Incidental Mutation 'R4635:Odad4'
ID |
349451 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Odad4
|
Ensembl Gene |
ENSMUSG00000006784 |
Gene Name |
outer dynein arm complex subunit 4 |
Synonyms |
4933404O19Rik, Ttc25 |
MMRRC Submission |
041899-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.089)
|
Stock # |
R4635 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
11 |
Chromosomal Location |
100436434-100463392 bp(+) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
C to T
at 100442333 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamine to Stop codon
at position 164
(Q164*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000090355
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006976]
[ENSMUST00000092684]
|
AlphaFold |
Q9D4B2 |
Predicted Effect |
probably null
Transcript: ENSMUST00000006976
AA Change: Q164*
|
SMART Domains |
Protein: ENSMUSP00000006976 Gene: ENSMUSG00000006784 AA Change: Q164*
Domain | Start | End | E-Value | Type |
TPR
|
11 |
44 |
3.69e1 |
SMART |
TPR
|
45 |
78 |
3.07e1 |
SMART |
TPR
|
79 |
112 |
4.96e0 |
SMART |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
191 |
208 |
N/A |
INTRINSIC |
TPR
|
318 |
351 |
4.96e0 |
SMART |
TPR
|
358 |
391 |
1.11e1 |
SMART |
Blast:TPR
|
395 |
428 |
7e-14 |
BLAST |
TPR
|
435 |
468 |
2.99e1 |
SMART |
low complexity region
|
493 |
505 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000092684
AA Change: Q164*
|
SMART Domains |
Protein: ENSMUSP00000090355 Gene: ENSMUSG00000006784 AA Change: Q164*
Domain | Start | End | E-Value | Type |
TPR
|
11 |
44 |
3.69e1 |
SMART |
TPR
|
45 |
78 |
3.07e1 |
SMART |
TPR
|
79 |
112 |
4.96e0 |
SMART |
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
low complexity region
|
191 |
208 |
N/A |
INTRINSIC |
TPR
|
318 |
351 |
4.96e0 |
SMART |
TPR
|
358 |
391 |
1.11e1 |
SMART |
Blast:TPR
|
395 |
428 |
5e-14 |
BLAST |
TPR
|
435 |
468 |
2.99e1 |
SMART |
coiled coil region
|
528 |
548 |
N/A |
INTRINSIC |
low complexity region
|
556 |
567 |
N/A |
INTRINSIC |
coiled coil region
|
599 |
624 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127389
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132143
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150331
|
Meta Mutation Damage Score |
0.9755 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
Validation Efficiency |
98% (39/40) |
MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele display partial preweaning lethality, impaired ciliary motility, and a variety of left-right body symmetry defects. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb1a |
A |
T |
5: 8,764,927 (GRCm39) |
K639I |
probably benign |
Het |
Amer3 |
C |
A |
1: 34,626,958 (GRCm39) |
T399K |
probably damaging |
Het |
Arfgef3 |
T |
C |
10: 18,510,603 (GRCm39) |
Y786C |
probably damaging |
Het |
Arhgef26 |
A |
G |
3: 62,247,861 (GRCm39) |
Y315C |
probably damaging |
Het |
Ccdc121 |
G |
A |
5: 31,645,435 (GRCm39) |
R396Q |
probably benign |
Het |
Chchd6 |
T |
C |
6: 89,444,448 (GRCm39) |
E178G |
probably damaging |
Het |
Chd3 |
TGCTGCCGCTGCCGC |
TGCTGCCGCTGCCGCTGCCGC |
11: 69,253,013 (GRCm39) |
|
probably benign |
Het |
Daam1 |
T |
A |
12: 72,005,518 (GRCm39) |
|
probably null |
Het |
Ddx60 |
A |
G |
8: 62,490,101 (GRCm39) |
E1690G |
probably benign |
Het |
Eme2 |
G |
T |
17: 25,113,882 (GRCm39) |
P48T |
probably benign |
Het |
Ferd3l |
T |
C |
12: 33,978,835 (GRCm39) |
M116T |
probably damaging |
Het |
Gm13141 |
GGTTTCTTGATGCCA |
G |
4: 147,612,561 (GRCm39) |
|
noncoding transcript |
Het |
Gtf2i |
T |
C |
5: 134,274,028 (GRCm39) |
N727D |
probably damaging |
Het |
Hao1 |
T |
A |
2: 134,365,072 (GRCm39) |
N185I |
probably damaging |
Het |
Kifap3 |
C |
T |
1: 163,642,004 (GRCm39) |
T195I |
probably damaging |
Het |
Mag |
A |
G |
7: 30,606,348 (GRCm39) |
F363S |
probably damaging |
Het |
Mef2a |
A |
G |
7: 66,890,175 (GRCm39) |
I135T |
possibly damaging |
Het |
Muc4 |
T |
C |
16: 32,753,802 (GRCm38) |
I1226T |
probably benign |
Het |
Nphs1 |
T |
C |
7: 30,167,432 (GRCm39) |
F787L |
probably benign |
Het |
Nr1h2 |
A |
C |
7: 44,201,961 (GRCm39) |
S42A |
probably benign |
Het |
Or10ag2 |
T |
A |
2: 87,249,043 (GRCm39) |
M217K |
probably benign |
Het |
Or4a76 |
A |
C |
2: 89,460,516 (GRCm39) |
I242S |
possibly damaging |
Het |
Or51aa2 |
T |
C |
7: 103,188,355 (GRCm39) |
I29V |
probably benign |
Het |
Or5ak23 |
T |
A |
2: 85,245,208 (GRCm39) |
N5I |
probably damaging |
Het |
Rab38 |
T |
C |
7: 88,099,854 (GRCm39) |
V123A |
probably damaging |
Het |
Scd1 |
T |
C |
19: 44,395,024 (GRCm39) |
Y67C |
probably damaging |
Het |
Scn5a |
T |
C |
9: 119,358,051 (GRCm39) |
N730S |
possibly damaging |
Het |
Shc2 |
C |
T |
10: 79,462,120 (GRCm39) |
C341Y |
probably benign |
Het |
Tfdp2 |
T |
A |
9: 96,179,727 (GRCm39) |
N113K |
probably damaging |
Het |
Tmc3 |
A |
G |
7: 83,234,290 (GRCm39) |
|
probably benign |
Het |
Top6bl |
A |
G |
19: 4,748,524 (GRCm39) |
|
probably benign |
Het |
Tox |
A |
T |
4: 6,990,501 (GRCm39) |
|
probably benign |
Het |
Tspoap1 |
A |
G |
11: 87,668,683 (GRCm39) |
K1319E |
probably benign |
Het |
Vit |
G |
A |
17: 78,881,641 (GRCm39) |
V135I |
probably benign |
Het |
Vwa5b1 |
T |
G |
4: 138,338,150 (GRCm39) |
S71R |
possibly damaging |
Het |
|
Other mutations in Odad4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02027:Odad4
|
APN |
11 |
100,460,728 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02379:Odad4
|
APN |
11 |
100,457,809 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL03091:Odad4
|
APN |
11 |
100,441,076 (GRCm39) |
nonsense |
probably null |
|
IGL02991:Odad4
|
UTSW |
11 |
100,444,698 (GRCm39) |
missense |
probably benign |
0.01 |
R0044:Odad4
|
UTSW |
11 |
100,457,827 (GRCm39) |
missense |
probably damaging |
1.00 |
R0137:Odad4
|
UTSW |
11 |
100,454,394 (GRCm39) |
missense |
probably damaging |
1.00 |
R0280:Odad4
|
UTSW |
11 |
100,441,091 (GRCm39) |
missense |
probably damaging |
1.00 |
R1373:Odad4
|
UTSW |
11 |
100,436,658 (GRCm39) |
missense |
probably damaging |
1.00 |
R1793:Odad4
|
UTSW |
11 |
100,460,679 (GRCm39) |
splice site |
probably null |
|
R2097:Odad4
|
UTSW |
11 |
100,454,408 (GRCm39) |
missense |
possibly damaging |
0.89 |
R2121:Odad4
|
UTSW |
11 |
100,457,837 (GRCm39) |
critical splice donor site |
probably null |
|
R2509:Odad4
|
UTSW |
11 |
100,444,361 (GRCm39) |
missense |
probably damaging |
0.99 |
R2655:Odad4
|
UTSW |
11 |
100,444,405 (GRCm39) |
missense |
probably damaging |
1.00 |
R4773:Odad4
|
UTSW |
11 |
100,440,742 (GRCm39) |
missense |
probably benign |
0.05 |
R4858:Odad4
|
UTSW |
11 |
100,441,147 (GRCm39) |
missense |
probably damaging |
0.96 |
R5164:Odad4
|
UTSW |
11 |
100,462,346 (GRCm39) |
nonsense |
probably null |
|
R5181:Odad4
|
UTSW |
11 |
100,440,719 (GRCm39) |
missense |
probably damaging |
1.00 |
R5707:Odad4
|
UTSW |
11 |
100,444,887 (GRCm39) |
missense |
probably damaging |
0.99 |
R5742:Odad4
|
UTSW |
11 |
100,436,699 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7634:Odad4
|
UTSW |
11 |
100,452,731 (GRCm39) |
critical splice donor site |
probably null |
|
R7851:Odad4
|
UTSW |
11 |
100,436,655 (GRCm39) |
missense |
probably damaging |
1.00 |
R8186:Odad4
|
UTSW |
11 |
100,454,505 (GRCm39) |
missense |
probably benign |
0.27 |
R8194:Odad4
|
UTSW |
11 |
100,454,502 (GRCm39) |
missense |
probably benign |
0.06 |
R8444:Odad4
|
UTSW |
11 |
100,452,731 (GRCm39) |
critical splice donor site |
probably null |
|
R8879:Odad4
|
UTSW |
11 |
100,457,752 (GRCm39) |
nonsense |
probably null |
|
X0018:Odad4
|
UTSW |
11 |
100,444,424 (GRCm39) |
missense |
probably damaging |
0.99 |
X0028:Odad4
|
UTSW |
11 |
100,436,724 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTCTTAGACTCTCGATCCACC -3'
(R):5'- CTGCATTCCAAGACAGGCTG -3'
Sequencing Primer
(F):5'- AGAGTTTCTCTGTGTAGCCCTG -3'
(R):5'- ACAGGCTGTCCCTTGAGCTC -3'
|
Posted On |
2015-10-08 |