Incidental Mutation 'R4620:Kif6'
ID 345283
Institutional Source Beutler Lab
Gene Symbol Kif6
Ensembl Gene ENSMUSG00000023999
Gene Name kinesin family member 6
Synonyms D130084M03Rik, D130004B10Rik
MMRRC Submission 042008-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.135) question?
Stock # R4620 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 49922164-50216875 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50208324 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 735 (V735A)
Ref Sequence ENSEMBL: ENSMUSP00000124674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000162854]
AlphaFold E9PX57
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159354
Predicted Effect probably benign
Transcript: ENSMUST00000162854
AA Change: V735A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000124674
Gene: ENSMUSG00000023999
AA Change: V735A

DomainStartEndE-ValueType
KISc 3 353 1.67e-121 SMART
coiled coil region 358 385 N/A INTRINSIC
Blast:KISc 400 606 1e-85 BLAST
Meta Mutation Damage Score 0.0706 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 99% (80/81)
MGI Phenotype PHENOTYPE: Mice homozgyos for an ENU-induced allele exhibit normal exercise capacity and cardiac function. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik A T 7: 130,945,335 (GRCm39) Y433* probably null Het
Apba2 C T 7: 64,364,215 (GRCm39) R331C probably damaging Het
Apod T C 16: 31,116,211 (GRCm39) D173G probably benign Het
B3gnt5 A T 16: 19,588,632 (GRCm39) M284L probably benign Het
Birc6 A C 17: 74,947,145 (GRCm39) T2955P probably benign Het
Blvra T C 2: 126,938,885 (GRCm39) I287T probably damaging Het
Capn5 T C 7: 97,778,578 (GRCm39) Y347C probably damaging Het
Cdcp2 A G 4: 106,963,927 (GRCm39) E259G probably damaging Het
Cdh2 A G 18: 16,781,665 (GRCm39) V85A probably benign Het
Cdk5rap2 A G 4: 70,184,943 (GRCm39) I1169T probably benign Het
Cenpj A G 14: 56,772,911 (GRCm39) V1043A probably damaging Het
Cfap54 T A 10: 92,805,619 (GRCm39) H1497L probably benign Het
Chat A G 14: 32,175,775 (GRCm39) M95T probably damaging Het
Csmd1 T C 8: 16,052,694 (GRCm39) probably null Het
Csmd3 T C 15: 47,449,149 (GRCm39) E3615G probably benign Het
Cyp2c68 A T 19: 39,701,006 (GRCm39) probably null Het
Dll1 C T 17: 15,590,828 (GRCm39) A332T probably benign Het
Dmrta1 A T 4: 89,577,021 (GRCm39) Q159L probably benign Het
Dnai3 A T 3: 145,748,564 (GRCm39) L850Q probably damaging Het
Eci3 A T 13: 35,132,741 (GRCm39) M212K probably damaging Het
Eml4 T C 17: 83,768,962 (GRCm39) F557L probably benign Het
Fat3 A T 9: 15,908,190 (GRCm39) V2604D probably damaging Het
Frem3 T C 8: 81,395,586 (GRCm39) V1871A possibly damaging Het
Gart T C 16: 91,422,321 (GRCm39) N732S probably damaging Het
Gas2l2 T C 11: 83,313,924 (GRCm39) I463V probably benign Het
H2-M3 C A 17: 37,583,310 (GRCm39) T257K probably damaging Het
Hdgf A G 3: 87,821,883 (GRCm39) N166S possibly damaging Het
Hoxb3 A T 11: 96,236,599 (GRCm39) N226Y probably damaging Het
Itgav T C 2: 83,586,246 (GRCm39) Y169H probably benign Het
Kalrn T G 16: 33,849,075 (GRCm39) I426L probably damaging Het
Kcnh3 G A 15: 99,131,982 (GRCm39) V646M probably damaging Het
Krt1c T A 15: 101,726,026 (GRCm39) I171F probably damaging Het
Megf8 G A 7: 25,054,523 (GRCm39) A1880T possibly damaging Het
Miox A T 15: 89,220,324 (GRCm39) Y172F probably benign Het
Myo18a G A 11: 77,708,773 (GRCm39) R48H possibly damaging Het
Ndufb7 T C 8: 84,293,487 (GRCm39) S14P probably damaging Het
Npepps A T 11: 97,129,070 (GRCm39) H371Q probably damaging Het
Or10d5j C T 9: 39,868,205 (GRCm39) V9M probably damaging Het
Or52e15 T A 7: 104,645,830 (GRCm39) I94F probably damaging Het
Or52e19 C T 7: 102,959,165 (GRCm39) T79I probably benign Het
Or8b12c A G 9: 37,716,115 (GRCm39) T303A probably benign Het
Orc5 A T 5: 22,734,174 (GRCm39) D203E probably damaging Het
Pappa A G 4: 65,245,265 (GRCm39) T1518A probably benign Het
Pde6a A G 18: 61,395,563 (GRCm39) D602G probably damaging Het
Pnliprp2 G A 19: 58,750,718 (GRCm39) V136I possibly damaging Het
Postn A C 3: 54,284,414 (GRCm39) D627A probably damaging Het
Prpf39 T C 12: 65,089,337 (GRCm39) V25A probably benign Het
Pxdc1 A G 13: 34,836,297 (GRCm39) I41T probably damaging Het
Rab11fip1 T A 8: 27,644,243 (GRCm39) E514V probably damaging Het
Rag1 A T 2: 101,474,025 (GRCm39) H372Q probably damaging Het
Ranbp1 A G 16: 18,057,968 (GRCm39) probably benign Het
Rexo5 A G 7: 119,426,526 (GRCm39) I317V probably benign Het
Rragc A G 4: 123,818,622 (GRCm39) Q279R probably damaging Het
Sbf1 A G 15: 89,191,129 (GRCm39) S187P probably damaging Het
Senp3 T A 11: 69,567,944 (GRCm39) Y432F probably benign Het
Slfn5 G A 11: 82,852,478 (GRCm39) C868Y probably damaging Het
Sorcs2 C T 5: 36,194,838 (GRCm39) A722T probably benign Het
Sptb A T 12: 76,630,581 (GRCm39) C2244* probably null Het
Srbd1 A T 17: 86,416,693 (GRCm39) F488L probably benign Het
Sucnr1 A G 3: 59,994,190 (GRCm39) I239M possibly damaging Het
Themis2 A G 4: 132,513,333 (GRCm39) W298R probably damaging Het
Tmem168 T G 6: 13,594,952 (GRCm39) N37T probably benign Het
Tmem62 A G 2: 120,826,845 (GRCm39) probably benign Het
Tmprss15 T C 16: 78,818,358 (GRCm39) D524G probably damaging Het
Trav5-4 G T 14: 53,941,853 (GRCm39) M75I probably benign Het
Trio T A 15: 27,871,257 (GRCm39) H620L probably damaging Het
Ubap2 C T 4: 41,233,698 (GRCm39) G64E probably damaging Het
Usp32 C A 11: 84,949,953 (GRCm39) probably null Het
Wdfy3 A T 5: 102,054,011 (GRCm39) F1603Y probably damaging Het
Xpo4 A T 14: 57,867,782 (GRCm39) L155Q probably damaging Het
Zbtb21 T C 16: 97,751,092 (GRCm39) T1092A possibly damaging Het
Zfp780b A T 7: 27,662,178 (GRCm39) Y792* probably null Het
Other mutations in Kif6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01793:Kif6 APN 17 49,931,521 (GRCm39) missense probably damaging 0.99
IGL02098:Kif6 APN 17 50,177,922 (GRCm39) missense probably benign 0.36
IGL02259:Kif6 APN 17 50,202,919 (GRCm39) splice site probably benign
IGL03003:Kif6 APN 17 50,060,899 (GRCm39) nonsense probably null
PIT4280001:Kif6 UTSW 17 50,062,148 (GRCm39) missense probably benign 0.32
R0044:Kif6 UTSW 17 50,139,284 (GRCm39) splice site probably benign
R1180:Kif6 UTSW 17 50,139,284 (GRCm39) splice site probably benign
R1432:Kif6 UTSW 17 49,927,728 (GRCm39) missense probably damaging 1.00
R1522:Kif6 UTSW 17 50,021,141 (GRCm39) missense probably damaging 0.99
R1760:Kif6 UTSW 17 49,922,311 (GRCm39) missense probably benign 0.00
R1770:Kif6 UTSW 17 50,210,677 (GRCm39) missense possibly damaging 0.92
R1809:Kif6 UTSW 17 50,208,812 (GRCm39) missense probably benign 0.00
R1854:Kif6 UTSW 17 50,208,799 (GRCm39) missense probably benign 0.25
R2176:Kif6 UTSW 17 50,062,258 (GRCm39) missense probably damaging 1.00
R3766:Kif6 UTSW 17 50,065,671 (GRCm39) splice site probably benign
R4661:Kif6 UTSW 17 50,060,909 (GRCm39) missense probably benign 0.21
R4972:Kif6 UTSW 17 50,014,647 (GRCm39) missense probably damaging 1.00
R5735:Kif6 UTSW 17 50,139,210 (GRCm39) missense probably damaging 1.00
R5950:Kif6 UTSW 17 50,022,116 (GRCm39) missense probably damaging 0.99
R6364:Kif6 UTSW 17 49,927,651 (GRCm39) missense probably benign 0.01
R7604:Kif6 UTSW 17 49,978,129 (GRCm39) missense probably damaging 1.00
R7879:Kif6 UTSW 17 50,139,214 (GRCm39) missense probably benign 0.08
R7966:Kif6 UTSW 17 49,993,453 (GRCm39) missense probably damaging 0.98
R8246:Kif6 UTSW 17 50,065,542 (GRCm39) nonsense probably null
R8487:Kif6 UTSW 17 49,978,164 (GRCm39) missense probably damaging 1.00
X0067:Kif6 UTSW 17 50,139,195 (GRCm39) missense probably benign 0.01
Z1177:Kif6 UTSW 17 50,022,128 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTTCTCGAGTTGCTGTCAGC -3'
(R):5'- GGGAAGGATTCTTCTGGCATTC -3'

Sequencing Primer
(F):5'- CGTCTGGGTGGCTCACTG -3'
(R):5'- CCTAATTCCGAGGGTGATGAC -3'
Posted On 2015-09-25