Incidental Mutation 'R4670:Magi1'
ID |
348354 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Magi1
|
Ensembl Gene |
ENSMUSG00000045095 |
Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
MMRRC Submission |
041926-MU
|
Accession Numbers |
|
Essential gene? |
Possibly essential
(E-score: 0.561)
|
Stock # |
R4670 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
A to T
at 93663624 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000144881
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000055224]
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000089317]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000093769]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203519]
[ENSMUST00000203519]
[ENSMUST00000203519]
[ENSMUST00000203519]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000203688]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204347]
[ENSMUST00000204347]
[ENSMUST00000204532]
[ENSMUST00000204532]
[ENSMUST00000204532]
|
AlphaFold |
Q6RHR9 |
Predicted Effect |
probably null
Transcript: ENSMUST00000055224
|
SMART Domains |
Protein: ENSMUSP00000062085 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
348 |
380 |
2.88e-9 |
SMART |
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000055224
|
SMART Domains |
Protein: ENSMUSP00000062085 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
348 |
380 |
2.88e-9 |
SMART |
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000055224
|
SMART Domains |
Protein: ENSMUSP00000062085 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
348 |
380 |
2.88e-9 |
SMART |
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000089317
|
SMART Domains |
Protein: ENSMUSP00000086730 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000089317
|
SMART Domains |
Protein: ENSMUSP00000086730 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000089317
|
SMART Domains |
Protein: ENSMUSP00000086730 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000093769
|
SMART Domains |
Protein: ENSMUSP00000091283 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000093769
|
SMART Domains |
Protein: ENSMUSP00000091283 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000093769
|
SMART Domains |
Protein: ENSMUSP00000091283 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203519
|
SMART Domains |
Protein: ENSMUSP00000145244 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
WW
|
301 |
333 |
9.65e-11 |
SMART |
WW
|
360 |
392 |
2.88e-9 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203688
|
SMART Domains |
Protein: ENSMUSP00000145515 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203688
|
SMART Domains |
Protein: ENSMUSP00000145515 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000203688
|
SMART Domains |
Protein: ENSMUSP00000145515 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
WW
|
74 |
106 |
9.65e-11 |
SMART |
WW
|
133 |
165 |
2.88e-9 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000204347
|
SMART Domains |
Protein: ENSMUSP00000144881 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000204347
|
SMART Domains |
Protein: ENSMUSP00000144881 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000204347
|
SMART Domains |
Protein: ENSMUSP00000144881 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
PDZ
|
26 |
105 |
4e-7 |
SMART |
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
WW
|
301 |
333 |
5.8e-13 |
SMART |
WW
|
360 |
392 |
1.7e-11 |
SMART |
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
SMART Domains |
Protein: ENSMUSP00000144769 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
WW
|
74 |
106 |
5.8e-13 |
SMART |
WW
|
133 |
165 |
1.7e-11 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
SMART Domains |
Protein: ENSMUSP00000144769 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
WW
|
74 |
106 |
5.8e-13 |
SMART |
WW
|
133 |
165 |
1.7e-11 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
SMART Domains |
Protein: ENSMUSP00000144769 Gene: ENSMUSG00000045095
Domain | Start | End | E-Value | Type |
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
WW
|
74 |
106 |
5.8e-13 |
SMART |
WW
|
133 |
165 |
1.7e-11 |
SMART |
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
Validation Efficiency |
97% (69/71) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
Other mutations in this stock |
Total: 63 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Acsm5 |
T |
A |
7: 119,130,983 (GRCm39) |
|
probably null |
Het |
Alb |
T |
A |
5: 90,610,665 (GRCm39) |
S82T |
probably benign |
Het |
Arf4 |
A |
G |
14: 26,374,248 (GRCm39) |
|
probably benign |
Het |
Arhgap22 |
T |
C |
14: 33,084,500 (GRCm39) |
C260R |
probably damaging |
Het |
Arhgap32 |
A |
G |
9: 32,081,441 (GRCm39) |
E153G |
probably benign |
Het |
Arhgef18 |
T |
A |
8: 3,484,897 (GRCm39) |
M200K |
probably damaging |
Het |
Atp1a4 |
T |
A |
1: 172,062,567 (GRCm39) |
N647Y |
probably benign |
Het |
Atp5f1c |
A |
T |
2: 10,064,428 (GRCm39) |
L226Q |
probably damaging |
Het |
Bcas1 |
T |
C |
2: 170,226,245 (GRCm39) |
K310R |
probably damaging |
Het |
Cadm3 |
T |
A |
1: 173,174,013 (GRCm39) |
T67S |
probably damaging |
Het |
Cartpt |
C |
T |
13: 100,036,588 (GRCm39) |
|
probably null |
Het |
Cenpj |
A |
T |
14: 56,790,840 (GRCm39) |
V403E |
possibly damaging |
Het |
Chst7 |
C |
A |
X: 19,927,110 (GRCm39) |
R386S |
probably damaging |
Het |
Cyp4f37 |
A |
T |
17: 32,844,126 (GRCm39) |
M77L |
probably benign |
Het |
Dnah7b |
A |
T |
1: 46,117,684 (GRCm39) |
D50V |
probably damaging |
Het |
Galnt4 |
A |
G |
10: 98,945,160 (GRCm39) |
D295G |
possibly damaging |
Het |
Gin1 |
C |
T |
1: 97,712,565 (GRCm39) |
P154S |
probably damaging |
Het |
Gm6471 |
G |
A |
7: 142,385,360 (GRCm39) |
|
noncoding transcript |
Het |
Gm6818 |
T |
A |
7: 38,101,981 (GRCm39) |
|
noncoding transcript |
Het |
Gm9271 |
T |
A |
7: 39,013,734 (GRCm39) |
|
noncoding transcript |
Het |
Gpam |
A |
G |
19: 55,084,551 (GRCm39) |
|
probably null |
Het |
Gpr183 |
T |
C |
14: 122,192,149 (GRCm39) |
D124G |
probably damaging |
Het |
Ift140 |
C |
A |
17: 25,317,935 (GRCm39) |
|
probably benign |
Het |
Itih5 |
A |
C |
2: 10,195,180 (GRCm39) |
I191L |
probably benign |
Het |
Jcad |
A |
G |
18: 4,674,175 (GRCm39) |
T646A |
probably benign |
Het |
Kank1 |
T |
C |
19: 25,387,944 (GRCm39) |
M511T |
probably benign |
Het |
Krt74 |
A |
T |
15: 101,667,304 (GRCm39) |
|
noncoding transcript |
Het |
Lrrc37a |
A |
G |
11: 103,395,363 (GRCm39) |
S21P |
probably benign |
Het |
Lrrc8c |
G |
A |
5: 105,756,240 (GRCm39) |
V672I |
probably benign |
Het |
Lypd4 |
T |
C |
7: 24,566,151 (GRCm39) |
R58G |
probably benign |
Het |
Mefv |
T |
A |
16: 3,526,071 (GRCm39) |
L745F |
possibly damaging |
Het |
Myh13 |
A |
T |
11: 67,255,564 (GRCm39) |
K1645* |
probably null |
Het |
Naip6 |
A |
G |
13: 100,431,239 (GRCm39) |
|
probably null |
Het |
Nlrp1c-ps |
T |
C |
11: 71,171,382 (GRCm39) |
|
noncoding transcript |
Het |
Nsmce3 |
A |
T |
7: 64,522,530 (GRCm39) |
L46Q |
probably benign |
Het |
Or51aa2 |
A |
G |
7: 103,188,393 (GRCm39) |
V16A |
possibly damaging |
Het |
Or6k6 |
T |
A |
1: 173,945,427 (GRCm39) |
M52L |
probably benign |
Het |
Or8k37 |
T |
C |
2: 86,469,512 (GRCm39) |
D180G |
possibly damaging |
Het |
P2ry12 |
T |
C |
3: 59,125,325 (GRCm39) |
|
probably null |
Het |
Pcx |
T |
A |
19: 4,669,916 (GRCm39) |
V861E |
probably damaging |
Het |
Pkp3 |
C |
T |
7: 140,662,612 (GRCm39) |
P75S |
probably benign |
Het |
Plscr4 |
T |
C |
9: 92,364,920 (GRCm39) |
|
probably null |
Het |
Pole |
A |
G |
5: 110,454,253 (GRCm39) |
T923A |
probably benign |
Het |
Ptgir |
A |
G |
7: 16,640,794 (GRCm39) |
M29V |
possibly damaging |
Het |
Rhot2 |
A |
C |
17: 26,060,305 (GRCm39) |
|
probably benign |
Het |
Rsrp1 |
A |
G |
4: 134,651,488 (GRCm39) |
Y84C |
unknown |
Het |
Sbf2 |
T |
C |
7: 109,934,606 (GRCm39) |
K1348E |
probably damaging |
Het |
Sgip1 |
A |
T |
4: 102,726,951 (GRCm39) |
N53Y |
probably damaging |
Het |
Snapc2 |
A |
G |
8: 4,304,998 (GRCm39) |
T127A |
possibly damaging |
Het |
Snx8 |
A |
G |
5: 140,341,713 (GRCm39) |
|
probably null |
Het |
Spag8 |
A |
G |
4: 43,653,378 (GRCm39) |
|
probably benign |
Het |
Srebf2 |
T |
C |
15: 82,076,503 (GRCm39) |
F718L |
probably damaging |
Het |
Szt2 |
C |
G |
4: 118,233,026 (GRCm39) |
|
probably benign |
Het |
Traf3ip2 |
C |
T |
10: 39,515,256 (GRCm39) |
P345S |
possibly damaging |
Het |
Tubgcp4 |
T |
A |
2: 121,004,146 (GRCm39) |
Y62* |
probably null |
Het |
Usp29 |
T |
A |
7: 6,965,914 (GRCm39) |
S586T |
possibly damaging |
Het |
Vasp |
T |
C |
7: 18,998,350 (GRCm39) |
N108S |
probably benign |
Het |
Vmn1r214 |
A |
G |
13: 23,219,141 (GRCm39) |
M212V |
probably benign |
Het |
Wipi2 |
G |
C |
5: 142,645,345 (GRCm39) |
A194P |
probably benign |
Het |
Zbtb4 |
T |
A |
11: 69,667,355 (GRCm39) |
I220N |
probably damaging |
Het |
Zcchc2 |
A |
T |
1: 105,917,996 (GRCm39) |
|
probably benign |
Het |
Zfp729a |
T |
A |
13: 67,769,534 (GRCm39) |
K232* |
probably null |
Het |
Zfp995 |
A |
T |
17: 22,106,320 (GRCm39) |
M1K |
probably null |
Het |
|
Other mutations in Magi1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
R4839:Magi1
|
UTSW |
6 |
93,671,177 (GRCm39) |
missense |
probably damaging |
1.00 |
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGTTCATCTGGTTAAATCACTTCGC -3'
(R):5'- GACTAATGCTGAGAAGATTGCCAC -3'
Sequencing Primer
(F):5'- CTGGTTAAATCACTTCGCAAAAAG -3'
(R):5'- GCTGAGAAGATTGCCACCATCAC -3'
|
Posted On |
2015-10-08 |