Incidental Mutation 'R4631:Vmn2r103'
ID |
349229 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r103
|
Ensembl Gene |
ENSMUSG00000091771 |
Gene Name |
vomeronasal 2, receptor 103 |
Synonyms |
EG627636 |
MMRRC Submission |
041896-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.058)
|
Stock # |
R4631 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
17 |
Chromosomal Location |
19993625-20032798 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 20013958 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 250
(I250T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126756
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172203]
|
AlphaFold |
E9PWW0 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000172203
AA Change: I250T
PolyPhen 2
Score 0.042 (Sensitivity: 0.94; Specificity: 0.83)
|
SMART Domains |
Protein: ENSMUSP00000126756 Gene: ENSMUSG00000091771 AA Change: I250T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
449 |
1.3e-37 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
3.5e-22 |
PFAM |
Pfam:7tm_3
|
595 |
830 |
1.1e-51 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
Validation Efficiency |
100% (84/84) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 77 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700017B05Rik |
A |
T |
9: 57,165,270 (GRCm39) |
L368Q |
probably damaging |
Het |
Abcc2 |
C |
T |
19: 43,803,146 (GRCm39) |
P661S |
possibly damaging |
Het |
Adgre4 |
T |
G |
17: 56,121,305 (GRCm39) |
M457R |
probably null |
Het |
Ank |
C |
A |
15: 27,467,176 (GRCm39) |
F29L |
probably benign |
Het |
Arhgap20 |
T |
C |
9: 51,751,653 (GRCm39) |
|
probably benign |
Het |
Atf6 |
T |
C |
1: 170,574,766 (GRCm39) |
|
probably null |
Het |
Bhmt1b |
G |
A |
18: 87,774,525 (GRCm39) |
R16H |
probably damaging |
Het |
Bod1l |
A |
G |
5: 41,975,078 (GRCm39) |
F2079L |
probably damaging |
Het |
Cd163 |
T |
C |
6: 124,306,045 (GRCm39) |
*1122Q |
probably null |
Het |
Ces2g |
T |
C |
8: 105,694,094 (GRCm39) |
|
probably null |
Het |
Cntnap3 |
A |
G |
13: 64,926,697 (GRCm39) |
Y558H |
probably benign |
Het |
Ctsm |
T |
A |
13: 61,685,510 (GRCm39) |
S301C |
probably null |
Het |
Dlc1 |
A |
C |
8: 37,404,712 (GRCm39) |
|
probably null |
Het |
Dlg2 |
A |
T |
7: 91,737,822 (GRCm39) |
I435F |
probably damaging |
Het |
Dnah5 |
T |
C |
15: 28,402,099 (GRCm39) |
V3420A |
probably damaging |
Het |
Dnah5 |
T |
A |
15: 28,420,140 (GRCm39) |
Y3813N |
probably damaging |
Het |
Dnajc13 |
A |
G |
9: 104,067,616 (GRCm39) |
M1181T |
probably damaging |
Het |
Drc3 |
C |
A |
11: 60,255,734 (GRCm39) |
T107N |
probably benign |
Het |
Dydc2 |
T |
C |
14: 40,771,286 (GRCm39) |
E131G |
probably benign |
Het |
Eif5b |
T |
C |
1: 38,080,828 (GRCm39) |
V723A |
probably damaging |
Het |
Fndc9 |
C |
A |
11: 46,128,675 (GRCm39) |
H65N |
possibly damaging |
Het |
Fzd1 |
A |
T |
5: 4,805,865 (GRCm39) |
Y572* |
probably null |
Het |
Gps1 |
T |
A |
11: 120,679,065 (GRCm39) |
|
probably null |
Het |
Gvin3 |
A |
G |
7: 106,198,730 (GRCm39) |
|
noncoding transcript |
Het |
Kazn |
G |
A |
4: 141,845,471 (GRCm39) |
|
probably benign |
Het |
Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
Kcnip1 |
T |
A |
11: 33,942,821 (GRCm39) |
|
noncoding transcript |
Het |
Kif19a |
A |
G |
11: 114,675,673 (GRCm39) |
I382V |
possibly damaging |
Het |
Krt1 |
C |
T |
15: 101,754,622 (GRCm39) |
G543S |
unknown |
Het |
Malsu1 |
A |
T |
6: 49,061,467 (GRCm39) |
E177V |
probably damaging |
Het |
Man2a2 |
A |
G |
7: 80,012,211 (GRCm39) |
F649L |
probably benign |
Het |
Map3k11 |
A |
G |
19: 5,740,941 (GRCm39) |
I223V |
probably benign |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Myh9 |
T |
G |
15: 77,681,228 (GRCm39) |
D164A |
probably damaging |
Het |
Myo16 |
T |
C |
8: 10,556,984 (GRCm39) |
I1040T |
probably damaging |
Het |
Myo18b |
C |
T |
5: 112,994,266 (GRCm39) |
A896T |
probably damaging |
Het |
Myocd |
G |
T |
11: 65,069,685 (GRCm39) |
N798K |
probably benign |
Het |
Or13c7b |
T |
C |
4: 43,820,563 (GRCm39) |
D266G |
probably benign |
Het |
Or1n1b |
T |
G |
2: 36,780,630 (GRCm39) |
T77P |
probably benign |
Het |
Or2l13b |
G |
A |
16: 19,348,891 (GRCm39) |
R260* |
probably null |
Het |
Or4c11 |
C |
T |
2: 88,695,174 (GRCm39) |
T75I |
probably benign |
Het |
Or4g7 |
T |
A |
2: 111,309,908 (GRCm39) |
W260R |
probably damaging |
Het |
Or52a5 |
A |
T |
7: 103,426,682 (GRCm39) |
L290Q |
probably damaging |
Het |
Or5b105 |
T |
A |
19: 13,080,636 (GRCm39) |
I11F |
probably benign |
Het |
Pcdh18 |
T |
A |
3: 49,710,890 (GRCm39) |
I142F |
probably damaging |
Het |
Pcyox1 |
T |
C |
6: 86,366,212 (GRCm39) |
E334G |
possibly damaging |
Het |
Pcyox1 |
T |
C |
6: 86,366,125 (GRCm39) |
D363G |
probably benign |
Het |
Pgm2 |
A |
G |
5: 64,263,290 (GRCm39) |
|
probably null |
Het |
Plagl1 |
T |
G |
10: 13,003,743 (GRCm39) |
|
probably benign |
Het |
Ppp1r9a |
A |
G |
6: 4,906,537 (GRCm39) |
D364G |
possibly damaging |
Het |
Rab2b |
T |
A |
14: 52,503,699 (GRCm39) |
H141L |
possibly damaging |
Het |
Rev3l |
A |
G |
10: 39,704,412 (GRCm39) |
K279E |
probably benign |
Het |
Rnf111 |
G |
T |
9: 70,357,678 (GRCm39) |
T607N |
probably benign |
Het |
Scn8a |
C |
A |
15: 100,914,384 (GRCm39) |
S1130* |
probably null |
Het |
Selenbp1 |
A |
G |
3: 94,851,879 (GRCm39) |
*473W |
probably null |
Het |
Sh3bp4 |
A |
C |
1: 89,071,995 (GRCm39) |
D281A |
probably damaging |
Het |
Skint5 |
T |
A |
4: 113,486,314 (GRCm39) |
|
probably null |
Het |
Slc1a4 |
A |
G |
11: 20,258,452 (GRCm39) |
L249P |
probably damaging |
Het |
Slc45a2 |
T |
A |
15: 11,012,662 (GRCm39) |
S222T |
probably benign |
Het |
Slc7a4 |
A |
G |
16: 17,392,255 (GRCm39) |
F393S |
probably damaging |
Het |
Slc9a2 |
A |
T |
1: 40,801,078 (GRCm39) |
D536V |
possibly damaging |
Het |
Stra6 |
T |
A |
9: 58,048,115 (GRCm39) |
|
probably benign |
Het |
Tmem145 |
A |
G |
7: 25,007,250 (GRCm39) |
D156G |
probably benign |
Het |
Tns3 |
A |
C |
11: 8,401,119 (GRCm39) |
F1060V |
probably benign |
Het |
Trak1 |
G |
A |
9: 121,283,491 (GRCm39) |
R419Q |
probably benign |
Het |
Trappc8 |
A |
G |
18: 21,000,865 (GRCm39) |
S273P |
probably benign |
Het |
Trmt11 |
A |
G |
10: 30,435,200 (GRCm39) |
S320P |
probably benign |
Het |
Ugt1a6a |
A |
T |
1: 88,066,980 (GRCm39) |
Y262F |
probably benign |
Het |
Vmn1r73 |
G |
A |
7: 11,490,758 (GRCm39) |
C192Y |
probably benign |
Het |
Vmn2r25 |
T |
A |
6: 123,829,962 (GRCm39) |
D63V |
possibly damaging |
Het |
Vps13b |
C |
T |
15: 35,646,278 (GRCm39) |
H1461Y |
possibly damaging |
Het |
Ythdc2 |
A |
T |
18: 45,020,698 (GRCm39) |
E1427D |
probably benign |
Het |
Zbed6 |
A |
T |
1: 133,586,482 (GRCm39) |
V285E |
probably damaging |
Het |
Zbtb26 |
A |
G |
2: 37,326,968 (GRCm39) |
F23L |
probably benign |
Het |
Zfp62 |
T |
A |
11: 49,108,632 (GRCm39) |
*908R |
probably null |
Het |
Zfp975 |
A |
T |
7: 42,312,369 (GRCm39) |
N81K |
probably benign |
Het |
Zkscan16 |
G |
A |
4: 58,951,918 (GRCm39) |
V198M |
probably damaging |
Het |
|
Other mutations in Vmn2r103 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00333:Vmn2r103
|
APN |
17 |
20,013,364 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL00939:Vmn2r103
|
APN |
17 |
20,015,227 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01120:Vmn2r103
|
APN |
17 |
20,013,259 (GRCm39) |
missense |
probably benign |
0.06 |
IGL01403:Vmn2r103
|
APN |
17 |
20,013,229 (GRCm39) |
missense |
probably benign |
|
IGL01404:Vmn2r103
|
APN |
17 |
20,032,696 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01713:Vmn2r103
|
APN |
17 |
20,014,330 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01802:Vmn2r103
|
APN |
17 |
20,019,470 (GRCm39) |
missense |
probably benign |
|
IGL02251:Vmn2r103
|
APN |
17 |
20,014,231 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02466:Vmn2r103
|
APN |
17 |
19,993,631 (GRCm39) |
missense |
probably benign |
|
IGL02555:Vmn2r103
|
APN |
17 |
20,031,873 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02668:Vmn2r103
|
APN |
17 |
20,014,389 (GRCm39) |
missense |
probably benign |
0.03 |
IGL02715:Vmn2r103
|
APN |
17 |
20,014,218 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02735:Vmn2r103
|
APN |
17 |
20,032,510 (GRCm39) |
missense |
probably benign |
0.27 |
IGL03101:Vmn2r103
|
APN |
17 |
19,993,782 (GRCm39) |
missense |
probably damaging |
0.98 |
R0003:Vmn2r103
|
UTSW |
17 |
20,032,241 (GRCm39) |
missense |
probably damaging |
0.99 |
R0052:Vmn2r103
|
UTSW |
17 |
20,031,903 (GRCm39) |
missense |
probably benign |
0.01 |
R0375:Vmn2r103
|
UTSW |
17 |
20,013,726 (GRCm39) |
missense |
probably benign |
0.12 |
R0375:Vmn2r103
|
UTSW |
17 |
20,013,121 (GRCm39) |
missense |
probably benign |
0.06 |
R0755:Vmn2r103
|
UTSW |
17 |
19,993,830 (GRCm39) |
missense |
probably benign |
0.01 |
R0837:Vmn2r103
|
UTSW |
17 |
20,014,189 (GRCm39) |
missense |
probably damaging |
0.99 |
R1345:Vmn2r103
|
UTSW |
17 |
20,014,509 (GRCm39) |
missense |
probably damaging |
1.00 |
R1396:Vmn2r103
|
UTSW |
17 |
20,013,230 (GRCm39) |
missense |
probably benign |
|
R1488:Vmn2r103
|
UTSW |
17 |
20,013,922 (GRCm39) |
missense |
probably damaging |
0.97 |
R1533:Vmn2r103
|
UTSW |
17 |
19,993,662 (GRCm39) |
missense |
probably benign |
0.01 |
R1590:Vmn2r103
|
UTSW |
17 |
20,014,496 (GRCm39) |
missense |
probably benign |
|
R1928:Vmn2r103
|
UTSW |
17 |
20,032,029 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1942:Vmn2r103
|
UTSW |
17 |
20,032,562 (GRCm39) |
missense |
probably benign |
0.02 |
R2071:Vmn2r103
|
UTSW |
17 |
20,014,056 (GRCm39) |
missense |
probably benign |
|
R2219:Vmn2r103
|
UTSW |
17 |
20,013,909 (GRCm39) |
missense |
probably damaging |
1.00 |
R2442:Vmn2r103
|
UTSW |
17 |
19,993,793 (GRCm39) |
missense |
probably benign |
0.00 |
R2889:Vmn2r103
|
UTSW |
17 |
20,013,862 (GRCm39) |
missense |
probably damaging |
1.00 |
R3762:Vmn2r103
|
UTSW |
17 |
20,032,411 (GRCm39) |
missense |
probably damaging |
0.98 |
R4014:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4331:Vmn2r103
|
UTSW |
17 |
20,014,495 (GRCm39) |
missense |
probably benign |
0.00 |
R4630:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
R4632:Vmn2r103
|
UTSW |
17 |
20,013,958 (GRCm39) |
missense |
probably benign |
0.04 |
R4660:Vmn2r103
|
UTSW |
17 |
20,032,077 (GRCm39) |
missense |
probably damaging |
1.00 |
R4801:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
R4802:Vmn2r103
|
UTSW |
17 |
20,015,338 (GRCm39) |
missense |
probably benign |
0.06 |
R4931:Vmn2r103
|
UTSW |
17 |
20,032,031 (GRCm39) |
missense |
probably benign |
0.01 |
R4995:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
R5309:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
R5312:Vmn2r103
|
UTSW |
17 |
20,013,296 (GRCm39) |
missense |
probably benign |
0.01 |
R5329:Vmn2r103
|
UTSW |
17 |
20,032,433 (GRCm39) |
missense |
probably damaging |
1.00 |
R5611:Vmn2r103
|
UTSW |
17 |
20,013,904 (GRCm39) |
missense |
probably damaging |
0.99 |
R5684:Vmn2r103
|
UTSW |
17 |
20,013,251 (GRCm39) |
missense |
probably benign |
0.02 |
R5715:Vmn2r103
|
UTSW |
17 |
20,015,201 (GRCm39) |
missense |
probably benign |
0.17 |
R5907:Vmn2r103
|
UTSW |
17 |
20,032,715 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6029:Vmn2r103
|
UTSW |
17 |
20,014,478 (GRCm39) |
nonsense |
probably null |
|
R6114:Vmn2r103
|
UTSW |
17 |
20,032,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R6285:Vmn2r103
|
UTSW |
17 |
20,032,406 (GRCm39) |
missense |
probably benign |
|
R6292:Vmn2r103
|
UTSW |
17 |
20,013,866 (GRCm39) |
missense |
possibly damaging |
0.67 |
R6334:Vmn2r103
|
UTSW |
17 |
20,014,344 (GRCm39) |
missense |
probably damaging |
0.97 |
R6501:Vmn2r103
|
UTSW |
17 |
20,032,166 (GRCm39) |
missense |
probably benign |
0.29 |
R6710:Vmn2r103
|
UTSW |
17 |
20,032,239 (GRCm39) |
missense |
probably damaging |
1.00 |
R6774:Vmn2r103
|
UTSW |
17 |
19,993,773 (GRCm39) |
missense |
probably benign |
0.14 |
R6981:Vmn2r103
|
UTSW |
17 |
20,013,739 (GRCm39) |
missense |
probably benign |
0.00 |
R7768:Vmn2r103
|
UTSW |
17 |
20,032,314 (GRCm39) |
missense |
probably damaging |
0.99 |
R7816:Vmn2r103
|
UTSW |
17 |
20,014,476 (GRCm39) |
missense |
probably benign |
0.06 |
R7885:Vmn2r103
|
UTSW |
17 |
20,013,385 (GRCm39) |
missense |
probably benign |
0.25 |
R8002:Vmn2r103
|
UTSW |
17 |
20,019,511 (GRCm39) |
missense |
probably damaging |
1.00 |
R8031:Vmn2r103
|
UTSW |
17 |
20,013,759 (GRCm39) |
missense |
probably benign |
0.00 |
R8140:Vmn2r103
|
UTSW |
17 |
20,032,058 (GRCm39) |
missense |
probably damaging |
1.00 |
R8186:Vmn2r103
|
UTSW |
17 |
20,032,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R8559:Vmn2r103
|
UTSW |
17 |
20,032,646 (GRCm39) |
missense |
probably benign |
0.01 |
R9413:Vmn2r103
|
UTSW |
17 |
20,032,158 (GRCm39) |
missense |
possibly damaging |
0.54 |
R9591:Vmn2r103
|
UTSW |
17 |
20,031,921 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9652:Vmn2r103
|
UTSW |
17 |
20,014,027 (GRCm39) |
missense |
probably benign |
0.01 |
R9680:Vmn2r103
|
UTSW |
17 |
20,019,525 (GRCm39) |
nonsense |
probably null |
|
R9743:Vmn2r103
|
UTSW |
17 |
20,032,475 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Vmn2r103
|
UTSW |
17 |
20,015,309 (GRCm39) |
missense |
probably benign |
0.08 |
|
Predicted Primers |
PCR Primer
(F):5'- GACCATGGTCAGTATCCTTCTC -3'
(R):5'- GAGTCTAACATGAAATAGTCAGCTCTG -3'
Sequencing Primer
(F):5'- TCTCTACCAGATGGCCCCTAAGG -3'
(R):5'- GTCAGCTCTGTCAATAACATGATG -3'
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Posted On |
2015-10-08 |