Incidental Mutation 'R4619:Kif3b'
ID 345155
Institutional Source Beutler Lab
Gene Symbol Kif3b
Ensembl Gene ENSMUSG00000027475
Gene Name kinesin family member 3B
Synonyms
MMRRC Submission 041885-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4619 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 153133333-153175310 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 153158594 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 132 (R132*)
Ref Sequence ENSEMBL: ENSMUSP00000028977 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028977]
AlphaFold Q61771
Predicted Effect probably null
Transcript: ENSMUST00000028977
AA Change: R132*
SMART Domains Protein: ENSMUSP00000028977
Gene: ENSMUSG00000027475
AA Change: R132*

DomainStartEndE-ValueType
KISc 7 348 6.36e-186 SMART
low complexity region 370 412 N/A INTRINSIC
low complexity region 437 458 N/A INTRINSIC
Blast:KISc 459 535 3e-10 BLAST
low complexity region 537 548 N/A INTRINSIC
Blast:KISc 549 626 4e-27 BLAST
low complexity region 685 697 N/A INTRINSIC
low complexity region 714 735 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygoous for a targeted null mutation are growth retarded and display neural tube defects, incomplete embryo turning, randomized left-right assymetry, pericardial edema, and die during the midgestational period. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G A 3: 137,775,520 (GRCm39) V1570I probably damaging Het
Alx4 A G 2: 93,473,106 (GRCm39) R35G probably damaging Het
Apod T C 16: 31,116,211 (GRCm39) D173G probably benign Het
Atp8b3 G A 10: 80,361,858 (GRCm39) T731I possibly damaging Het
Birc6 A C 17: 74,947,145 (GRCm39) T2955P probably benign Het
Cdh15 G A 8: 123,587,612 (GRCm39) D179N probably damaging Het
Cntnap5c G T 17: 58,717,263 (GRCm39) V1282L probably benign Het
Crocc2 G A 1: 93,141,372 (GRCm39) R1175H probably benign Het
Dbh A G 2: 27,064,836 (GRCm39) D349G probably damaging Het
Dync1h1 A G 12: 110,605,278 (GRCm39) I2372V probably benign Het
Fer1l4 A T 2: 155,889,007 (GRCm39) W389R probably damaging Het
Fndc1 T C 17: 7,984,036 (GRCm39) T1297A unknown Het
Gart T C 16: 91,422,321 (GRCm39) N732S probably damaging Het
Gas2l2 T C 11: 83,313,924 (GRCm39) I463V probably benign Het
Gm5591 G A 7: 38,220,072 (GRCm39) S267L probably benign Het
Gzmk A G 13: 113,309,657 (GRCm39) V92A probably damaging Het
Hspg2 C T 4: 137,273,884 (GRCm39) R2680W probably damaging Het
Insyn2a A G 7: 134,520,270 (GRCm39) Y87H probably damaging Het
Kcnh3 G A 15: 99,131,982 (GRCm39) V646M probably damaging Het
Kcnk7 A C 19: 5,756,463 (GRCm39) I230L probably benign Het
Klra5 T C 6: 129,885,776 (GRCm39) S128G probably benign Het
Krba1 C T 6: 48,383,282 (GRCm39) R4* probably null Het
Krt1c T A 15: 101,726,026 (GRCm39) I171F probably damaging Het
Lss A G 10: 76,372,089 (GRCm39) D148G probably benign Het
Mavs G T 2: 131,082,370 (GRCm39) A85S probably damaging Het
Mipep T C 14: 61,140,865 (GRCm39) C566R probably damaging Het
Myocd T A 11: 65,069,254 (GRCm39) probably benign Het
Ndufa9 C T 6: 126,804,498 (GRCm39) probably null Het
Nolc1 G A 19: 46,071,959 (GRCm39) G583D probably damaging Het
Nucb2 T C 7: 116,127,059 (GRCm39) probably null Het
Or1i2 T C 10: 78,448,409 (GRCm39) D22G probably benign Het
Or52e19 C T 7: 102,959,165 (GRCm39) T79I probably benign Het
Or5p63 A T 7: 107,811,301 (GRCm39) I145N possibly damaging Het
Pank4 C A 4: 155,061,076 (GRCm39) D508E probably benign Het
Phb1 T A 11: 95,562,416 (GRCm39) probably benign Het
Pign T A 1: 105,449,715 (GRCm39) probably benign Het
Plec T C 15: 76,076,382 (GRCm39) K349E probably benign Het
Ppp1r3c A T 19: 36,711,743 (GRCm39) V9E possibly damaging Het
Rap1gap T A 4: 137,443,422 (GRCm39) V130D probably damaging Het
Senp3 T A 11: 69,567,944 (GRCm39) Y432F probably benign Het
Serpina3f T C 12: 104,183,549 (GRCm39) I137T possibly damaging Het
Slc46a3 T A 5: 147,823,540 (GRCm39) K101* probably null Het
Snph G A 2: 151,436,434 (GRCm39) Q96* probably null Het
Sptb A T 12: 76,630,581 (GRCm39) C2244* probably null Het
Srbd1 A T 17: 86,416,693 (GRCm39) F488L probably benign Het
Ssc5d A T 7: 4,932,524 (GRCm39) H396L probably damaging Het
Sulf1 A C 1: 12,856,876 (GRCm39) R42S probably damaging Het
Taf1a T A 1: 183,181,752 (GRCm39) probably benign Het
Thoc5 T A 11: 4,876,218 (GRCm39) M609K probably damaging Het
Tiam2 A T 17: 3,568,617 (GRCm39) I1588F probably damaging Het
Tmcc1 C T 6: 116,020,247 (GRCm39) V402I probably damaging Het
Tmprss15 T C 16: 78,818,358 (GRCm39) D524G probably damaging Het
Trbv31 T C 6: 41,534,901 (GRCm39) I21V probably benign Het
Vmn1r74 A T 7: 11,581,398 (GRCm39) T233S possibly damaging Het
Vmn1r74 G C 7: 11,581,403 (GRCm39) Q234H probably damaging Het
Vsx1 A T 2: 150,530,529 (GRCm39) S118T probably benign Het
Wnt9b G A 11: 103,621,949 (GRCm39) T236I probably benign Het
Zbtb21 T C 16: 97,751,092 (GRCm39) T1092A possibly damaging Het
Zc3hc1 G A 6: 30,387,523 (GRCm39) T52I probably benign Het
Zfp558 T A 9: 18,367,577 (GRCm39) N404Y possibly damaging Het
Zfp735 A T 11: 73,602,031 (GRCm39) D325V probably damaging Het
Zhx3 A T 2: 160,623,879 (GRCm39) M96K probably damaging Het
Other mutations in Kif3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00162:Kif3b APN 2 153,159,051 (GRCm39) missense probably damaging 0.99
IGL00927:Kif3b APN 2 153,158,381 (GRCm39) missense possibly damaging 0.89
IGL02121:Kif3b APN 2 153,159,194 (GRCm39) missense probably damaging 0.99
IGL02302:Kif3b APN 2 153,158,868 (GRCm39) missense probably damaging 1.00
IGL02306:Kif3b APN 2 153,162,572 (GRCm39) missense probably damaging 1.00
IGL02348:Kif3b APN 2 153,158,813 (GRCm39) missense probably damaging 0.98
IGL03111:Kif3b APN 2 153,171,988 (GRCm39) missense probably benign 0.00
R1463:Kif3b UTSW 2 153,172,073 (GRCm39) makesense probably null
R1474:Kif3b UTSW 2 153,162,235 (GRCm39) missense probably damaging 1.00
R1485:Kif3b UTSW 2 153,164,851 (GRCm39) splice site probably null
R1538:Kif3b UTSW 2 153,159,382 (GRCm39) small deletion probably benign
R1834:Kif3b UTSW 2 153,159,405 (GRCm39) missense probably benign 0.22
R2371:Kif3b UTSW 2 153,164,743 (GRCm39) missense possibly damaging 0.66
R4051:Kif3b UTSW 2 153,165,477 (GRCm39) missense probably damaging 0.99
R4208:Kif3b UTSW 2 153,165,477 (GRCm39) missense probably damaging 0.99
R4504:Kif3b UTSW 2 153,165,564 (GRCm39) critical splice donor site probably null
R4806:Kif3b UTSW 2 153,162,288 (GRCm39) missense probably damaging 1.00
R4911:Kif3b UTSW 2 153,159,212 (GRCm39) nonsense probably null
R7017:Kif3b UTSW 2 153,171,644 (GRCm39) missense possibly damaging 0.87
R7990:Kif3b UTSW 2 153,159,383 (GRCm39) missense probably benign 0.01
R8056:Kif3b UTSW 2 153,171,979 (GRCm39) missense possibly damaging 0.93
R8503:Kif3b UTSW 2 153,162,824 (GRCm39) critical splice donor site probably null
R8515:Kif3b UTSW 2 153,158,427 (GRCm39) missense probably damaging 1.00
R9041:Kif3b UTSW 2 153,159,468 (GRCm39) missense probably benign 0.01
R9524:Kif3b UTSW 2 153,159,460 (GRCm39) missense probably benign 0.38
X0026:Kif3b UTSW 2 153,158,241 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAACGCCAAGCAGTTTGAGC -3'
(R):5'- GGTTTCCCACATTCATCACATG -3'

Sequencing Primer
(F):5'- AGCTCTATGATGAGACGTTCCGAC -3'
(R):5'- CCACATTCATCACATGCTCTATC -3'
Posted On 2015-09-25