Incidental Mutation 'R4672:Gcn1'
| ID |
348516 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gcn1
|
| Ensembl Gene |
ENSMUSG00000041638 |
| Gene Name |
GCN1 activator of EIF2AK4 |
| Synonyms |
Gcn1l1, G431004K08Rik, GCN1L |
| MMRRC Submission |
041927-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.939)
|
| Stock # |
R4672 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
115703313-115760713 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 115744579 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 1592
(T1592A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000069432
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000064454]
|
| AlphaFold |
E9PVA8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000064454
AA Change: T1592A
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000069432
Gene: ENSMUSG00000041638
AA Change: T1592A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
64 |
84 |
N/A |
INTRINSIC |
|
low complexity region
|
108 |
117 |
N/A |
INTRINSIC |
|
low complexity region
|
142 |
154 |
N/A |
INTRINSIC |
|
Pfam:DUF3554
|
357 |
705 |
2e-61 |
PFAM |
|
coiled coil region
|
806 |
866 |
N/A |
INTRINSIC |
|
Blast:ARM
|
1028 |
1068 |
6e-11 |
BLAST |
|
coiled coil region
|
1180 |
1203 |
N/A |
INTRINSIC |
|
low complexity region
|
1457 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1501 |
1510 |
N/A |
INTRINSIC |
|
ARM
|
1527 |
1567 |
3.69e1 |
SMART |
|
Blast:ARM
|
1602 |
1644 |
1e-5 |
BLAST |
|
Blast:EZ_HEAT
|
1671 |
1704 |
1e-7 |
BLAST |
|
low complexity region
|
1926 |
1934 |
N/A |
INTRINSIC |
|
low complexity region
|
1956 |
1972 |
N/A |
INTRINSIC |
|
ARM
|
2034 |
2070 |
9.27e1 |
SMART |
|
low complexity region
|
2326 |
2334 |
N/A |
INTRINSIC |
|
ARM
|
2416 |
2455 |
2.16e1 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000094427
|
| SMART Domains |
Protein: ENSMUSP00000091994
Gene: ENSMUSG00000041638
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:HEAT
|
42 |
72 |
5.8e-5 |
PFAM |
|
low complexity region
|
310 |
318 |
N/A |
INTRINSIC |
|
Pfam:HEAT_EZ
|
326 |
374 |
2.2e-5 |
PFAM |
|
Blast:EZ_HEAT
|
403 |
439 |
1e-15 |
BLAST |
|
Pfam:HEAT_EZ
|
703 |
757 |
1.3e-5 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000122964
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151030
AA Change: D1193G
|
| Meta Mutation Damage Score |
0.2559 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
98% (113/115) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca8a |
G |
A |
11: 109,962,702 (GRCm39) |
L483F |
possibly damaging |
Het |
| Abca8b |
A |
G |
11: 109,827,274 (GRCm39) |
F1507L |
possibly damaging |
Het |
| Adamdec1 |
C |
A |
14: 68,815,353 (GRCm39) |
E104* |
probably null |
Het |
| Adamts16 |
G |
A |
13: 70,927,637 (GRCm39) |
|
probably benign |
Het |
| Alppl2 |
T |
C |
1: 87,017,187 (GRCm39) |
|
probably benign |
Het |
| Aplnr |
A |
G |
2: 84,967,524 (GRCm39) |
Y183C |
probably damaging |
Het |
| Atm |
G |
A |
9: 53,433,501 (GRCm39) |
R250W |
probably damaging |
Het |
| B4galt7 |
T |
C |
13: 55,757,132 (GRCm39) |
L275P |
probably damaging |
Het |
| Bltp1 |
A |
G |
3: 36,944,139 (GRCm39) |
*330W |
probably null |
Het |
| Ccdc178 |
G |
A |
18: 22,283,501 (GRCm39) |
Q10* |
probably null |
Het |
| Ccr9 |
T |
C |
9: 123,608,752 (GRCm39) |
Y145H |
probably damaging |
Het |
| Cd209f |
C |
T |
8: 4,153,685 (GRCm39) |
G188D |
probably damaging |
Het |
| Cep70 |
T |
A |
9: 99,136,365 (GRCm39) |
S23T |
possibly damaging |
Het |
| Cpped1 |
C |
A |
16: 11,623,238 (GRCm39) |
E294* |
probably null |
Het |
| Crisp1 |
T |
A |
17: 40,605,404 (GRCm39) |
|
probably null |
Het |
| Disp1 |
T |
C |
1: 182,880,215 (GRCm39) |
|
probably null |
Het |
| Dlg2 |
A |
T |
7: 91,935,743 (GRCm39) |
M624L |
probably damaging |
Het |
| Elf2 |
A |
G |
3: 51,163,855 (GRCm39) |
V558A |
probably damaging |
Het |
| Eno2 |
T |
C |
6: 124,743,109 (GRCm39) |
D209G |
probably damaging |
Het |
| Fam187b |
G |
A |
7: 30,676,968 (GRCm39) |
R159H |
probably damaging |
Het |
| Fh1 |
G |
A |
1: 175,431,617 (GRCm39) |
A423V |
probably benign |
Het |
| Frg1 |
C |
T |
8: 41,853,846 (GRCm39) |
D164N |
probably benign |
Het |
| Fsbp |
T |
G |
4: 11,579,841 (GRCm39) |
N36K |
probably benign |
Het |
| Gimap3 |
A |
G |
6: 48,742,687 (GRCm39) |
I81T |
probably damaging |
Het |
| Gjb6 |
C |
T |
14: 57,362,235 (GRCm39) |
V9I |
probably benign |
Het |
| Gkap1 |
T |
C |
13: 58,411,770 (GRCm39) |
S68G |
possibly damaging |
Het |
| Gpatch8 |
A |
T |
11: 102,369,784 (GRCm39) |
S1251R |
probably damaging |
Het |
| Gria4 |
A |
G |
9: 4,664,981 (GRCm39) |
F92L |
possibly damaging |
Het |
| H2-Q1 |
C |
A |
17: 35,539,906 (GRCm39) |
D58E |
probably damaging |
Het |
| Hs1bp3 |
G |
T |
12: 8,391,983 (GRCm39) |
G362* |
probably null |
Het |
| Igfn1 |
T |
A |
1: 135,893,107 (GRCm39) |
H2114L |
possibly damaging |
Het |
| Igkv12-98 |
A |
G |
6: 68,547,940 (GRCm39) |
Q22R |
probably benign |
Het |
| Ing3 |
A |
G |
6: 21,965,729 (GRCm39) |
|
probably null |
Het |
| Insr |
C |
T |
8: 3,217,501 (GRCm39) |
|
probably null |
Het |
| Kdm3b |
T |
C |
18: 34,941,630 (GRCm39) |
S374P |
probably benign |
Het |
| Kif14 |
A |
C |
1: 136,449,016 (GRCm39) |
Q1472P |
probably benign |
Het |
| Kif14 |
G |
T |
1: 136,449,017 (GRCm39) |
Q1472H |
probably benign |
Het |
| Knstrn |
A |
G |
2: 118,664,512 (GRCm39) |
E202G |
probably damaging |
Het |
| Knstrn |
G |
T |
2: 118,664,513 (GRCm39) |
E202D |
possibly damaging |
Het |
| Krt12 |
A |
G |
11: 99,309,509 (GRCm39) |
|
probably benign |
Het |
| Lgi3 |
A |
T |
14: 70,771,897 (GRCm39) |
I195F |
possibly damaging |
Het |
| Lima1 |
T |
C |
15: 99,741,590 (GRCm39) |
N29D |
probably damaging |
Het |
| Liph |
T |
C |
16: 21,802,806 (GRCm39) |
I88V |
probably benign |
Het |
| Lrrk1 |
A |
G |
7: 65,929,120 (GRCm39) |
S86P |
probably benign |
Het |
| Lsamp |
A |
G |
16: 41,775,697 (GRCm39) |
R166G |
probably damaging |
Het |
| Mamdc2 |
T |
A |
19: 23,328,148 (GRCm39) |
N407Y |
probably damaging |
Het |
| Mast3 |
CATA |
CA |
8: 71,237,441 (GRCm39) |
|
probably null |
Het |
| Megf6 |
T |
A |
4: 154,333,909 (GRCm39) |
N212K |
probably damaging |
Het |
| Met |
A |
C |
6: 17,571,803 (GRCm39) |
D1374A |
probably benign |
Het |
| Mrc2 |
A |
G |
11: 105,233,923 (GRCm39) |
T902A |
probably benign |
Het |
| Mroh3 |
T |
A |
1: 136,118,713 (GRCm39) |
T535S |
probably benign |
Het |
| Muc1 |
G |
T |
3: 89,139,384 (GRCm39) |
V595L |
probably damaging |
Het |
| Myh2 |
T |
A |
11: 67,079,303 (GRCm39) |
L957Q |
probably damaging |
Het |
| Myorg |
T |
A |
4: 41,499,061 (GRCm39) |
M190L |
probably benign |
Het |
| Ncl |
A |
T |
1: 86,284,324 (GRCm39) |
D257E |
probably benign |
Het |
| Nipbl |
T |
A |
15: 8,332,468 (GRCm39) |
D2263V |
probably damaging |
Het |
| Optc |
C |
A |
1: 133,825,555 (GRCm39) |
V324L |
possibly damaging |
Het |
| Or4k15 |
A |
G |
14: 50,364,714 (GRCm39) |
N227D |
probably benign |
Het |
| Or4k42 |
A |
T |
2: 111,319,902 (GRCm39) |
N200K |
possibly damaging |
Het |
| Or7g35 |
A |
G |
9: 19,496,726 (GRCm39) |
K298E |
possibly damaging |
Het |
| Osbpl9 |
A |
G |
4: 108,921,806 (GRCm39) |
I604T |
possibly damaging |
Het |
| Otog |
C |
A |
7: 45,939,210 (GRCm39) |
A2080D |
probably damaging |
Het |
| Parp6 |
G |
C |
9: 59,547,393 (GRCm39) |
R460P |
probably damaging |
Het |
| Phactr4 |
G |
T |
4: 132,098,017 (GRCm39) |
P417Q |
probably damaging |
Het |
| Pigt |
T |
C |
2: 164,339,498 (GRCm39) |
|
probably benign |
Het |
| Plekha5 |
A |
G |
6: 140,470,655 (GRCm39) |
I99V |
probably damaging |
Het |
| Plxna3 |
T |
G |
X: 73,382,554 (GRCm39) |
|
probably null |
Het |
| Ppp2r1b |
G |
A |
9: 50,779,019 (GRCm39) |
M362I |
probably damaging |
Het |
| Pramel34 |
T |
A |
5: 93,784,182 (GRCm39) |
R230S |
probably damaging |
Het |
| Rad51 |
A |
G |
2: 118,954,327 (GRCm39) |
I136V |
probably benign |
Het |
| Rad54b |
T |
A |
4: 11,609,449 (GRCm39) |
H633Q |
probably benign |
Het |
| Rasal2 |
A |
G |
1: 157,071,231 (GRCm39) |
F41S |
probably benign |
Het |
| Reep3 |
T |
A |
10: 66,857,629 (GRCm39) |
H154L |
probably benign |
Het |
| Rp1l1 |
T |
G |
14: 64,268,719 (GRCm39) |
V1435G |
probably damaging |
Het |
| Rps6ka5 |
C |
A |
12: 100,620,546 (GRCm39) |
K125N |
possibly damaging |
Het |
| Rsad1 |
A |
T |
11: 94,434,444 (GRCm39) |
M330K |
probably damaging |
Het |
| Scand1 |
A |
G |
2: 156,153,850 (GRCm39) |
|
probably null |
Het |
| Setd6 |
A |
G |
8: 96,444,640 (GRCm39) |
H111R |
probably null |
Het |
| Slc27a3 |
T |
C |
3: 90,294,953 (GRCm39) |
N368S |
possibly damaging |
Het |
| Slc38a2 |
T |
C |
15: 96,596,518 (GRCm39) |
T32A |
probably benign |
Het |
| Smg7 |
A |
G |
1: 152,721,164 (GRCm39) |
S683P |
probably damaging |
Het |
| Smyd2 |
A |
T |
1: 189,642,101 (GRCm39) |
L62M |
probably damaging |
Het |
| Sox5 |
T |
C |
6: 143,779,075 (GRCm39) |
Y687C |
probably damaging |
Het |
| Spaca6 |
T |
A |
17: 18,057,005 (GRCm39) |
C53* |
probably null |
Het |
| Spata31e4 |
T |
C |
13: 50,857,208 (GRCm39) |
Y949H |
probably benign |
Het |
| Spire2 |
T |
C |
8: 124,084,850 (GRCm39) |
V230A |
probably benign |
Het |
| Sptbn2 |
G |
T |
19: 4,782,524 (GRCm39) |
V487L |
probably benign |
Het |
| Stk3 |
T |
A |
15: 35,099,603 (GRCm39) |
I110L |
probably benign |
Het |
| Stox2 |
T |
A |
8: 47,645,141 (GRCm39) |
Y773F |
probably damaging |
Het |
| Tbrg1 |
C |
A |
9: 37,562,632 (GRCm39) |
A259S |
probably damaging |
Het |
| Tnfsf18 |
C |
A |
1: 161,331,307 (GRCm39) |
D152E |
probably benign |
Het |
| Tpr |
G |
A |
1: 150,299,318 (GRCm39) |
A1173T |
probably benign |
Het |
| Trrap |
T |
C |
5: 144,722,290 (GRCm39) |
L271P |
probably damaging |
Het |
| Ttn |
G |
T |
2: 76,657,419 (GRCm39) |
|
probably benign |
Het |
| U2surp |
A |
G |
9: 95,375,198 (GRCm39) |
S192P |
possibly damaging |
Het |
| Ubr4 |
C |
T |
4: 139,138,027 (GRCm39) |
S1128L |
probably damaging |
Het |
| Ucma |
G |
A |
2: 4,981,465 (GRCm39) |
|
probably null |
Het |
| Urb1 |
A |
T |
16: 90,569,522 (GRCm39) |
D1401E |
probably benign |
Het |
| Usp54 |
A |
T |
14: 20,631,597 (GRCm39) |
|
probably benign |
Het |
| Vmn1r31 |
A |
G |
6: 58,449,056 (GRCm39) |
Y270H |
probably damaging |
Het |
| Vmn1r90 |
T |
A |
7: 14,295,493 (GRCm39) |
T202S |
probably benign |
Het |
| Vmn2r88 |
A |
G |
14: 51,655,612 (GRCm39) |
Y616C |
probably damaging |
Het |
| Vmn2r95 |
T |
A |
17: 18,672,413 (GRCm39) |
W717R |
probably damaging |
Het |
| Zcchc4 |
C |
A |
5: 52,953,947 (GRCm39) |
T209K |
probably benign |
Het |
| Zfp955b |
T |
A |
17: 33,524,233 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Gcn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00869:Gcn1
|
APN |
5 |
115,726,202 (GRCm39) |
splice site |
probably benign |
|
|
IGL00974:Gcn1
|
APN |
5 |
115,751,852 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL01566:Gcn1
|
APN |
5 |
115,749,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01843:Gcn1
|
APN |
5 |
115,757,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01885:Gcn1
|
APN |
5 |
115,714,174 (GRCm39) |
splice site |
probably null |
|
|
IGL02081:Gcn1
|
APN |
5 |
115,723,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02118:Gcn1
|
APN |
5 |
115,748,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02150:Gcn1
|
APN |
5 |
115,747,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02190:Gcn1
|
APN |
5 |
115,752,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02219:Gcn1
|
APN |
5 |
115,751,826 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02507:Gcn1
|
APN |
5 |
115,723,940 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02644:Gcn1
|
APN |
5 |
115,713,250 (GRCm39) |
missense |
probably benign |
|
|
IGL02678:Gcn1
|
APN |
5 |
115,751,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02748:Gcn1
|
APN |
5 |
115,748,859 (GRCm39) |
splice site |
probably null |
|
|
IGL02755:Gcn1
|
APN |
5 |
115,742,065 (GRCm39) |
splice site |
probably null |
|
|
IGL02896:Gcn1
|
APN |
5 |
115,757,707 (GRCm39) |
splice site |
probably benign |
|
|
cusp
|
UTSW |
5 |
115,749,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
farthing
|
UTSW |
5 |
115,714,167 (GRCm39) |
splice site |
probably benign |
|
|
IGL03147:Gcn1
|
UTSW |
5 |
115,748,917 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0362:Gcn1
|
UTSW |
5 |
115,714,167 (GRCm39) |
splice site |
probably benign |
|
|
R0540:Gcn1
|
UTSW |
5 |
115,727,015 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0569:Gcn1
|
UTSW |
5 |
115,733,118 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0570:Gcn1
|
UTSW |
5 |
115,730,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0584:Gcn1
|
UTSW |
5 |
115,733,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Gcn1
|
UTSW |
5 |
115,719,148 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0656:Gcn1
|
UTSW |
5 |
115,727,362 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0801:Gcn1
|
UTSW |
5 |
115,729,065 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0890:Gcn1
|
UTSW |
5 |
115,717,852 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1400:Gcn1
|
UTSW |
5 |
115,752,220 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1485:Gcn1
|
UTSW |
5 |
115,712,676 (GRCm39) |
missense |
probably benign |
|
|
R1574:Gcn1
|
UTSW |
5 |
115,753,611 (GRCm39) |
missense |
probably benign |
|
|
R1574:Gcn1
|
UTSW |
5 |
115,753,611 (GRCm39) |
missense |
probably benign |
|
|
R1673:Gcn1
|
UTSW |
5 |
115,720,356 (GRCm39) |
missense |
probably benign |
|
|
R1894:Gcn1
|
UTSW |
5 |
115,727,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2114:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2116:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2117:Gcn1
|
UTSW |
5 |
115,736,884 (GRCm39) |
missense |
probably benign |
0.35 |
|
R2152:Gcn1
|
UTSW |
5 |
115,747,888 (GRCm39) |
missense |
probably benign |
0.07 |
|
R2162:Gcn1
|
UTSW |
5 |
115,730,191 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2216:Gcn1
|
UTSW |
5 |
115,731,720 (GRCm39) |
missense |
probably benign |
|
|
R2218:Gcn1
|
UTSW |
5 |
115,757,720 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2278:Gcn1
|
UTSW |
5 |
115,749,234 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2280:Gcn1
|
UTSW |
5 |
115,750,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3719:Gcn1
|
UTSW |
5 |
115,717,876 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3729:Gcn1
|
UTSW |
5 |
115,721,453 (GRCm39) |
splice site |
probably benign |
|
|
R3833:Gcn1
|
UTSW |
5 |
115,730,191 (GRCm39) |
missense |
probably benign |
0.18 |
|
R3932:Gcn1
|
UTSW |
5 |
115,725,893 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4067:Gcn1
|
UTSW |
5 |
115,737,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4152:Gcn1
|
UTSW |
5 |
115,751,413 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4179:Gcn1
|
UTSW |
5 |
115,726,109 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4292:Gcn1
|
UTSW |
5 |
115,714,207 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4350:Gcn1
|
UTSW |
5 |
115,741,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4493:Gcn1
|
UTSW |
5 |
115,732,203 (GRCm39) |
missense |
probably benign |
|
|
R4749:Gcn1
|
UTSW |
5 |
115,752,461 (GRCm39) |
missense |
probably benign |
|
|
R4753:Gcn1
|
UTSW |
5 |
115,754,537 (GRCm39) |
missense |
probably benign |
|
|
R4826:Gcn1
|
UTSW |
5 |
115,731,752 (GRCm39) |
missense |
probably benign |
|
|
R4873:Gcn1
|
UTSW |
5 |
115,714,229 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4875:Gcn1
|
UTSW |
5 |
115,714,229 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4932:Gcn1
|
UTSW |
5 |
115,730,203 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4992:Gcn1
|
UTSW |
5 |
115,737,225 (GRCm39) |
missense |
probably benign |
0.29 |
|
R5049:Gcn1
|
UTSW |
5 |
115,744,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5211:Gcn1
|
UTSW |
5 |
115,757,371 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5226:Gcn1
|
UTSW |
5 |
115,726,126 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5338:Gcn1
|
UTSW |
5 |
115,721,462 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5914:Gcn1
|
UTSW |
5 |
115,748,194 (GRCm39) |
synonymous |
silent |
|
|
R5932:Gcn1
|
UTSW |
5 |
115,730,435 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6422:Gcn1
|
UTSW |
5 |
115,747,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6435:Gcn1
|
UTSW |
5 |
115,749,081 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6607:Gcn1
|
UTSW |
5 |
115,747,537 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6724:Gcn1
|
UTSW |
5 |
115,747,217 (GRCm39) |
splice site |
probably null |
|
|
R6861:Gcn1
|
UTSW |
5 |
115,749,108 (GRCm39) |
missense |
probably benign |
|
|
R6875:Gcn1
|
UTSW |
5 |
115,726,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6910:Gcn1
|
UTSW |
5 |
115,744,597 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6975:Gcn1
|
UTSW |
5 |
115,751,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7027:Gcn1
|
UTSW |
5 |
115,754,605 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7038:Gcn1
|
UTSW |
5 |
115,749,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7171:Gcn1
|
UTSW |
5 |
115,728,352 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7276:Gcn1
|
UTSW |
5 |
115,749,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7456:Gcn1
|
UTSW |
5 |
115,743,005 (GRCm39) |
nonsense |
probably null |
|
|
R7473:Gcn1
|
UTSW |
5 |
115,719,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7517:Gcn1
|
UTSW |
5 |
115,757,755 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7714:Gcn1
|
UTSW |
5 |
115,733,359 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7752:Gcn1
|
UTSW |
5 |
115,753,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7812:Gcn1
|
UTSW |
5 |
115,731,751 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7922:Gcn1
|
UTSW |
5 |
115,752,527 (GRCm39) |
missense |
probably benign |
|
|
R8070:Gcn1
|
UTSW |
5 |
115,727,057 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8218:Gcn1
|
UTSW |
5 |
115,719,588 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8329:Gcn1
|
UTSW |
5 |
115,747,921 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8413:Gcn1
|
UTSW |
5 |
115,717,698 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8795:Gcn1
|
UTSW |
5 |
115,752,454 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8802:Gcn1
|
UTSW |
5 |
115,747,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8899:Gcn1
|
UTSW |
5 |
115,717,220 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8946:Gcn1
|
UTSW |
5 |
115,733,404 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8963:Gcn1
|
UTSW |
5 |
115,727,153 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9006:Gcn1
|
UTSW |
5 |
115,719,566 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9163:Gcn1
|
UTSW |
5 |
115,742,944 (GRCm39) |
missense |
probably benign |
|
|
R9177:Gcn1
|
UTSW |
5 |
115,719,867 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9187:Gcn1
|
UTSW |
5 |
115,752,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9411:Gcn1
|
UTSW |
5 |
115,733,098 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9541:Gcn1
|
UTSW |
5 |
115,754,416 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9574:Gcn1
|
UTSW |
5 |
115,713,341 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9630:Gcn1
|
UTSW |
5 |
115,741,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9651:Gcn1
|
UTSW |
5 |
115,747,665 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9761:Gcn1
|
UTSW |
5 |
115,729,064 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9765:Gcn1
|
UTSW |
5 |
115,735,131 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Gcn1
|
UTSW |
5 |
115,752,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1191:Gcn1
|
UTSW |
5 |
115,713,352 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCATCCTGTTGAAACTAGCCC -3'
(R):5'- TACCTTCTGGTCTGTCAGGGAG -3'
Sequencing Primer
(F):5'- GAAACTAGCCCGTTCTCAGTG -3'
(R):5'- GGGAGTACATGTTGCCAATAATCTGC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation