Mutagenetix > Incidental Mutations

Incidental Mutation 'R4618:Olfr1342'

345079

Institutional Source

Beutler Lab

Gene Symbol

Olfr1342

Ensembl Gene

ENSMUSG00000043383

Gene Name

olfactory receptor 1342

Synonyms

GA_x6K02T2QD9B-18856980-18857927, MOR258-3

MMRRC Submission

041884-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R4618 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

118687486-118692756 bp(-) (GRCm38)

Type of Mutation

utr 3 prime

DNA Base Change (assembly)

A to T at 118689470 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149966 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060562] [ENSMUST00000060562] [ENSMUST00000216226]

AlphaFold

Q8VFY3

Predicted Effect

probably benign
Transcript: ENSMUST00000060562

SMART Domains

Protein: ENSMUSP00000053925
Gene: ENSMUSG00000043383

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
Pfam:7tm_4	34	311	1.5e-55	PFAM
Pfam:7TM_GPCR_Srsx	38	243	1.6e-5	PFAM
Pfam:7tm_1	44	293	4.2e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000060562

SMART Domains

Protein: ENSMUSP00000053925
Gene: ENSMUSG00000043383

Domain	Start	End	E-Value	Type
low complexity region	10	24	N/A	INTRINSIC
Pfam:7tm_4	34	311	1.5e-55	PFAM
Pfam:7TM_GPCR_Srsx	38	243	1.6e-5	PFAM
Pfam:7tm_1	44	293	4.2e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000216226

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.2%

Validation Efficiency

98% (89/91)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930432M17Rik	A	T	3: 121,679,446	K83N	unknown	Het
Adamtsl3	T	A	7: 82,606,520	M1580K	probably benign	Het
Adprhl1	A	G	8: 13,242,250		probably null	Het
Akap3	G	T	6: 126,866,443	C675F	probably benign	Het
Asap1	A	T	15: 64,152,895	H318Q	probably damaging	Het
Atf7ip	G	T	6: 136,565,106	A18S	probably damaging	Het
Bcl2a1a	A	C	9: 88,957,304	N85T	probably damaging	Het
Btnl6	G	A	17: 34,514,146	P248S	probably damaging	Het
C9	A	G	15: 6,491,463	D51G	probably damaging	Het
Ccdc14	T	A	16: 34,706,495	C257S	probably benign	Het
Cd5l	A	G	3: 87,368,619	T299A	probably benign	Het
Endou	C	T	15: 97,713,882	V292M	possibly damaging	Het
Fbxo36	T	C	1: 84,900,028	I137T	probably damaging	Het
Fcer1a	T	C	1: 173,222,641	I161V	possibly damaging	Het
Fsip2	A	G	2: 82,987,759	Y4612C	probably benign	Het
Gcnt2	T	A	13: 40,958,194	L353*	probably null	Het
Ghrhr	T	C	6: 55,381,754	F172S	probably damaging	Het
Gins1	T	A	2: 150,917,861		probably null	Het
Gm16519	T	G	17: 70,929,242	L62R	probably damaging	Het
Gm4758	T	A	16: 36,312,590	D76E	possibly damaging	Het
Gpr20	T	C	15: 73,695,736	N268S	probably benign	Het
Greb1l	A	G	18: 10,498,965	T283A	probably benign	Het
Grin2c	T	A	11: 115,252,747	D729V	probably damaging	Het
Heatr4	T	G	12: 83,978,067	T327P	probably damaging	Het
Hes2	A	C	4: 152,160,388	S105R	probably benign	Het
Hsph1	A	G	5: 149,618,843	V705A	probably benign	Het
Ighv1-82	T	C	12: 115,952,660	T77A	probably benign	Het
Itih1	A	T	14: 30,929,831	D851E	probably benign	Het
Klhdc7b	A	G	15: 89,387,269	T785A	probably benign	Het
Lmbr1	G	T	5: 29,346,865	A74E	probably damaging	Het
Lonp1	A	C	17: 56,622,511	H175Q	probably benign	Het
Maml2	T	C	9: 13,620,075	F195S	probably damaging	Het
Man2b2	G	T	5: 36,817,639	T436K	probably benign	Het
Man2c1	T	C	9: 57,142,155		probably null	Het
Mettl11b	A	T	1: 163,725,028	F10I	probably damaging	Het
Mrps15	G	A	4: 126,047,044		probably benign	Het
Mtrf1l	C	A	10: 5,817,586	V177F	probably benign	Het
Naxd	A	T	8: 11,509,489	I213F	probably damaging	Het
Nbeal1	T	A	1: 60,228,731		probably benign	Het
Nfatc1	T	C	18: 80,697,832	I318V	probably damaging	Het
Nid2	T	A	14: 19,808,010	I1297N	probably damaging	Het
Nol10	T	C	12: 17,348,561	V3A	probably damaging	Het
Nop14	G	T	5: 34,639,218	P765Q	probably damaging	Het
Noxa1	C	T	2: 25,091,749	G114D	probably damaging	Het
Olfr1100	A	G	2: 86,978,274	I174T	possibly damaging	Het
Olfr714	G	A	7: 107,074,554	C242Y	probably damaging	Het
Olfr73	A	G	2: 88,034,554	V195A	probably benign	Het
Opa1	T	C	16: 29,587,039	W141R	probably damaging	Het
Pde4d	A	T	13: 109,933,877	M7L	probably benign	Het
Phykpl	G	A	11: 51,592,229	A188T	probably damaging	Het
Pkd2l1	C	A	19: 44,154,134	A490S	probably damaging	Het
Pkhd1l1	T	A	15: 44,539,682	V2260D	probably damaging	Het
Ptprt	T	C	2: 161,553,845	E1136G	probably damaging	Het
Rad21	A	T	15: 51,970,024	L353Q	probably damaging	Het
Rfx4	G	T	10: 84,880,896	A425S	probably benign	Het
Rnf38	A	G	4: 44,142,450	S169P	probably damaging	Het
Samd9l	C	A	6: 3,376,347	V305F	probably damaging	Het
Serpini1	A	G	3: 75,616,576	K164E	probably benign	Het
Sirt6	A	G	10: 81,626,574	L37P	probably damaging	Het
Sorbs1	T	C	19: 40,373,518	T141A	probably damaging	Het
Tacc2	A	T	7: 130,626,216	T1563S	probably benign	Het
Tbc1d14	A	C	5: 36,530,381		probably benign	Het
Tbrg4	G	A	11: 6,620,185		probably benign	Het
Tox2	T	C	2: 163,320,647	L479P	probably damaging	Het
Tpp1	A	T	7: 105,751,706	L38Q	probably benign	Het
Trhr	A	G	15: 44,197,641	N186D	probably benign	Het
Trmt1l	C	T	1: 151,454,048	Q581*	probably null	Het
Tsen54	T	A	11: 115,815,421		probably benign	Het
Tsg101	A	G	7: 46,892,509	I138T	possibly damaging	Het
Usp22	A	G	11: 61,161,443	S237P	probably damaging	Het
Vmn1r209	A	G	13: 22,806,449	S24P	possibly damaging	Het
Vmn2r18	A	T	5: 151,584,959	H233Q	possibly damaging	Het
Vmn2r45	A	T	7: 8,483,437	I284N	probably benign	Het
Vmn2r66	T	C	7: 84,995,088	I705V	possibly damaging	Het
Vsig1	G	T	X: 140,926,386	A95S	probably benign	Het
Zdhhc11	T	A	13: 73,979,230	M242K	probably benign	Het
Zfp352	A	G	4: 90,225,081	K486R	probably benign	Het

Other mutations in Olfr1342

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01823:Olfr1342	APN	4	118689721	missense	probably damaging	1.00
IGL02391:Olfr1342	APN	4	118690341	missense	probably damaging	1.00
R0648:Olfr1342	UTSW	4	118690072	missense	probably benign
R1565:Olfr1342	UTSW	4	118690192	missense	probably damaging	1.00
R1675:Olfr1342	UTSW	4	118689948	missense	probably benign	0.00
R1823:Olfr1342	UTSW	4	118690192	missense	probably damaging	1.00
R2343:Olfr1342	UTSW	4	118690187	missense	probably benign	0.30
R4941:Olfr1342	UTSW	4	118689892	missense	possibly damaging	0.76
R5408:Olfr1342	UTSW	4	118690444	missense	probably benign	0.00
R5587:Olfr1342	UTSW	4	118689870	missense	probably damaging	1.00
R5895:Olfr1342	UTSW	4	118690117	missense	probably damaging	0.97
R6023:Olfr1342	UTSW	4	118690074	missense	probably damaging	1.00
R6307:Olfr1342	UTSW	4	118689948	missense	probably benign	0.00
R6324:Olfr1342	UTSW	4	118690531	start gained	probably benign
R6890:Olfr1342	UTSW	4	118689531	missense	possibly damaging	0.72
R7218:Olfr1342	UTSW	4	118690018	missense	probably benign
R7408:Olfr1342	UTSW	4	118689662	missense	probably damaging	0.98
R7555:Olfr1342	UTSW	4	118689642	missense	possibly damaging	0.94
R7749:Olfr1342	UTSW	4	118690228	missense	probably damaging	1.00
R8098:Olfr1342	UTSW	4	118690209	missense	possibly damaging	0.88
R8493:Olfr1342	UTSW	4	118690032	missense	probably benign	0.01
Z1176:Olfr1342	UTSW	4	118690272	missense	probably benign	0.31

Predicted Primers

PCR Primer
(F):5'- AGCCCATGGAAAGCAATCAATG -3'
(R):5'- GCCAGCCATGATCATGTACATG -3'

Sequencing Primer
(F):5'- GCCCATGGAAAGCAATCAATGTCTAC -3'
(R):5'- CGGTTCTTGGTATGACCCAGAAC -3'

Posted On

2015-09-25