Incidental Mutation 'R4620:Dnai3'
ID 345221
Institutional Source Beutler Lab
Gene Symbol Dnai3
Ensembl Gene ENSMUSG00000043020
Gene Name dynein axonemal intermediate chain 3
Synonyms 4931433A13Rik, Wdr63, Ida7, IC140
MMRRC Submission 042008-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R4620 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 145746281-145813855 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 145748564 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 850 (L850Q)
Ref Sequence ENSEMBL: ENSMUSP00000124475 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160285]
AlphaFold B2RY71
Predicted Effect probably damaging
Transcript: ENSMUST00000160285
AA Change: L850Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000124475
Gene: ENSMUSG00000043020
AA Change: L850Q

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
low complexity region 26 35 N/A INTRINSIC
low complexity region 133 150 N/A INTRINSIC
low complexity region 165 180 N/A INTRINSIC
Blast:WD40 321 367 6e-19 BLAST
low complexity region 375 383 N/A INTRINSIC
WD40 390 429 6.34e-2 SMART
WD40 470 527 1.15e-4 SMART
low complexity region 536 553 N/A INTRINSIC
WD40 693 732 1.07e1 SMART
WD40 737 776 1.1e2 SMART
coiled coil region 867 902 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161104
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196412
Meta Mutation Damage Score 0.1463 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 99% (80/81)
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik A T 7: 130,945,335 (GRCm39) Y433* probably null Het
Apba2 C T 7: 64,364,215 (GRCm39) R331C probably damaging Het
Apod T C 16: 31,116,211 (GRCm39) D173G probably benign Het
B3gnt5 A T 16: 19,588,632 (GRCm39) M284L probably benign Het
Birc6 A C 17: 74,947,145 (GRCm39) T2955P probably benign Het
Blvra T C 2: 126,938,885 (GRCm39) I287T probably damaging Het
Capn5 T C 7: 97,778,578 (GRCm39) Y347C probably damaging Het
Cdcp2 A G 4: 106,963,927 (GRCm39) E259G probably damaging Het
Cdh2 A G 18: 16,781,665 (GRCm39) V85A probably benign Het
Cdk5rap2 A G 4: 70,184,943 (GRCm39) I1169T probably benign Het
Cenpj A G 14: 56,772,911 (GRCm39) V1043A probably damaging Het
Cfap54 T A 10: 92,805,619 (GRCm39) H1497L probably benign Het
Chat A G 14: 32,175,775 (GRCm39) M95T probably damaging Het
Csmd1 T C 8: 16,052,694 (GRCm39) probably null Het
Csmd3 T C 15: 47,449,149 (GRCm39) E3615G probably benign Het
Cyp2c68 A T 19: 39,701,006 (GRCm39) probably null Het
Dll1 C T 17: 15,590,828 (GRCm39) A332T probably benign Het
Dmrta1 A T 4: 89,577,021 (GRCm39) Q159L probably benign Het
Eci3 A T 13: 35,132,741 (GRCm39) M212K probably damaging Het
Eml4 T C 17: 83,768,962 (GRCm39) F557L probably benign Het
Fat3 A T 9: 15,908,190 (GRCm39) V2604D probably damaging Het
Frem3 T C 8: 81,395,586 (GRCm39) V1871A possibly damaging Het
Gart T C 16: 91,422,321 (GRCm39) N732S probably damaging Het
Gas2l2 T C 11: 83,313,924 (GRCm39) I463V probably benign Het
H2-M3 C A 17: 37,583,310 (GRCm39) T257K probably damaging Het
Hdgf A G 3: 87,821,883 (GRCm39) N166S possibly damaging Het
Hoxb3 A T 11: 96,236,599 (GRCm39) N226Y probably damaging Het
Itgav T C 2: 83,586,246 (GRCm39) Y169H probably benign Het
Kalrn T G 16: 33,849,075 (GRCm39) I426L probably damaging Het
Kcnh3 G A 15: 99,131,982 (GRCm39) V646M probably damaging Het
Kif6 T C 17: 50,208,324 (GRCm39) V735A probably benign Het
Krt1c T A 15: 101,726,026 (GRCm39) I171F probably damaging Het
Megf8 G A 7: 25,054,523 (GRCm39) A1880T possibly damaging Het
Miox A T 15: 89,220,324 (GRCm39) Y172F probably benign Het
Myo18a G A 11: 77,708,773 (GRCm39) R48H possibly damaging Het
Ndufb7 T C 8: 84,293,487 (GRCm39) S14P probably damaging Het
Npepps A T 11: 97,129,070 (GRCm39) H371Q probably damaging Het
Or10d5j C T 9: 39,868,205 (GRCm39) V9M probably damaging Het
Or52e15 T A 7: 104,645,830 (GRCm39) I94F probably damaging Het
Or52e19 C T 7: 102,959,165 (GRCm39) T79I probably benign Het
Or8b12c A G 9: 37,716,115 (GRCm39) T303A probably benign Het
Orc5 A T 5: 22,734,174 (GRCm39) D203E probably damaging Het
Pappa A G 4: 65,245,265 (GRCm39) T1518A probably benign Het
Pde6a A G 18: 61,395,563 (GRCm39) D602G probably damaging Het
Pnliprp2 G A 19: 58,750,718 (GRCm39) V136I possibly damaging Het
Postn A C 3: 54,284,414 (GRCm39) D627A probably damaging Het
Prpf39 T C 12: 65,089,337 (GRCm39) V25A probably benign Het
Pxdc1 A G 13: 34,836,297 (GRCm39) I41T probably damaging Het
Rab11fip1 T A 8: 27,644,243 (GRCm39) E514V probably damaging Het
Rag1 A T 2: 101,474,025 (GRCm39) H372Q probably damaging Het
Ranbp1 A G 16: 18,057,968 (GRCm39) probably benign Het
Rexo5 A G 7: 119,426,526 (GRCm39) I317V probably benign Het
Rragc A G 4: 123,818,622 (GRCm39) Q279R probably damaging Het
Sbf1 A G 15: 89,191,129 (GRCm39) S187P probably damaging Het
Senp3 T A 11: 69,567,944 (GRCm39) Y432F probably benign Het
Slfn5 G A 11: 82,852,478 (GRCm39) C868Y probably damaging Het
Sorcs2 C T 5: 36,194,838 (GRCm39) A722T probably benign Het
Sptb A T 12: 76,630,581 (GRCm39) C2244* probably null Het
Srbd1 A T 17: 86,416,693 (GRCm39) F488L probably benign Het
Sucnr1 A G 3: 59,994,190 (GRCm39) I239M possibly damaging Het
Themis2 A G 4: 132,513,333 (GRCm39) W298R probably damaging Het
Tmem168 T G 6: 13,594,952 (GRCm39) N37T probably benign Het
Tmem62 A G 2: 120,826,845 (GRCm39) probably benign Het
Tmprss15 T C 16: 78,818,358 (GRCm39) D524G probably damaging Het
Trav5-4 G T 14: 53,941,853 (GRCm39) M75I probably benign Het
Trio T A 15: 27,871,257 (GRCm39) H620L probably damaging Het
Ubap2 C T 4: 41,233,698 (GRCm39) G64E probably damaging Het
Usp32 C A 11: 84,949,953 (GRCm39) probably null Het
Wdfy3 A T 5: 102,054,011 (GRCm39) F1603Y probably damaging Het
Xpo4 A T 14: 57,867,782 (GRCm39) L155Q probably damaging Het
Zbtb21 T C 16: 97,751,092 (GRCm39) T1092A possibly damaging Het
Zfp780b A T 7: 27,662,178 (GRCm39) Y792* probably null Het
Other mutations in Dnai3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Dnai3 APN 3 145,788,759 (GRCm39) missense probably benign
IGL00565:Dnai3 APN 3 145,750,674 (GRCm39) splice site probably benign
IGL01339:Dnai3 APN 3 145,748,591 (GRCm39) missense probably benign 0.14
IGL01952:Dnai3 APN 3 145,802,918 (GRCm39) missense probably damaging 0.96
IGL02663:Dnai3 APN 3 145,760,312 (GRCm39) missense possibly damaging 0.53
IGL02710:Dnai3 APN 3 145,753,903 (GRCm39) missense possibly damaging 0.96
P0041:Dnai3 UTSW 3 145,786,997 (GRCm39) missense possibly damaging 0.96
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0014:Dnai3 UTSW 3 145,787,178 (GRCm39) splice site probably null
R0498:Dnai3 UTSW 3 145,787,119 (GRCm39) missense possibly damaging 0.54
R0589:Dnai3 UTSW 3 145,768,086 (GRCm39) missense probably benign 0.01
R1484:Dnai3 UTSW 3 145,802,996 (GRCm39) missense probably benign 0.02
R1537:Dnai3 UTSW 3 145,748,504 (GRCm39) missense probably damaging 0.98
R1611:Dnai3 UTSW 3 145,801,113 (GRCm39) missense probably damaging 1.00
R1743:Dnai3 UTSW 3 145,803,017 (GRCm39) missense possibly damaging 0.81
R1861:Dnai3 UTSW 3 145,788,801 (GRCm39) missense probably damaging 1.00
R1991:Dnai3 UTSW 3 145,769,235 (GRCm39) missense possibly damaging 0.82
R2185:Dnai3 UTSW 3 145,772,619 (GRCm39) missense possibly damaging 0.76
R4299:Dnai3 UTSW 3 145,774,561 (GRCm39) missense probably damaging 1.00
R4649:Dnai3 UTSW 3 145,753,922 (GRCm39) missense probably damaging 1.00
R4914:Dnai3 UTSW 3 145,772,582 (GRCm39) missense probably damaging 0.98
R4948:Dnai3 UTSW 3 145,788,820 (GRCm39) nonsense probably null
R5578:Dnai3 UTSW 3 145,802,983 (GRCm39) nonsense probably null
R6130:Dnai3 UTSW 3 145,748,559 (GRCm39) missense probably benign 0.25
R6162:Dnai3 UTSW 3 145,750,617 (GRCm39) missense probably damaging 1.00
R6291:Dnai3 UTSW 3 145,772,648 (GRCm39) missense probably benign 0.00
R6390:Dnai3 UTSW 3 145,801,143 (GRCm39) missense probably damaging 1.00
R6560:Dnai3 UTSW 3 145,801,161 (GRCm39) missense possibly damaging 0.79
R6893:Dnai3 UTSW 3 145,786,184 (GRCm39) missense probably damaging 1.00
R7090:Dnai3 UTSW 3 145,746,582 (GRCm39) missense possibly damaging 0.80
R7102:Dnai3 UTSW 3 145,761,459 (GRCm39) missense possibly damaging 0.49
R7111:Dnai3 UTSW 3 145,803,028 (GRCm39) missense probably damaging 0.99
R7260:Dnai3 UTSW 3 145,752,295 (GRCm39) missense probably benign 0.01
R7288:Dnai3 UTSW 3 145,787,007 (GRCm39) missense probably damaging 0.97
R7411:Dnai3 UTSW 3 145,802,900 (GRCm39) missense probably damaging 0.98
R7417:Dnai3 UTSW 3 145,798,835 (GRCm39) splice site probably null
R7466:Dnai3 UTSW 3 145,761,373 (GRCm39) missense probably benign 0.01
R7860:Dnai3 UTSW 3 145,772,675 (GRCm39) missense probably damaging 0.99
R7964:Dnai3 UTSW 3 145,774,531 (GRCm39) missense probably benign 0.09
R8013:Dnai3 UTSW 3 145,787,040 (GRCm39) missense probably damaging 1.00
R8059:Dnai3 UTSW 3 145,752,428 (GRCm39) missense possibly damaging 0.75
R8191:Dnai3 UTSW 3 145,800,066 (GRCm39) missense probably damaging 1.00
R8354:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8454:Dnai3 UTSW 3 145,802,982 (GRCm39) missense probably damaging 1.00
R8770:Dnai3 UTSW 3 145,752,298 (GRCm39) missense probably benign 0.01
R8967:Dnai3 UTSW 3 145,761,395 (GRCm39) missense possibly damaging 0.95
R9135:Dnai3 UTSW 3 145,772,589 (GRCm39) missense probably benign 0.39
R9310:Dnai3 UTSW 3 145,802,895 (GRCm39) critical splice donor site probably null
R9664:Dnai3 UTSW 3 145,748,594 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TAAGGGAGCACACAGGACTC -3'
(R):5'- TTCCACTATGGTTAAGAAGGTGG -3'

Sequencing Primer
(F):5'- ACACAGGACTCTCGTGGGATG -3'
(R):5'- TTGGTGTCATCAGGCGAC -3'
Posted On 2015-09-25