Mutagenetix > Incidental Mutation

Incidental Mutation 'R4599:Olfr676'

345439

Institutional Source

Beutler Lab

Gene Symbol

Olfr676

Ensembl Gene

ENSMUSG00000073915

Gene Name

olfactory receptor 676

Synonyms

MOR32-1, GA_x6K02T2PBJ9-7664016-7664969

MMRRC Submission

041815-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.072) question?

Stock #

R4599 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105032698-105037750 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 105036073 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 292 (I292V)

Ref Sequence

ENSEMBL: ENSMUSP00000151474 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098162] [ENSMUST00000219602]

AlphaFold

Q8VGZ9

Predicted Effect

probably benign
Transcript: ENSMUST00000098162
AA Change: I292V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000095765
Gene: ENSMUSG00000073915
AA Change: I292V

Domain	Start	End	E-Value	Type
Pfam:7tm_4	41	317	3e-113	PFAM
Pfam:7TM_GPCR_Srsx	45	316	4.5e-7	PFAM
Pfam:7tm_1	51	301	1.5e-15	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215533

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000219042

Predicted Effect

probably benign
Transcript: ENSMUST00000219602
AA Change: I292V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca14	T	C	7: 120,255,403	V930A	probably benign	Het
Ankrd13b	T	C	11: 77,471,668	R677G	probably benign	Het
Apc	T	A	18: 34,317,987	Y2611*	probably null	Het
Apold1	A	G	6: 134,984,069	Y162C	probably damaging	Het
Atp6v0a4	T	C	6: 38,078,802	I325V	probably benign	Het
Cab39	A	G	1: 85,848,329	Y249C	probably damaging	Het
Cd22	T	A	7: 30,875,900	H239L	probably damaging	Het
Chrna7	A	G	7: 63,103,790	M327T	probably damaging	Het
Clock	T	C	5: 76,235,810	M499V	probably benign	Het
Clspn	A	G	4: 126,581,460	E1002G	probably benign	Het
Clta	C	T	4: 44,012,819	P10S	probably damaging	Het
Col5a3	A	G	9: 20,774,559		probably null	Het
Coq6	T	C	12: 84,362,139	V30A	probably benign	Het
Csmd2	G	T	4: 127,988,128	R20L	probably benign	Het
D430041D05Rik	A	T	2: 104,208,183	V1547D	probably damaging	Het
Dapk1	C	T	13: 60,718,047	P153S	probably benign	Het
Dock2	T	A	11: 34,239,536	Y1545F	probably damaging	Het
Dpp6	G	T	5: 27,634,548	G354C	probably damaging	Het
Dyrk1b	T	C	7: 28,182,431	L105P	probably damaging	Het
Epor	A	G	9: 21,961,859	S86P	probably benign	Het
Fam166b	T	C	4: 43,427,574	H250R	possibly damaging	Het
Gale	C	A	4: 135,967,837	S341*	probably null	Het
Galnt4	T	A	10: 99,109,493	V360E	probably damaging	Het
Gart	A	T	16: 91,622,945	C24*	probably null	Het
Gcnt2	G	T	13: 40,887,490	V42L	probably benign	Het
Herc6	A	G	6: 57,659,713	I805V	probably benign	Het
Ints12	T	A	3: 133,098,453	I67N	probably benign	Het
Irx1	C	A	13: 71,960,113	R150L	probably damaging	Het
Kif26b	A	G	1: 178,530,459	Y45C	unknown	Het
Krt35	T	C	11: 100,094,008	T275A	probably damaging	Het
Laptm5	G	T	4: 130,916,005		probably benign	Het
Lin7a	T	C	10: 107,412,166	S111P	unknown	Het
Med27	A	G	2: 29,524,458	D159G	probably damaging	Het
Msh2	A	G	17: 87,708,578	K546R	probably damaging	Het
Myo1a	A	T	10: 127,720,151		probably null	Het
Myo1c	T	C	11: 75,668,193	F604L	probably damaging	Het
Myrip	A	G	9: 120,464,784	K782E	probably damaging	Het
Ndc80	T	C	17: 71,521,068	D88G	probably damaging	Het
Nrxn2	A	G	19: 6,455,252	D375G	probably damaging	Het
Olfr1380	T	C	11: 49,564,718	S266P	probably damaging	Het
Padi3	T	C	4: 140,798,111	H187R	probably damaging	Het
Pcdhgb1	A	T	18: 37,681,557	N367I	probably damaging	Het
Pdrg1	T	C	2: 153,012,390	I77V	probably benign	Het
Pfas	T	C	11: 68,991,069	E930G	probably benign	Het
Pik3cb	C	T	9: 99,061,764	R662Q	probably benign	Het
Pla2g4e	T	G	2: 120,186,382	H226P	possibly damaging	Het
Plxnd1	A	T	6: 115,994,276	V177E	probably damaging	Het
Prmt7	A	G	8: 106,250,329	S558G	possibly damaging	Het
Pspc1	A	C	14: 56,777,789		probably null	Het
Rilp	T	C	11: 75,512,760	S343P	probably benign	Het
Ror1	A	G	4: 100,407,910	M194V	probably damaging	Het
Rsu1	T	C	2: 13,170,004	Y225C	probably damaging	Het
Rundc1	A	G	11: 101,433,926	N486S	probably damaging	Het
Sema6d	T	A	2: 124,654,231	I65N	probably damaging	Het
Slc5a11	A	G	7: 123,258,378	E230G	probably benign	Het
Spint1	T	C	2: 119,246,460	S342P	probably damaging	Het
Stard3nl	A	G	13: 19,367,753	S214P	probably damaging	Het
Tcp10a	A	C	17: 7,336,924	T271P	probably damaging	Het
Tie1	A	G	4: 118,472,634	Y1091H	probably benign	Het
Tlr12	T	C	4: 128,617,332	Y375C	probably benign	Het
Tmem107	T	A	11: 69,071,448	M77K	probably damaging	Het
Tns2	C	T	15: 102,108,934	R281C	probably damaging	Het
Tns3	T	C	11: 8,531,747	K202E	probably damaging	Het
Tspoap1	C	T	11: 87,779,521	P1634L	probably damaging	Het
Ttc7b	G	A	12: 100,500,117	R79C	probably damaging	Het
Ush2a	A	G	1: 188,911,647	N4402S	probably benign	Het
Vmn2r13	A	T	5: 109,156,456	I703N	probably damaging	Het
Xrcc4	A	G	13: 90,062,007		probably null	Het
Zp3	A	T	5: 135,984,235	K168*	probably null	Het

Other mutations in Olfr676

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02034:Olfr676	APN	7	105035390	missense	probably benign
IGL02244:Olfr676	APN	7	105035945	missense	probably damaging	1.00
IGL03493:Olfr676	APN	7	105035944	missense	probably damaging	1.00
R1181:Olfr676	UTSW	7	105035814	missense	probably damaging	1.00
R1223:Olfr676	UTSW	7	105035566	missense	probably benign	0.01
R1460:Olfr676	UTSW	7	105035708	missense	possibly damaging	0.80
R1768:Olfr676	UTSW	7	105035950	missense	probably benign	0.00
R2256:Olfr676	UTSW	7	105035819	missense	probably benign	0.00
R2257:Olfr676	UTSW	7	105035819	missense	probably benign	0.00
R3846:Olfr676	UTSW	7	105035689	missense	probably benign	0.40
R4486:Olfr676	UTSW	7	105035303	missense	probably benign	0.00
R4488:Olfr676	UTSW	7	105035303	missense	probably benign	0.00
R4489:Olfr676	UTSW	7	105035303	missense	probably benign	0.00
R4598:Olfr676	UTSW	7	105036073	missense	probably benign	0.19
R4701:Olfr676	UTSW	7	105035591	missense	probably damaging	1.00
R4855:Olfr676	UTSW	7	105035651	missense	probably damaging	0.99
R5083:Olfr676	UTSW	7	105035411	missense	probably damaging	1.00
R5743:Olfr676	UTSW	7	105036156	splice site	probably null
R5798:Olfr676	UTSW	7	105036137	missense	probably benign	0.00
R6279:Olfr676	UTSW	7	105035671	missense	probably benign	0.25
R6300:Olfr676	UTSW	7	105035671	missense	probably benign	0.25
R7400:Olfr676	UTSW	7	105035210	missense	probably benign
R7672:Olfr676	UTSW	7	105035543	missense	probably damaging	1.00
R7698:Olfr676	UTSW	7	105035907	missense	probably benign	0.01
R8468:Olfr676	UTSW	7	105035746	missense	probably damaging	0.97
R9297:Olfr676	UTSW	7	105035623	missense	probably damaging	1.00
R9318:Olfr676	UTSW	7	105035623	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCTAGGATCTTATATGCCGTCTTTC -3'
(R):5'- AGCTGCTTTCTGATCCACTG -3'

Sequencing Primer
(F):5'- CATCTTCCTTCTCAAGATGCTCG -3'
(R):5'- GCTTTCTGATCCACTGTTACATTG -3'

Posted On

2015-09-25