Incidental Mutation 'R0255:Lrrc7'
| ID |
34644 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrc7
|
| Ensembl Gene |
ENSMUSG00000028176 |
| Gene Name |
leucine rich repeat containing 7 |
| Synonyms |
densin |
| MMRRC Submission |
038486-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.798)
|
| Stock # |
R0255 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
157788528-158267858 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 157866475 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 1077
(Q1077*)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106044]
[ENSMUST00000199890]
[ENSMUST00000200137]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000106044
AA Change: Q1089*
|
| SMART Domains |
Protein: ENSMUSP00000101659
Gene: ENSMUSG00000028176
AA Change: Q1089*
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1349 |
1378 |
2e-11 |
BLAST |
|
PDZ
|
1460 |
1540 |
1.33e-19 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000199890
AA Change: Q1089*
|
| SMART Domains |
Protein: ENSMUSP00000142440
Gene: ENSMUSG00000028176
AA Change: Q1089*
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
9e-6 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1328 |
1364 |
1e-15 |
BLAST |
|
low complexity region
|
1374 |
1387 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000200137
AA Change: Q1089*
|
| SMART Domains |
Protein: ENSMUSP00000142498
Gene: ENSMUSG00000028176
AA Change: Q1089*
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
52 |
69 |
7.6e-1 |
SMART |
|
LRR
|
73 |
92 |
4.2e-1 |
SMART |
|
LRR
|
96 |
115 |
3.4e-1 |
SMART |
|
LRR
|
142 |
164 |
1.8e-1 |
SMART |
|
LRR
|
165 |
184 |
1.5e-1 |
SMART |
|
LRR
|
188 |
207 |
2e-2 |
SMART |
|
LRR
|
211 |
233 |
1.3e-1 |
SMART |
|
LRR
|
234 |
257 |
1.7e-1 |
SMART |
|
LRR
|
257 |
276 |
1e0 |
SMART |
|
LRR
|
280 |
299 |
3.1e-2 |
SMART |
|
LRR
|
303 |
322 |
6.6e-1 |
SMART |
|
LRR
|
326 |
345 |
2.1e-1 |
SMART |
|
LRR
|
372 |
391 |
1.2e-1 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1302 |
1331 |
2e-11 |
BLAST |
|
PDZ
|
1413 |
1493 |
6.4e-22 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000200196
AA Change: Q1077*
|
| Meta Mutation Damage Score |
0.9704 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.6%
|
| Validation Efficiency |
93% (102/110) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Gene trapped(2) |
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700113H08Rik |
T |
C |
10: 87,061,907 (GRCm39) |
F119S |
probably damaging |
Het |
| Abca13 |
C |
A |
11: 9,531,545 (GRCm39) |
Q4591K |
probably damaging |
Het |
| Anapc1 |
A |
T |
2: 128,476,631 (GRCm39) |
M1329K |
probably damaging |
Het |
| Aoah |
A |
T |
13: 21,163,710 (GRCm39) |
K338* |
probably null |
Het |
| Ascc3 |
A |
T |
10: 50,521,154 (GRCm39) |
T416S |
probably benign |
Het |
| Baz2a |
A |
G |
10: 127,950,508 (GRCm39) |
T484A |
possibly damaging |
Het |
| Btnl6 |
T |
C |
17: 34,727,477 (GRCm39) |
N351S |
probably benign |
Het |
| Cacna1s |
T |
G |
1: 136,046,544 (GRCm39) |
I1772S |
possibly damaging |
Het |
| Ccdc8 |
A |
G |
7: 16,729,582 (GRCm39) |
D357G |
unknown |
Het |
| Ccna1 |
T |
C |
3: 54,958,049 (GRCm39) |
E152G |
probably damaging |
Het |
| Cct4 |
A |
G |
11: 22,949,073 (GRCm39) |
D273G |
probably damaging |
Het |
| Cd9 |
A |
G |
6: 125,440,703 (GRCm39) |
V96A |
probably damaging |
Het |
| Cdc5l |
G |
A |
17: 45,726,610 (GRCm39) |
R321W |
probably damaging |
Het |
| Cdh20 |
T |
C |
1: 109,922,036 (GRCm39) |
S43P |
probably benign |
Het |
| Cep95 |
G |
A |
11: 106,702,097 (GRCm39) |
V365M |
probably benign |
Het |
| Ces1c |
T |
C |
8: 93,854,152 (GRCm39) |
T128A |
probably benign |
Het |
| Chil5 |
A |
G |
3: 105,926,583 (GRCm39) |
V82A |
probably damaging |
Het |
| Clmn |
T |
C |
12: 104,748,023 (GRCm39) |
D508G |
probably benign |
Het |
| Cog8 |
A |
T |
8: 107,775,777 (GRCm39) |
|
probably benign |
Het |
| Cst3 |
A |
T |
2: 148,717,089 (GRCm39) |
V70E |
probably damaging |
Het |
| Ctcf |
A |
G |
8: 106,390,671 (GRCm39) |
T93A |
possibly damaging |
Het |
| Ctsk |
C |
A |
3: 95,416,188 (GRCm39) |
N315K |
probably benign |
Het |
| Cyp2j12 |
G |
T |
4: 96,029,262 (GRCm39) |
D6E |
probably benign |
Het |
| Dhx34 |
A |
G |
7: 15,939,917 (GRCm39) |
V655A |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,583,593 (GRCm39) |
Y203C |
probably damaging |
Het |
| Dok7 |
A |
T |
5: 35,221,678 (GRCm39) |
D26V |
probably damaging |
Het |
| Epha8 |
G |
A |
4: 136,667,597 (GRCm39) |
H295Y |
probably damaging |
Het |
| Esf1 |
A |
G |
2: 139,990,843 (GRCm39) |
|
probably benign |
Het |
| Fam83c |
A |
G |
2: 155,671,672 (GRCm39) |
S588P |
probably benign |
Het |
| Fat3 |
G |
A |
9: 15,881,002 (GRCm39) |
|
probably benign |
Het |
| Fhdc1 |
T |
C |
3: 84,360,817 (GRCm39) |
|
probably benign |
Het |
| Frmd4b |
A |
G |
6: 97,285,047 (GRCm39) |
V338A |
probably damaging |
Het |
| Fsd1l |
A |
G |
4: 53,694,727 (GRCm39) |
T394A |
probably damaging |
Het |
| Gbf1 |
A |
G |
19: 46,242,549 (GRCm39) |
|
probably benign |
Het |
| Glg1 |
G |
T |
8: 111,886,490 (GRCm39) |
Q1101K |
possibly damaging |
Het |
| Glt8d2 |
T |
A |
10: 82,487,361 (GRCm39) |
|
probably null |
Het |
| Gm19345 |
T |
C |
7: 19,588,855 (GRCm39) |
|
probably benign |
Het |
| Gpr179 |
A |
T |
11: 97,226,892 (GRCm39) |
D1754E |
probably benign |
Het |
| Hydin |
A |
G |
8: 111,291,650 (GRCm39) |
T3381A |
probably benign |
Het |
| Igkv12-41 |
G |
A |
6: 69,835,822 (GRCm39) |
T16I |
possibly damaging |
Het |
| Insl5 |
A |
G |
4: 102,875,313 (GRCm39) |
*146Q |
probably null |
Het |
| Iqce |
A |
T |
5: 140,651,957 (GRCm39) |
I655N |
possibly damaging |
Het |
| Irf2bp1 |
G |
A |
7: 18,738,927 (GRCm39) |
R189H |
possibly damaging |
Het |
| Itprid2 |
T |
A |
2: 79,490,810 (GRCm39) |
L976Q |
probably damaging |
Het |
| Itsn1 |
C |
T |
16: 91,602,978 (GRCm39) |
|
probably benign |
Het |
| Kansl3 |
A |
T |
1: 36,384,050 (GRCm39) |
I724N |
probably benign |
Het |
| Kcna4 |
T |
C |
2: 107,126,907 (GRCm39) |
I547T |
probably damaging |
Het |
| Klk1b4 |
A |
T |
7: 43,860,158 (GRCm39) |
I91F |
probably benign |
Het |
| Lmbr1 |
A |
G |
5: 29,457,753 (GRCm39) |
S282P |
probably damaging |
Het |
| Lrrc17 |
G |
A |
5: 21,765,967 (GRCm39) |
A150T |
probably benign |
Het |
| Lrrc2 |
A |
G |
9: 110,809,966 (GRCm39) |
E334G |
possibly damaging |
Het |
| Mapk8 |
A |
T |
14: 33,109,264 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,638,650 (GRCm39) |
T1560S |
probably benign |
Het |
| Mdh1b |
C |
A |
1: 63,758,777 (GRCm39) |
A272S |
probably damaging |
Het |
| Myo15b |
T |
C |
11: 115,777,109 (GRCm39) |
Y912H |
probably damaging |
Het |
| Nf1 |
T |
G |
11: 79,299,525 (GRCm39) |
|
probably null |
Het |
| Nme7 |
T |
A |
1: 164,172,944 (GRCm39) |
D218E |
probably damaging |
Het |
| Nsun7 |
T |
A |
5: 66,446,751 (GRCm39) |
|
probably benign |
Het |
| Nxpe2 |
A |
G |
9: 48,251,870 (GRCm39) |
|
probably null |
Het |
| Or1e34 |
A |
G |
11: 73,778,655 (GRCm39) |
V181A |
probably benign |
Het |
| Or2ag16 |
G |
A |
7: 106,352,196 (GRCm39) |
T133I |
probably benign |
Het |
| Or2n1c |
T |
G |
17: 38,519,286 (GRCm39) |
I50R |
probably benign |
Het |
| Or5p53 |
T |
A |
7: 107,533,375 (GRCm39) |
V216D |
probably damaging |
Het |
| P2ry1 |
T |
C |
3: 60,910,951 (GRCm39) |
V30A |
probably benign |
Het |
| Pgm2 |
T |
A |
5: 64,269,386 (GRCm39) |
I491N |
possibly damaging |
Het |
| Pkd1l3 |
A |
T |
8: 110,365,386 (GRCm39) |
D1169V |
probably damaging |
Het |
| Poldip2 |
T |
A |
11: 78,403,189 (GRCm39) |
S18T |
probably benign |
Het |
| Prg4 |
C |
T |
1: 150,331,558 (GRCm39) |
|
probably benign |
Het |
| Prkab2 |
T |
A |
3: 97,574,728 (GRCm39) |
Y241* |
probably null |
Het |
| Prmt7 |
A |
G |
8: 106,953,839 (GRCm39) |
|
probably benign |
Het |
| Proser3 |
T |
A |
7: 30,245,842 (GRCm39) |
R80W |
probably damaging |
Het |
| Prr12 |
A |
G |
7: 44,699,415 (GRCm39) |
|
probably benign |
Het |
| Psmd1 |
A |
T |
1: 86,006,304 (GRCm39) |
L223F |
probably damaging |
Het |
| Rab13 |
A |
G |
3: 90,131,088 (GRCm39) |
|
probably benign |
Het |
| Rgl1 |
C |
T |
1: 152,428,347 (GRCm39) |
C294Y |
probably damaging |
Het |
| Rpl21-ps4 |
C |
A |
14: 11,227,556 (GRCm38) |
|
noncoding transcript |
Het |
| Rusc2 |
T |
C |
4: 43,423,954 (GRCm39) |
V1036A |
probably damaging |
Het |
| Sae1 |
T |
A |
7: 16,104,247 (GRCm39) |
K121* |
probably null |
Het |
| Sap130 |
C |
T |
18: 31,813,559 (GRCm39) |
P539S |
probably damaging |
Het |
| Saxo4 |
C |
T |
19: 10,452,418 (GRCm39) |
R364Q |
probably damaging |
Het |
| Scube2 |
A |
G |
7: 109,424,079 (GRCm39) |
L475P |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,321,198 (GRCm39) |
D1298G |
probably damaging |
Het |
| Serpinb9b |
T |
C |
13: 33,222,003 (GRCm39) |
F206L |
probably benign |
Het |
| Sh3bp1 |
T |
A |
15: 78,788,534 (GRCm39) |
Y202* |
probably null |
Het |
| Shprh |
T |
A |
10: 11,062,135 (GRCm39) |
C1177S |
possibly damaging |
Het |
| Slc27a6 |
T |
C |
18: 58,742,937 (GRCm39) |
Y542H |
possibly damaging |
Het |
| Slc41a1 |
T |
C |
1: 131,771,650 (GRCm39) |
|
probably benign |
Het |
| Slc46a1 |
T |
C |
11: 78,361,625 (GRCm39) |
F424L |
probably damaging |
Het |
| Slc66a2 |
C |
T |
18: 80,306,733 (GRCm39) |
A101V |
probably benign |
Het |
| Slc6a12 |
G |
A |
6: 121,333,877 (GRCm39) |
V238I |
probably damaging |
Het |
| Slc6a20a |
A |
G |
9: 123,493,686 (GRCm39) |
V65A |
probably damaging |
Het |
| Slc9c1 |
T |
A |
16: 45,374,663 (GRCm39) |
S343T |
probably benign |
Het |
| Spcs3 |
C |
A |
8: 54,981,415 (GRCm39) |
R60I |
probably benign |
Het |
| Tbc1d16 |
C |
A |
11: 119,038,401 (GRCm39) |
R764L |
possibly damaging |
Het |
| Tcaf2 |
A |
T |
6: 42,619,838 (GRCm39) |
V63E |
possibly damaging |
Het |
| Tmc1 |
G |
T |
19: 20,766,951 (GRCm39) |
A750E |
possibly damaging |
Het |
| Tmem273 |
A |
G |
14: 32,530,320 (GRCm39) |
K83E |
possibly damaging |
Het |
| Tmem81 |
C |
G |
1: 132,435,567 (GRCm39) |
I124M |
probably damaging |
Het |
| Tmx3 |
T |
C |
18: 90,558,130 (GRCm39) |
I394T |
probably damaging |
Het |
| Trank1 |
G |
A |
9: 111,195,092 (GRCm39) |
E1039K |
possibly damaging |
Het |
| Trpc4ap |
A |
G |
2: 155,499,866 (GRCm39) |
|
probably benign |
Het |
| Tsen54 |
T |
C |
11: 115,706,234 (GRCm39) |
C123R |
probably damaging |
Het |
| Ubtd1 |
A |
G |
19: 42,020,373 (GRCm39) |
D39G |
possibly damaging |
Het |
| Vmn1r181 |
A |
T |
7: 23,683,759 (GRCm39) |
M75L |
probably benign |
Het |
| Zc3h7a |
T |
C |
16: 10,958,601 (GRCm39) |
T847A |
probably damaging |
Het |
| Zc3hav1 |
A |
G |
6: 38,313,485 (GRCm39) |
C187R |
probably damaging |
Het |
| Zfp692 |
G |
A |
11: 58,201,229 (GRCm39) |
|
probably benign |
Het |
| Zmiz1 |
G |
A |
14: 25,654,919 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Lrrc7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00594:Lrrc7
|
APN |
3 |
157,892,647 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00644:Lrrc7
|
APN |
3 |
157,908,005 (GRCm39) |
nonsense |
probably null |
|
|
IGL00822:Lrrc7
|
APN |
3 |
157,891,111 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00927:Lrrc7
|
APN |
3 |
157,866,727 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00946:Lrrc7
|
APN |
3 |
157,866,993 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00948:Lrrc7
|
APN |
3 |
157,867,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01838:Lrrc7
|
APN |
3 |
157,891,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Lrrc7
|
APN |
3 |
157,946,080 (GRCm39) |
splice site |
probably benign |
|
|
IGL02514:Lrrc7
|
APN |
3 |
157,865,929 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02545:Lrrc7
|
APN |
3 |
157,891,011 (GRCm39) |
splice site |
probably benign |
|
|
IGL02665:Lrrc7
|
APN |
3 |
157,866,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03129:Lrrc7
|
APN |
3 |
157,866,696 (GRCm39) |
missense |
probably benign |
0.02 |
|
N/A:Lrrc7
|
UTSW |
3 |
157,865,977 (GRCm39) |
missense |
probably benign |
|
|
R0021:Lrrc7
|
UTSW |
3 |
157,866,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Lrrc7
|
UTSW |
3 |
157,869,897 (GRCm39) |
splice site |
probably benign |
|
|
R0278:Lrrc7
|
UTSW |
3 |
157,885,432 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0409:Lrrc7
|
UTSW |
3 |
157,867,063 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0612:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0866:Lrrc7
|
UTSW |
3 |
157,869,903 (GRCm39) |
splice site |
probably benign |
|
|
R1077:Lrrc7
|
UTSW |
3 |
157,866,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1103:Lrrc7
|
UTSW |
3 |
157,854,343 (GRCm39) |
splice site |
probably benign |
|
|
R1157:Lrrc7
|
UTSW |
3 |
157,865,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1187:Lrrc7
|
UTSW |
3 |
157,866,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Lrrc7
|
UTSW |
3 |
157,840,968 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1433:Lrrc7
|
UTSW |
3 |
157,882,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1450:Lrrc7
|
UTSW |
3 |
157,892,681 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1595:Lrrc7
|
UTSW |
3 |
157,882,914 (GRCm39) |
nonsense |
probably null |
|
|
R1659:Lrrc7
|
UTSW |
3 |
157,867,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1693:Lrrc7
|
UTSW |
3 |
157,790,170 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1774:Lrrc7
|
UTSW |
3 |
157,865,929 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2273:Lrrc7
|
UTSW |
3 |
157,892,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2276:Lrrc7
|
UTSW |
3 |
157,885,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2302:Lrrc7
|
UTSW |
3 |
157,840,881 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2326:Lrrc7
|
UTSW |
3 |
157,876,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2371:Lrrc7
|
UTSW |
3 |
157,866,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2383:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R2679:Lrrc7
|
UTSW |
3 |
157,880,745 (GRCm39) |
nonsense |
probably null |
|
|
R2698:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R2858:Lrrc7
|
UTSW |
3 |
157,867,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3758:Lrrc7
|
UTSW |
3 |
157,869,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3791:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R3805:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3806:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3807:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3892:Lrrc7
|
UTSW |
3 |
157,866,333 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3912:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3963:Lrrc7
|
UTSW |
3 |
157,866,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4666:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4671:Lrrc7
|
UTSW |
3 |
157,908,132 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4688:Lrrc7
|
UTSW |
3 |
157,854,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4726:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4728:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4783:Lrrc7
|
UTSW |
3 |
157,832,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4867:Lrrc7
|
UTSW |
3 |
157,866,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4907:Lrrc7
|
UTSW |
3 |
157,866,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Lrrc7
|
UTSW |
3 |
157,887,217 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5107:Lrrc7
|
UTSW |
3 |
157,867,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5295:Lrrc7
|
UTSW |
3 |
157,876,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5348:Lrrc7
|
UTSW |
3 |
157,880,963 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5468:Lrrc7
|
UTSW |
3 |
158,024,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Lrrc7
|
UTSW |
3 |
157,876,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5897:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6179:Lrrc7
|
UTSW |
3 |
158,059,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6312:Lrrc7
|
UTSW |
3 |
157,866,246 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6313:Lrrc7
|
UTSW |
3 |
157,866,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6366:Lrrc7
|
UTSW |
3 |
157,841,012 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6389:Lrrc7
|
UTSW |
3 |
157,891,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Lrrc7
|
UTSW |
3 |
157,840,940 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6956:Lrrc7
|
UTSW |
3 |
157,994,668 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6969:Lrrc7
|
UTSW |
3 |
157,862,550 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7073:Lrrc7
|
UTSW |
3 |
157,832,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Lrrc7
|
UTSW |
3 |
157,866,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Lrrc7
|
UTSW |
3 |
157,903,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7398:Lrrc7
|
UTSW |
3 |
157,997,595 (GRCm39) |
nonsense |
probably null |
|
|
R7403:Lrrc7
|
UTSW |
3 |
157,854,311 (GRCm39) |
nonsense |
probably null |
|
|
R7407:Lrrc7
|
UTSW |
3 |
157,840,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Lrrc7
|
UTSW |
3 |
157,903,778 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7453:Lrrc7
|
UTSW |
3 |
157,891,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7461:Lrrc7
|
UTSW |
3 |
157,892,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7807:Lrrc7
|
UTSW |
3 |
157,866,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7872:Lrrc7
|
UTSW |
3 |
158,059,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8215:Lrrc7
|
UTSW |
3 |
157,915,387 (GRCm39) |
missense |
probably benign |
|
|
R8367:Lrrc7
|
UTSW |
3 |
157,908,007 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8867:Lrrc7
|
UTSW |
3 |
157,867,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8880:Lrrc7
|
UTSW |
3 |
157,867,381 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8941:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R8958:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9068:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9069:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9180:Lrrc7
|
UTSW |
3 |
157,867,011 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9193:Lrrc7
|
UTSW |
3 |
158,059,011 (GRCm39) |
nonsense |
probably null |
|
|
R9309:Lrrc7
|
UTSW |
3 |
157,915,361 (GRCm39) |
nonsense |
probably null |
|
|
R9418:Lrrc7
|
UTSW |
3 |
157,908,023 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9474:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9515:Lrrc7
|
UTSW |
3 |
157,867,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9639:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9682:Lrrc7
|
UTSW |
3 |
157,882,954 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9731:Lrrc7
|
UTSW |
3 |
157,880,888 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCACTGACCCTTCTGAACATGG -3'
(R):5'- ATGTCCAGTATGTCCAGGAGCCAG -3'
Sequencing Primer
(F):5'- GCCATCTCGGTGGAGCTG -3'
(R):5'- TCAGTACCCATGTTGGATGAC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation