Incidental Mutation 'R4600:Pde4dip'
| ID |
345496 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4dip
|
| Ensembl Gene |
ENSMUSG00000038170 |
| Gene Name |
phosphodiesterase 4D interacting protein (myomegalin) |
| Synonyms |
Usmg4, D3Bwg1078e, D130016K21Rik, 9430063L05Rik, 4732458A06Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4600 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
97597144-97796023 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 97603260 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Aspartic acid
at position 2243
(V2243D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000088254
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090750]
[ENSMUST00000168438]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000090750
AA Change: V2243D
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000088254
Gene: ENSMUSG00000038170
AA Change: V2243D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Cnn_1N
|
124 |
196 |
3.2e-26 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
4.03e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
6.59e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
4.03e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
6.59e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1780 |
N/A |
INTRINSIC |
|
low complexity region
|
1836 |
1851 |
N/A |
INTRINSIC |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1951 |
N/A |
INTRINSIC |
|
coiled coil region
|
1962 |
2138 |
N/A |
INTRINSIC |
|
coiled coil region
|
2162 |
2197 |
N/A |
INTRINSIC |
|
coiled coil region
|
2387 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000168438
AA Change: V2192D
PolyPhen 2
Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000131170
Gene: ENSMUSG00000038170
AA Change: V2192D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Microtub_assoc
|
124 |
198 |
1.4e-31 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
3.56e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
5.83e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
3.56e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
5.83e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1769 |
N/A |
INTRINSIC |
|
low complexity region
|
1785 |
1800 |
N/A |
INTRINSIC |
|
low complexity region
|
1809 |
1823 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1900 |
N/A |
INTRINSIC |
|
coiled coil region
|
1911 |
2087 |
N/A |
INTRINSIC |
|
coiled coil region
|
2111 |
2146 |
N/A |
INTRINSIC |
|
coiled coil region
|
2336 |
2380 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197791
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200063
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
C |
12: 71,195,037 (GRCm39) |
F145L |
possibly damaging |
Het |
| Aars2 |
T |
A |
17: 45,827,847 (GRCm39) |
D555E |
probably damaging |
Het |
| Ago1 |
C |
A |
4: 126,354,185 (GRCm39) |
M208I |
probably benign |
Het |
| Ak7 |
G |
A |
12: 105,679,834 (GRCm39) |
V123M |
probably benign |
Het |
| Amfr |
A |
G |
8: 94,700,849 (GRCm39) |
L537P |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,058,568 (GRCm39) |
D2317G |
probably damaging |
Het |
| Asb6 |
T |
A |
2: 30,714,483 (GRCm39) |
D209V |
probably damaging |
Het |
| AY358078 |
T |
A |
14: 52,063,532 (GRCm39) |
C393S |
possibly damaging |
Het |
| Baz2a |
T |
A |
10: 127,957,052 (GRCm39) |
C932S |
probably damaging |
Het |
| Btnl10 |
A |
G |
11: 58,814,426 (GRCm39) |
I369V |
probably benign |
Het |
| Ccdc66 |
T |
C |
14: 27,222,377 (GRCm39) |
N122S |
probably damaging |
Het |
| Cfap96 |
A |
T |
8: 46,423,505 (GRCm39) |
I69N |
probably damaging |
Het |
| Clic4 |
A |
T |
4: 134,966,300 (GRCm39) |
|
probably null |
Het |
| Col6a3 |
A |
G |
1: 90,709,626 (GRCm39) |
S1857P |
unknown |
Het |
| Cracr2a |
A |
C |
6: 127,580,851 (GRCm39) |
D9A |
probably benign |
Het |
| Cspg4b |
A |
G |
13: 113,455,783 (GRCm39) |
R610G |
possibly damaging |
Het |
| Dcst1 |
T |
C |
3: 89,263,643 (GRCm39) |
E384G |
probably benign |
Het |
| Ddx4 |
T |
C |
13: 112,748,594 (GRCm39) |
K435E |
probably damaging |
Het |
| Deaf1 |
T |
A |
7: 140,890,884 (GRCm39) |
T433S |
possibly damaging |
Het |
| Dnah3 |
T |
A |
7: 119,689,169 (GRCm39) |
M82L |
probably benign |
Het |
| Dnhd1 |
G |
T |
7: 105,352,851 (GRCm39) |
R2668L |
probably damaging |
Het |
| Efcab6 |
C |
T |
15: 83,831,126 (GRCm39) |
G596D |
probably benign |
Het |
| Ercc3 |
G |
A |
18: 32,378,624 (GRCm39) |
A202T |
probably benign |
Het |
| Fam181b |
C |
A |
7: 92,729,992 (GRCm39) |
A255E |
possibly damaging |
Het |
| Fam83e |
T |
A |
7: 45,372,924 (GRCm39) |
D178E |
probably benign |
Het |
| Frem2 |
A |
G |
3: 53,455,228 (GRCm39) |
L2116S |
possibly damaging |
Het |
| Gm16494 |
T |
A |
17: 47,327,723 (GRCm39) |
K54* |
probably null |
Het |
| Golgb1 |
A |
G |
16: 36,738,987 (GRCm39) |
D2442G |
probably damaging |
Het |
| Greb1l |
G |
A |
18: 10,553,705 (GRCm39) |
A1569T |
probably damaging |
Het |
| Grik5 |
C |
G |
7: 24,767,489 (GRCm39) |
E64Q |
probably damaging |
Het |
| Gstm5 |
A |
G |
3: 107,805,302 (GRCm39) |
Y130C |
probably damaging |
Het |
| Gucy2e |
C |
G |
11: 69,126,994 (GRCm39) |
A160P |
possibly damaging |
Het |
| Hydin |
A |
T |
8: 111,293,582 (GRCm39) |
T3510S |
probably benign |
Het |
| Ift70a1 |
T |
C |
2: 75,810,977 (GRCm39) |
T369A |
probably benign |
Het |
| Itgb2 |
A |
G |
10: 77,381,949 (GRCm39) |
I84V |
probably benign |
Het |
| Itsn1 |
A |
G |
16: 91,696,475 (GRCm39) |
Q26R |
probably damaging |
Het |
| Kat6a |
A |
G |
8: 23,429,327 (GRCm39) |
S1561G |
probably benign |
Het |
| Khnyn |
G |
A |
14: 56,124,438 (GRCm39) |
V231I |
probably benign |
Het |
| Kif21b |
A |
G |
1: 136,075,602 (GRCm39) |
D243G |
probably benign |
Het |
| Klk4 |
T |
A |
7: 43,534,762 (GRCm39) |
N240K |
probably damaging |
Het |
| Knl1 |
T |
C |
2: 118,901,025 (GRCm39) |
S909P |
possibly damaging |
Het |
| Lamb1 |
A |
C |
12: 31,373,528 (GRCm39) |
D1419A |
probably benign |
Het |
| Lin9 |
T |
A |
1: 180,508,759 (GRCm39) |
V421D |
probably damaging |
Het |
| Lipt2 |
T |
C |
7: 99,809,519 (GRCm39) |
L202P |
probably benign |
Het |
| Mbd5 |
T |
G |
2: 49,147,209 (GRCm39) |
M473R |
probably benign |
Het |
| Mcc |
A |
T |
18: 44,652,587 (GRCm39) |
I279N |
probably damaging |
Het |
| Mcpt9 |
C |
T |
14: 56,266,049 (GRCm39) |
V60M |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mslnl |
G |
A |
17: 25,961,908 (GRCm39) |
V128M |
probably damaging |
Het |
| Mylk2 |
G |
A |
2: 152,759,476 (GRCm39) |
V389M |
probably damaging |
Het |
| Ndufs7 |
T |
A |
10: 80,092,501 (GRCm39) |
Y203* |
probably null |
Het |
| Nup160 |
T |
A |
2: 90,515,541 (GRCm39) |
|
probably null |
Het |
| Nup88 |
G |
A |
11: 70,860,522 (GRCm39) |
R62* |
probably null |
Het |
| Or2g7 |
T |
C |
17: 38,378,853 (GRCm39) |
S264P |
probably damaging |
Het |
| Or51af1 |
T |
A |
7: 103,141,788 (GRCm39) |
Q99L |
probably damaging |
Het |
| Or6c207 |
G |
A |
10: 129,104,274 (GRCm39) |
A306V |
probably benign |
Het |
| Or8b8 |
T |
A |
9: 37,809,622 (GRCm39) |
S307R |
probably benign |
Het |
| Or8g33 |
A |
G |
9: 39,337,731 (GRCm39) |
M212T |
probably benign |
Het |
| Os9 |
T |
C |
10: 126,934,223 (GRCm39) |
N471S |
probably benign |
Het |
| Otof |
C |
T |
5: 30,529,244 (GRCm39) |
V1757M |
probably damaging |
Het |
| Pakap |
A |
T |
4: 57,709,954 (GRCm39) |
T300S |
probably benign |
Het |
| Pald1 |
T |
C |
10: 61,184,395 (GRCm39) |
T241A |
probably benign |
Het |
| Pappa2 |
G |
A |
1: 158,642,015 (GRCm39) |
S1347L |
probably damaging |
Het |
| Pccb |
T |
C |
9: 100,916,832 (GRCm39) |
T27A |
probably benign |
Het |
| Pkd2l2 |
C |
A |
18: 34,571,254 (GRCm39) |
Q590K |
probably benign |
Het |
| Pmepa1 |
G |
A |
2: 173,070,120 (GRCm39) |
P145L |
possibly damaging |
Het |
| Ppp3cb |
T |
C |
14: 20,570,714 (GRCm39) |
N339S |
possibly damaging |
Het |
| Rnf133 |
T |
C |
6: 23,649,041 (GRCm39) |
E296G |
possibly damaging |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Serpinb12 |
T |
A |
1: 106,876,883 (GRCm39) |
D66E |
probably benign |
Het |
| Slc35e2 |
T |
C |
4: 155,702,106 (GRCm39) |
F290S |
probably benign |
Het |
| Slc46a2 |
C |
T |
4: 59,911,886 (GRCm39) |
C442Y |
probably damaging |
Het |
| Slc7a1 |
A |
G |
5: 148,278,869 (GRCm39) |
L301P |
probably damaging |
Het |
| Spg21 |
A |
G |
9: 65,383,257 (GRCm39) |
T148A |
probably benign |
Het |
| Stox2 |
A |
G |
8: 47,645,970 (GRCm39) |
S497P |
probably damaging |
Het |
| Sult1c2 |
C |
A |
17: 54,280,983 (GRCm39) |
W40L |
probably benign |
Het |
| Sytl2 |
T |
C |
7: 90,024,977 (GRCm39) |
S322P |
probably benign |
Het |
| Telo2 |
C |
A |
17: 25,324,122 (GRCm39) |
R531L |
possibly damaging |
Het |
| Thbs3 |
T |
C |
3: 89,131,897 (GRCm39) |
V719A |
probably damaging |
Het |
| Tlr9 |
T |
A |
9: 106,101,732 (GRCm39) |
L341Q |
probably damaging |
Het |
| Tmprss5 |
A |
G |
9: 49,024,548 (GRCm39) |
N230D |
possibly damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Tpo |
C |
T |
12: 30,148,228 (GRCm39) |
V558M |
probably benign |
Het |
| Trex1 |
T |
G |
9: 108,887,352 (GRCm39) |
Q213P |
possibly damaging |
Het |
| Ttc7b |
G |
A |
12: 100,466,376 (GRCm39) |
R79C |
probably damaging |
Het |
| Ugt1a6a |
A |
G |
1: 88,066,586 (GRCm39) |
K131E |
probably benign |
Het |
| Vipr1 |
T |
A |
9: 121,494,202 (GRCm39) |
|
probably null |
Het |
| Vmn1r22 |
T |
C |
6: 57,877,860 (GRCm39) |
D39G |
probably damaging |
Het |
| Vmn2r58 |
A |
T |
7: 41,522,046 (GRCm39) |
C17S |
probably benign |
Het |
| Vps41 |
T |
C |
13: 18,929,453 (GRCm39) |
Y63H |
probably damaging |
Het |
| Xdh |
G |
T |
17: 74,217,195 (GRCm39) |
T691N |
probably benign |
Het |
| Zfp518b |
T |
C |
5: 38,830,970 (GRCm39) |
N345S |
probably damaging |
Het |
| Zfp536 |
T |
A |
7: 37,267,918 (GRCm39) |
K499N |
probably damaging |
Het |
| Zfp963 |
A |
T |
8: 70,195,510 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Pde4dip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Pde4dip
|
APN |
3 |
97,674,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00543:Pde4dip
|
APN |
3 |
97,664,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00979:Pde4dip
|
APN |
3 |
97,655,074 (GRCm39) |
splice site |
probably benign |
|
|
IGL01483:Pde4dip
|
APN |
3 |
97,661,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02122:Pde4dip
|
APN |
3 |
97,674,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Pde4dip
|
APN |
3 |
97,674,097 (GRCm39) |
missense |
probably benign |
|
|
IGL02814:Pde4dip
|
APN |
3 |
97,674,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02826:Pde4dip
|
APN |
3 |
97,674,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D3080:Pde4dip
|
UTSW |
3 |
97,674,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pde4dip
|
UTSW |
3 |
97,660,442 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Pde4dip
|
UTSW |
3 |
97,674,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0277:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0304:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0616:Pde4dip
|
UTSW |
3 |
97,654,849 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0676:Pde4dip
|
UTSW |
3 |
97,624,413 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Pde4dip
|
UTSW |
3 |
97,620,512 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Pde4dip
|
UTSW |
3 |
97,631,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Pde4dip
|
UTSW |
3 |
97,627,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Pde4dip
|
UTSW |
3 |
97,610,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Pde4dip
|
UTSW |
3 |
97,661,576 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1769:Pde4dip
|
UTSW |
3 |
97,603,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1934:Pde4dip
|
UTSW |
3 |
97,600,007 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1980:Pde4dip
|
UTSW |
3 |
97,664,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2088:Pde4dip
|
UTSW |
3 |
97,661,749 (GRCm39) |
missense |
probably null |
1.00 |
|
R2143:Pde4dip
|
UTSW |
3 |
97,795,835 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2149:Pde4dip
|
UTSW |
3 |
97,700,152 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2156:Pde4dip
|
UTSW |
3 |
97,631,534 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2158:Pde4dip
|
UTSW |
3 |
97,664,937 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2240:Pde4dip
|
UTSW |
3 |
97,631,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2249:Pde4dip
|
UTSW |
3 |
97,700,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2256:Pde4dip
|
UTSW |
3 |
97,625,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Pde4dip
|
UTSW |
3 |
97,608,933 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2921:Pde4dip
|
UTSW |
3 |
97,626,885 (GRCm39) |
missense |
probably benign |
|
|
R3407:Pde4dip
|
UTSW |
3 |
97,661,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3736:Pde4dip
|
UTSW |
3 |
97,631,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Pde4dip
|
UTSW |
3 |
97,622,868 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3883:Pde4dip
|
UTSW |
3 |
97,620,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4437:Pde4dip
|
UTSW |
3 |
97,673,885 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4528:Pde4dip
|
UTSW |
3 |
97,624,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Pde4dip
|
UTSW |
3 |
97,661,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Pde4dip
|
UTSW |
3 |
97,674,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4678:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4679:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Pde4dip
|
UTSW |
3 |
97,750,993 (GRCm39) |
nonsense |
probably null |
|
|
R4770:Pde4dip
|
UTSW |
3 |
97,674,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Pde4dip
|
UTSW |
3 |
97,616,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Pde4dip
|
UTSW |
3 |
97,622,644 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4943:Pde4dip
|
UTSW |
3 |
97,662,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5131:Pde4dip
|
UTSW |
3 |
97,616,830 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5408:Pde4dip
|
UTSW |
3 |
97,704,052 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5583:Pde4dip
|
UTSW |
3 |
97,654,892 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5677:Pde4dip
|
UTSW |
3 |
97,748,964 (GRCm39) |
nonsense |
probably null |
|
|
R5689:Pde4dip
|
UTSW |
3 |
97,599,683 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Pde4dip
|
UTSW |
3 |
97,616,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Pde4dip
|
UTSW |
3 |
97,631,504 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6279:Pde4dip
|
UTSW |
3 |
97,606,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6341:Pde4dip
|
UTSW |
3 |
97,602,227 (GRCm39) |
missense |
probably benign |
|
|
R6440:Pde4dip
|
UTSW |
3 |
97,674,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Pde4dip
|
UTSW |
3 |
97,617,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Pde4dip
|
UTSW |
3 |
97,662,907 (GRCm39) |
nonsense |
probably null |
|
|
R6706:Pde4dip
|
UTSW |
3 |
97,648,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4dip
|
UTSW |
3 |
97,625,555 (GRCm39) |
nonsense |
probably null |
|
|
R6798:Pde4dip
|
UTSW |
3 |
97,795,850 (GRCm39) |
missense |
probably benign |
|
|
R6804:Pde4dip
|
UTSW |
3 |
97,700,564 (GRCm39) |
nonsense |
probably null |
|
|
R6862:Pde4dip
|
UTSW |
3 |
97,674,340 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6957:Pde4dip
|
UTSW |
3 |
97,731,649 (GRCm39) |
splice site |
probably null |
|
|
R6983:Pde4dip
|
UTSW |
3 |
97,625,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pde4dip
|
UTSW |
3 |
97,622,738 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7025:Pde4dip
|
UTSW |
3 |
97,631,499 (GRCm39) |
nonsense |
probably null |
|
|
R7136:Pde4dip
|
UTSW |
3 |
97,601,379 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7178:Pde4dip
|
UTSW |
3 |
97,622,946 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7269:Pde4dip
|
UTSW |
3 |
97,674,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Pde4dip
|
UTSW |
3 |
97,666,198 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7354:Pde4dip
|
UTSW |
3 |
97,626,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7357:Pde4dip
|
UTSW |
3 |
97,622,857 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7360:Pde4dip
|
UTSW |
3 |
97,625,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7371:Pde4dip
|
UTSW |
3 |
97,664,587 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7432:Pde4dip
|
UTSW |
3 |
97,602,408 (GRCm39) |
missense |
probably benign |
|
|
R7536:Pde4dip
|
UTSW |
3 |
97,664,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7542:Pde4dip
|
UTSW |
3 |
97,673,971 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7609:Pde4dip
|
UTSW |
3 |
97,622,881 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7650:Pde4dip
|
UTSW |
3 |
97,606,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7800:Pde4dip
|
UTSW |
3 |
97,622,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Pde4dip
|
UTSW |
3 |
97,622,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Pde4dip
|
UTSW |
3 |
97,622,539 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Pde4dip
|
UTSW |
3 |
97,614,254 (GRCm39) |
missense |
probably null |
0.94 |
|
R8139:Pde4dip
|
UTSW |
3 |
97,604,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8144:Pde4dip
|
UTSW |
3 |
97,622,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Pde4dip
|
UTSW |
3 |
97,674,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8294:Pde4dip
|
UTSW |
3 |
97,674,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8406:Pde4dip
|
UTSW |
3 |
97,606,428 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8911:Pde4dip
|
UTSW |
3 |
97,650,917 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8912:Pde4dip
|
UTSW |
3 |
97,617,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8960:Pde4dip
|
UTSW |
3 |
97,700,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Pde4dip
|
UTSW |
3 |
97,673,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Pde4dip
|
UTSW |
3 |
97,599,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9085:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9103:Pde4dip
|
UTSW |
3 |
97,749,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9163:Pde4dip
|
UTSW |
3 |
97,659,123 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9182:Pde4dip
|
UTSW |
3 |
97,602,314 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9185:Pde4dip
|
UTSW |
3 |
97,666,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Pde4dip
|
UTSW |
3 |
97,607,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Pde4dip
|
UTSW |
3 |
97,625,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9415:Pde4dip
|
UTSW |
3 |
97,660,468 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9500:Pde4dip
|
UTSW |
3 |
97,795,896 (GRCm39) |
missense |
unknown |
|
|
R9595:Pde4dip
|
UTSW |
3 |
97,602,207 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9689:Pde4dip
|
UTSW |
3 |
97,649,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Pde4dip
|
UTSW |
3 |
97,603,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTCAAGGGCAGAGCAATGAC -3'
(R):5'- TCAATAGAAGAGCGCACACTAG -3'
Sequencing Primer
(F):5'- CAACCAAGGCAGAGGACTGTG -3'
(R):5'- ACACTAGGTGCCCTGCC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation