Incidental Mutation 'R4606:Pnma2'
ID 346041
Institutional Source Beutler Lab
Gene Symbol Pnma2
Ensembl Gene ENSMUSG00000046204
Gene Name paraneoplastic antigen MA2
Synonyms
MMRRC Submission 041817-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4606 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 66911170-66921023 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 66916232 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 35 (I35T)
Ref Sequence ENSEMBL: ENSMUSP00000112629 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089236] [ENSMUST00000122431]
AlphaFold Q8BHK0
Predicted Effect probably benign
Transcript: ENSMUST00000089236
AA Change: I35T

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000086646
Gene: ENSMUSG00000046204
AA Change: I35T

DomainStartEndE-ValueType
Pfam:PNMA 1 328 1.9e-119 PFAM
Pfam:Retrotrans_gag 204 303 2.8e-8 PFAM
low complexity region 343 357 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000122431
AA Change: I35T

PolyPhen 2 Score 0.030 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000112629
Gene: ENSMUSG00000046204
AA Change: I35T

DomainStartEndE-ValueType
Pfam:PNMA 1 329 7.1e-111 PFAM
Pfam:Retrotrans_gag 204 303 3.3e-8 PFAM
low complexity region 343 357 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000165831
Predicted Effect noncoding transcript
Transcript: ENSMUST00000168010
Meta Mutation Damage Score 0.1378 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 96% (69/72)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A T 8: 79,210,745 W178R probably benign Het
Abcb5 T C 12: 118,932,610 probably null Het
Akr1b3 C A 6: 34,306,664 probably benign Het
Arid1a A G 4: 133,687,323 F1199S unknown Het
Atp4b A G 8: 13,389,998 F116S probably damaging Het
Atp6v1b1 T C 6: 83,752,461 S127P probably damaging Het
Blk C T 14: 63,374,203 V428I probably benign Het
C87414 A T 5: 93,636,602 D137E probably damaging Het
Ccser1 T C 6: 61,311,584 S244P probably damaging Het
Ceacam1 T A 7: 25,474,526 I235F probably damaging Het
Cyp2g1 T A 7: 26,814,154 Y173N possibly damaging Het
Ddr2 T A 1: 170,001,852 I278F probably benign Het
Degs1 T C 1: 182,276,823 D299G probably damaging Het
Dip2b G A 15: 100,215,329 V1542I possibly damaging Het
Dmxl1 T A 18: 49,962,181 S2942R probably damaging Het
Dpf1 T A 7: 29,316,590 probably benign Het
Ephb6 A G 6: 41,616,574 Y518C probably benign Het
Eps15l1 A T 8: 72,373,916 F606I possibly damaging Het
Extl1 A G 4: 134,371,379 S114P probably damaging Het
Extl1 A C 4: 134,371,380 D113E probably benign Het
Fat1 T C 8: 44,950,683 V157A possibly damaging Het
Fcho1 A T 8: 71,712,480 D444E probably benign Het
Fgd3 T A 13: 49,296,560 D71V probably damaging Het
Fgd5 T A 6: 91,988,209 D316E possibly damaging Het
Gys2 A T 6: 142,454,484 F334I possibly damaging Het
Ik G T 18: 36,753,555 R360L possibly damaging Het
Kazn A C 4: 142,118,288 probably null Het
Kmt2d A T 15: 98,839,716 probably benign Het
Krr1 T C 10: 111,975,677 probably benign Het
Krt83 C T 15: 101,487,049 E389K probably benign Het
Lrrc4c T C 2: 97,630,313 V428A probably benign Het
Lvrn C A 18: 46,864,765 T260K possibly damaging Het
Mcc C T 18: 44,468,421 E614K probably damaging Het
Msrb3 A T 10: 120,849,997 V81D probably damaging Het
Muc19 C T 15: 91,934,383 noncoding transcript Het
Myadm T A 7: 3,297,400 L226* probably null Het
Myof C T 19: 37,967,099 V526M probably damaging Het
Nckap5l A G 15: 99,429,323 probably benign Het
Olfr1010 T A 2: 85,753,940 probably benign Het
Olfr1260 C A 2: 89,978,006 A76D possibly damaging Het
Olfr1270 G T 2: 90,148,816 probably benign Het
Olfr398 A G 11: 73,983,892 S239P probably damaging Het
Pars2 T C 4: 106,654,050 V307A probably benign Het
Pcdhb1 T G 18: 37,265,528 Y177* probably null Het
Pcdhb4 T A 18: 37,308,652 D338E probably damaging Het
Pik3r2 G A 8: 70,772,136 R199* probably null Het
Pla2g4f C T 2: 120,313,986 R24Q probably benign Het
Podn C A 4: 108,017,867 A568S probably benign Het
Pou3f1 A T 4: 124,658,836 E377V probably damaging Het
Ppfia1 T C 7: 144,485,192 D494G probably damaging Het
Ptpn9 A T 9: 57,022,211 T71S possibly damaging Het
Ptprz1 C T 6: 23,001,487 P1192L possibly damaging Het
Rnd2 C T 11: 101,468,999 L57F probably damaging Het
Rnf217 T A 10: 31,517,476 K370* probably null Het
Rpap2 G A 5: 107,601,795 V62I possibly damaging Het
Scaper A T 9: 55,655,903 probably null Het
Sos2 T C 12: 69,614,606 probably benign Het
Sptbn5 C T 2: 120,067,446 probably null Het
Sumo1 A G 1: 59,644,509 probably benign Het
Syne2 C A 12: 75,989,253 N3771K probably damaging Het
Tbx18 T C 9: 87,730,769 I26V possibly damaging Het
Trpm3 T A 19: 22,978,624 M1140K probably benign Het
Usp29 G A 7: 6,963,357 probably null Het
Wdr7 C T 18: 63,779,945 Q946* probably null Het
Ythdf1 T C 2: 180,912,182 D46G probably damaging Het
Zfp217 T C 2: 170,119,750 N219S possibly damaging Het
Zkscan3 A G 13: 21,393,783 I256T probably benign Het
Other mutations in Pnma2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1752:Pnma2 UTSW 14 66916336 missense probably benign
R1834:Pnma2 UTSW 14 66917213 missense possibly damaging 0.53
R4878:Pnma2 UTSW 14 66917054 nonsense probably null
R5185:Pnma2 UTSW 14 66916129 start codon destroyed possibly damaging 0.78
R5242:Pnma2 UTSW 14 66916297 missense probably benign 0.04
R5274:Pnma2 UTSW 14 66916760 missense probably damaging 1.00
R5928:Pnma2 UTSW 14 66916874 missense probably benign 0.02
R7156:Pnma2 UTSW 14 66916531 missense probably benign 0.19
R7352:Pnma2 UTSW 14 66916421 missense possibly damaging 0.93
R7577:Pnma2 UTSW 14 66915979 start gained probably benign
R8411:Pnma2 UTSW 14 66916313 missense possibly damaging 0.48
R8558:Pnma2 UTSW 14 66916523 missense probably benign 0.27
R9165:Pnma2 UTSW 14 66917123 missense probably damaging 1.00
R9385:Pnma2 UTSW 14 66915922 start gained probably benign
R9799:Pnma2 UTSW 14 66916560 missense probably benign 0.07
Predicted Primers PCR Primer
(F):5'- AAGGGACAGAGCATTTGGCC -3'
(R):5'- AAAGAGGTTCAGTCTTTGGAGAAACTC -3'

Sequencing Primer
(F):5'- CCAAGAGGCTTTGAGACCTC -3'
(R):5'- GGGTCTTGAAGATCACTTTCCAGAC -3'
Posted On 2015-09-25