Incidental Mutation 'R4606:Krt87'
ID 346045
Institutional Source Beutler Lab
Gene Symbol Krt87
Ensembl Gene ENSMUSG00000047641
Gene Name keratin 87
Synonyms Krt2-25, Krt83
MMRRC Submission 041817-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R4606 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 101329371-101336685 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 101384930 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 389 (E389K)
Ref Sequence ENSEMBL: ENSMUSP00000023718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023718]
AlphaFold Q6IMF0
Predicted Effect probably benign
Transcript: ENSMUST00000023718
AA Change: E389K

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000023718
Gene: ENSMUSG00000067613
AA Change: E389K

DomainStartEndE-ValueType
Pfam:Keratin_2_head 2 100 5.9e-16 PFAM
Filament 103 414 7.02e-149 SMART
low complexity region 422 436 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159029
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230173
Meta Mutation Damage Score 0.5039 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 96% (69/72)
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A T 8: 79,937,374 (GRCm39) W178R probably benign Het
Abcb5 T C 12: 118,896,345 (GRCm39) probably null Het
Akr1b1 C A 6: 34,283,599 (GRCm39) probably benign Het
Arid1a A G 4: 133,414,634 (GRCm39) F1199S unknown Het
Atp4b A G 8: 13,439,998 (GRCm39) F116S probably damaging Het
Atp6v1b1 T C 6: 83,729,443 (GRCm39) S127P probably damaging Het
Blk C T 14: 63,611,652 (GRCm39) V428I probably benign Het
Ccser1 T C 6: 61,288,568 (GRCm39) S244P probably damaging Het
Ceacam1 T A 7: 25,173,951 (GRCm39) I235F probably damaging Het
Cyp2g1 T A 7: 26,513,579 (GRCm39) Y173N possibly damaging Het
Ddr2 T A 1: 169,829,421 (GRCm39) I278F probably benign Het
Degs1 T C 1: 182,104,388 (GRCm39) D299G probably damaging Het
Dip2b G A 15: 100,113,210 (GRCm39) V1542I possibly damaging Het
Dmxl1 T A 18: 50,095,248 (GRCm39) S2942R probably damaging Het
Dpf1 T A 7: 29,016,015 (GRCm39) probably benign Het
Ephb6 A G 6: 41,593,508 (GRCm39) Y518C probably benign Het
Eps15l1 A T 8: 73,127,760 (GRCm39) F606I possibly damaging Het
Extl1 A G 4: 134,098,690 (GRCm39) S114P probably damaging Het
Extl1 A C 4: 134,098,691 (GRCm39) D113E probably benign Het
Fat1 T C 8: 45,403,720 (GRCm39) V157A possibly damaging Het
Fcho1 A T 8: 72,165,124 (GRCm39) D444E probably benign Het
Fgd3 T A 13: 49,450,036 (GRCm39) D71V probably damaging Het
Fgd5 T A 6: 91,965,190 (GRCm39) D316E possibly damaging Het
Gys2 A T 6: 142,400,210 (GRCm39) F334I possibly damaging Het
Ik G T 18: 36,886,608 (GRCm39) R360L possibly damaging Het
Kazn A C 4: 141,845,599 (GRCm39) probably null Het
Kmt2d A T 15: 98,737,597 (GRCm39) probably benign Het
Krr1 T C 10: 111,811,582 (GRCm39) probably benign Het
Lrrc4c T C 2: 97,460,658 (GRCm39) V428A probably benign Het
Lvrn C A 18: 46,997,832 (GRCm39) T260K possibly damaging Het
Mcc C T 18: 44,601,488 (GRCm39) E614K probably damaging Het
Msrb3 A T 10: 120,685,902 (GRCm39) V81D probably damaging Het
Muc19 C T 15: 91,832,268 (GRCm39) noncoding transcript Het
Myadm T A 7: 3,345,916 (GRCm39) L226* probably null Het
Myof C T 19: 37,955,547 (GRCm39) V526M probably damaging Het
Nckap5l A G 15: 99,327,204 (GRCm39) probably benign Het
Or1r1 A G 11: 73,874,718 (GRCm39) S239P probably damaging Het
Or4b1 G T 2: 89,979,160 (GRCm39) probably benign Het
Or4c35 C A 2: 89,808,350 (GRCm39) A76D possibly damaging Het
Or9g10 T A 2: 85,584,284 (GRCm39) probably benign Het
Pars2 T C 4: 106,511,247 (GRCm39) V307A probably benign Het
Pcdhb1 T G 18: 37,398,581 (GRCm39) Y177* probably null Het
Pcdhb4 T A 18: 37,441,705 (GRCm39) D338E probably damaging Het
Pik3r2 G A 8: 71,224,780 (GRCm39) R199* probably null Het
Pla2g4f C T 2: 120,144,467 (GRCm39) R24Q probably benign Het
Pnma2 T C 14: 67,153,681 (GRCm39) I35T probably benign Het
Podn C A 4: 107,875,064 (GRCm39) A568S probably benign Het
Pou3f1 A T 4: 124,552,629 (GRCm39) E377V probably damaging Het
Ppfia1 T C 7: 144,038,929 (GRCm39) D494G probably damaging Het
Pramel34 A T 5: 93,784,461 (GRCm39) D137E probably damaging Het
Ptpn9 A T 9: 56,929,495 (GRCm39) T71S possibly damaging Het
Ptprz1 C T 6: 23,001,486 (GRCm39) P1192L possibly damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rnf217 T A 10: 31,393,472 (GRCm39) K370* probably null Het
Rpap2 G A 5: 107,749,661 (GRCm39) V62I possibly damaging Het
Scaper A T 9: 55,563,187 (GRCm39) probably null Het
Sos2 T C 12: 69,661,380 (GRCm39) probably benign Het
Sptbn5 C T 2: 119,897,927 (GRCm39) probably null Het
Sumo1 A G 1: 59,683,668 (GRCm39) probably benign Het
Syne2 C A 12: 76,036,027 (GRCm39) N3771K probably damaging Het
Tbx18 T C 9: 87,612,822 (GRCm39) I26V possibly damaging Het
Trpm3 T A 19: 22,955,988 (GRCm39) M1140K probably benign Het
Usp29 G A 7: 6,966,356 (GRCm39) probably null Het
Wdr7 C T 18: 63,913,016 (GRCm39) Q946* probably null Het
Ythdf1 T C 2: 180,553,975 (GRCm39) D46G probably damaging Het
Zfp217 T C 2: 169,961,670 (GRCm39) N219S possibly damaging Het
Zkscan3 A G 13: 21,577,953 (GRCm39) I256T probably benign Het
Other mutations in Krt87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Krt87 APN 15 101,386,092 (GRCm39) missense probably benign 0.17
IGL00987:Krt87 APN 15 101,336,327 (GRCm39) missense probably benign 0.00
IGL01019:Krt87 APN 15 101,336,312 (GRCm39) missense possibly damaging 0.84
IGL01066:Krt87 APN 15 101,336,266 (GRCm39) critical splice donor site probably null
IGL01087:Krt87 APN 15 101,329,706 (GRCm39) missense probably benign 0.27
IGL01315:Krt87 APN 15 101,384,848 (GRCm39) splice site probably benign
IGL01572:Krt87 APN 15 101,334,414 (GRCm39) missense probably benign 0.33
IGL01702:Krt87 APN 15 101,389,099 (GRCm39) missense probably benign 0.18
IGL02123:Krt87 APN 15 101,385,466 (GRCm39) missense possibly damaging 0.49
IGL02353:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02360:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02395:Krt87 APN 15 101,385,833 (GRCm39) missense probably benign 0.18
IGL02633:Krt87 APN 15 101,389,095 (GRCm39) missense probably damaging 1.00
IGL02716:Krt87 APN 15 101,332,485 (GRCm39) missense possibly damaging 0.52
IGL03287:Krt87 APN 15 101,330,218 (GRCm39) splice site probably benign
R0144:Krt87 UTSW 15 101,336,542 (GRCm39) missense probably benign 0.04
R0357:Krt87 UTSW 15 101,384,900 (GRCm39) missense probably benign 0.17
R0650:Krt87 UTSW 15 101,384,921 (GRCm39) missense probably damaging 0.99
R0928:Krt87 UTSW 15 101,389,161 (GRCm39) missense probably benign 0.00
R1126:Krt87 UTSW 15 101,385,363 (GRCm39) missense probably damaging 0.98
R1196:Krt87 UTSW 15 101,389,314 (GRCm39) missense probably benign 0.03
R1252:Krt87 UTSW 15 101,385,711 (GRCm39) missense probably damaging 1.00
R1513:Krt87 UTSW 15 101,387,538 (GRCm39) missense probably benign 0.30
R1612:Krt87 UTSW 15 101,386,092 (GRCm39) missense probably benign 0.17
R1870:Krt87 UTSW 15 101,385,071 (GRCm39) missense probably benign
R2173:Krt87 UTSW 15 101,385,818 (GRCm39) missense probably damaging 0.98
R2196:Krt87 UTSW 15 101,336,314 (GRCm39) missense probably damaging 0.99
R2209:Krt87 UTSW 15 101,330,989 (GRCm39) missense probably benign 0.42
R2432:Krt87 UTSW 15 101,386,037 (GRCm39) nonsense probably null
R2568:Krt87 UTSW 15 101,385,708 (GRCm39) missense possibly damaging 0.67
R2696:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign 0.01
R3508:Krt87 UTSW 15 101,386,039 (GRCm39) missense probably benign 0.04
R4364:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4366:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4721:Krt87 UTSW 15 101,385,863 (GRCm39) missense probably damaging 1.00
R4784:Krt87 UTSW 15 101,385,837 (GRCm39) missense probably damaging 1.00
R4987:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign
R5008:Krt87 UTSW 15 101,389,105 (GRCm39) missense probably damaging 1.00
R5101:Krt87 UTSW 15 101,385,391 (GRCm39) missense probably benign 0.14
R5367:Krt87 UTSW 15 101,384,875 (GRCm39) missense probably damaging 1.00
R5516:Krt87 UTSW 15 101,385,002 (GRCm39) nonsense probably null
R5651:Krt87 UTSW 15 101,331,910 (GRCm39) missense possibly damaging 0.94
R5949:Krt87 UTSW 15 101,385,476 (GRCm39) missense probably damaging 0.99
R5972:Krt87 UTSW 15 101,385,467 (GRCm39) missense probably benign
R6036:Krt87 UTSW 15 101,385,412 (GRCm39) missense possibly damaging 0.78
R6036:Krt87 UTSW 15 101,385,412 (GRCm39) missense possibly damaging 0.78
R6135:Krt87 UTSW 15 101,385,415 (GRCm39) missense probably damaging 1.00
R6437:Krt87 UTSW 15 101,336,273 (GRCm39) missense possibly damaging 0.95
R6615:Krt87 UTSW 15 101,334,443 (GRCm39) missense probably benign 0.02
R6680:Krt87 UTSW 15 101,331,859 (GRCm39) missense probably damaging 1.00
R7151:Krt87 UTSW 15 101,387,529 (GRCm39) missense probably damaging 1.00
R7186:Krt87 UTSW 15 101,385,083 (GRCm39) splice site probably null
R7297:Krt87 UTSW 15 101,387,528 (GRCm39) missense probably benign 0.42
R7541:Krt87 UTSW 15 101,336,515 (GRCm39) missense probably damaging 1.00
R7617:Krt87 UTSW 15 101,336,426 (GRCm39) missense probably benign 0.38
R7708:Krt87 UTSW 15 101,385,813 (GRCm39) missense probably benign 0.00
R7796:Krt87 UTSW 15 101,383,865 (GRCm39) missense possibly damaging 0.95
R8172:Krt87 UTSW 15 101,383,284 (GRCm39) missense probably benign 0.25
R8463:Krt87 UTSW 15 101,332,506 (GRCm39) missense probably benign 0.05
R8669:Krt87 UTSW 15 101,385,777 (GRCm39) missense probably benign 0.00
R8695:Krt87 UTSW 15 101,331,901 (GRCm39) missense probably benign 0.00
R8771:Krt87 UTSW 15 101,385,779 (GRCm39) missense probably benign 0.00
R9478:Krt87 UTSW 15 101,385,449 (GRCm39) missense probably benign 0.06
R9489:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9592:Krt87 UTSW 15 101,386,060 (GRCm39) missense probably benign
R9605:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9629:Krt87 UTSW 15 101,389,048 (GRCm39) missense probably benign 0.01
R9642:Krt87 UTSW 15 101,385,074 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACTTAAGGCCAGTTCAAGAGCAC -3'
(R):5'- TGGTGACAGACAGTGAGACC -3'

Sequencing Primer
(F):5'- GCCAGTTCAAGAGCACTGAGC -3'
(R):5'- AGGGACCCTTGGCTATCTC -3'
Posted On 2015-09-25