Incidental Mutation 'R4615:Or10ak14'
ID 345011
Institutional Source Beutler Lab
Gene Symbol Or10ak14
Ensembl Gene ENSMUSG00000095218
Gene Name olfactory receptor family 10 subfamily AK member 14
Synonyms GA_x6K02T2QD9B-18795136-18796077, MOR259-4P, MOR259-9, Olfr1338, MOR259-4P, Olfr1524-ps1
MMRRC Submission 041826-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.778) question?
Stock # R4615 (G1)
Quality Score 225
Status Not validated
Chromosome 4
Chromosomal Location 118610386-118614155 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 118611334 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 134 (T134A)
Ref Sequence ENSEMBL: ENSMUSP00000092427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084315] [ENSMUST00000214922] [ENSMUST00000216559]
AlphaFold A0A1L1SSB4
Predicted Effect probably benign
Transcript: ENSMUST00000084315
AA Change: T134A

PolyPhen 2 Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000092427
Gene: ENSMUSG00000095218
AA Change: T134A

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 1e-8 PFAM
Pfam:7tm_1 42 291 1.8e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214922
AA Change: T136A

PolyPhen 2 Score 0.289 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000216559
AA Change: T136A

PolyPhen 2 Score 0.289 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 T C 1: 71,369,493 (GRCm39) I363V probably benign Het
Abcc9 C G 6: 142,634,833 (GRCm39) A144P possibly damaging Het
Adgrv1 C T 13: 81,642,688 (GRCm39) probably null Het
Adprhl1 A G 8: 13,292,250 (GRCm39) probably null Het
Angptl3 A T 4: 98,919,598 (GRCm39) E119D probably benign Het
Atp8b1 T C 18: 64,686,170 (GRCm39) N671S probably null Het
C9 A G 15: 6,520,944 (GRCm39) D51G probably damaging Het
Carmil2 A G 8: 106,421,706 (GRCm39) D1019G possibly damaging Het
Cdh8 A T 8: 100,006,254 (GRCm39) I111K probably damaging Het
Cep120 T C 18: 53,847,913 (GRCm39) R649G probably damaging Het
Clptm1l A T 13: 73,755,857 (GRCm39) K158* probably null Het
Cmtm1 CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT 8: 105,036,102 (GRCm39) probably benign Het
Cnga1 A C 5: 72,762,117 (GRCm39) L466V probably damaging Het
Cpsf1 T C 15: 76,481,137 (GRCm39) T1240A possibly damaging Het
Cubn A G 2: 13,433,560 (GRCm39) S1117P probably damaging Het
Cyp2b9 T A 7: 25,900,550 (GRCm39) L396Q probably damaging Het
Cyp8b1 A T 9: 121,745,164 (GRCm39) L56* probably null Het
Dcbld2 A G 16: 58,276,457 (GRCm39) T458A probably benign Het
Dio2 G T 12: 90,696,595 (GRCm39) P131Q probably damaging Het
Dlg5 T C 14: 24,208,236 (GRCm39) Y990C probably damaging Het
Dsc3 T C 18: 20,104,545 (GRCm39) D594G possibly damaging Het
Dsp A G 13: 38,375,608 (GRCm39) E1131G probably damaging Het
Fdx1 A T 9: 51,859,945 (GRCm39) Y21* probably null Het
Gal3st4 A G 5: 138,264,525 (GRCm39) V158A probably damaging Het
Gm10269 T A 18: 20,815,820 (GRCm39) E67D probably benign Het
Gm5773 A G 3: 93,681,339 (GRCm39) H337R probably benign Het
Gng2 C T 14: 19,941,395 (GRCm39) V16I possibly damaging Het
Gpr20 T C 15: 73,567,585 (GRCm39) N268S probably benign Het
Ighv1-82 T C 12: 115,916,280 (GRCm39) T77A probably benign Het
Itprid2 A G 2: 79,492,726 (GRCm39) E1091G probably damaging Het
Lama2 C A 10: 26,857,520 (GRCm39) V3110F probably damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Mtmr4 T C 11: 87,501,761 (GRCm39) L548S probably damaging Het
Ncapg A T 5: 45,844,741 (GRCm39) M579L probably benign Het
Oog3 A T 4: 143,884,899 (GRCm39) Y346N probably benign Het
Or14c39 T C 7: 86,343,936 (GRCm39) S91P probably damaging Het
Orm2 A G 4: 63,281,536 (GRCm39) D89G probably damaging Het
Pcdhb4 T A 18: 37,441,553 (GRCm39) S288T probably benign Het
Pcsk2 G T 2: 143,637,889 (GRCm39) C375F probably damaging Het
Pdcd10 T C 3: 75,428,398 (GRCm39) I138M probably damaging Het
Pde8a T C 7: 80,970,485 (GRCm39) W536R probably damaging Het
Phkg2 C T 7: 127,176,792 (GRCm39) R61W probably damaging Het
Plcl1 A T 1: 55,737,293 (GRCm39) N878I probably benign Het
Prkdc A T 16: 15,480,938 (GRCm39) D353V probably damaging Het
Psme4 C T 11: 30,784,287 (GRCm39) T954I probably benign Het
Ran A G 5: 129,099,162 (GRCm39) I115V probably benign Het
Reln A G 5: 22,177,870 (GRCm39) L1867P possibly damaging Het
S100a1 A G 3: 90,418,562 (GRCm39) V84A possibly damaging Het
Sall2 G A 14: 52,550,207 (GRCm39) P994L probably benign Het
Shtn1 A T 19: 59,010,648 (GRCm39) I273N probably benign Het
Slc17a9 T C 2: 180,373,699 (GRCm39) I40T probably benign Het
Slc29a2 T C 19: 5,079,292 (GRCm39) V305A probably damaging Het
Taar2 T A 10: 23,817,263 (GRCm39) F268I probably benign Het
Taf3 G A 2: 9,956,901 (GRCm39) T422I probably damaging Het
Tgs1 T C 4: 3,585,156 (GRCm39) F99L probably damaging Het
Tox2 T C 2: 163,162,567 (GRCm39) L479P probably damaging Het
Ttn A G 2: 76,597,219 (GRCm39) I19898T probably damaging Het
Ulk1 G T 5: 110,936,912 (GRCm39) T3N probably damaging Het
Vars1 A T 17: 35,232,857 (GRCm39) K900N probably damaging Het
Vmn2r15 A G 5: 109,441,348 (GRCm39) V170A possibly damaging Het
Vmn2r53 A T 7: 12,316,229 (GRCm39) L530Q probably damaging Het
Zar1l G T 5: 150,441,528 (GRCm39) Q33K probably benign Het
Zdhhc16 T C 19: 41,932,122 (GRCm39) V358A possibly damaging Het
Other mutations in Or10ak14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01092:Or10ak14 APN 4 118,610,959 (GRCm39) missense possibly damaging 0.78
IGL02726:Or10ak14 APN 4 118,610,961 (GRCm39) missense probably benign 0.00
IGL02928:Or10ak14 APN 4 118,611,697 (GRCm39) missense probably damaging 1.00
IGL03102:Or10ak14 APN 4 118,611,131 (GRCm39) missense probably benign 0.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0299:Or10ak14 UTSW 4 118,611,732 (GRCm39) start codon destroyed probably null 0.82
R0501:Or10ak14 UTSW 4 118,611,027 (GRCm39) missense probably benign 0.00
R1301:Or10ak14 UTSW 4 118,610,816 (GRCm39) missense probably benign
R1719:Or10ak14 UTSW 4 118,610,797 (GRCm39) missense possibly damaging 0.78
R2327:Or10ak14 UTSW 4 118,611,331 (GRCm39) missense probably benign 0.13
R3110:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R3112:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R4582:Or10ak14 UTSW 4 118,611,090 (GRCm39) missense probably damaging 1.00
R5640:Or10ak14 UTSW 4 118,610,986 (GRCm39) missense probably benign 0.07
R6513:Or10ak14 UTSW 4 118,611,224 (GRCm39) nonsense probably null
R6889:Or10ak14 UTSW 4 118,611,504 (GRCm39) missense probably damaging 0.99
R7157:Or10ak14 UTSW 4 118,611,615 (GRCm39) missense possibly damaging 0.93
R7168:Or10ak14 UTSW 4 118,611,048 (GRCm39) missense probably damaging 0.98
R7378:Or10ak14 UTSW 4 118,611,372 (GRCm39) missense possibly damaging 0.74
R7451:Or10ak14 UTSW 4 118,610,884 (GRCm39) missense probably benign 0.03
R7770:Or10ak14 UTSW 4 118,611,254 (GRCm39) missense probably benign 0.04
R7847:Or10ak14 UTSW 4 118,611,565 (GRCm39) missense possibly damaging 0.79
R8839:Or10ak14 UTSW 4 118,611,411 (GRCm39) missense probably damaging 0.99
R8942:Or10ak14 UTSW 4 118,611,594 (GRCm39) missense possibly damaging 0.94
R9274:Or10ak14 UTSW 4 118,610,883 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCCATGCAAGCCAGACTACG -3'
(R):5'- ACAGCTGCACACTCCTATGTAC -3'

Sequencing Primer
(F):5'- GACTACGCACTGAAGGACCTTC -3'
(R):5'- TGGATATGAGCTATGTCACTACCACC -3'
Posted On 2015-09-25