Incidental Mutation 'R4612:Arhgap32'
ID 344843
Institutional Source Beutler Lab
Gene Symbol Arhgap32
Ensembl Gene ENSMUSG00000041444
Gene Name Rho GTPase activating protein 32
Synonyms p200RhoGAP, Grit, PX-RICS, GC-GAP, 3426406O18Rik
MMRRC Submission 041823-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4612 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 32027432-32179742 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 32170775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Aspartic acid at position 1185 (G1185D)
Ref Sequence ENSEMBL: ENSMUSP00000138145 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168954] [ENSMUST00000174641] [ENSMUST00000182802]
AlphaFold Q811P8
Predicted Effect probably damaging
Transcript: ENSMUST00000168954
AA Change: G1185D

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000128448
Gene: ENSMUSG00000041444
AA Change: G1185D

DomainStartEndE-ValueType
RhoGAP 34 215 9.6e-60 SMART
Blast:RhoGAP 232 298 7e-31 BLAST
low complexity region 518 533 N/A INTRINSIC
low complexity region 669 689 N/A INTRINSIC
low complexity region 696 710 N/A INTRINSIC
low complexity region 913 926 N/A INTRINSIC
low complexity region 960 974 N/A INTRINSIC
low complexity region 997 1008 N/A INTRINSIC
low complexity region 1076 1093 N/A INTRINSIC
low complexity region 1304 1317 N/A INTRINSIC
low complexity region 1691 1700 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000174641
AA Change: G1534D

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000133898
Gene: ENSMUSG00000041444
AA Change: G1534D

DomainStartEndE-ValueType
Pfam:PX 132 226 5.6e-7 PFAM
SH3 262 320 7.4e-11 SMART
RhoGAP 383 564 9.6e-60 SMART
Blast:RhoGAP 581 647 9e-31 BLAST
low complexity region 867 882 N/A INTRINSIC
low complexity region 1018 1038 N/A INTRINSIC
low complexity region 1045 1059 N/A INTRINSIC
low complexity region 1262 1275 N/A INTRINSIC
low complexity region 1309 1323 N/A INTRINSIC
low complexity region 1346 1357 N/A INTRINSIC
low complexity region 1425 1442 N/A INTRINSIC
low complexity region 1653 1666 N/A INTRINSIC
low complexity region 2040 2049 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000182802
AA Change: G1185D

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000138145
Gene: ENSMUSG00000041444
AA Change: G1185D

DomainStartEndE-ValueType
RhoGAP 34 215 9.6e-60 SMART
Blast:RhoGAP 232 298 7e-31 BLAST
low complexity region 518 533 N/A INTRINSIC
low complexity region 669 689 N/A INTRINSIC
low complexity region 696 710 N/A INTRINSIC
low complexity region 913 926 N/A INTRINSIC
low complexity region 960 974 N/A INTRINSIC
low complexity region 997 1008 N/A INTRINSIC
low complexity region 1076 1093 N/A INTRINSIC
low complexity region 1304 1317 N/A INTRINSIC
low complexity region 1691 1700 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a null mutation are fertile but display abnormal neurite growth. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 109 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700019D03Rik T C 1: 52,964,635 (GRCm39) D31G probably benign Het
5730455P16Rik A T 11: 80,268,806 (GRCm39) M1K probably null Het
Abca15 A G 7: 119,934,384 (GRCm39) D120G probably benign Het
Adam26a A T 8: 44,021,830 (GRCm39) N553K probably damaging Het
Adam32 A T 8: 25,362,752 (GRCm39) C558S probably damaging Het
Adam34l A T 8: 44,079,587 (GRCm39) F212L probably benign Het
Adam39 A T 8: 41,278,958 (GRCm39) S450C probably damaging Het
Agap2 A T 10: 126,915,965 (GRCm39) T159S unknown Het
Ahnak G A 19: 8,981,088 (GRCm39) V791I probably benign Het
Ak7 T G 12: 105,727,772 (GRCm39) L468R probably damaging Het
Akap12 A G 10: 4,304,456 (GRCm39) D422G probably damaging Het
Antxr1 T A 6: 87,265,155 (GRCm39) I129F probably damaging Het
Atf7ip2 A T 16: 10,059,427 (GRCm39) E322D probably benign Het
Atg4b T C 1: 93,714,263 (GRCm39) F349L probably damaging Het
Atp6v1c1 A G 15: 38,677,856 (GRCm39) K127R probably damaging Het
Atxn1l C T 8: 110,458,736 (GRCm39) V509M possibly damaging Het
B3glct T A 5: 149,663,022 (GRCm39) I260N probably damaging Het
Bcl2l12 G A 7: 44,646,009 (GRCm39) P70L probably damaging Het
Bok T A 1: 93,621,900 (GRCm39) F157L probably damaging Het
Bves G A 10: 45,215,373 (GRCm39) G16D probably benign Het
Cacna1b T A 2: 24,516,864 (GRCm39) K65* probably null Het
Casc3 A G 11: 98,713,784 (GRCm39) T339A probably benign Het
Ccdc18 C T 5: 108,283,307 (GRCm39) S6L probably benign Het
Cd86 A G 16: 36,435,692 (GRCm39) Y242H probably benign Het
Chd3 A C 11: 69,244,035 (GRCm39) Y1249* probably null Het
Chrne T C 11: 70,507,848 (GRCm39) T284A probably damaging Het
Col12a1 T C 9: 79,523,339 (GRCm39) D2746G probably damaging Het
Cryaa T A 17: 31,897,448 (GRCm39) M72K probably benign Het
Csmd1 G T 8: 15,971,908 (GRCm39) probably null Het
Det1 A T 7: 78,493,454 (GRCm39) N183K probably damaging Het
Dis3 C A 14: 99,328,871 (GRCm39) V294L probably benign Het
Dnah2 G A 11: 69,374,193 (GRCm39) L1493F possibly damaging Het
Dsc2 A T 18: 20,174,876 (GRCm39) D466E probably damaging Het
Dsg4 T A 18: 20,595,470 (GRCm39) S558T probably benign Het
Dzip3 A T 16: 48,772,403 (GRCm39) L422* probably null Het
Elp6 T C 9: 110,143,087 (GRCm39) F100S probably damaging Het
Epg5 C T 18: 78,025,629 (GRCm39) T1224I possibly damaging Het
Exoc1l A T 5: 76,664,345 (GRCm39) N145Y probably damaging Het
F830016B08Rik T A 18: 60,434,087 (GRCm39) I390N probably benign Het
Fam110c A G 12: 31,124,655 (GRCm39) T206A unknown Het
Fam187b G A 7: 30,676,518 (GRCm39) G9D possibly damaging Het
Fat1 A G 8: 45,478,184 (GRCm39) D2410G probably damaging Het
Fbln1 T A 15: 85,122,760 (GRCm39) F390Y probably benign Het
Fgg A G 3: 82,917,397 (GRCm39) N142S probably damaging Het
Fhip1a G A 3: 85,637,679 (GRCm39) R207* probably null Het
Flcn T C 11: 59,683,513 (GRCm39) T555A probably damaging Het
Foxq1 G T 13: 31,742,808 (GRCm39) probably benign Het
Gm3233 A T 10: 77,595,498 (GRCm39) probably benign Het
Gprc5a G A 6: 135,055,927 (GRCm39) V125I probably damaging Het
Gria2 T C 3: 80,639,358 (GRCm39) D218G probably damaging Het
Gtf3c5 C T 2: 28,469,596 (GRCm39) A103T probably benign Het
Hspg2 C T 4: 137,246,251 (GRCm39) R1010C probably damaging Het
Hspg2 A G 4: 137,266,886 (GRCm39) T1964A possibly damaging Het
Htatip2 G T 7: 49,422,345 (GRCm39) E188* probably null Het
Ifna13 T G 4: 88,562,113 (GRCm39) E170D probably damaging Het
Il4ra A G 7: 125,175,255 (GRCm39) T488A probably benign Het
Jup G T 11: 100,272,660 (GRCm39) H251N probably damaging Het
Kif21a A T 15: 90,852,426 (GRCm39) probably null Het
Klhl28 T A 12: 65,004,034 (GRCm39) I160L probably damaging Het
Klk1b5 A T 7: 43,494,696 (GRCm39) T60S possibly damaging Het
Kntc1 A G 5: 123,950,706 (GRCm39) R1995G probably damaging Het
Lrig2 A C 3: 104,370,099 (GRCm39) I844M probably damaging Het
Lrp2 C T 2: 69,288,771 (GRCm39) W3698* probably null Het
Lyar T A 5: 38,382,053 (GRCm39) S12T possibly damaging Het
Map3k19 T C 1: 127,743,037 (GRCm39) K1507E probably benign Het
Mre11a G A 9: 14,714,199 (GRCm39) G267R probably damaging Het
Mthfd1l A G 10: 3,980,717 (GRCm39) Q473R probably damaging Het
Ncald T A 15: 37,397,593 (GRCm39) E29V probably benign Het
Neb T C 2: 52,177,255 (GRCm39) D1362G probably damaging Het
Nme2 T C 11: 93,846,428 (GRCm39) T7A possibly damaging Het
Nod2 T A 8: 89,391,664 (GRCm39) L657Q possibly damaging Het
Nrm T A 17: 36,174,421 (GRCm39) V75E probably benign Het
Ogfod1 A C 8: 94,763,975 (GRCm39) K20T possibly damaging Het
Omp T C 7: 97,794,348 (GRCm39) N93S probably damaging Het
Or10h28 T A 17: 33,488,454 (GRCm39) V252E probably benign Het
Or14a256 T A 7: 86,264,944 (GRCm39) Q303L probably benign Het
Or5h27 T C 16: 59,006,674 (GRCm39) I57M probably damaging Het
Pcdhb15 A C 18: 37,608,648 (GRCm39) T627P probably damaging Het
Pld1 A G 3: 28,185,882 (GRCm39) T1036A possibly damaging Het
Pogk C A 1: 166,226,334 (GRCm39) E606* probably null Het
Ppp1r10 T A 17: 36,238,823 (GRCm39) L292Q probably damaging Het
Prpf6 T C 2: 181,273,872 (GRCm39) C339R possibly damaging Het
Psd T A 19: 46,301,778 (GRCm39) D937V probably benign Het
Rbak T C 5: 143,160,222 (GRCm39) Q277R probably benign Het
Sbno1 T A 5: 124,542,087 (GRCm39) Y355F probably damaging Het
Sec23ip C T 7: 128,352,226 (GRCm39) Q201* probably null Het
Serpinb3a T C 1: 106,975,337 (GRCm39) K157E probably damaging Het
Slc22a28 A T 19: 8,078,770 (GRCm39) N306K probably damaging Het
Smarca2 C A 19: 26,753,625 (GRCm39) D1584E possibly damaging Het
Snx29 C A 16: 11,265,359 (GRCm39) Q530K probably damaging Het
Stard10 C A 7: 100,994,877 (GRCm39) Q278K possibly damaging Het
Tgm2 C T 2: 157,966,124 (GRCm39) C510Y probably benign Het
Tlr9 C T 9: 106,101,006 (GRCm39) P99L probably damaging Het
Tmco4 T C 4: 138,717,871 (GRCm39) W4R probably benign Het
Tmem151a T A 19: 5,121,862 (GRCm39) probably benign Het
Tmem255b T C 8: 13,504,228 (GRCm39) V140A probably benign Het
Trbj1-2 C T 6: 41,510,950 (GRCm39) probably benign Het
Trpm2 T C 10: 77,781,750 (GRCm39) T290A probably damaging Het
Tsc22d1 G A 14: 76,656,445 (GRCm39) E120K possibly damaging Het
Ttc29 A G 8: 79,052,175 (GRCm39) D352G probably benign Het
Usp25 A T 16: 76,830,833 (GRCm39) I30F possibly damaging Het
Usp34 A C 11: 23,382,268 (GRCm39) N1993T probably damaging Het
Vmn2r124 A C 17: 18,283,284 (GRCm39) H326P probably benign Het
Vmn2r92 C A 17: 18,387,132 (GRCm39) T157K probably benign Het
Vstm5 A T 9: 15,168,789 (GRCm39) I118F probably benign Het
Vwa7 T C 17: 35,242,426 (GRCm39) V510A probably damaging Het
Zfhx4 G A 3: 5,462,123 (GRCm39) S1266N probably damaging Het
Zfp763 T A 17: 33,237,922 (GRCm39) N408Y probably benign Het
Zswim5 C T 4: 116,843,901 (GRCm39) H980Y probably damaging Het
Other mutations in Arhgap32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01020:Arhgap32 APN 9 32,168,657 (GRCm39) missense probably benign 0.00
IGL01317:Arhgap32 APN 9 32,168,260 (GRCm39) missense probably benign 0.30
IGL01614:Arhgap32 APN 9 32,171,801 (GRCm39) missense probably damaging 1.00
IGL01791:Arhgap32 APN 9 32,158,486 (GRCm39) missense probably damaging 0.96
IGL02318:Arhgap32 APN 9 32,170,627 (GRCm39) missense probably benign 0.00
IGL02542:Arhgap32 APN 9 32,166,944 (GRCm39) missense probably damaging 1.00
IGL02568:Arhgap32 APN 9 32,158,490 (GRCm39) missense probably damaging 1.00
IGL02627:Arhgap32 APN 9 32,157,302 (GRCm39) missense probably damaging 1.00
IGL02927:Arhgap32 APN 9 32,172,431 (GRCm39) missense possibly damaging 0.95
IGL03157:Arhgap32 APN 9 32,170,430 (GRCm39) missense probably damaging 1.00
IGL03286:Arhgap32 APN 9 32,170,816 (GRCm39) missense probably benign 0.06
PIT4445001:Arhgap32 UTSW 9 32,172,152 (GRCm39) missense probably damaging 1.00
R0004:Arhgap32 UTSW 9 32,063,294 (GRCm39) missense probably damaging 0.98
R0335:Arhgap32 UTSW 9 32,171,056 (GRCm39) missense probably benign 0.00
R0380:Arhgap32 UTSW 9 32,157,773 (GRCm39) missense probably damaging 1.00
R0396:Arhgap32 UTSW 9 32,156,551 (GRCm39) critical splice donor site probably null
R0494:Arhgap32 UTSW 9 32,170,199 (GRCm39) missense probably damaging 0.98
R0508:Arhgap32 UTSW 9 32,101,364 (GRCm39) splice site probably benign
R0856:Arhgap32 UTSW 9 32,171,516 (GRCm39) missense probably damaging 1.00
R0990:Arhgap32 UTSW 9 32,166,677 (GRCm39) missense probably damaging 1.00
R1312:Arhgap32 UTSW 9 32,166,608 (GRCm39) missense probably benign
R1455:Arhgap32 UTSW 9 32,171,381 (GRCm39) missense probably benign 0.08
R1515:Arhgap32 UTSW 9 32,027,498 (GRCm39) missense probably benign
R1523:Arhgap32 UTSW 9 32,168,048 (GRCm39) missense probably damaging 1.00
R1651:Arhgap32 UTSW 9 32,171,096 (GRCm39) missense probably damaging 1.00
R1743:Arhgap32 UTSW 9 32,170,727 (GRCm39) missense probably benign 0.00
R1999:Arhgap32 UTSW 9 32,027,436 (GRCm39) missense possibly damaging 0.52
R2098:Arhgap32 UTSW 9 32,171,207 (GRCm39) missense probably damaging 1.00
R2150:Arhgap32 UTSW 9 32,027,436 (GRCm39) missense possibly damaging 0.52
R2256:Arhgap32 UTSW 9 32,158,793 (GRCm39) missense probably damaging 0.99
R2257:Arhgap32 UTSW 9 32,158,793 (GRCm39) missense probably damaging 0.99
R2989:Arhgap32 UTSW 9 32,150,694 (GRCm39) missense possibly damaging 0.54
R3780:Arhgap32 UTSW 9 32,063,315 (GRCm39) splice site probably null
R3793:Arhgap32 UTSW 9 32,166,669 (GRCm39) missense probably damaging 1.00
R3846:Arhgap32 UTSW 9 32,101,320 (GRCm39) missense probably benign 0.03
R4086:Arhgap32 UTSW 9 32,158,362 (GRCm39) unclassified probably benign
R4177:Arhgap32 UTSW 9 32,158,510 (GRCm39) missense probably null 1.00
R4230:Arhgap32 UTSW 9 32,168,770 (GRCm39) missense probably benign 0.10
R4280:Arhgap32 UTSW 9 32,171,185 (GRCm39) missense probably damaging 0.98
R4504:Arhgap32 UTSW 9 32,093,135 (GRCm39) splice site probably null
R4587:Arhgap32 UTSW 9 32,172,241 (GRCm39) missense probably benign 0.02
R4622:Arhgap32 UTSW 9 32,150,644 (GRCm39) missense possibly damaging 0.75
R4670:Arhgap32 UTSW 9 32,081,441 (GRCm39) missense probably benign 0.03
R4784:Arhgap32 UTSW 9 32,172,076 (GRCm39) missense probably damaging 1.00
R4784:Arhgap32 UTSW 9 32,040,949 (GRCm39) missense probably damaging 0.99
R4785:Arhgap32 UTSW 9 32,172,076 (GRCm39) missense probably damaging 1.00
R4785:Arhgap32 UTSW 9 32,040,949 (GRCm39) missense probably damaging 0.99
R4906:Arhgap32 UTSW 9 32,156,552 (GRCm39) critical splice donor site probably null
R5046:Arhgap32 UTSW 9 32,168,095 (GRCm39) missense probably damaging 1.00
R5360:Arhgap32 UTSW 9 32,170,967 (GRCm39) missense probably damaging 1.00
R5382:Arhgap32 UTSW 9 32,063,306 (GRCm39) missense probably damaging 1.00
R5445:Arhgap32 UTSW 9 32,159,678 (GRCm39) missense probably benign 0.19
R5637:Arhgap32 UTSW 9 32,158,502 (GRCm39) missense probably damaging 1.00
R5659:Arhgap32 UTSW 9 32,093,256 (GRCm39) missense probably damaging 1.00
R5801:Arhgap32 UTSW 9 32,167,084 (GRCm39) missense probably benign 0.01
R6002:Arhgap32 UTSW 9 32,168,275 (GRCm39) missense probably benign 0.00
R6109:Arhgap32 UTSW 9 32,171,407 (GRCm39) missense probably damaging 1.00
R6405:Arhgap32 UTSW 9 32,159,784 (GRCm39) missense probably benign 0.31
R6922:Arhgap32 UTSW 9 32,063,983 (GRCm39) missense possibly damaging 0.86
R7009:Arhgap32 UTSW 9 32,157,272 (GRCm39) missense probably damaging 1.00
R7137:Arhgap32 UTSW 9 32,063,232 (GRCm39) missense probably benign 0.32
R7183:Arhgap32 UTSW 9 32,097,679 (GRCm39) missense probably benign 0.15
R7251:Arhgap32 UTSW 9 32,119,481 (GRCm39) missense probably damaging 1.00
R7287:Arhgap32 UTSW 9 32,063,993 (GRCm39) missense
R7289:Arhgap32 UTSW 9 32,168,234 (GRCm39) missense probably benign 0.02
R7289:Arhgap32 UTSW 9 32,168,233 (GRCm39) missense possibly damaging 0.92
R7391:Arhgap32 UTSW 9 32,093,235 (GRCm39) missense probably benign 0.00
R7408:Arhgap32 UTSW 9 32,157,220 (GRCm39) missense probably benign 0.06
R7566:Arhgap32 UTSW 9 32,162,018 (GRCm39) missense probably benign 0.10
R7584:Arhgap32 UTSW 9 32,168,263 (GRCm39) missense probably benign 0.16
R7653:Arhgap32 UTSW 9 32,168,441 (GRCm39) missense probably benign
R7884:Arhgap32 UTSW 9 32,171,810 (GRCm39) missense possibly damaging 0.87
R8087:Arhgap32 UTSW 9 32,168,324 (GRCm39) missense probably benign 0.00
R8109:Arhgap32 UTSW 9 32,093,150 (GRCm39) missense probably benign 0.09
R8131:Arhgap32 UTSW 9 32,158,426 (GRCm39) missense probably damaging 1.00
R8155:Arhgap32 UTSW 9 32,093,196 (GRCm39) missense probably damaging 1.00
R8232:Arhgap32 UTSW 9 32,168,198 (GRCm39) missense probably damaging 1.00
R8303:Arhgap32 UTSW 9 32,172,205 (GRCm39) missense probably benign 0.00
R8304:Arhgap32 UTSW 9 32,167,233 (GRCm39) nonsense probably null
R8696:Arhgap32 UTSW 9 32,159,799 (GRCm39) missense possibly damaging 0.90
R8832:Arhgap32 UTSW 9 32,172,115 (GRCm39) missense possibly damaging 0.94
R9112:Arhgap32 UTSW 9 32,157,309 (GRCm39) missense probably damaging 0.99
R9170:Arhgap32 UTSW 9 32,162,039 (GRCm39) missense possibly damaging 0.47
R9279:Arhgap32 UTSW 9 32,168,655 (GRCm39) missense probably benign 0.01
R9431:Arhgap32 UTSW 9 32,170,463 (GRCm39) missense probably damaging 1.00
R9522:Arhgap32 UTSW 9 32,027,450 (GRCm39) missense probably benign
R9526:Arhgap32 UTSW 9 32,172,026 (GRCm39) missense probably benign 0.28
R9661:Arhgap32 UTSW 9 32,168,531 (GRCm39) missense probably benign 0.01
X0027:Arhgap32 UTSW 9 32,161,937 (GRCm39) critical splice acceptor site probably null
X0063:Arhgap32 UTSW 9 32,172,365 (GRCm39) missense probably damaging 1.00
Z1177:Arhgap32 UTSW 9 32,171,976 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- CCTTTGCTAGGCCTGATGTCAC -3'
(R):5'- AGGCTGGTTCATCATCTGGG -3'

Sequencing Primer
(F):5'- TAGGCCTGATGTCACCGCAG -3'
(R):5'- ACTTCTGTCCGTGAAATGGGAAC -3'
Posted On 2015-09-25