Incidental Mutation 'R4630:Myo1g'
ID 349129
Institutional Source Beutler Lab
Gene Symbol Myo1g
Ensembl Gene ENSMUSG00000020437
Gene Name myosin IG
Synonyms E430002D17Rik
MMRRC Submission 041895-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4630 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 6456548-6470960 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 6469047 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 85 (Y85C)
Ref Sequence ENSEMBL: ENSMUSP00000003459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000003459] [ENSMUST00000134489] [ENSMUST00000144725] [ENSMUST00000146536]
AlphaFold Q5SUA5
Predicted Effect probably damaging
Transcript: ENSMUST00000003459
AA Change: Y85C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000003459
Gene: ENSMUSG00000020437
AA Change: Y85C

DomainStartEndE-ValueType
MYSc 9 714 N/A SMART
IQ 715 737 2.79e0 SMART
Pfam:Myosin_TH1 821 1024 2.8e-42 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131823
Predicted Effect silent
Transcript: ENSMUST00000134489
SMART Domains Protein: ENSMUSP00000122356
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Pfam:Myosin_head 51 99 5.9e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000144725
SMART Domains Protein: ENSMUSP00000120975
Gene: ENSMUSG00000020437

DomainStartEndE-ValueType
Blast:MYSc 9 43 8e-14 BLAST
low complexity region 48 60 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000146536
AA Change: T64A
SMART Domains Protein: ENSMUSP00000122438
Gene: ENSMUSG00000020437
AA Change: T64A

DomainStartEndE-ValueType
Blast:MYSc 9 38 2e-13 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156878
Meta Mutation Damage Score 0.8467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 97% (74/76)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced B cell spreading, migration and homing and impaired T cell motility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110070M22Rik A T 13: 119,624,622 (GRCm39) probably benign Het
Alkbh2 C T 5: 114,262,287 (GRCm39) E148K probably damaging Het
Aopep T C 13: 63,215,906 (GRCm39) S393P probably benign Het
BC024139 T G 15: 76,009,294 (GRCm39) Q240P probably benign Het
Bckdha A T 7: 25,330,884 (GRCm39) I44N probably damaging Het
Brpf1 T C 6: 113,286,867 (GRCm39) Y32H probably damaging Het
Catip A G 1: 74,408,072 (GRCm39) probably benign Het
Ccdc138 T C 10: 58,409,477 (GRCm39) L602P probably damaging Het
Cilp A T 9: 65,187,162 (GRCm39) T1086S probably benign Het
Comp A T 8: 70,827,032 (GRCm39) I58F possibly damaging Het
Crygs T C 16: 22,624,268 (GRCm39) E113G possibly damaging Het
Dnmt3b C T 2: 153,512,235 (GRCm39) R319* probably null Het
Eif3a A G 19: 60,758,366 (GRCm39) I804T unknown Het
Eif3a A T 19: 60,766,424 (GRCm39) H301Q probably benign Het
Elf3 A T 1: 135,184,478 (GRCm39) probably benign Het
Fads2b C A 2: 85,348,990 (GRCm39) G41* probably null Het
Gm10384 A G 15: 36,872,017 (GRCm39) noncoding transcript Het
Gm11627 T A 11: 102,469,657 (GRCm39) probably benign Het
Gpr183 A T 14: 122,192,261 (GRCm39) Y87N probably damaging Het
Gpr183 G C 14: 122,192,262 (GRCm39) Y86* probably null Het
Gpr26 T C 7: 131,568,709 (GRCm39) V18A probably damaging Het
Herc1 T A 9: 66,340,996 (GRCm39) probably null Het
Hint2 C T 4: 43,656,396 (GRCm39) probably benign Het
Jag1 A T 2: 136,927,899 (GRCm39) D837E probably damaging Het
Jmjd1c C A 10: 66,993,753 (GRCm39) S78* probably null Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Krt1 C T 15: 101,754,622 (GRCm39) G543S unknown Het
Lalba T C 15: 98,380,549 (GRCm39) M2V probably benign Het
Lama1 T A 17: 68,101,295 (GRCm39) D1929E probably benign Het
Macf1 T C 4: 123,367,432 (GRCm39) K878R possibly damaging Het
Mboat4 T C 8: 34,591,108 (GRCm39) S182P probably damaging Het
Muc5b A T 7: 141,411,721 (GRCm39) T1556S unknown Het
Ncapd2 C A 6: 125,156,196 (GRCm39) probably null Het
Nox3 T C 17: 3,744,257 (GRCm39) D96G possibly damaging Het
Or10a48 T C 7: 108,424,802 (GRCm39) M135V probably damaging Het
Or1e17 T C 11: 73,831,822 (GRCm39) L250P probably damaging Het
Or6c212 A G 10: 129,559,350 (GRCm39) L21P probably damaging Het
Pacs1 C T 19: 5,206,384 (GRCm39) probably null Het
Pgap4 C G 4: 49,586,254 (GRCm39) V305L probably benign Het
Pgm5 C A 19: 24,812,110 (GRCm39) G141* probably null Het
Pik3r4 A G 9: 105,532,098 (GRCm39) M557V probably benign Het
Pld4 T A 12: 112,731,498 (GRCm39) V217D probably damaging Het
Pphln1-ps1 T C 16: 13,495,278 (GRCm39) S126P probably damaging Het
Ppp1r3c T C 19: 36,710,915 (GRCm39) E285G probably benign Het
Pradc1 T A 6: 85,424,275 (GRCm39) M24L possibly damaging Het
Prepl T C 17: 85,390,659 (GRCm39) T100A probably benign Het
Rmi2 C T 16: 10,704,073 (GRCm39) T138I probably benign Het
Rtkn A T 6: 83,129,163 (GRCm39) K540* probably null Het
Sag C A 1: 87,762,340 (GRCm39) T335K probably damaging Het
Setd4 A G 16: 93,388,114 (GRCm39) L124P probably benign Het
Sh3gl2 A G 4: 85,297,646 (GRCm39) D208G probably damaging Het
Sult4a1 T C 15: 83,989,779 (GRCm39) T8A possibly damaging Het
Tert A G 13: 73,797,110 (GRCm39) D1116G probably damaging Het
Tlr4 A G 4: 66,757,477 (GRCm39) E90G probably benign Het
Tmem123 T C 9: 7,791,393 (GRCm39) L164P probably damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Trak1 G A 9: 121,283,491 (GRCm39) R419Q probably benign Het
Trp53bp1 G T 2: 121,038,368 (GRCm39) A1490D probably damaging Het
Ttc16 T C 2: 32,665,389 (GRCm39) probably benign Het
Tyw5 T A 1: 57,427,686 (GRCm39) Q306L probably damaging Het
Ube2j2 T A 4: 156,039,715 (GRCm39) I14N probably damaging Het
Vmn2r103 T C 17: 20,013,958 (GRCm39) I250T probably benign Het
Zar1 A G 5: 72,738,249 (GRCm39) V51A probably benign Het
Zbtb38 T G 9: 96,570,904 (GRCm39) N60T probably damaging Het
Zfp354a T C 11: 50,961,045 (GRCm39) S417P probably damaging Het
Zfp410 A T 12: 84,372,510 (GRCm39) D112V probably damaging Het
Zfp518a C T 19: 40,901,423 (GRCm39) Q451* probably null Het
Zfp64 T C 2: 168,768,463 (GRCm39) N383S possibly damaging Het
Zfp687 A T 3: 94,919,799 (GRCm39) probably null Het
Other mutations in Myo1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01287:Myo1g APN 11 6,465,856 (GRCm39) missense possibly damaging 0.70
IGL01608:Myo1g APN 11 6,466,780 (GRCm39) missense possibly damaging 0.61
IGL01679:Myo1g APN 11 6,468,006 (GRCm39) missense possibly damaging 0.90
IGL01830:Myo1g APN 11 6,464,522 (GRCm39) nonsense probably null
IGL02332:Myo1g APN 11 6,470,766 (GRCm39) missense possibly damaging 0.61
IGL02813:Myo1g APN 11 6,468,743 (GRCm39) makesense probably null
IGL02988:Myo1g APN 11 6,458,183 (GRCm39) splice site probably benign
IGL03178:Myo1g APN 11 6,462,181 (GRCm39) missense probably damaging 1.00
R0004:Myo1g UTSW 11 6,465,901 (GRCm39) missense probably damaging 1.00
R0334:Myo1g UTSW 11 6,461,084 (GRCm39) splice site probably benign
R0513:Myo1g UTSW 11 6,460,203 (GRCm39) missense probably benign 0.00
R0730:Myo1g UTSW 11 6,470,794 (GRCm39) missense probably damaging 1.00
R1054:Myo1g UTSW 11 6,468,987 (GRCm39) missense probably damaging 1.00
R1434:Myo1g UTSW 11 6,459,372 (GRCm39) missense probably benign 0.00
R1500:Myo1g UTSW 11 6,470,811 (GRCm39) missense probably benign
R1513:Myo1g UTSW 11 6,465,140 (GRCm39) missense probably damaging 0.99
R1720:Myo1g UTSW 11 6,462,490 (GRCm39) missense probably benign 0.44
R1774:Myo1g UTSW 11 6,465,988 (GRCm39) missense probably damaging 1.00
R1809:Myo1g UTSW 11 6,462,283 (GRCm39) missense probably benign 0.02
R1957:Myo1g UTSW 11 6,462,159 (GRCm39) critical splice donor site probably null
R1978:Myo1g UTSW 11 6,470,829 (GRCm39) missense possibly damaging 0.53
R2212:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R2438:Myo1g UTSW 11 6,461,542 (GRCm39) missense probably damaging 1.00
R2566:Myo1g UTSW 11 6,462,539 (GRCm39) critical splice acceptor site probably null
R3158:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3159:Myo1g UTSW 11 6,464,527 (GRCm39) missense possibly damaging 0.62
R3413:Myo1g UTSW 11 6,467,870 (GRCm39) missense possibly damaging 0.88
R3816:Myo1g UTSW 11 6,460,926 (GRCm39) missense probably benign 0.02
R3872:Myo1g UTSW 11 6,464,886 (GRCm39) missense possibly damaging 0.94
R3946:Myo1g UTSW 11 6,470,760 (GRCm39) missense possibly damaging 0.89
R4551:Myo1g UTSW 11 6,467,874 (GRCm39) missense probably damaging 1.00
R4625:Myo1g UTSW 11 6,462,240 (GRCm39) missense probably damaging 1.00
R4700:Myo1g UTSW 11 6,466,785 (GRCm39) splice site probably null
R4713:Myo1g UTSW 11 6,466,080 (GRCm39) missense probably null 1.00
R4964:Myo1g UTSW 11 6,465,976 (GRCm39) missense probably damaging 1.00
R5183:Myo1g UTSW 11 6,458,243 (GRCm39) missense probably damaging 1.00
R5191:Myo1g UTSW 11 6,465,105 (GRCm39) missense probably benign
R5192:Myo1g UTSW 11 6,464,816 (GRCm39) missense probably damaging 1.00
R5726:Myo1g UTSW 11 6,459,420 (GRCm39) missense probably benign 0.06
R5841:Myo1g UTSW 11 6,457,000 (GRCm39) missense probably benign 0.05
R5942:Myo1g UTSW 11 6,464,888 (GRCm39) missense probably damaging 1.00
R6225:Myo1g UTSW 11 6,469,168 (GRCm39) missense probably damaging 1.00
R6517:Myo1g UTSW 11 6,462,509 (GRCm39) missense probably damaging 0.99
R6563:Myo1g UTSW 11 6,467,146 (GRCm39) missense possibly damaging 0.91
R7214:Myo1g UTSW 11 6,461,055 (GRCm39) missense probably damaging 1.00
R7258:Myo1g UTSW 11 6,459,416 (GRCm39) missense possibly damaging 0.92
R7265:Myo1g UTSW 11 6,460,933 (GRCm39) missense possibly damaging 0.92
R7750:Myo1g UTSW 11 6,464,849 (GRCm39) missense probably damaging 1.00
R8683:Myo1g UTSW 11 6,467,569 (GRCm39) critical splice donor site probably null
R8910:Myo1g UTSW 11 6,468,009 (GRCm39) missense possibly damaging 0.66
R9035:Myo1g UTSW 11 6,464,916 (GRCm39) missense probably damaging 1.00
R9103:Myo1g UTSW 11 6,466,153 (GRCm39) missense possibly damaging 0.88
R9162:Myo1g UTSW 11 6,460,897 (GRCm39) missense probably damaging 0.98
R9487:Myo1g UTSW 11 6,456,913 (GRCm39) missense probably benign
X0017:Myo1g UTSW 11 6,466,077 (GRCm39) critical splice donor site probably null
X0061:Myo1g UTSW 11 6,467,967 (GRCm39) missense probably damaging 1.00
Z1176:Myo1g UTSW 11 6,469,045 (GRCm39) missense probably damaging 1.00
Z1177:Myo1g UTSW 11 6,467,935 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTAGCCCAGATCCTTGTCC -3'
(R):5'- AAGTCAGTGAGGTCCCTTTTC -3'

Sequencing Primer
(F):5'- AGATCCTTGTCCCAGTCCAAC -3'
(R):5'- GCCTCTCATGGATGTGAATATAGAAG -3'
Posted On 2015-10-08