105,238,453 (GRCm39) |
missense |
probably benign |
0.41 |
|
X0062:Mrc2
|
UTSW |
11 |
105,238,301 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,238,186 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Mrc2
|
UTSW |
11 |
105,232,202 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTGAGCTGCCAGAGAAGAGTG -3'
(R):5'- TGTGGAAGGAACCCATTGG -3'
Sequencing Primer
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation