Incidental Mutation 'R0103:Plxnb2'
| ID |
34504 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxnb2
|
| Ensembl Gene |
ENSMUSG00000036606 |
| Gene Name |
plexin B2 |
| Synonyms |
Debt, 1110007H23Rik |
| MMRRC Submission |
038389-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.954)
|
| Stock # |
R0103 (G1)
|
| Quality Score |
186 |
|
Status
|
Validated
(trace)
|
| Chromosome |
15 |
| Chromosomal Location |
89155549-89180788 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 89161769 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 968
(Y968H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104955
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060808]
[ENSMUST00000109331]
|
| AlphaFold |
B2RXS4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000060808
AA Change: Y968H
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000051731
Gene: ENSMUSG00000036606
AA Change: Y968H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1275 |
1809 |
1.6e-225 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000109331
AA Change: Y968H
PolyPhen 2
Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000104955
Gene: ENSMUSG00000036606
AA Change: Y968H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Sema
|
34 |
452 |
8.87e-92 |
SMART |
|
PSI
|
470 |
521 |
1.94e-10 |
SMART |
|
PSI
|
616 |
669 |
4.09e-1 |
SMART |
|
PSI
|
761 |
804 |
7.02e-8 |
SMART |
|
IPT
|
805 |
896 |
8.14e-19 |
SMART |
|
IPT
|
897 |
983 |
1.1e-15 |
SMART |
|
IPT
|
985 |
1096 |
5.06e-6 |
SMART |
|
Pfam:Plexin_cytopl
|
1274 |
1809 |
4.4e-251 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131062
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139372
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151418
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197760
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000229966
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000230393
|
| Meta Mutation Damage Score |
0.5800 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.8%
|
| Validation Efficiency |
99% (84/85) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca13 |
A |
C |
11: 9,273,951 (GRCm38) |
R443S |
probably damaging |
Het |
| Anapc1 |
T |
C |
2: 128,680,452 (GRCm38) |
|
probably benign |
Het |
| Aqr |
T |
A |
2: 114,149,016 (GRCm38) |
I313F |
probably damaging |
Het |
| Arfgap3 |
A |
T |
15: 83,322,721 (GRCm38) |
|
probably benign |
Het |
| Asah2 |
G |
T |
19: 32,018,977 (GRCm38) |
H374N |
probably benign |
Het |
| Avl9 |
G |
T |
6: 56,736,483 (GRCm38) |
R242L |
probably benign |
Het |
| Ccdc106 |
C |
A |
7: 5,057,545 (GRCm38) |
Q35K |
probably benign |
Het |
| Ccm2l |
G |
T |
2: 153,067,919 (GRCm38) |
E64* |
probably null |
Het |
| Cep85l |
A |
T |
10: 53,278,174 (GRCm38) |
D776E |
possibly damaging |
Het |
| Cfap52 |
T |
A |
11: 67,925,125 (GRCm38) |
I611F |
possibly damaging |
Het |
| Cldn22 |
C |
T |
8: 47,824,554 (GRCm38) |
T9M |
probably benign |
Het |
| Coa7 |
T |
C |
4: 108,338,141 (GRCm38) |
L89P |
possibly damaging |
Het |
| Cox7a2l |
A |
T |
17: 83,514,272 (GRCm38) |
Y2N |
probably damaging |
Het |
| Ctns |
A |
C |
11: 73,185,311 (GRCm38) |
I299M |
probably damaging |
Het |
| Cyp27a1 |
A |
C |
1: 74,735,915 (GRCm38) |
E301A |
probably benign |
Het |
| Cyp2b13 |
A |
T |
7: 26,088,710 (GRCm38) |
K421M |
probably damaging |
Het |
| Cyp4f40 |
C |
A |
17: 32,676,309 (GRCm38) |
C468* |
probably null |
Het |
| Cyp4f40 |
G |
T |
17: 32,676,308 (GRCm38) |
C468F |
probably damaging |
Het |
| Dcun1d5 |
G |
A |
9: 7,188,788 (GRCm38) |
C74Y |
probably damaging |
Het |
| Dennd4c |
A |
G |
4: 86,812,446 (GRCm38) |
Y860C |
probably benign |
Het |
| Dgkz |
T |
C |
2: 91,934,205 (GRCm38) |
T1028A |
probably benign |
Het |
| Dhx58 |
T |
C |
11: 100,695,270 (GRCm38) |
T642A |
probably damaging |
Het |
| Dlg4 |
A |
G |
11: 70,031,193 (GRCm38) |
Y87C |
probably damaging |
Het |
| Dnah6 |
C |
T |
6: 73,092,172 (GRCm38) |
E2511K |
probably damaging |
Het |
| Entpd5 |
C |
A |
12: 84,396,943 (GRCm38) |
E9* |
probably null |
Het |
| Fbln2 |
A |
C |
6: 91,271,550 (GRCm38) |
I1066L |
probably benign |
Het |
| Fhl2 |
C |
T |
1: 43,153,221 (GRCm38) |
R4H |
probably benign |
Het |
| Frmpd1 |
T |
A |
4: 45,229,884 (GRCm38) |
I17K |
probably damaging |
Het |
| Galnt2l |
A |
G |
8: 122,269,733 (GRCm38) |
|
probably benign |
Het |
| Gbp7 |
T |
A |
3: 142,546,538 (GRCm38) |
N627K |
probably benign |
Het |
| Gnptab |
A |
G |
10: 88,429,519 (GRCm38) |
Y331C |
probably damaging |
Het |
| Hdac4 |
T |
C |
1: 91,975,644 (GRCm38) |
E521G |
possibly damaging |
Het |
| Hibadh |
T |
A |
6: 52,557,877 (GRCm38) |
M173L |
probably benign |
Het |
| Iba57 |
C |
T |
11: 59,163,613 (GRCm38) |
A27T |
probably benign |
Het |
| Itga1 |
T |
C |
13: 115,016,254 (GRCm38) |
I211V |
probably benign |
Het |
| Keg1 |
A |
T |
19: 12,718,916 (GRCm38) |
I155F |
possibly damaging |
Het |
| Krt84 |
T |
C |
15: 101,530,236 (GRCm38) |
E272G |
probably damaging |
Het |
| Lrp2 |
C |
A |
2: 69,477,040 (GRCm38) |
V2892L |
probably benign |
Het |
| Ltb |
A |
G |
17: 35,195,040 (GRCm38) |
|
probably benign |
Het |
| Masp1 |
G |
A |
16: 23,458,018 (GRCm38) |
P579L |
probably damaging |
Het |
| Mtor |
T |
A |
4: 148,533,902 (GRCm38) |
M1724K |
probably benign |
Het |
| Myo3a |
T |
G |
2: 22,544,322 (GRCm38) |
|
probably benign |
Het |
| Myo9b |
C |
T |
8: 71,323,849 (GRCm38) |
|
probably benign |
Het |
| Ncor1 |
G |
T |
11: 62,343,045 (GRCm38) |
Q444K |
possibly damaging |
Het |
| Nek7 |
A |
T |
1: 138,544,242 (GRCm38) |
C53* |
probably null |
Het |
| Obscn |
G |
T |
11: 59,062,696 (GRCm38) |
Y4044* |
probably null |
Het |
| Or5b105 |
G |
A |
19: 13,103,278 (GRCm38) |
R3C |
possibly damaging |
Het |
| Pcdh15 |
A |
T |
10: 74,210,425 (GRCm38) |
D178V |
probably damaging |
Het |
| Pcsk6 |
T |
C |
7: 65,929,097 (GRCm38) |
|
probably benign |
Het |
| Phxr4 |
T |
C |
9: 13,431,791 (GRCm38) |
|
probably benign |
Het |
| Pkhd1 |
T |
A |
1: 20,523,359 (GRCm38) |
D1510V |
probably benign |
Het |
| Pkhd1l1 |
T |
C |
15: 44,597,141 (GRCm38) |
C4249R |
probably benign |
Het |
| Prpf39 |
T |
C |
12: 65,055,283 (GRCm38) |
V378A |
possibly damaging |
Het |
| Psd2 |
A |
G |
18: 36,004,717 (GRCm38) |
N455S |
probably damaging |
Het |
| Ptch2 |
C |
A |
4: 117,109,425 (GRCm38) |
|
probably benign |
Het |
| Rab4b |
A |
G |
7: 27,174,502 (GRCm38) |
I117T |
probably benign |
Het |
| Rad9b |
A |
T |
5: 122,331,527 (GRCm38) |
V348E |
probably damaging |
Het |
| Rcor1 |
T |
C |
12: 111,109,778 (GRCm38) |
|
probably benign |
Het |
| Rhoc |
A |
T |
3: 104,791,991 (GRCm38) |
E32V |
possibly damaging |
Het |
| Rnf40 |
T |
G |
7: 127,600,571 (GRCm38) |
V925G |
probably damaging |
Het |
| Rptor |
G |
T |
11: 119,884,967 (GRCm38) |
R988L |
probably benign |
Het |
| Slc25a32 |
A |
T |
15: 39,099,897 (GRCm38) |
Y176* |
probably null |
Het |
| Slc7a1 |
T |
A |
5: 148,352,426 (GRCm38) |
K4* |
probably null |
Het |
| Ss18 |
A |
C |
18: 14,679,421 (GRCm38) |
Y38D |
probably damaging |
Het |
| Syt4 |
T |
A |
18: 31,447,220 (GRCm38) |
|
probably benign |
Het |
| Taar4 |
A |
T |
10: 23,961,406 (GRCm38) |
N305Y |
probably damaging |
Het |
| Taar7b |
A |
T |
10: 24,000,294 (GRCm38) |
Y119F |
probably benign |
Het |
| Tcaf1 |
G |
T |
6: 42,686,390 (GRCm38) |
D185E |
probably benign |
Het |
| Tmem138 |
T |
C |
19: 10,574,952 (GRCm38) |
N62S |
possibly damaging |
Het |
| Tnfaip2 |
C |
T |
12: 111,445,810 (GRCm38) |
T215M |
probably benign |
Het |
| Tnfrsf21 |
C |
T |
17: 43,038,213 (GRCm38) |
H239Y |
probably benign |
Het |
| Tnfrsf25 |
C |
T |
4: 152,116,948 (GRCm38) |
P65S |
possibly damaging |
Het |
| Trp53bp1 |
A |
T |
2: 121,236,759 (GRCm38) |
S495R |
possibly damaging |
Het |
| Trpv3 |
T |
C |
11: 73,293,979 (GRCm38) |
F597S |
probably damaging |
Het |
| Tsc22d4 |
A |
C |
5: 137,747,116 (GRCm38) |
M1L |
possibly damaging |
Het |
| Ttc39a |
A |
G |
4: 109,421,453 (GRCm38) |
|
probably null |
Het |
| Ttn |
T |
G |
2: 76,761,226 (GRCm38) |
H21033P |
probably damaging |
Het |
| Ugt2a3 |
A |
G |
5: 87,336,718 (GRCm38) |
V149A |
possibly damaging |
Het |
| Ush2a |
T |
G |
1: 188,319,070 (GRCm38) |
I251R |
possibly damaging |
Het |
| Vamp4 |
T |
C |
1: 162,589,539 (GRCm38) |
C114R |
possibly damaging |
Het |
| Wdr33 |
T |
C |
18: 31,833,335 (GRCm38) |
V135A |
probably damaging |
Het |
| Zc3h13 |
T |
A |
14: 75,330,468 (GRCm38) |
V1067E |
probably damaging |
Het |
| Zcwpw1 |
G |
A |
5: 137,810,113 (GRCm38) |
W274* |
probably null |
Het |
| Zfp219 |
T |
A |
14: 52,006,706 (GRCm38) |
H627L |
probably damaging |
Het |
|
| Other mutations in Plxnb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00546:Plxnb2
|
APN |
15 |
89,162,366 (GRCm38) |
splice site |
probably benign |
|
|
IGL01574:Plxnb2
|
APN |
15 |
89,162,683 (GRCm38) |
splice site |
probably null |
|
|
IGL01695:Plxnb2
|
APN |
15 |
89,157,214 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
IGL01763:Plxnb2
|
APN |
15 |
89,161,981 (GRCm38) |
splice site |
probably null |
|
|
IGL01921:Plxnb2
|
APN |
15 |
89,164,271 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
IGL02129:Plxnb2
|
APN |
15 |
89,160,410 (GRCm38) |
missense |
probably benign |
0.04 |
|
IGL02153:Plxnb2
|
APN |
15 |
89,165,813 (GRCm38) |
nonsense |
probably null |
|
|
IGL02637:Plxnb2
|
APN |
15 |
89,164,057 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL02892:Plxnb2
|
APN |
15 |
89,161,222 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL03108:Plxnb2
|
APN |
15 |
89,158,031 (GRCm38) |
missense |
probably benign |
0.32 |
|
IGL03115:Plxnb2
|
APN |
15 |
89,162,438 (GRCm38) |
splice site |
probably benign |
|
|
P0040:Plxnb2
|
UTSW |
15 |
89,162,935 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0022:Plxnb2
|
UTSW |
15 |
89,163,276 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0095:Plxnb2
|
UTSW |
15 |
89,165,331 (GRCm38) |
missense |
probably benign |
|
|
R0544:Plxnb2
|
UTSW |
15 |
89,158,613 (GRCm38) |
splice site |
probably benign |
|
|
R0671:Plxnb2
|
UTSW |
15 |
89,157,981 (GRCm38) |
missense |
probably benign |
0.14 |
|
R1279:Plxnb2
|
UTSW |
15 |
89,162,321 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1530:Plxnb2
|
UTSW |
15 |
89,167,192 (GRCm38) |
missense |
probably benign |
|
|
R1542:Plxnb2
|
UTSW |
15 |
89,165,921 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1610:Plxnb2
|
UTSW |
15 |
89,158,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1686:Plxnb2
|
UTSW |
15 |
89,162,462 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1702:Plxnb2
|
UTSW |
15 |
89,161,984 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1996:Plxnb2
|
UTSW |
15 |
89,158,768 (GRCm38) |
missense |
probably benign |
0.13 |
|
R1997:Plxnb2
|
UTSW |
15 |
89,158,768 (GRCm38) |
missense |
probably benign |
0.13 |
|
R2031:Plxnb2
|
UTSW |
15 |
89,162,810 (GRCm38) |
nonsense |
probably null |
|
|
R2049:Plxnb2
|
UTSW |
15 |
89,159,002 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2072:Plxnb2
|
UTSW |
15 |
89,158,451 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2076:Plxnb2
|
UTSW |
15 |
89,158,026 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Plxnb2
|
UTSW |
15 |
89,156,562 (GRCm38) |
missense |
probably benign |
0.04 |
|
R2418:Plxnb2
|
UTSW |
15 |
89,161,069 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R2419:Plxnb2
|
UTSW |
15 |
89,161,069 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R3752:Plxnb2
|
UTSW |
15 |
89,157,255 (GRCm38) |
splice site |
probably benign |
|
|
R3825:Plxnb2
|
UTSW |
15 |
89,166,399 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4154:Plxnb2
|
UTSW |
15 |
89,159,642 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4197:Plxnb2
|
UTSW |
15 |
89,157,018 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4385:Plxnb2
|
UTSW |
15 |
89,160,623 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4434:Plxnb2
|
UTSW |
15 |
89,162,803 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4678:Plxnb2
|
UTSW |
15 |
89,160,928 (GRCm38) |
missense |
probably benign |
0.37 |
|
R4717:Plxnb2
|
UTSW |
15 |
89,157,419 (GRCm38) |
nonsense |
probably null |
|
|
R4773:Plxnb2
|
UTSW |
15 |
89,166,947 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4905:Plxnb2
|
UTSW |
15 |
89,157,411 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5368:Plxnb2
|
UTSW |
15 |
89,159,593 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5418:Plxnb2
|
UTSW |
15 |
89,166,491 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5484:Plxnb2
|
UTSW |
15 |
89,164,209 (GRCm38) |
splice site |
probably null |
|
|
R5520:Plxnb2
|
UTSW |
15 |
89,167,543 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R5566:Plxnb2
|
UTSW |
15 |
89,164,020 (GRCm38) |
missense |
probably benign |
0.05 |
|
R5568:Plxnb2
|
UTSW |
15 |
89,157,435 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5619:Plxnb2
|
UTSW |
15 |
89,162,809 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5685:Plxnb2
|
UTSW |
15 |
89,167,032 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5688:Plxnb2
|
UTSW |
15 |
89,158,696 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5809:Plxnb2
|
UTSW |
15 |
89,167,571 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R5813:Plxnb2
|
UTSW |
15 |
89,160,759 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R5866:Plxnb2
|
UTSW |
15 |
89,167,572 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6016:Plxnb2
|
UTSW |
15 |
89,161,022 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R6117:Plxnb2
|
UTSW |
15 |
89,158,000 (GRCm38) |
missense |
probably benign |
0.04 |
|
R6187:Plxnb2
|
UTSW |
15 |
89,167,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6260:Plxnb2
|
UTSW |
15 |
89,165,291 (GRCm38) |
missense |
probably benign |
0.22 |
|
R6263:Plxnb2
|
UTSW |
15 |
89,161,986 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6269:Plxnb2
|
UTSW |
15 |
89,160,713 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6351:Plxnb2
|
UTSW |
15 |
89,157,770 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6522:Plxnb2
|
UTSW |
15 |
89,164,426 (GRCm38) |
missense |
probably benign |
0.18 |
|
R6856:Plxnb2
|
UTSW |
15 |
89,164,320 (GRCm38) |
missense |
probably benign |
0.27 |
|
R6930:Plxnb2
|
UTSW |
15 |
89,160,389 (GRCm38) |
missense |
probably benign |
|
|
R7354:Plxnb2
|
UTSW |
15 |
89,165,725 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R7513:Plxnb2
|
UTSW |
15 |
89,158,322 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7522:Plxnb2
|
UTSW |
15 |
89,161,774 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7730:Plxnb2
|
UTSW |
15 |
89,162,330 (GRCm38) |
missense |
probably benign |
|
|
R7766:Plxnb2
|
UTSW |
15 |
89,161,271 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7781:Plxnb2
|
UTSW |
15 |
89,157,022 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R8126:Plxnb2
|
UTSW |
15 |
89,163,303 (GRCm38) |
missense |
probably benign |
|
|
R8131:Plxnb2
|
UTSW |
15 |
89,158,713 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8372:Plxnb2
|
UTSW |
15 |
89,158,493 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8736:Plxnb2
|
UTSW |
15 |
89,162,058 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8772:Plxnb2
|
UTSW |
15 |
89,162,746 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9022:Plxnb2
|
UTSW |
15 |
89,164,268 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9044:Plxnb2
|
UTSW |
15 |
89,160,363 (GRCm38) |
splice site |
probably benign |
|
|
R9253:Plxnb2
|
UTSW |
15 |
89,167,812 (GRCm38) |
missense |
probably benign |
|
|
R9398:Plxnb2
|
UTSW |
15 |
89,160,919 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9562:Plxnb2
|
UTSW |
15 |
89,165,933 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9568:Plxnb2
|
UTSW |
15 |
89,160,957 (GRCm38) |
nonsense |
probably null |
|
|
R9613:Plxnb2
|
UTSW |
15 |
89,164,293 (GRCm38) |
missense |
probably benign |
0.01 |
|
X0027:Plxnb2
|
UTSW |
15 |
89,160,713 (GRCm38) |
missense |
probably benign |
0.18 |
|
Z1177:Plxnb2
|
UTSW |
15 |
89,159,096 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTAAGGAGGAAGCCCATCAGAGTG -3'
(R):5'- CCCTTGTGAAGTGTATGTGTCGCC -3'
Sequencing Primer
(F):5'- AGCCCATCAGAGTGCAGTG -3'
(R):5'- TCTGGGGAGAGGGTGGG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation