Incidental Mutation 'R4606:Olfr1270'
ID 345992
Institutional Source Beutler Lab
Gene Symbol Olfr1270
Ensembl Gene ENSMUSG00000075065
Gene Name olfactory receptor 1270
Synonyms MOR227-1, GA_x6K02T2Q125-51584440-51583526
MMRRC Submission 041817-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R4606 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 90145255-90153091 bp(-) (GRCm38)
Type of Mutation utr 3 prime
DNA Base Change (assembly) G to T at 90148816 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000150561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099754] [ENSMUST00000213946] [ENSMUST00000215578] [ENSMUST00000215975] [ENSMUST00000216354] [ENSMUST00000217139]
AlphaFold Q8VGP3
Predicted Effect probably benign
Transcript: ENSMUST00000099754
SMART Domains Protein: ENSMUSP00000097343
Gene: ENSMUSG00000075065

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.3e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 300 7.5e-6 PFAM
Pfam:7tm_1 39 285 2e-24 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165784
SMART Domains Protein: ENSMUSP00000126140
Gene: ENSMUSG00000091703

DomainStartEndE-ValueType
HOX 19 81 1.29e-3 SMART
low complexity region 118 128 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000213946
Predicted Effect probably benign
Transcript: ENSMUST00000215578
Predicted Effect probably benign
Transcript: ENSMUST00000215975
Predicted Effect probably benign
Transcript: ENSMUST00000216354
Predicted Effect probably benign
Transcript: ENSMUST00000217139
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 96% (69/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A T 8: 79,210,745 W178R probably benign Het
Abcb5 T C 12: 118,932,610 probably null Het
Akr1b3 C A 6: 34,306,664 probably benign Het
Arid1a A G 4: 133,687,323 F1199S unknown Het
Atp4b A G 8: 13,389,998 F116S probably damaging Het
Atp6v1b1 T C 6: 83,752,461 S127P probably damaging Het
Blk C T 14: 63,374,203 V428I probably benign Het
C87414 A T 5: 93,636,602 D137E probably damaging Het
Ccser1 T C 6: 61,311,584 S244P probably damaging Het
Ceacam1 T A 7: 25,474,526 I235F probably damaging Het
Cyp2g1 T A 7: 26,814,154 Y173N possibly damaging Het
Ddr2 T A 1: 170,001,852 I278F probably benign Het
Degs1 T C 1: 182,276,823 D299G probably damaging Het
Dip2b G A 15: 100,215,329 V1542I possibly damaging Het
Dmxl1 T A 18: 49,962,181 S2942R probably damaging Het
Dpf1 T A 7: 29,316,590 probably benign Het
Ephb6 A G 6: 41,616,574 Y518C probably benign Het
Eps15l1 A T 8: 72,373,916 F606I possibly damaging Het
Extl1 A G 4: 134,371,379 S114P probably damaging Het
Extl1 A C 4: 134,371,380 D113E probably benign Het
Fat1 T C 8: 44,950,683 V157A possibly damaging Het
Fcho1 A T 8: 71,712,480 D444E probably benign Het
Fgd3 T A 13: 49,296,560 D71V probably damaging Het
Fgd5 T A 6: 91,988,209 D316E possibly damaging Het
Gys2 A T 6: 142,454,484 F334I possibly damaging Het
Ik G T 18: 36,753,555 R360L possibly damaging Het
Kazn A C 4: 142,118,288 probably null Het
Kmt2d A T 15: 98,839,716 probably benign Het
Krr1 T C 10: 111,975,677 probably benign Het
Krt83 C T 15: 101,487,049 E389K probably benign Het
Lrrc4c T C 2: 97,630,313 V428A probably benign Het
Lvrn C A 18: 46,864,765 T260K possibly damaging Het
Mcc C T 18: 44,468,421 E614K probably damaging Het
Msrb3 A T 10: 120,849,997 V81D probably damaging Het
Muc19 C T 15: 91,934,383 noncoding transcript Het
Myadm T A 7: 3,297,400 L226* probably null Het
Myof C T 19: 37,967,099 V526M probably damaging Het
Nckap5l A G 15: 99,429,323 probably benign Het
Olfr1010 T A 2: 85,753,940 probably benign Het
Olfr1260 C A 2: 89,978,006 A76D possibly damaging Het
Olfr398 A G 11: 73,983,892 S239P probably damaging Het
Pars2 T C 4: 106,654,050 V307A probably benign Het
Pcdhb1 T G 18: 37,265,528 Y177* probably null Het
Pcdhb4 T A 18: 37,308,652 D338E probably damaging Het
Pik3r2 G A 8: 70,772,136 R199* probably null Het
Pla2g4f C T 2: 120,313,986 R24Q probably benign Het
Pnma2 T C 14: 66,916,232 I35T probably benign Het
Podn C A 4: 108,017,867 A568S probably benign Het
Pou3f1 A T 4: 124,658,836 E377V probably damaging Het
Ppfia1 T C 7: 144,485,192 D494G probably damaging Het
Ptpn9 A T 9: 57,022,211 T71S possibly damaging Het
Ptprz1 C T 6: 23,001,487 P1192L possibly damaging Het
Rnd2 C T 11: 101,468,999 L57F probably damaging Het
Rnf217 T A 10: 31,517,476 K370* probably null Het
Rpap2 G A 5: 107,601,795 V62I possibly damaging Het
Scaper A T 9: 55,655,903 probably null Het
Sos2 T C 12: 69,614,606 probably benign Het
Sptbn5 C T 2: 120,067,446 probably null Het
Sumo1 A G 1: 59,644,509 probably benign Het
Syne2 C A 12: 75,989,253 N3771K probably damaging Het
Tbx18 T C 9: 87,730,769 I26V possibly damaging Het
Trpm3 T A 19: 22,978,624 M1140K probably benign Het
Usp29 G A 7: 6,963,357 probably null Het
Wdr7 C T 18: 63,779,945 Q946* probably null Het
Ythdf1 T C 2: 180,912,182 D46G probably damaging Het
Zfp217 T C 2: 170,119,750 N219S possibly damaging Het
Zkscan3 A G 13: 21,393,783 I256T probably benign Het
Other mutations in Olfr1270
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02648:Olfr1270 APN 2 90149353 missense possibly damaging 0.61
IGL03034:Olfr1270 APN 2 90149833 missense probably damaging 1.00
R0726:Olfr1270 UTSW 2 90149283 missense probably damaging 1.00
R1573:Olfr1270 UTSW 2 90148724 utr 3 prime probably benign
R1965:Olfr1270 UTSW 2 90149404 missense probably damaging 0.98
R1966:Olfr1270 UTSW 2 90149404 missense probably damaging 0.98
R2353:Olfr1270 UTSW 2 90149718 missense probably damaging 0.98
R3805:Olfr1270 UTSW 2 90148461 utr 3 prime probably benign
R4662:Olfr1270 UTSW 2 90149878 missense probably damaging 1.00
R6198:Olfr1270 UTSW 2 90149438 missense probably damaging 1.00
R6596:Olfr1270 UTSW 2 90149278 missense possibly damaging 0.73
R6957:Olfr1270 UTSW 2 90149150 nonsense probably null
R7408:Olfr1270 UTSW 2 90149844 missense probably benign
R7418:Olfr1270 UTSW 2 90149487 missense probably damaging 1.00
R7454:Olfr1270 UTSW 2 90149419 missense possibly damaging 0.78
R7935:Olfr1270 UTSW 2 90149584 missense probably benign 0.00
R9006:Olfr1270 UTSW 2 90149983 missense probably damaging 1.00
R9157:Olfr1270 UTSW 2 90149178 missense possibly damaging 0.85
R9454:Olfr1270 UTSW 2 90149476 missense probably damaging 1.00
R9478:Olfr1270 UTSW 2 90149251 missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- AGACCTCATCAGATCCTGGTTC -3'
(R):5'- CACACTCAGAAATGCAGAGGTG -3'

Sequencing Primer
(F):5'- AGATCCTGGTTCATCACTCAGCG -3'
(R):5'- GACATGCCATCTCTGCTT -3'
Posted On 2015-09-25