Mutagenetix > Incidental Mutation

Incidental Mutation 'R4633:Tas2r102'

349344

Institutional Source

Beutler Lab

Gene Symbol

Tas2r102

Ensembl Gene

ENSMUSG00000056901

Gene Name

taste receptor, type 2, member 102

Synonyms

Tas2r2, mt2r51, mGR02, STC 9-7

MMRRC Submission

041898-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4633 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

132762131-132763174 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 132762679 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 183 (N183K)

Ref Sequence

ENSEMBL: ENSMUSP00000068332 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000069268]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000069268
AA Change: N183K

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000068332
Gene: ENSMUSG00000056901
AA Change: N183K

Domain	Start	End	E-Value	Type
Pfam:TAS2R	21	317	3.6e-100	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000204939

Meta Mutation Damage Score

0.1202

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.9%

Validation Efficiency

95% (73/77)

Allele List at MGI

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca3	T	A	17: 24,387,529	L786Q	probably null	Het
Abcb6	A	T	1: 75,177,782		probably benign	Het
Alg10b	T	C	15: 90,228,294	V447A	probably benign	Het
Alkbh2	C	T	5: 114,124,226	E148K	probably damaging	Het
B4galt7	A	G	13: 55,608,750	H203R	probably damaging	Het
Ccdc130	T	C	8: 84,260,395	T158A	probably benign	Het
Cd44	T	G	2: 102,853,047	D214A	possibly damaging	Het
Ces1c	T	C	8: 93,118,386	D275G	probably benign	Het
Cnot11	G	T	1: 39,536,218	W127L	probably benign	Het
Csmd1	A	G	8: 16,002,620	I2168T	probably damaging	Het
Cyp3a59	T	C	5: 146,094,438	F137S	probably damaging	Het
Dst	T	A	1: 34,170,434	L1234Q	probably damaging	Het
Erbb2	T	A	11: 98,432,988	I676N	possibly damaging	Het
Erlin1	G	A	19: 44,040,765	R243C	probably damaging	Het
Fanci	T	C	7: 79,427,242	L576P	probably damaging	Het
Fzd1	A	T	5: 4,755,865	Y572*	probably null	Het
Glg1	C	T	8: 111,177,644		probably null	Het
Gm884	A	T	11: 103,619,131		probably benign	Het
Gpr139	A	T	7: 119,144,405	I319N	probably damaging	Het
Hectd4	C	A	5: 121,349,216	H3425N	probably benign	Het
Itga10	A	G	3: 96,647,704	D118G	possibly damaging	Het
Klra13-ps	T	G	6: 130,291,173		noncoding transcript	Het
Krt1	C	T	15: 101,846,187	G543S	unknown	Het
Krt5	T	A	15: 101,711,607	D225V	probably damaging	Het
Krtap4-9	G	T	11: 99,785,554		probably benign	Het
Lama1	C	A	17: 67,798,584	A2029E	probably damaging	Het
Lrp2	T	A	2: 69,461,417	T3473S	probably benign	Het
Lrriq1	G	A	10: 103,200,563	R910*	probably null	Het
Map1b	C	T	13: 99,434,942	V424M	probably damaging	Het
Mkl2	T	C	16: 13,379,873	I85T	possibly damaging	Het
Mylk2	T	C	2: 152,917,415	S369P	probably benign	Het
Myom3	T	G	4: 135,775,699	F362L	probably benign	Het
Nomo1	A	G	7: 46,050,260		probably benign	Het
Olfr1362	A	G	13: 21,611,228	V247A	probably damaging	Het
Olfr168	C	T	16: 19,530,284	G212D	possibly damaging	Het
Olfr59	T	G	11: 74,289,294	M216R	probably benign	Het
Olfr982	T	A	9: 40,074,334	V13E	probably damaging	Het
Parp4	C	T	14: 56,647,591	L1376F	unknown	Het
Phykpl	C	A	11: 51,593,608	A208E	probably damaging	Het
Pla2g15	T	C	8: 106,160,255	F126S	probably damaging	Het
Polq	T	G	16: 37,048,542	M479R	probably damaging	Het
Prpf4b	A	G	13: 34,900,442	T938A	probably damaging	Het
Psma1	A	G	7: 114,271,134	M63T	probably damaging	Het
Rbpms2	T	C	9: 65,651,636	S174P	probably benign	Het
Rcc1	G	T	4: 132,335,769	S162R	probably damaging	Het
Rev3l	T	G	10: 39,846,186	L2520R	probably damaging	Het
Rhobtb1	T	A	10: 69,249,613		probably null	Het
Rps19	G	T	7: 24,889,170		probably benign	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,579,907		probably benign	Het
Selenof	C	T	3: 144,596,861	R116*	probably null	Het
Slc16a11	T	C	11: 70,216,379		probably null	Het
Stk3	A	G	15: 34,958,928	V296A	probably damaging	Het
Taar8b	C	A	10: 24,092,252	E15*	probably null	Het
Tcrg-C4	G	T	13: 19,352,287	V172F	probably benign	Het
Tet2	T	A	3: 133,485,549	E1041D	probably benign	Het
Tm9sf1	A	G	14: 55,641,203	V244A	probably damaging	Het
Trim24	T	A	6: 37,956,436	I650K	probably damaging	Het
Trim59	G	T	3: 69,037,414	Q198K	probably benign	Het
Ttc28	C	T	5: 111,224,001	T772I	probably damaging	Het
Tvp23a	C	T	16: 10,427,045	V146M	probably benign	Het
Usp17la	A	T	7: 104,860,221	D11V	possibly damaging	Het
Usp48	A	G	4: 137,634,900	K32R	probably damaging	Het
Uspl1	A	G	5: 149,214,392	K801E	probably damaging	Het
Utp20	T	C	10: 88,752,952	I2452V	probably benign	Het
Vps18	T	C	2: 119,293,276	L228P	probably damaging	Het
Zfp410	A	T	12: 84,325,736	D112V	probably damaging	Het
Zfp872	G	T	9: 22,197,194		probably null	Het
Zswim8	A	G	14: 20,718,823	E1110G	probably damaging	Het

Other mutations in Tas2r102

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00685:Tas2r102	APN	6	132762525	missense	possibly damaging	0.58
IGL01777:Tas2r102	APN	6	132762852	missense	probably damaging	0.98
IGL01956:Tas2r102	APN	6	132762453	nonsense	probably null
IGL02126:Tas2r102	APN	6	132762644	missense	probably damaging	1.00
IGL02650:Tas2r102	APN	6	132762210	missense	probably null	0.00
R0483:Tas2r102	UTSW	6	132762365	missense	probably damaging	1.00
R0573:Tas2r102	UTSW	6	132762673	missense	probably damaging	0.98
R0726:Tas2r102	UTSW	6	132762452	missense	probably damaging	1.00
R1777:Tas2r102	UTSW	6	132762291	missense	probably benign	0.08
R3615:Tas2r102	UTSW	6	132762818	nonsense	probably null
R3616:Tas2r102	UTSW	6	132762818	nonsense	probably null
R4556:Tas2r102	UTSW	6	132762915	missense	probably damaging	1.00
R4724:Tas2r102	UTSW	6	132762557	missense	probably damaging	0.97
R5268:Tas2r102	UTSW	6	132762397	missense	probably damaging	0.98
R5494:Tas2r102	UTSW	6	132763143	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- TGGCTTGCCACAACTCTCAG -3'
(R):5'- ATAATTCTCAAGGCATTCATGTGGG -3'

Sequencing Primer
(F):5'- AGCGTCTTTTATTTACTCAGAATAGC -3'
(R):5'- CAAGGCATTCATGTGGGCCTTG -3'

Posted On

2015-10-08