Incidental Mutation 'R0265:Ltbp2'
ID 34874
Institutional Source Beutler Lab
Gene Symbol Ltbp2
Ensembl Gene ENSMUSG00000002020
Gene Name latent transforming growth factor beta binding protein 2
Synonyms
MMRRC Submission 038491-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.794) question?
Stock # R0265 (G1)
Quality Score 138
Status Validated
Chromosome 12
Chromosomal Location 84829986-84923306 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 84832743 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000127255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002073] [ENSMUST00000002073] [ENSMUST00000110254] [ENSMUST00000110254] [ENSMUST00000163189] [ENSMUST00000163189] [ENSMUST00000166383] [ENSMUST00000166383]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000002073
SMART Domains Protein: ENSMUSP00000002073
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
signal peptide 1 35 N/A INTRINSIC
low complexity region 99 108 N/A INTRINSIC
EGF 184 213 6.55e-1 SMART
low complexity region 255 275 N/A INTRINSIC
EGF 384 413 8.19e-2 SMART
low complexity region 515 526 N/A INTRINSIC
Pfam:TB 546 582 3.8e-9 PFAM
EGF_CA 606 646 8.05e-10 SMART
Pfam:TB 666 707 3.4e-17 PFAM
EGF_CA 832 874 7.18e-7 SMART
EGF_CA 875 917 1.75e-10 SMART
EGF_CA 918 957 1.53e-10 SMART
EGF_CA 958 997 3.51e-10 SMART
EGF_CA 998 1038 8.3e-12 SMART
EGF_CA 1039 1080 4.56e-9 SMART
EGF_CA 1081 1122 4.56e-9 SMART
EGF_CA 1123 1163 8.76e-11 SMART
EGF_CA 1164 1205 4.38e-11 SMART
EGF_CA 1206 1246 1.75e-10 SMART
EGF_CA 1247 1290 2.24e-8 SMART
EGF_CA 1291 1332 6.01e-9 SMART
EGF 1336 1375 1.95e1 SMART
Pfam:TB 1410 1450 1.4e-13 PFAM
EGF_CA 1473 1515 2.31e-10 SMART
EGF_CA 1516 1555 7.93e-9 SMART
Pfam:TB 1582 1623 1e-13 PFAM
low complexity region 1691 1704 N/A INTRINSIC
EGF 1724 1761 4e-5 SMART
EGF_CA 1762 1806 1.91e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000002073
SMART Domains Protein: ENSMUSP00000002073
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
signal peptide 1 35 N/A INTRINSIC
low complexity region 99 108 N/A INTRINSIC
EGF 184 213 6.55e-1 SMART
low complexity region 255 275 N/A INTRINSIC
EGF 384 413 8.19e-2 SMART
low complexity region 515 526 N/A INTRINSIC
Pfam:TB 546 582 3.8e-9 PFAM
EGF_CA 606 646 8.05e-10 SMART
Pfam:TB 666 707 3.4e-17 PFAM
EGF_CA 832 874 7.18e-7 SMART
EGF_CA 875 917 1.75e-10 SMART
EGF_CA 918 957 1.53e-10 SMART
EGF_CA 958 997 3.51e-10 SMART
EGF_CA 998 1038 8.3e-12 SMART
EGF_CA 1039 1080 4.56e-9 SMART
EGF_CA 1081 1122 4.56e-9 SMART
EGF_CA 1123 1163 8.76e-11 SMART
EGF_CA 1164 1205 4.38e-11 SMART
EGF_CA 1206 1246 1.75e-10 SMART
EGF_CA 1247 1290 2.24e-8 SMART
EGF_CA 1291 1332 6.01e-9 SMART
EGF 1336 1375 1.95e1 SMART
Pfam:TB 1410 1450 1.4e-13 PFAM
EGF_CA 1473 1515 2.31e-10 SMART
EGF_CA 1516 1555 7.93e-9 SMART
Pfam:TB 1582 1623 1e-13 PFAM
low complexity region 1691 1704 N/A INTRINSIC
EGF 1724 1761 4e-5 SMART
EGF_CA 1762 1806 1.91e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110254
SMART Domains Protein: ENSMUSP00000105883
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
low complexity region 119 128 N/A INTRINSIC
EGF 204 233 6.55e-1 SMART
low complexity region 275 295 N/A INTRINSIC
EGF 404 433 8.19e-2 SMART
low complexity region 535 546 N/A INTRINSIC
Pfam:TB 565 602 4e-8 PFAM
EGF_CA 626 666 8.05e-10 SMART
Pfam:TB 685 727 3.7e-16 PFAM
EGF_CA 852 894 7.18e-7 SMART
EGF_CA 895 934 1.53e-10 SMART
EGF_CA 935 974 3.51e-10 SMART
EGF_CA 975 1015 8.3e-12 SMART
EGF_CA 1016 1057 4.56e-9 SMART
EGF_CA 1058 1099 4.56e-9 SMART
EGF_CA 1100 1140 8.76e-11 SMART
EGF_CA 1141 1182 4.38e-11 SMART
EGF_CA 1183 1223 1.75e-10 SMART
EGF_CA 1224 1267 2.24e-8 SMART
EGF_CA 1268 1309 6.01e-9 SMART
EGF 1313 1352 1.95e1 SMART
Pfam:TB 1387 1427 1.4e-11 PFAM
EGF_CA 1450 1492 2.31e-10 SMART
EGF_CA 1493 1532 7.93e-9 SMART
Pfam:TB 1558 1600 4.6e-13 PFAM
low complexity region 1668 1681 N/A INTRINSIC
EGF 1701 1738 4e-5 SMART
EGF_CA 1739 1783 1.91e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000110254
SMART Domains Protein: ENSMUSP00000105883
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
low complexity region 119 128 N/A INTRINSIC
EGF 204 233 6.55e-1 SMART
low complexity region 275 295 N/A INTRINSIC
EGF 404 433 8.19e-2 SMART
low complexity region 535 546 N/A INTRINSIC
Pfam:TB 565 602 4e-8 PFAM
EGF_CA 626 666 8.05e-10 SMART
Pfam:TB 685 727 3.7e-16 PFAM
EGF_CA 852 894 7.18e-7 SMART
EGF_CA 895 934 1.53e-10 SMART
EGF_CA 935 974 3.51e-10 SMART
EGF_CA 975 1015 8.3e-12 SMART
EGF_CA 1016 1057 4.56e-9 SMART
EGF_CA 1058 1099 4.56e-9 SMART
EGF_CA 1100 1140 8.76e-11 SMART
EGF_CA 1141 1182 4.38e-11 SMART
EGF_CA 1183 1223 1.75e-10 SMART
EGF_CA 1224 1267 2.24e-8 SMART
EGF_CA 1268 1309 6.01e-9 SMART
EGF 1313 1352 1.95e1 SMART
Pfam:TB 1387 1427 1.4e-11 PFAM
EGF_CA 1450 1492 2.31e-10 SMART
EGF_CA 1493 1532 7.93e-9 SMART
Pfam:TB 1558 1600 4.6e-13 PFAM
low complexity region 1668 1681 N/A INTRINSIC
EGF 1701 1738 4e-5 SMART
EGF_CA 1739 1783 1.91e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163189
SMART Domains Protein: ENSMUSP00000127693
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
signal peptide 1 35 N/A INTRINSIC
low complexity region 99 108 N/A INTRINSIC
EGF 184 213 6.55e-1 SMART
low complexity region 255 275 N/A INTRINSIC
EGF 384 413 8.19e-2 SMART
low complexity region 515 526 N/A INTRINSIC
Pfam:TB 545 582 4e-8 PFAM
EGF_CA 606 646 8.05e-10 SMART
Pfam:TB 665 707 3.8e-16 PFAM
EGF_CA 832 874 7.18e-7 SMART
EGF_CA 875 914 1.53e-10 SMART
EGF_CA 915 954 3.51e-10 SMART
EGF_CA 955 995 8.3e-12 SMART
EGF_CA 996 1037 4.56e-9 SMART
EGF_CA 1038 1079 4.56e-9 SMART
EGF_CA 1080 1120 8.76e-11 SMART
EGF_CA 1121 1162 4.38e-11 SMART
EGF_CA 1163 1203 1.75e-10 SMART
EGF_CA 1204 1247 2.24e-8 SMART
EGF_CA 1248 1289 6.01e-9 SMART
EGF 1293 1332 1.95e1 SMART
Pfam:TB 1367 1407 1.5e-11 PFAM
EGF_CA 1430 1472 2.31e-10 SMART
EGF_CA 1473 1512 7.93e-9 SMART
Pfam:TB 1538 1580 4.7e-13 PFAM
low complexity region 1648 1661 N/A INTRINSIC
EGF 1681 1718 4e-5 SMART
EGF_CA 1719 1763 1.91e-11 SMART
Predicted Effect probably null
Transcript: ENSMUST00000163189
SMART Domains Protein: ENSMUSP00000127693
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
signal peptide 1 35 N/A INTRINSIC
low complexity region 99 108 N/A INTRINSIC
EGF 184 213 6.55e-1 SMART
low complexity region 255 275 N/A INTRINSIC
EGF 384 413 8.19e-2 SMART
low complexity region 515 526 N/A INTRINSIC
Pfam:TB 545 582 4e-8 PFAM
EGF_CA 606 646 8.05e-10 SMART
Pfam:TB 665 707 3.8e-16 PFAM
EGF_CA 832 874 7.18e-7 SMART
EGF_CA 875 914 1.53e-10 SMART
EGF_CA 915 954 3.51e-10 SMART
EGF_CA 955 995 8.3e-12 SMART
EGF_CA 996 1037 4.56e-9 SMART
EGF_CA 1038 1079 4.56e-9 SMART
EGF_CA 1080 1120 8.76e-11 SMART
EGF_CA 1121 1162 4.38e-11 SMART
EGF_CA 1163 1203 1.75e-10 SMART
EGF_CA 1204 1247 2.24e-8 SMART
EGF_CA 1248 1289 6.01e-9 SMART
EGF 1293 1332 1.95e1 SMART
Pfam:TB 1367 1407 1.5e-11 PFAM
EGF_CA 1430 1472 2.31e-10 SMART
EGF_CA 1473 1512 7.93e-9 SMART
Pfam:TB 1538 1580 4.7e-13 PFAM
low complexity region 1648 1661 N/A INTRINSIC
EGF 1681 1718 4e-5 SMART
EGF_CA 1719 1763 1.91e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163214
SMART Domains Protein: ENSMUSP00000132067
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
EGF_CA 6 46 8.76e-11 SMART
EGF_CA 47 90 2.24e-8 SMART
EGF_CA 91 132 6.01e-9 SMART
EGF 136 175 1.95e1 SMART
Pfam:TB 210 250 1.5e-14 PFAM
EGF 276 307 1.5e1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000166383
SMART Domains Protein: ENSMUSP00000127255
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
EGF_CA 8 49 2.13e-9 SMART
Pfam:TB 75 117 1.3e-14 PFAM
low complexity region 185 198 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000166383
SMART Domains Protein: ENSMUSP00000127255
Gene: ENSMUSG00000002020

DomainStartEndE-ValueType
EGF_CA 8 49 2.13e-9 SMART
Pfam:TB 75 117 1.3e-14 PFAM
low complexity region 185 198 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.5%
  • 3x: 97.4%
  • 10x: 95.6%
  • 20x: 92.0%
Validation Efficiency 99% (83/84)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a null allele exhibit early embryonic lethality prior to E6.5. Mice homozygous for a different null allele are viable, fertile, and developmentally normal but develop lens dislocations due to ciliary zonule fragmentation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 A G 7: 119,822,850 (GRCm39) I321V probably benign Het
Adcy7 A G 8: 89,051,391 (GRCm39) D837G probably damaging Het
Aldh1a1 T A 19: 20,617,440 (GRCm39) Y457* probably null Het
Alox5 T C 6: 116,397,323 (GRCm39) Y287C probably benign Het
Ano8 T C 8: 71,933,168 (GRCm39) probably benign Het
Ap3b1 A G 13: 94,630,189 (GRCm39) K815E unknown Het
Atp11a A T 8: 12,906,930 (GRCm39) probably benign Het
Atp6v0a1 A T 11: 100,939,341 (GRCm39) D702V possibly damaging Het
Cacna1b T A 2: 24,651,856 (GRCm39) N108Y probably damaging Het
Ccdc57 G C 11: 120,812,637 (GRCm39) A39G probably benign Het
Cdhr1 A T 14: 36,803,333 (GRCm39) V581D probably benign Het
Cfap20dc T G 14: 8,431,667 (GRCm38) Y655S probably damaging Het
Cyp2b23 A G 7: 26,372,304 (GRCm39) probably benign Het
D430041D05Rik G C 2: 103,998,295 (GRCm39) P1836R probably damaging Het
Ddit4l C T 3: 137,330,048 (GRCm39) probably benign Het
Dnah8 A T 17: 30,909,245 (GRCm39) I1024F probably benign Het
Dync2i1 T C 12: 116,221,026 (GRCm39) probably benign Het
Edc3 T A 9: 57,634,621 (GRCm39) F213I probably damaging Het
Edrf1 G A 7: 133,258,774 (GRCm39) D717N probably damaging Het
Efna5 G A 17: 62,958,068 (GRCm39) P63S probably damaging Het
Elapor2 T C 5: 9,484,681 (GRCm39) L486P probably damaging Het
Entpd3 A G 9: 120,387,547 (GRCm39) Y248C probably damaging Het
Flcn G A 11: 59,686,635 (GRCm39) Q373* probably null Het
Fry T C 5: 150,358,241 (GRCm39) V1908A probably damaging Het
Gabrg3 A T 7: 57,031,365 (GRCm39) Y58* probably null Het
Gabrp A T 11: 33,502,614 (GRCm39) Y417N probably damaging Het
Golga2 C A 2: 32,194,964 (GRCm39) probably null Het
Grip2 C A 6: 91,750,773 (GRCm39) probably null Het
Gsx2 A G 5: 75,237,729 (GRCm39) Y227C probably damaging Het
H2ac1 T C 13: 24,118,632 (GRCm39) V63A probably benign Het
Hif3a T C 7: 16,769,793 (GRCm39) *665W probably null Het
Hsd3b1 C A 3: 98,760,089 (GRCm39) V301L probably damaging Het
Ifitm5 T C 7: 140,529,921 (GRCm39) probably benign Het
Inpp4a A T 1: 37,418,067 (GRCm39) D498V probably damaging Het
Itga1 A T 13: 115,128,995 (GRCm39) D554E probably benign Het
Itk G A 11: 46,280,285 (GRCm39) probably benign Het
Kdm3b T A 18: 34,928,716 (GRCm39) probably benign Het
Klhl6 A G 16: 19,766,984 (GRCm39) V470A probably benign Het
Lamb3 T A 1: 193,002,839 (GRCm39) W95R probably damaging Het
Lbhd2 T A 12: 111,376,676 (GRCm39) I41N probably damaging Het
Lrp4 A T 2: 91,321,015 (GRCm39) S1014C probably damaging Het
Map3k19 A G 1: 127,749,919 (GRCm39) I1144T possibly damaging Het
Mfsd10 T C 5: 34,792,507 (GRCm39) probably benign Het
Mocos A G 18: 24,799,333 (GRCm39) D189G probably benign Het
Mvb12a T A 8: 71,999,654 (GRCm39) F224L probably damaging Het
Myo15a A T 11: 60,405,723 (GRCm39) probably null Het
Nos2 A T 11: 78,828,428 (GRCm39) H249L probably damaging Het
Notum A G 11: 120,549,160 (GRCm39) M184T probably benign Het
Nvl C A 1: 180,962,395 (GRCm39) D192Y probably damaging Het
Or10j3 A G 1: 173,031,484 (GRCm39) K187R probably benign Het
Or4f57 T C 2: 111,790,839 (GRCm39) Y193C probably damaging Het
Or5ac22 A T 16: 59,135,434 (GRCm39) F112Y probably damaging Het
Or5m12 T A 2: 85,734,591 (GRCm39) N269I probably benign Het
Or8k27 C A 2: 86,276,303 (GRCm39) V8L probably benign Het
Osgin1 A G 8: 120,172,396 (GRCm39) I397V possibly damaging Het
Otulin A G 15: 27,616,510 (GRCm39) V123A probably damaging Het
P4ha1 A G 10: 59,184,081 (GRCm39) Y181C probably damaging Het
Pcdhgc5 A T 18: 37,954,403 (GRCm39) D559V probably damaging Het
Phf2 T C 13: 48,982,270 (GRCm39) N151S unknown Het
Plxnc1 C A 10: 94,648,991 (GRCm39) G1263C probably benign Het
Rad51ap1 A G 6: 126,901,160 (GRCm39) *338Q probably null Het
Raver1 A G 9: 20,986,955 (GRCm39) S676P probably benign Het
Rfx8 T C 1: 39,727,737 (GRCm39) E196G possibly damaging Het
Rreb1 A T 13: 38,100,131 (GRCm39) K187* probably null Het
Rxfp1 T C 3: 79,574,961 (GRCm39) T217A probably benign Het
Rxra T C 2: 27,642,442 (GRCm39) L305P probably damaging Het
Sardh T C 2: 27,117,078 (GRCm39) probably benign Het
Skor2 A T 18: 76,964,293 (GRCm39) E952D probably damaging Het
Slc22a29 A T 19: 8,147,334 (GRCm39) S343T probably benign Het
Sorbs2 T C 8: 46,238,374 (GRCm39) probably benign Het
Supt7l C T 5: 31,673,262 (GRCm39) V329I probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Tac1 T C 6: 7,559,165 (GRCm39) probably benign Het
Tcn2 A T 11: 3,872,044 (GRCm39) V361D probably damaging Het
Tm2d3 G A 7: 65,347,582 (GRCm39) A170T possibly damaging Het
Tnks G A 8: 35,307,124 (GRCm39) R1142* probably null Het
Ttll7 C A 3: 146,649,915 (GRCm39) Y648* probably null Het
Umod G T 7: 119,065,296 (GRCm39) Q578K probably benign Het
Upf2 G A 2: 6,032,015 (GRCm39) probably benign Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Washc5 A G 15: 59,210,809 (GRCm39) I1013T probably benign Het
Zfp704 C A 3: 9,630,217 (GRCm39) R48L probably damaging Het
Other mutations in Ltbp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00471:Ltbp2 APN 12 84,837,838 (GRCm39) missense probably damaging 1.00
IGL00938:Ltbp2 APN 12 84,878,573 (GRCm39) missense probably benign 0.03
IGL01397:Ltbp2 APN 12 84,837,042 (GRCm39) missense probably damaging 1.00
IGL01570:Ltbp2 APN 12 84,840,807 (GRCm39) missense probably benign 0.05
IGL01631:Ltbp2 APN 12 84,855,920 (GRCm39) critical splice donor site probably null
IGL01662:Ltbp2 APN 12 84,856,020 (GRCm39) missense probably benign 0.00
IGL01728:Ltbp2 APN 12 84,837,783 (GRCm39) missense probably damaging 0.99
IGL01839:Ltbp2 APN 12 84,840,432 (GRCm39) missense possibly damaging 0.48
IGL01946:Ltbp2 APN 12 84,877,522 (GRCm39) missense probably damaging 1.00
IGL01977:Ltbp2 APN 12 84,876,973 (GRCm39) missense probably damaging 1.00
IGL02220:Ltbp2 APN 12 84,876,083 (GRCm39) missense possibly damaging 0.93
IGL02340:Ltbp2 APN 12 84,839,729 (GRCm39) critical splice donor site probably null
IGL02430:Ltbp2 APN 12 84,846,175 (GRCm39) missense probably damaging 1.00
IGL02492:Ltbp2 APN 12 84,856,439 (GRCm39) missense probably damaging 1.00
IGL02517:Ltbp2 APN 12 84,832,091 (GRCm39) missense probably benign 0.42
IGL02794:Ltbp2 APN 12 84,838,709 (GRCm39) missense probably damaging 1.00
deft UTSW 12 84,900,686 (GRCm39) missense probably damaging 0.98
masterful UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
practiced UTSW 12 84,856,122 (GRCm39) missense probably damaging 1.00
R0045:Ltbp2 UTSW 12 84,860,062 (GRCm39) missense probably damaging 1.00
R0045:Ltbp2 UTSW 12 84,856,361 (GRCm39) missense probably damaging 1.00
R0091:Ltbp2 UTSW 12 84,840,507 (GRCm39) missense probably damaging 1.00
R0094:Ltbp2 UTSW 12 84,846,200 (GRCm39) missense probably damaging 1.00
R0166:Ltbp2 UTSW 12 84,833,132 (GRCm39) missense probably benign 0.28
R0394:Ltbp2 UTSW 12 84,853,198 (GRCm39) splice site probably benign
R0535:Ltbp2 UTSW 12 84,837,826 (GRCm39) missense probably damaging 1.00
R0535:Ltbp2 UTSW 12 84,831,632 (GRCm39) missense probably damaging 1.00
R1465:Ltbp2 UTSW 12 84,860,074 (GRCm39) missense probably damaging 1.00
R1465:Ltbp2 UTSW 12 84,860,074 (GRCm39) missense probably damaging 1.00
R1513:Ltbp2 UTSW 12 84,838,718 (GRCm39) missense probably damaging 1.00
R1858:Ltbp2 UTSW 12 84,877,555 (GRCm39) nonsense probably null
R1880:Ltbp2 UTSW 12 84,876,045 (GRCm39) missense probably benign 0.45
R1894:Ltbp2 UTSW 12 84,834,735 (GRCm39) missense probably damaging 1.00
R1900:Ltbp2 UTSW 12 84,877,432 (GRCm39) missense probably damaging 1.00
R1903:Ltbp2 UTSW 12 84,876,879 (GRCm39) missense probably benign 0.01
R1912:Ltbp2 UTSW 12 84,832,637 (GRCm39) missense probably damaging 0.98
R1993:Ltbp2 UTSW 12 84,855,220 (GRCm39) critical splice acceptor site probably null
R1995:Ltbp2 UTSW 12 84,855,220 (GRCm39) critical splice acceptor site probably null
R2069:Ltbp2 UTSW 12 84,840,507 (GRCm39) missense probably damaging 1.00
R2126:Ltbp2 UTSW 12 84,832,483 (GRCm39) splice site probably null
R2139:Ltbp2 UTSW 12 84,862,753 (GRCm39) missense probably damaging 1.00
R2341:Ltbp2 UTSW 12 84,855,937 (GRCm39) missense probably benign 0.08
R2511:Ltbp2 UTSW 12 84,851,183 (GRCm39) splice site probably null
R3737:Ltbp2 UTSW 12 84,851,248 (GRCm39) missense probably damaging 1.00
R3738:Ltbp2 UTSW 12 84,851,248 (GRCm39) missense probably damaging 1.00
R3739:Ltbp2 UTSW 12 84,851,248 (GRCm39) missense probably damaging 1.00
R3889:Ltbp2 UTSW 12 84,831,681 (GRCm39) unclassified probably benign
R4034:Ltbp2 UTSW 12 84,851,248 (GRCm39) missense probably damaging 1.00
R4542:Ltbp2 UTSW 12 84,878,593 (GRCm39) nonsense probably null
R4621:Ltbp2 UTSW 12 84,856,122 (GRCm39) missense probably damaging 1.00
R4623:Ltbp2 UTSW 12 84,856,122 (GRCm39) missense probably damaging 1.00
R4831:Ltbp2 UTSW 12 84,840,414 (GRCm39) missense possibly damaging 0.55
R5080:Ltbp2 UTSW 12 84,850,638 (GRCm39) missense probably damaging 1.00
R5116:Ltbp2 UTSW 12 84,856,511 (GRCm39) missense probably damaging 1.00
R5351:Ltbp2 UTSW 12 84,837,132 (GRCm39) missense possibly damaging 0.95
R5445:Ltbp2 UTSW 12 84,856,428 (GRCm39) missense probably null 1.00
R5608:Ltbp2 UTSW 12 84,834,238 (GRCm39) splice site probably null
R5784:Ltbp2 UTSW 12 84,915,513 (GRCm39) missense probably damaging 1.00
R5838:Ltbp2 UTSW 12 84,835,875 (GRCm39) missense probably benign 0.16
R5859:Ltbp2 UTSW 12 84,840,837 (GRCm39) missense possibly damaging 0.52
R6004:Ltbp2 UTSW 12 84,922,923 (GRCm39) missense probably benign 0.00
R6028:Ltbp2 UTSW 12 84,831,626 (GRCm39) missense probably damaging 1.00
R6347:Ltbp2 UTSW 12 84,900,686 (GRCm39) missense probably damaging 0.98
R6615:Ltbp2 UTSW 12 84,860,091 (GRCm39) missense probably damaging 1.00
R6636:Ltbp2 UTSW 12 84,922,612 (GRCm39) missense probably benign 0.00
R6637:Ltbp2 UTSW 12 84,922,612 (GRCm39) missense probably benign 0.00
R6755:Ltbp2 UTSW 12 84,841,847 (GRCm39) missense probably damaging 1.00
R6759:Ltbp2 UTSW 12 84,834,184 (GRCm39) missense probably damaging 0.99
R6806:Ltbp2 UTSW 12 84,856,012 (GRCm39) missense possibly damaging 0.74
R6968:Ltbp2 UTSW 12 84,835,857 (GRCm39) critical splice donor site probably null
R7084:Ltbp2 UTSW 12 84,915,459 (GRCm39) missense probably damaging 1.00
R7250:Ltbp2 UTSW 12 84,834,166 (GRCm39) nonsense probably null
R7374:Ltbp2 UTSW 12 84,876,949 (GRCm39) missense probably damaging 1.00
R7501:Ltbp2 UTSW 12 84,877,419 (GRCm39) missense probably damaging 1.00
R7523:Ltbp2 UTSW 12 84,837,808 (GRCm39) missense probably benign 0.00
R7754:Ltbp2 UTSW 12 84,860,012 (GRCm39) critical splice donor site probably null
R7827:Ltbp2 UTSW 12 84,836,655 (GRCm39) missense probably benign 0.19
R8042:Ltbp2 UTSW 12 84,838,673 (GRCm39) missense probably damaging 0.99
R8110:Ltbp2 UTSW 12 84,850,676 (GRCm39) nonsense probably null
R8411:Ltbp2 UTSW 12 84,833,187 (GRCm39) missense probably damaging 1.00
R8688:Ltbp2 UTSW 12 84,850,578 (GRCm39) missense probably benign 0.20
R8711:Ltbp2 UTSW 12 84,900,515 (GRCm39) missense probably benign 0.00
R8712:Ltbp2 UTSW 12 84,853,124 (GRCm39) missense probably benign 0.08
R8893:Ltbp2 UTSW 12 84,875,316 (GRCm39) missense probably damaging 1.00
R8978:Ltbp2 UTSW 12 84,834,164 (GRCm39) missense probably benign 0.00
R9016:Ltbp2 UTSW 12 84,856,467 (GRCm39) missense probably benign 0.02
R9123:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9129:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9132:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9144:Ltbp2 UTSW 12 84,856,426 (GRCm39) missense probably damaging 1.00
R9150:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9152:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9156:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9157:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9158:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9159:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9160:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9199:Ltbp2 UTSW 12 84,832,750 (GRCm39) missense probably benign 0.09
R9212:Ltbp2 UTSW 12 84,839,824 (GRCm39) missense probably damaging 1.00
R9275:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9276:Ltbp2 UTSW 12 84,876,885 (GRCm39) missense possibly damaging 0.79
R9276:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9278:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9279:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9280:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9281:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9312:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9313:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9331:Ltbp2 UTSW 12 84,922,965 (GRCm39) missense probably benign
R9355:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9375:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9377:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9378:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9450:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9457:Ltbp2 UTSW 12 84,835,927 (GRCm39) missense probably benign 0.19
R9486:Ltbp2 UTSW 12 84,878,648 (GRCm39) missense possibly damaging 0.49
R9505:Ltbp2 UTSW 12 84,900,638 (GRCm39) missense probably damaging 1.00
R9512:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9581:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9582:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9645:Ltbp2 UTSW 12 84,837,864 (GRCm39) missense probably benign 0.00
R9747:Ltbp2 UTSW 12 84,915,515 (GRCm39) missense probably damaging 1.00
R9792:Ltbp2 UTSW 12 84,876,128 (GRCm39) missense probably damaging 0.99
R9795:Ltbp2 UTSW 12 84,876,128 (GRCm39) missense probably damaging 0.99
X0017:Ltbp2 UTSW 12 84,875,302 (GRCm39) missense probably damaging 1.00
X0026:Ltbp2 UTSW 12 84,876,973 (GRCm39) missense probably damaging 1.00
Z1176:Ltbp2 UTSW 12 84,922,627 (GRCm39) missense probably benign 0.01
Z1177:Ltbp2 UTSW 12 84,876,090 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- CTGAATGACCTGGACTAAGGGCAAG -3'
(R):5'- CAAAAGGCCACTTCTGGACCTTCTC -3'

Sequencing Primer
(F):5'- ATCTTGGCAGCAGCATTCTG -3'
(R):5'- CCACTTTTTCCTCACACCACAG -3'
Posted On 2013-05-09