Incidental Mutation 'R4674:Dido1'
| ID |
348677 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
041929-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R4674 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 180329352 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 357
(S357P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000119689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087517]
[ENSMUST00000103055]
[ENSMUST00000103056]
[ENSMUST00000103057]
[ENSMUST00000130986]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000087517
AA Change: S357P
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: S357P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000103054
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103055
AA Change: S357P
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000099344
Gene: ENSMUSG00000038914
AA Change: S357P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103056
AA Change: S357P
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: S357P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103057
AA Change: S357P
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: S357P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000130986
AA Change: S357P
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000119689
Gene: ENSMUSG00000038914
AA Change: S357P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb1b |
T |
C |
5: 8,860,615 (GRCm39) |
I112T |
probably benign |
Het |
| Acvr1b |
T |
C |
15: 101,100,939 (GRCm39) |
I367T |
possibly damaging |
Het |
| Akr1b8 |
G |
A |
6: 34,333,359 (GRCm39) |
|
probably null |
Het |
| Ash1l |
T |
C |
3: 88,979,783 (GRCm39) |
V2769A |
possibly damaging |
Het |
| Asxl3 |
A |
T |
18: 22,650,795 (GRCm39) |
D928V |
probably damaging |
Het |
| Atp1a4 |
A |
T |
1: 172,085,223 (GRCm39) |
V66E |
possibly damaging |
Het |
| Cald1 |
AAGAGAGAGAGAGAG |
AAGAGAGAGAGAG |
6: 34,723,108 (GRCm39) |
|
probably null |
Het |
| Cbx2 |
T |
A |
11: 118,919,935 (GRCm39) |
I500N |
probably damaging |
Het |
| Ccdc82 |
A |
T |
9: 13,252,260 (GRCm39) |
H184L |
probably benign |
Het |
| Cd84 |
A |
T |
1: 171,700,887 (GRCm39) |
H216L |
possibly damaging |
Het |
| Ceacam15 |
T |
C |
7: 16,407,410 (GRCm39) |
T36A |
probably benign |
Het |
| Cebpd |
A |
G |
16: 15,705,385 (GRCm39) |
D66G |
probably damaging |
Het |
| Clec1b |
C |
A |
6: 129,377,097 (GRCm39) |
L47I |
probably damaging |
Het |
| Cracr2b |
A |
G |
7: 141,043,451 (GRCm39) |
D43G |
probably damaging |
Het |
| Crbn |
T |
A |
6: 106,767,932 (GRCm39) |
Q173L |
possibly damaging |
Het |
| Cspg4 |
T |
C |
9: 56,805,489 (GRCm39) |
V2100A |
probably damaging |
Het |
| Cyp46a1 |
T |
C |
12: 108,324,345 (GRCm39) |
L374P |
probably damaging |
Het |
| Dhx16 |
T |
A |
17: 36,196,831 (GRCm39) |
V607E |
probably damaging |
Het |
| Dnah6 |
T |
A |
6: 73,169,405 (GRCm39) |
I399F |
probably benign |
Het |
| Dock10 |
T |
C |
1: 80,584,337 (GRCm39) |
E123G |
possibly damaging |
Het |
| Dstyk |
A |
G |
1: 132,391,128 (GRCm39) |
D843G |
probably benign |
Het |
| Efcab12 |
C |
A |
6: 115,800,610 (GRCm39) |
V138F |
probably damaging |
Het |
| Egf |
A |
G |
3: 129,511,689 (GRCm39) |
F493L |
probably damaging |
Het |
| Ephx1 |
A |
G |
1: 180,822,256 (GRCm39) |
F220S |
probably damaging |
Het |
| Exoc6 |
T |
C |
19: 37,597,530 (GRCm39) |
F644L |
probably damaging |
Het |
| F13b |
A |
G |
1: 139,429,542 (GRCm39) |
Y20C |
unknown |
Het |
| Fam184b |
T |
A |
5: 45,740,230 (GRCm39) |
K319* |
probably null |
Het |
| Flrt2 |
T |
A |
12: 95,747,462 (GRCm39) |
L600* |
probably null |
Het |
| Gbgt1 |
T |
C |
2: 28,388,453 (GRCm39) |
F46S |
possibly damaging |
Het |
| Gli2 |
T |
C |
1: 118,763,759 (GRCm39) |
E1464G |
probably damaging |
Het |
| Hdac9 |
A |
G |
12: 34,423,959 (GRCm39) |
V501A |
possibly damaging |
Het |
| Heca |
T |
C |
10: 17,791,057 (GRCm39) |
H333R |
probably benign |
Het |
| Hirip3 |
G |
A |
7: 126,463,834 (GRCm39) |
|
probably null |
Het |
| Igsf8 |
G |
A |
1: 172,146,479 (GRCm39) |
W51* |
probably null |
Het |
| Kif21a |
C |
A |
15: 90,824,748 (GRCm39) |
R1342L |
possibly damaging |
Het |
| Krt73 |
T |
C |
15: 101,710,510 (GRCm39) |
N75D |
probably benign |
Het |
| Macf1 |
T |
A |
4: 123,366,190 (GRCm39) |
Y1292F |
probably benign |
Het |
| Macroh2a1 |
A |
C |
13: 56,230,997 (GRCm39) |
C297G |
possibly damaging |
Het |
| Mapk14 |
A |
G |
17: 28,963,996 (GRCm39) |
|
probably null |
Het |
| Mgat5 |
T |
A |
1: 127,318,495 (GRCm39) |
V330D |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Naip1 |
A |
T |
13: 100,580,682 (GRCm39) |
F188L |
probably damaging |
Het |
| Ncoa3 |
T |
C |
2: 165,901,731 (GRCm39) |
S1035P |
probably benign |
Het |
| Ndn |
T |
A |
7: 61,998,570 (GRCm39) |
W139R |
probably damaging |
Het |
| Nes |
T |
C |
3: 87,879,102 (GRCm39) |
V198A |
possibly damaging |
Het |
| Or4c107 |
G |
T |
2: 88,789,216 (GRCm39) |
M135I |
probably damaging |
Het |
| Or4c35 |
A |
G |
2: 89,808,250 (GRCm39) |
I43V |
possibly damaging |
Het |
| Or51ab3 |
T |
G |
7: 103,201,183 (GRCm39) |
L64V |
probably damaging |
Het |
| Or52p1 |
T |
A |
7: 104,267,631 (GRCm39) |
C248* |
probably null |
Het |
| Or5b111 |
T |
A |
19: 13,291,178 (GRCm39) |
H157L |
probably benign |
Het |
| Or5p72 |
T |
C |
7: 108,022,309 (GRCm39) |
V177A |
possibly damaging |
Het |
| Pcf11 |
G |
A |
7: 92,308,985 (GRCm39) |
|
probably benign |
Het |
| Pde1a |
TCC |
TC |
2: 79,728,525 (GRCm39) |
|
probably benign |
Het |
| Pipox |
T |
G |
11: 77,784,596 (GRCm39) |
Q4P |
probably benign |
Het |
| Pla2g4c |
C |
T |
7: 13,077,439 (GRCm39) |
T327I |
probably null |
Het |
| Plppr1 |
C |
T |
4: 49,323,384 (GRCm39) |
R225W |
probably damaging |
Het |
| Pnpla6 |
T |
A |
8: 3,571,412 (GRCm39) |
V145D |
probably damaging |
Het |
| Pnpla7 |
T |
C |
2: 24,942,329 (GRCm39) |
Y83H |
probably damaging |
Het |
| Rif1 |
T |
A |
2: 51,996,954 (GRCm39) |
L970Q |
probably null |
Het |
| Rimklb |
C |
A |
6: 122,433,242 (GRCm39) |
E303* |
probably null |
Het |
| Rpl13a |
A |
T |
7: 44,776,242 (GRCm39) |
|
probably benign |
Het |
| Rttn |
T |
A |
18: 89,029,135 (GRCm39) |
|
probably null |
Het |
| Sf3b3 |
G |
A |
8: 111,571,137 (GRCm39) |
R10W |
probably damaging |
Het |
| Skint4 |
G |
A |
4: 111,975,430 (GRCm39) |
C130Y |
probably damaging |
Het |
| Snap91 |
A |
G |
9: 86,674,070 (GRCm39) |
S593P |
possibly damaging |
Het |
| Ssb |
A |
G |
2: 69,699,194 (GRCm39) |
Q209R |
probably benign |
Het |
| Stap1 |
A |
T |
5: 86,229,044 (GRCm39) |
I71L |
probably benign |
Het |
| Syna |
C |
A |
5: 134,587,209 (GRCm39) |
R580L |
probably damaging |
Het |
| Tacc2 |
T |
A |
7: 130,226,591 (GRCm39) |
M1111K |
possibly damaging |
Het |
| Tanc2 |
T |
C |
11: 105,758,306 (GRCm39) |
L689P |
probably damaging |
Het |
| Tasor2 |
T |
C |
13: 3,623,686 (GRCm39) |
E1406G |
possibly damaging |
Het |
| Tcstv7b |
T |
C |
13: 120,702,362 (GRCm39) |
W53R |
probably damaging |
Het |
| Tdrd5 |
A |
C |
1: 156,105,005 (GRCm39) |
C463W |
probably damaging |
Het |
| Tet1 |
A |
G |
10: 62,674,627 (GRCm39) |
F1150L |
probably damaging |
Het |
| Tia1 |
T |
A |
6: 86,397,382 (GRCm39) |
F118L |
probably damaging |
Het |
| Trav3-1 |
A |
T |
14: 52,818,460 (GRCm39) |
T45S |
possibly damaging |
Het |
| Uaca |
A |
T |
9: 60,761,711 (GRCm39) |
Y235F |
possibly damaging |
Het |
| Ube4b |
T |
C |
4: 149,415,827 (GRCm39) |
N44S |
possibly damaging |
Het |
| Vmn2r93 |
T |
A |
17: 18,525,255 (GRCm39) |
H304Q |
probably benign |
Het |
| Wdr18 |
A |
G |
10: 79,801,069 (GRCm39) |
I161V |
probably benign |
Het |
| Zfp112 |
A |
G |
7: 23,826,399 (GRCm39) |
H789R |
probably damaging |
Het |
| Zfp873 |
A |
G |
10: 81,895,814 (GRCm39) |
T182A |
possibly damaging |
Het |
| Zscan2 |
T |
A |
7: 80,525,150 (GRCm39) |
S290R |
probably damaging |
Het |
| Zup1 |
A |
T |
10: 33,824,980 (GRCm39) |
D167E |
possibly damaging |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4786:Dido1
|
UTSW |
2 |
180,312,664 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCCGTACAGATACAGTAACTG -3'
(R):5'- GGGTATTTCTGAGGCCCGAG -3'
Sequencing Primer
(F):5'- GTACAGATACAGTAACTGCCCAC -3'
(R):5'- AGGGCGGCTCCTGGAAAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation