|Institutional Source||Beutler Lab|
|Gene Name||WD repeat domain 18|
|Is this an essential gene?||Probably essential (E-score: 0.962)|
|Stock #||R0257 (G1)|
|Chromosomal Location||79960152-79970203 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||A to G at 79961119 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000041049 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000045247]|
|Coding Region Coverage||
|Validation Efficiency||99% (67/68)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Wdr18||
(F):5'- AACACAGAGCTTCCTTCTTGTCCG -3'
(R):5'- ACCAGCAGGTTGAACACTGTCC -3'
(F):5'- ctaaccctgagccgcac -3'
(R):5'- AGGTTGAACACTGTCCTGTATC -3'