Incidental Mutation 'R4599:Rsu1'
ID 345406
Institutional Source Beutler Lab
Gene Symbol Rsu1
Ensembl Gene ENSMUSG00000026727
Gene Name Ras suppressor protein 1
Synonyms rsp-1, RsuI
MMRRC Submission 041815-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.177) question?
Stock # R4599 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 13076821-13271415 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13170004 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 225 (Y225C)
Ref Sequence ENSEMBL: ENSMUSP00000110439 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028059] [ENSMUST00000114791] [ENSMUST00000191959]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000028059
AA Change: Y242C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000028059
Gene: ENSMUSG00000026727
AA Change: Y242C

DomainStartEndE-ValueType
LRR 39 61 1.12e1 SMART
LRR 62 84 5.26e0 SMART
LRR 85 107 2.17e-1 SMART
LRR 108 132 3.65e1 SMART
LRR 133 155 1.37e1 SMART
LRR 156 177 1.71e1 SMART
LRR_TYP 179 202 8.34e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000114791
AA Change: Y225C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110439
Gene: ENSMUSG00000026727
AA Change: Y225C

DomainStartEndE-ValueType
Blast:CUB 1 36 6e-13 BLAST
LRR 45 67 5.26e0 SMART
LRR 68 90 2.17e-1 SMART
LRR 91 115 3.65e1 SMART
LRR 116 138 1.37e1 SMART
LRR 139 160 1.71e1 SMART
LRR_TYP 162 185 8.34e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000161912
SMART Domains Protein: ENSMUSP00000125279
Gene: ENSMUSG00000026727

DomainStartEndE-ValueType
Blast:CUB 1 38 7e-17 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000191959
SMART Domains Protein: ENSMUSP00000141763
Gene: ENSMUSG00000026727

DomainStartEndE-ValueType
Blast:CUB 1 36 2e-15 BLAST
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 T C 7: 120,255,403 V930A probably benign Het
Ankrd13b T C 11: 77,471,668 R677G probably benign Het
Apc T A 18: 34,317,987 Y2611* probably null Het
Apold1 A G 6: 134,984,069 Y162C probably damaging Het
Atp6v0a4 T C 6: 38,078,802 I325V probably benign Het
Cab39 A G 1: 85,848,329 Y249C probably damaging Het
Cd22 T A 7: 30,875,900 H239L probably damaging Het
Chrna7 A G 7: 63,103,790 M327T probably damaging Het
Clock T C 5: 76,235,810 M499V probably benign Het
Clspn A G 4: 126,581,460 E1002G probably benign Het
Clta C T 4: 44,012,819 P10S probably damaging Het
Col5a3 A G 9: 20,774,559 probably null Het
Coq6 T C 12: 84,362,139 V30A probably benign Het
Csmd2 G T 4: 127,988,128 R20L probably benign Het
D430041D05Rik A T 2: 104,208,183 V1547D probably damaging Het
Dapk1 C T 13: 60,718,047 P153S probably benign Het
Dock2 T A 11: 34,239,536 Y1545F probably damaging Het
Dpp6 G T 5: 27,634,548 G354C probably damaging Het
Dyrk1b T C 7: 28,182,431 L105P probably damaging Het
Epor A G 9: 21,961,859 S86P probably benign Het
Fam166b T C 4: 43,427,574 H250R possibly damaging Het
Gale C A 4: 135,967,837 S341* probably null Het
Galnt4 T A 10: 99,109,493 V360E probably damaging Het
Gart A T 16: 91,622,945 C24* probably null Het
Gcnt2 G T 13: 40,887,490 V42L probably benign Het
Herc6 A G 6: 57,659,713 I805V probably benign Het
Ints12 T A 3: 133,098,453 I67N probably benign Het
Irx1 C A 13: 71,960,113 R150L probably damaging Het
Kif26b A G 1: 178,530,459 Y45C unknown Het
Krt35 T C 11: 100,094,008 T275A probably damaging Het
Laptm5 G T 4: 130,916,005 probably benign Het
Lin7a T C 10: 107,412,166 S111P unknown Het
Med27 A G 2: 29,524,458 D159G probably damaging Het
Msh2 A G 17: 87,708,578 K546R probably damaging Het
Myo1a A T 10: 127,720,151 probably null Het
Myo1c T C 11: 75,668,193 F604L probably damaging Het
Myrip A G 9: 120,464,784 K782E probably damaging Het
Ndc80 T C 17: 71,521,068 D88G probably damaging Het
Nrxn2 A G 19: 6,455,252 D375G probably damaging Het
Olfr1380 T C 11: 49,564,718 S266P probably damaging Het
Olfr676 A G 7: 105,036,073 I292V probably benign Het
Padi3 T C 4: 140,798,111 H187R probably damaging Het
Pcdhgb1 A T 18: 37,681,557 N367I probably damaging Het
Pdrg1 T C 2: 153,012,390 I77V probably benign Het
Pfas T C 11: 68,991,069 E930G probably benign Het
Pik3cb C T 9: 99,061,764 R662Q probably benign Het
Pla2g4e T G 2: 120,186,382 H226P possibly damaging Het
Plxnd1 A T 6: 115,994,276 V177E probably damaging Het
Prmt7 A G 8: 106,250,329 S558G possibly damaging Het
Pspc1 A C 14: 56,777,789 probably null Het
Rilp T C 11: 75,512,760 S343P probably benign Het
Ror1 A G 4: 100,407,910 M194V probably damaging Het
Rundc1 A G 11: 101,433,926 N486S probably damaging Het
Sema6d T A 2: 124,654,231 I65N probably damaging Het
Slc5a11 A G 7: 123,258,378 E230G probably benign Het
Spint1 T C 2: 119,246,460 S342P probably damaging Het
Stard3nl A G 13: 19,367,753 S214P probably damaging Het
Tcp10a A C 17: 7,336,924 T271P probably damaging Het
Tie1 A G 4: 118,472,634 Y1091H probably benign Het
Tlr12 T C 4: 128,617,332 Y375C probably benign Het
Tmem107 T A 11: 69,071,448 M77K probably damaging Het
Tns2 C T 15: 102,108,934 R281C probably damaging Het
Tns3 T C 11: 8,531,747 K202E probably damaging Het
Tspoap1 C T 11: 87,779,521 P1634L probably damaging Het
Ttc7b G A 12: 100,500,117 R79C probably damaging Het
Ush2a A G 1: 188,911,647 N4402S probably benign Het
Vmn2r13 A T 5: 109,156,456 I703N probably damaging Het
Xrcc4 A G 13: 90,062,007 probably null Het
Zp3 A T 5: 135,984,235 K168* probably null Het
Other mutations in Rsu1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02411:Rsu1 APN 2 13077497 utr 3 prime probably benign
IGL02494:Rsu1 APN 2 13217191 splice site probably null
R0276:Rsu1 UTSW 2 13170135 intron probably benign
R3052:Rsu1 UTSW 2 13170135 intron probably benign
R4598:Rsu1 UTSW 2 13170004 missense probably damaging 1.00
R4797:Rsu1 UTSW 2 13216726 intron probably benign
R5896:Rsu1 UTSW 2 13224359 missense probably damaging 1.00
R7292:Rsu1 UTSW 2 13170016 missense probably damaging 1.00
R7469:Rsu1 UTSW 2 13077560 missense probably benign
R7485:Rsu1 UTSW 2 13216875 missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- GTGAAATTCCTGGAATACCATGG -3'
(R):5'- TGGATGATAGACCTTTCAACTTCC -3'

Sequencing Primer
(F):5'- CTCTAAGCAGAATTGGCAAAAATGC -3'
(R):5'- ATGATAGACCTTTCAACTTCCCTTTG -3'
Posted On 2015-09-25