Incidental Mutation 'R0254:Rgs22'
ID 34598
Institutional Source Beutler Lab
Gene Symbol Rgs22
Ensembl Gene ENSMUSG00000037627
Gene Name regulator of G-protein signalling 22
Synonyms
MMRRC Submission 038485-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0254 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 36009625-36140546 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36104698 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 121 (I121V)
Ref Sequence ENSEMBL: ENSMUSP00000134259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172831]
AlphaFold G3UYX5
Predicted Effect probably damaging
Transcript: ENSMUST00000172831
AA Change: I121V

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000134259
Gene: ENSMUSG00000037627
AA Change: I121V

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
low complexity region 62 76 N/A INTRINSIC
low complexity region 173 179 N/A INTRINSIC
low complexity region 376 391 N/A INTRINSIC
RGS 845 973 3.15e-2 SMART
RGS 1014 1134 1.56e-15 SMART
Meta Mutation Damage Score 0.1385 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.7%
Validation Efficiency 100% (100/100)
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700034J05Rik T A 6: 146,853,902 (GRCm39) M252L probably benign Het
Abca6 A G 11: 110,127,615 (GRCm39) V314A probably benign Het
Abcb1b A T 5: 8,877,409 (GRCm39) E656D probably benign Het
Abhd4 T C 14: 54,500,691 (GRCm39) I160T probably benign Het
Aco2 T C 15: 81,773,557 (GRCm39) V32A probably damaging Het
Actl6b A G 5: 137,552,406 (GRCm39) probably benign Het
Akap13 T C 7: 75,386,352 (GRCm39) probably benign Het
Alpk3 A T 7: 80,726,722 (GRCm39) T136S probably benign Het
Ap1g1 G T 8: 110,529,749 (GRCm39) M56I probably benign Het
Arid2 C T 15: 96,268,452 (GRCm39) T855I probably damaging Het
Asprv1 T C 6: 86,606,077 (GRCm39) F308L probably damaging Het
Ass1 A T 2: 31,404,831 (GRCm39) N371Y probably damaging Het
Atp11b T A 3: 35,866,259 (GRCm39) M378K possibly damaging Het
Atp1a3 T C 7: 24,680,937 (GRCm39) probably benign Het
Blk C A 14: 63,618,253 (GRCm39) A218S probably benign Het
C4b T A 17: 34,953,750 (GRCm39) T953S probably benign Het
Cdadc1 T C 14: 59,813,356 (GRCm39) probably benign Het
Cdca2 C A 14: 67,914,627 (GRCm39) L877F probably damaging Het
Ceacam10 G T 7: 24,477,733 (GRCm39) V83L probably damaging Het
Cep290 A T 10: 100,350,436 (GRCm39) I677F probably benign Het
Clip1 A T 5: 123,755,395 (GRCm39) probably benign Het
Col11a2 G T 17: 34,283,777 (GRCm39) probably benign Het
Coro1c A T 5: 113,983,313 (GRCm39) V405D probably benign Het
Crebrf A G 17: 26,958,568 (GRCm39) T13A probably benign Het
Cspg4 A G 9: 56,804,694 (GRCm39) E1835G probably damaging Het
Cubn A T 2: 13,480,846 (GRCm39) probably null Het
Cubn T C 2: 13,429,505 (GRCm39) N1332S probably benign Het
Cubn T C 2: 13,445,325 (GRCm39) T1014A possibly damaging Het
Efnb1 T C X: 98,180,634 (GRCm39) probably benign Het
Elf2 G T 3: 51,215,611 (GRCm39) P33Q probably damaging Het
Fap C T 2: 62,333,746 (GRCm39) G633D probably damaging Het
Gm10288 T C 3: 146,544,675 (GRCm39) noncoding transcript Het
Got2 T C 8: 96,596,166 (GRCm39) N318S probably benign Het
Guk1 A T 11: 59,076,854 (GRCm39) F76L probably damaging Het
H2-K2 A T 17: 34,215,639 (GRCm39) probably benign Het
Helz2 C A 2: 180,874,552 (GRCm39) G1981C probably damaging Het
Hinfp G A 9: 44,209,536 (GRCm39) H250Y probably damaging Het
Hnrnpm C T 17: 33,871,242 (GRCm39) probably null Het
Hsd11b2 T A 8: 106,249,699 (GRCm39) V270E possibly damaging Het
Igbp1b A T 6: 138,635,201 (GRCm39) M81K probably damaging Het
Kif11 A G 19: 37,399,957 (GRCm39) T815A probably benign Het
Kit G A 5: 75,781,581 (GRCm39) V337I probably benign Het
Klf11 T C 12: 24,703,582 (GRCm39) S6P probably damaging Het
Klk13 T C 7: 43,373,245 (GRCm39) V193A probably benign Het
Krt73 T A 15: 101,708,324 (GRCm39) probably benign Het
L1td1 T A 4: 98,625,419 (GRCm39) L538* probably null Het
Macf1 A G 4: 123,326,572 (GRCm39) L2061P probably damaging Het
Mcm2 A G 6: 88,860,998 (GRCm39) I900T probably damaging Het
Med16 A T 10: 79,736,034 (GRCm39) N371K possibly damaging Het
Mepce A C 5: 137,783,698 (GRCm39) D209E possibly damaging Het
Mrc2 C G 11: 105,238,692 (GRCm39) P1249R probably benign Het
Mx2 A T 16: 97,357,295 (GRCm39) I463L probably benign Het
Naaa A T 5: 92,412,994 (GRCm39) N73K probably damaging Het
Nags T A 11: 102,038,771 (GRCm39) L404Q probably damaging Het
Neb A G 2: 52,133,402 (GRCm39) Y3379H probably damaging Het
Nhsl1 A G 10: 18,348,733 (GRCm39) E120G probably damaging Het
Or11j4 T C 14: 50,630,536 (GRCm39) S108P probably damaging Het
Or4f53 A C 2: 111,087,466 (GRCm39) N2T probably benign Het
Or51a42 T C 7: 103,708,728 (GRCm39) H27R probably benign Het
Or51ah3 T A 7: 103,209,829 (GRCm39) Y48* probably null Het
Or51f5 C A 7: 102,424,076 (GRCm39) S115* probably null Het
Pcnt A G 10: 76,228,414 (GRCm39) F1584L probably benign Het
Pdgfra G A 5: 75,328,596 (GRCm39) V243I probably damaging Het
Polr2a T C 11: 69,634,497 (GRCm39) I689V possibly damaging Het
Ppfia4 C A 1: 134,251,962 (GRCm39) probably benign Het
Prmt8 C A 6: 127,688,771 (GRCm39) V200L probably damaging Het
Prpf8 T A 11: 75,397,188 (GRCm39) I2007N possibly damaging Het
Ptpn6 T C 6: 124,705,113 (GRCm39) E230G probably damaging Het
R3hcc1l G A 19: 42,551,587 (GRCm39) V195I probably damaging Het
Rb1cc1 C T 1: 6,333,071 (GRCm39) T1330I probably damaging Het
Reep3 G T 10: 66,857,575 (GRCm39) T172N probably benign Het
Rfwd3 A G 8: 112,020,655 (GRCm39) V236A probably benign Het
Robo1 T A 16: 72,461,058 (GRCm39) F11I probably benign Het
Rsrc2 A G 5: 123,878,910 (GRCm39) probably benign Het
Rubcn A G 16: 32,668,316 (GRCm39) V117A probably benign Het
Scamp1 T G 13: 94,347,088 (GRCm39) N192T probably benign Het
Scn8a T A 15: 100,916,245 (GRCm39) I1218N probably damaging Het
Serinc1 A G 10: 57,399,304 (GRCm39) S200P probably damaging Het
Serpinb9f T A 13: 33,518,574 (GRCm39) F358Y probably damaging Het
Slc12a5 T C 2: 164,839,165 (GRCm39) probably null Het
Slc5a4b T C 10: 75,906,462 (GRCm39) M386V possibly damaging Het
Smarca5 A G 8: 81,431,329 (GRCm39) F963L probably benign Het
Smchd1 A T 17: 71,718,886 (GRCm39) F828I probably benign Het
Smr2l A T 5: 88,430,230 (GRCm39) H42L possibly damaging Het
Stab2 G T 10: 86,733,824 (GRCm39) Q1333K probably benign Het
Svop T C 5: 114,176,600 (GRCm39) S349G probably benign Het
Tdrd1 G A 19: 56,830,998 (GRCm39) S271N probably benign Het
Tec G A 5: 72,941,081 (GRCm39) P159S probably benign Het
Tec T C 5: 72,920,899 (GRCm39) probably benign Het
Tfip11 G A 5: 112,483,521 (GRCm39) M645I probably benign Het
Thap12 A T 7: 98,364,488 (GRCm39) T219S probably benign Het
Tmem87a C T 2: 120,205,988 (GRCm39) R329H probably damaging Het
Tpsab1 A G 17: 25,562,719 (GRCm39) Y227H probably damaging Het
Urah G A 7: 140,417,602 (GRCm39) V114I probably benign Het
Wnt5a G A 14: 28,244,811 (GRCm39) E353K probably damaging Het
Zfp1004 G A 2: 150,033,784 (GRCm39) R35K possibly damaging Het
Zfp101 A T 17: 33,599,952 (GRCm39) H601Q possibly damaging Het
Other mutations in Rgs22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Rgs22 APN 15 36,100,077 (GRCm39) missense possibly damaging 0.93
IGL00594:Rgs22 APN 15 36,083,777 (GRCm39) missense probably benign 0.00
IGL01464:Rgs22 APN 15 36,083,787 (GRCm39) missense possibly damaging 0.90
IGL01686:Rgs22 APN 15 36,103,981 (GRCm39) missense probably benign 0.00
IGL01761:Rgs22 APN 15 36,103,897 (GRCm39) missense probably damaging 0.99
IGL02045:Rgs22 APN 15 36,013,300 (GRCm39) missense probably benign 0.33
IGL02378:Rgs22 APN 15 36,103,951 (GRCm39) missense probably benign 0.00
IGL02490:Rgs22 APN 15 36,054,993 (GRCm39) missense probably damaging 1.00
IGL03219:Rgs22 APN 15 36,107,194 (GRCm39) missense probably damaging 1.00
IGL03229:Rgs22 APN 15 36,015,925 (GRCm39) splice site probably benign
IGL03328:Rgs22 APN 15 36,043,350 (GRCm39) critical splice donor site probably null
3-1:Rgs22 UTSW 15 36,100,182 (GRCm39) missense possibly damaging 0.48
R0463:Rgs22 UTSW 15 36,093,084 (GRCm39) missense probably damaging 1.00
R0467:Rgs22 UTSW 15 36,099,941 (GRCm39) nonsense probably null
R0486:Rgs22 UTSW 15 36,093,028 (GRCm39) missense probably damaging 0.98
R0554:Rgs22 UTSW 15 36,054,855 (GRCm39) missense probably benign 0.10
R0602:Rgs22 UTSW 15 36,140,018 (GRCm39) splice site probably benign
R0906:Rgs22 UTSW 15 36,104,048 (GRCm39) intron probably benign
R1159:Rgs22 UTSW 15 36,040,839 (GRCm39) missense probably damaging 1.00
R1300:Rgs22 UTSW 15 36,101,908 (GRCm39) missense probably benign 0.43
R1439:Rgs22 UTSW 15 36,025,939 (GRCm39) splice site probably benign
R1491:Rgs22 UTSW 15 36,093,047 (GRCm39) missense probably damaging 0.98
R1502:Rgs22 UTSW 15 36,080,997 (GRCm39) missense probably damaging 1.00
R1514:Rgs22 UTSW 15 36,013,246 (GRCm39) missense probably benign 0.00
R1538:Rgs22 UTSW 15 36,048,922 (GRCm39) missense probably damaging 1.00
R1784:Rgs22 UTSW 15 36,087,582 (GRCm39) missense probably damaging 1.00
R1938:Rgs22 UTSW 15 36,101,950 (GRCm39) missense probably benign 0.00
R1972:Rgs22 UTSW 15 36,103,982 (GRCm39) missense probably benign 0.01
R2109:Rgs22 UTSW 15 36,099,880 (GRCm39) nonsense probably null
R2208:Rgs22 UTSW 15 36,050,378 (GRCm39) missense probably benign 0.01
R3696:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3697:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3698:Rgs22 UTSW 15 36,100,038 (GRCm39) missense probably benign 0.00
R3879:Rgs22 UTSW 15 36,107,051 (GRCm39) missense possibly damaging 0.52
R4080:Rgs22 UTSW 15 36,107,222 (GRCm39) missense probably damaging 1.00
R4363:Rgs22 UTSW 15 36,104,020 (GRCm39) missense probably damaging 0.99
R4591:Rgs22 UTSW 15 36,100,282 (GRCm39) missense probably benign 0.01
R4673:Rgs22 UTSW 15 36,100,079 (GRCm39) missense probably benign 0.04
R4829:Rgs22 UTSW 15 36,104,034 (GRCm39) missense probably damaging 1.00
R4831:Rgs22 UTSW 15 36,050,294 (GRCm39) missense probably benign 0.00
R4865:Rgs22 UTSW 15 36,100,358 (GRCm39) missense probably damaging 1.00
R4907:Rgs22 UTSW 15 36,087,570 (GRCm39) missense possibly damaging 0.61
R4944:Rgs22 UTSW 15 36,026,088 (GRCm39) missense possibly damaging 0.83
R4975:Rgs22 UTSW 15 36,055,022 (GRCm39) nonsense probably null
R5056:Rgs22 UTSW 15 36,050,391 (GRCm39) splice site probably null
R5126:Rgs22 UTSW 15 36,040,790 (GRCm39) missense probably damaging 0.96
R5138:Rgs22 UTSW 15 36,099,934 (GRCm39) missense probably benign 0.04
R5444:Rgs22 UTSW 15 36,015,773 (GRCm39) missense possibly damaging 0.83
R5507:Rgs22 UTSW 15 36,099,798 (GRCm39) missense probably damaging 0.99
R5640:Rgs22 UTSW 15 36,107,101 (GRCm39) missense probably benign 0.00
R5969:Rgs22 UTSW 15 36,015,782 (GRCm39) missense probably benign 0.00
R6005:Rgs22 UTSW 15 36,010,713 (GRCm39) missense probably benign 0.39
R6053:Rgs22 UTSW 15 36,100,153 (GRCm39) missense probably benign 0.04
R6134:Rgs22 UTSW 15 36,107,194 (GRCm39) missense probably damaging 1.00
R6230:Rgs22 UTSW 15 36,100,176 (GRCm39) missense probably benign 0.02
R6295:Rgs22 UTSW 15 36,087,520 (GRCm39) missense probably benign 0.00
R6352:Rgs22 UTSW 15 36,093,067 (GRCm39) missense probably damaging 1.00
R6809:Rgs22 UTSW 15 36,048,910 (GRCm39) missense probably damaging 1.00
R6900:Rgs22 UTSW 15 36,010,893 (GRCm39) missense possibly damaging 0.61
R6947:Rgs22 UTSW 15 36,104,036 (GRCm39) critical splice acceptor site probably null
R7102:Rgs22 UTSW 15 36,122,459 (GRCm39) missense probably damaging 1.00
R7126:Rgs22 UTSW 15 36,103,954 (GRCm39) missense probably damaging 0.97
R7263:Rgs22 UTSW 15 36,015,789 (GRCm39) missense possibly damaging 0.86
R7623:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R7732:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R7748:Rgs22 UTSW 15 36,122,415 (GRCm39) critical splice donor site probably null
R7771:Rgs22 UTSW 15 36,050,224 (GRCm39) missense possibly damaging 0.94
R7835:Rgs22 UTSW 15 36,082,057 (GRCm39) critical splice donor site probably null
R7849:Rgs22 UTSW 15 36,099,858 (GRCm39) missense probably damaging 1.00
R7954:Rgs22 UTSW 15 36,082,148 (GRCm39) missense possibly damaging 0.75
R8384:Rgs22 UTSW 15 36,046,158 (GRCm39) critical splice donor site probably null
R8516:Rgs22 UTSW 15 36,010,481 (GRCm39) makesense probably null
R8904:Rgs22 UTSW 15 36,026,127 (GRCm39) missense probably damaging 1.00
R8923:Rgs22 UTSW 15 36,093,106 (GRCm39) missense probably damaging 1.00
R9287:Rgs22 UTSW 15 36,098,409 (GRCm39) missense probably damaging 1.00
R9324:Rgs22 UTSW 15 36,087,544 (GRCm39) missense probably benign
R9660:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
R9679:Rgs22 UTSW 15 36,087,587 (GRCm39) missense probably benign 0.00
R9728:Rgs22 UTSW 15 36,040,856 (GRCm39) missense probably benign 0.08
RF035:Rgs22 UTSW 15 36,010,981 (GRCm39) critical splice acceptor site probably benign
RF043:Rgs22 UTSW 15 36,010,982 (GRCm39) critical splice acceptor site probably benign
Predicted Primers
Posted On 2013-05-09