Incidental Mutation 'R4622:Adgrb3'
| ID |
346196 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb3
|
| Ensembl Gene |
ENSMUSG00000033569 |
| Gene Name |
adhesion G protein-coupled receptor B3 |
| Synonyms |
Bai3, A830096D10Rik |
| MMRRC Submission |
041887-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.409)
|
| Stock # |
R4622 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
25106557-25868788 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 25865569 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 91
(D91E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116231
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041838]
[ENSMUST00000135518]
[ENSMUST00000146592]
[ENSMUST00000151309]
|
| AlphaFold |
Q80ZF8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000041838
AA Change: D91E
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000035612
Gene: ENSMUSG00000033569
AA Change: D91E
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000135518
AA Change: D91E
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000119804
Gene: ENSMUSG00000033569
AA Change: D91E
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
586 |
810 |
1.7e-52 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
874 |
1143 |
2.1e-64 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146592
|
| SMART Domains |
Protein: ENSMUSP00000116759
Gene: ENSMUSG00000033569
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
16 |
N/A |
INTRINSIC |
|
TSP1
|
87 |
136 |
2.1e-12 |
SMART |
|
TSP1
|
141 |
191 |
7.97e-13 |
SMART |
|
TSP1
|
196 |
246 |
6.28e-11 |
SMART |
|
TSP1
|
251 |
301 |
1.48e-7 |
SMART |
|
HormR
|
303 |
369 |
4.15e-20 |
SMART |
|
Pfam:DUF3497
|
379 |
603 |
2.5e-52 |
PFAM |
|
GPS
|
608 |
661 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
667 |
903 |
5.4e-66 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000151309
AA Change: D91E
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000116231
Gene: ENSMUSG00000033569
AA Change: D91E
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
7 |
29 |
N/A |
INTRINSIC |
|
low complexity region
|
212 |
223 |
N/A |
INTRINSIC |
|
TSP1
|
294 |
343 |
2.1e-12 |
SMART |
|
TSP1
|
348 |
398 |
7.97e-13 |
SMART |
|
TSP1
|
403 |
453 |
6.28e-11 |
SMART |
|
TSP1
|
458 |
508 |
1.48e-7 |
SMART |
|
HormR
|
510 |
576 |
4.15e-20 |
SMART |
|
Pfam:GAIN
|
589 |
794 |
1.1e-44 |
PFAM |
|
GPS
|
815 |
868 |
1.24e-21 |
SMART |
|
Pfam:7tm_2
|
875 |
1143 |
2.7e-63 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000189254
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000194343
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195754
|
| Meta Mutation Damage Score |
0.3733 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
98% (107/109) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in Purkinje cells exhibit impaired motor learning with alterned climbing fiber electrophysiology. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 99 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
A |
T |
3: 59,914,474 (GRCm39) |
N26Y |
probably damaging |
Het |
| Aass |
C |
T |
6: 23,092,329 (GRCm39) |
D194N |
probably damaging |
Het |
| Acp7 |
T |
C |
7: 28,313,822 (GRCm39) |
Y404C |
probably damaging |
Het |
| Acsl1 |
A |
T |
8: 46,979,410 (GRCm39) |
I421L |
probably benign |
Het |
| Adgrg3 |
T |
C |
8: 95,767,153 (GRCm39) |
S503P |
probably damaging |
Het |
| Adgrg6 |
A |
T |
10: 14,317,243 (GRCm39) |
C526S |
probably damaging |
Het |
| Arhgap32 |
A |
T |
9: 32,150,644 (GRCm39) |
I15F |
possibly damaging |
Het |
| Arid1b |
G |
T |
17: 5,045,325 (GRCm39) |
|
probably benign |
Het |
| Asnsd1 |
A |
G |
1: 53,387,378 (GRCm39) |
V83A |
probably benign |
Het |
| Atg101 |
A |
G |
15: 101,191,213 (GRCm39) |
|
probably benign |
Het |
| Atp8a1 |
T |
C |
5: 67,840,056 (GRCm39) |
|
probably benign |
Het |
| Aurkb |
T |
A |
11: 68,939,188 (GRCm39) |
L137Q |
probably damaging |
Het |
| AY702103 |
A |
T |
17: 50,547,029 (GRCm39) |
|
noncoding transcript |
Het |
| B3gnt9 |
A |
G |
8: 105,980,477 (GRCm39) |
S304P |
probably benign |
Het |
| Babam2 |
T |
C |
5: 32,164,656 (GRCm39) |
V310A |
probably damaging |
Het |
| Batf |
A |
G |
12: 85,755,327 (GRCm39) |
D60G |
possibly damaging |
Het |
| Baz1a |
A |
T |
12: 54,988,300 (GRCm39) |
I283K |
probably benign |
Het |
| Bmerb1 |
A |
C |
16: 13,911,786 (GRCm39) |
E44A |
possibly damaging |
Het |
| Bst1 |
T |
G |
5: 43,976,261 (GRCm39) |
|
probably benign |
Het |
| C2 |
C |
A |
17: 35,082,650 (GRCm39) |
V490L |
probably damaging |
Het |
| Cacna1e |
T |
C |
1: 154,347,311 (GRCm39) |
E952G |
possibly damaging |
Het |
| Ccnyl1 |
A |
G |
1: 64,757,417 (GRCm39) |
D262G |
probably damaging |
Het |
| Cdc42bpa |
A |
T |
1: 179,902,223 (GRCm39) |
K493N |
probably damaging |
Het |
| Cenpe |
A |
G |
3: 134,949,469 (GRCm39) |
T85A |
probably benign |
Het |
| Ces2e |
T |
A |
8: 105,655,341 (GRCm39) |
|
probably null |
Het |
| Chd3 |
T |
A |
11: 69,239,834 (GRCm39) |
R1665W |
probably damaging |
Het |
| Cpm |
A |
G |
10: 117,506,202 (GRCm39) |
N188D |
possibly damaging |
Het |
| Cspg4b |
A |
G |
13: 113,456,615 (GRCm39) |
D887G |
probably benign |
Het |
| Ctnnd2 |
A |
T |
15: 30,887,315 (GRCm39) |
M781L |
probably benign |
Het |
| Ctnnd2 |
A |
G |
15: 31,009,259 (GRCm39) |
T1094A |
probably benign |
Het |
| Cux1 |
T |
C |
5: 136,337,154 (GRCm39) |
K657R |
probably damaging |
Het |
| Ddx54 |
G |
A |
5: 120,764,488 (GRCm39) |
V732M |
probably damaging |
Het |
| Ecrg4 |
G |
T |
1: 43,781,481 (GRCm39) |
R121L |
possibly damaging |
Het |
| Efna5 |
T |
C |
17: 62,958,040 (GRCm39) |
D72G |
probably benign |
Het |
| Eva1c |
T |
A |
16: 90,694,343 (GRCm39) |
|
probably null |
Het |
| Evi5l |
T |
C |
8: 4,252,909 (GRCm39) |
|
probably benign |
Het |
| Fasl |
A |
G |
1: 161,614,703 (GRCm39) |
L120P |
probably benign |
Het |
| H2-M9 |
A |
T |
17: 36,952,716 (GRCm39) |
|
probably null |
Het |
| Hdgf |
C |
A |
3: 87,821,884 (GRCm39) |
N198K |
possibly damaging |
Het |
| Hspa9 |
A |
T |
18: 35,082,090 (GRCm39) |
M172K |
possibly damaging |
Het |
| Il1r1 |
A |
C |
1: 40,351,580 (GRCm39) |
L406F |
probably damaging |
Het |
| Il31 |
T |
C |
5: 123,618,498 (GRCm39) |
D96G |
probably damaging |
Het |
| Inhbc |
A |
G |
10: 127,193,146 (GRCm39) |
I290T |
probably benign |
Het |
| Lrp2 |
A |
T |
2: 69,290,693 (GRCm39) |
V3589D |
possibly damaging |
Het |
| Lrrc14 |
A |
T |
15: 76,600,540 (GRCm39) |
|
probably benign |
Het |
| Lyst |
G |
A |
13: 13,848,983 (GRCm39) |
A2057T |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,266,141 (GRCm39) |
|
probably null |
Het |
| Mapk10 |
C |
A |
5: 103,137,590 (GRCm39) |
G209V |
probably damaging |
Het |
| Mcoln1 |
A |
G |
8: 3,555,923 (GRCm39) |
I73V |
probably damaging |
Het |
| Met |
G |
T |
6: 17,513,383 (GRCm39) |
R411L |
probably benign |
Het |
| Mplkipl1 |
C |
T |
19: 61,164,364 (GRCm39) |
G24R |
unknown |
Het |
| Mrpl4 |
G |
A |
9: 20,918,793 (GRCm39) |
R176Q |
probably damaging |
Het |
| Mrtfb |
G |
A |
16: 13,150,570 (GRCm39) |
G102D |
probably damaging |
Het |
| Mtmr3 |
T |
C |
11: 4,441,067 (GRCm39) |
T528A |
possibly damaging |
Het |
| Mtmr7 |
A |
T |
8: 41,034,583 (GRCm39) |
N246K |
probably damaging |
Het |
| Mycbp2 |
G |
T |
14: 103,457,415 (GRCm39) |
T1627K |
probably benign |
Het |
| Necab3 |
A |
G |
2: 154,397,502 (GRCm39) |
|
probably null |
Het |
| Nr1d1 |
C |
T |
11: 98,660,710 (GRCm39) |
C419Y |
probably damaging |
Het |
| Nwd1 |
C |
A |
8: 73,393,928 (GRCm39) |
A397E |
probably damaging |
Het |
| Oas1f |
A |
T |
5: 120,986,390 (GRCm39) |
K114N |
probably damaging |
Het |
| Or13a18 |
T |
A |
7: 140,190,611 (GRCm39) |
C169* |
probably null |
Het |
| Or1e35 |
C |
A |
11: 73,797,737 (GRCm39) |
V194F |
possibly damaging |
Het |
| Or51ab3 |
G |
T |
7: 103,201,361 (GRCm39) |
R123L |
probably benign |
Het |
| Or5k8 |
A |
T |
16: 58,644,469 (GRCm39) |
I201N |
possibly damaging |
Het |
| Or5w13 |
T |
A |
2: 87,523,987 (GRCm39) |
K80* |
probably null |
Het |
| Osbpl8 |
T |
C |
10: 111,127,357 (GRCm39) |
S814P |
probably benign |
Het |
| Pcdhgb7 |
A |
T |
18: 37,886,183 (GRCm39) |
Q451L |
probably benign |
Het |
| Pde7b |
C |
T |
10: 20,294,538 (GRCm39) |
R300Q |
probably damaging |
Het |
| Pgghg |
A |
G |
7: 140,521,409 (GRCm39) |
|
probably null |
Het |
| Plcg1 |
A |
G |
2: 160,589,688 (GRCm39) |
|
probably benign |
Het |
| Plxna2 |
A |
T |
1: 194,494,458 (GRCm39) |
I1892L |
probably benign |
Het |
| Ppt2 |
A |
G |
17: 34,844,875 (GRCm39) |
V123A |
probably benign |
Het |
| Prdx5 |
G |
T |
19: 6,884,341 (GRCm39) |
|
probably benign |
Het |
| Prpf40b |
A |
G |
15: 99,214,197 (GRCm39) |
D819G |
probably benign |
Het |
| Prss3l |
A |
T |
6: 41,422,246 (GRCm39) |
I53N |
probably damaging |
Het |
| Psap |
T |
G |
10: 60,136,630 (GRCm39) |
C536W |
probably damaging |
Het |
| Rab3gap1 |
T |
C |
1: 127,870,156 (GRCm39) |
C919R |
probably benign |
Het |
| Racgap1 |
C |
A |
15: 99,524,087 (GRCm39) |
S440I |
probably benign |
Het |
| Rec8 |
C |
T |
14: 55,862,215 (GRCm39) |
R480C |
probably damaging |
Het |
| Reg3d |
A |
G |
6: 78,354,442 (GRCm39) |
L53S |
probably benign |
Het |
| Rnft2 |
T |
A |
5: 118,370,471 (GRCm39) |
S244C |
probably damaging |
Het |
| Scn2a |
T |
C |
2: 65,582,371 (GRCm39) |
V1573A |
probably benign |
Het |
| Selenoo |
G |
T |
15: 88,979,910 (GRCm39) |
G353* |
probably null |
Het |
| Siva1 |
A |
G |
12: 112,611,501 (GRCm39) |
Y34C |
probably damaging |
Het |
| Slc2a4 |
C |
T |
11: 69,835,600 (GRCm39) |
|
probably benign |
Het |
| Slc39a12 |
A |
T |
2: 14,405,136 (GRCm39) |
T243S |
probably benign |
Het |
| Slc9b2 |
T |
C |
3: 135,038,279 (GRCm39) |
I453T |
probably damaging |
Het |
| Spag17 |
A |
G |
3: 100,010,559 (GRCm39) |
T2018A |
probably benign |
Het |
| Tbc1d24 |
A |
T |
17: 24,427,865 (GRCm39) |
D32E |
probably benign |
Het |
| Tet1 |
T |
A |
10: 62,655,253 (GRCm39) |
H1556L |
possibly damaging |
Het |
| Tmem59 |
A |
T |
4: 107,047,915 (GRCm39) |
|
probably benign |
Het |
| Ttn |
A |
T |
2: 76,731,296 (GRCm39) |
|
probably benign |
Het |
| Uimc1 |
A |
T |
13: 55,225,307 (GRCm39) |
L89H |
probably damaging |
Het |
| Vipas39 |
A |
G |
12: 87,291,317 (GRCm39) |
I343T |
probably damaging |
Het |
| Vmn2r71 |
G |
T |
7: 85,269,817 (GRCm39) |
V443L |
probably benign |
Het |
| Zbtb14 |
G |
A |
17: 69,695,342 (GRCm39) |
D347N |
possibly damaging |
Het |
| Zfp980 |
G |
T |
4: 145,428,627 (GRCm39) |
C452F |
probably damaging |
Het |
| Zmym5 |
T |
A |
14: 57,049,693 (GRCm39) |
|
probably benign |
Het |
| Znfx1 |
T |
C |
2: 166,883,673 (GRCm39) |
T145A |
possibly damaging |
Het |
|
| Other mutations in Adgrb3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00164:Adgrb3
|
APN |
1 |
25,267,581 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00507:Adgrb3
|
APN |
1 |
25,113,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00828:Adgrb3
|
APN |
1 |
25,527,200 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01285:Adgrb3
|
APN |
1 |
25,132,868 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL01309:Adgrb3
|
APN |
1 |
25,151,352 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01540:Adgrb3
|
APN |
1 |
25,151,252 (GRCm39) |
splice site |
probably null |
|
|
IGL01608:Adgrb3
|
APN |
1 |
25,592,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01638:Adgrb3
|
APN |
1 |
25,598,832 (GRCm39) |
splice site |
probably benign |
|
|
IGL01657:Adgrb3
|
APN |
1 |
25,865,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01666:Adgrb3
|
APN |
1 |
25,499,832 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01712:Adgrb3
|
APN |
1 |
25,865,360 (GRCm39) |
missense |
probably benign |
|
|
IGL01767:Adgrb3
|
APN |
1 |
25,598,895 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01987:Adgrb3
|
APN |
1 |
25,140,512 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02201:Adgrb3
|
APN |
1 |
25,459,631 (GRCm39) |
splice site |
probably benign |
|
|
IGL02584:Adgrb3
|
APN |
1 |
25,544,065 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02685:Adgrb3
|
APN |
1 |
25,123,323 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02886:Adgrb3
|
APN |
1 |
25,543,991 (GRCm39) |
splice site |
probably null |
|
|
IGL02929:Adgrb3
|
APN |
1 |
25,592,905 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03153:Adgrb3
|
APN |
1 |
25,570,978 (GRCm39) |
nonsense |
probably null |
|
|
IGL03165:Adgrb3
|
APN |
1 |
25,133,475 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03227:Adgrb3
|
APN |
1 |
25,586,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03392:Adgrb3
|
APN |
1 |
25,543,529 (GRCm39) |
missense |
probably damaging |
0.99 |
|
schwach
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0007:Adgrb3
|
UTSW |
1 |
25,150,772 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0048:Adgrb3
|
UTSW |
1 |
25,140,563 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0322:Adgrb3
|
UTSW |
1 |
25,260,829 (GRCm39) |
splice site |
probably benign |
|
|
R0442:Adgrb3
|
UTSW |
1 |
25,435,551 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0563:Adgrb3
|
UTSW |
1 |
25,586,635 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1168:Adgrb3
|
UTSW |
1 |
25,865,280 (GRCm39) |
missense |
probably benign |
|
|
R1252:Adgrb3
|
UTSW |
1 |
25,167,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1264:Adgrb3
|
UTSW |
1 |
25,598,931 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1543:Adgrb3
|
UTSW |
1 |
25,527,169 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1577:Adgrb3
|
UTSW |
1 |
25,133,264 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1581:Adgrb3
|
UTSW |
1 |
25,133,153 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1583:Adgrb3
|
UTSW |
1 |
25,265,912 (GRCm39) |
splice site |
probably null |
|
|
R1653:Adgrb3
|
UTSW |
1 |
25,140,584 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1725:Adgrb3
|
UTSW |
1 |
25,865,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1792:Adgrb3
|
UTSW |
1 |
25,267,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Adgrb3
|
UTSW |
1 |
25,571,658 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1838:Adgrb3
|
UTSW |
1 |
25,123,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1869:Adgrb3
|
UTSW |
1 |
25,865,519 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R1971:Adgrb3
|
UTSW |
1 |
25,586,525 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2005:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.25 |
|
R2134:Adgrb3
|
UTSW |
1 |
25,133,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2142:Adgrb3
|
UTSW |
1 |
25,107,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Adgrb3
|
UTSW |
1 |
25,150,898 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R3740:Adgrb3
|
UTSW |
1 |
25,865,535 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3877:Adgrb3
|
UTSW |
1 |
25,150,906 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4120:Adgrb3
|
UTSW |
1 |
25,133,388 (GRCm39) |
nonsense |
probably null |
|
|
R4344:Adgrb3
|
UTSW |
1 |
25,865,829 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R4363:Adgrb3
|
UTSW |
1 |
25,151,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4438:Adgrb3
|
UTSW |
1 |
25,870,108 (GRCm39) |
unclassified |
probably benign |
|
|
R4465:Adgrb3
|
UTSW |
1 |
25,133,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4480:Adgrb3
|
UTSW |
1 |
25,150,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4554:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4557:Adgrb3
|
UTSW |
1 |
25,123,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4713:Adgrb3
|
UTSW |
1 |
25,586,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4772:Adgrb3
|
UTSW |
1 |
25,570,956 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4890:Adgrb3
|
UTSW |
1 |
25,260,908 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5045:Adgrb3
|
UTSW |
1 |
25,113,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5061:Adgrb3
|
UTSW |
1 |
25,107,209 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5097:Adgrb3
|
UTSW |
1 |
25,865,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5227:Adgrb3
|
UTSW |
1 |
25,133,033 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R5241:Adgrb3
|
UTSW |
1 |
25,150,871 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5328:Adgrb3
|
UTSW |
1 |
25,133,356 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5372:Adgrb3
|
UTSW |
1 |
25,167,940 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5703:Adgrb3
|
UTSW |
1 |
25,459,640 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5747:Adgrb3
|
UTSW |
1 |
25,865,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5998:Adgrb3
|
UTSW |
1 |
25,470,582 (GRCm39) |
splice site |
probably null |
|
|
R6006:Adgrb3
|
UTSW |
1 |
25,865,612 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6077:Adgrb3
|
UTSW |
1 |
25,133,081 (GRCm39) |
nonsense |
probably null |
|
|
R6183:Adgrb3
|
UTSW |
1 |
25,133,451 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6190:Adgrb3
|
UTSW |
1 |
25,459,728 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6249:Adgrb3
|
UTSW |
1 |
25,471,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6310:Adgrb3
|
UTSW |
1 |
25,150,799 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6450:Adgrb3
|
UTSW |
1 |
25,459,683 (GRCm39) |
missense |
probably benign |
|
|
R6678:Adgrb3
|
UTSW |
1 |
25,499,891 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6679:Adgrb3
|
UTSW |
1 |
25,170,377 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6685:Adgrb3
|
UTSW |
1 |
25,150,817 (GRCm39) |
nonsense |
probably null |
|
|
R6730:Adgrb3
|
UTSW |
1 |
25,133,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6805:Adgrb3
|
UTSW |
1 |
25,865,253 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6847:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6929:Adgrb3
|
UTSW |
1 |
25,150,852 (GRCm39) |
nonsense |
probably null |
|
|
R6953:Adgrb3
|
UTSW |
1 |
25,865,592 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7062:Adgrb3
|
UTSW |
1 |
25,865,166 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7244:Adgrb3
|
UTSW |
1 |
25,170,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7292:Adgrb3
|
UTSW |
1 |
25,570,957 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7325:Adgrb3
|
UTSW |
1 |
25,571,711 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7378:Adgrb3
|
UTSW |
1 |
25,571,000 (GRCm39) |
nonsense |
probably null |
|
|
R7489:Adgrb3
|
UTSW |
1 |
25,586,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7615:Adgrb3
|
UTSW |
1 |
25,137,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7623:Adgrb3
|
UTSW |
1 |
25,586,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7787:Adgrb3
|
UTSW |
1 |
25,471,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7837:Adgrb3
|
UTSW |
1 |
25,167,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8064:Adgrb3
|
UTSW |
1 |
25,459,637 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8152:Adgrb3
|
UTSW |
1 |
25,260,838 (GRCm39) |
splice site |
probably null |
|
|
R8161:Adgrb3
|
UTSW |
1 |
25,133,003 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8225:Adgrb3
|
UTSW |
1 |
25,865,597 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8417:Adgrb3
|
UTSW |
1 |
25,527,134 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8694:Adgrb3
|
UTSW |
1 |
25,865,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8742:Adgrb3
|
UTSW |
1 |
25,265,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8886:Adgrb3
|
UTSW |
1 |
25,150,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8941:Adgrb3
|
UTSW |
1 |
25,133,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8958:Adgrb3
|
UTSW |
1 |
25,865,190 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8979:Adgrb3
|
UTSW |
1 |
25,527,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9064:Adgrb3
|
UTSW |
1 |
25,570,965 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9252:Adgrb3
|
UTSW |
1 |
25,865,496 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9401:Adgrb3
|
UTSW |
1 |
25,592,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Adgrb3
|
UTSW |
1 |
25,592,849 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Adgrb3
|
UTSW |
1 |
25,170,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb3
|
UTSW |
1 |
25,132,995 (GRCm39) |
missense |
probably benign |
0.37 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGCAACCAAACTGGCTC -3'
(R):5'- CCACTTTGGTGAAGGGAGTC -3'
Sequencing Primer
(F):5'- GGGCTCACCTTGTTCAGTAC -3'
(R):5'- AGGGAGTCATTTATGGATCCTATTC -3'
|
| Posted On |
2015-09-25 |
Incidental Mutation