Mutagenetix > Incidental Mutations

Incidental Mutation 'R0266:Vmn2r92'

34956

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r92

Ensembl Gene

ENSMUSG00000091350

Gene Name

vomeronasal 2, receptor 92

Synonyms

EG627111

MMRRC Submission

038492-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R0266 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

18151887-18188886 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 18167957 bp

Zygosity

Heterozygous

Amino Acid Change

Alanine to Valine at position 408 (A408V)

Ref Sequence

ENSEMBL: ENSMUSP00000128685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169686]

Predicted Effect

probably damaging
Transcript: ENSMUST00000169686
AA Change: A408V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000128685
Gene: ENSMUSG00000091350
AA Change: A408V

Domain	Start	End	E-Value	Type
signal peptide	1	20	N/A	INTRINSIC
Pfam:ANF_receptor	83	463	4.7e-38	PFAM
Pfam:NCD3G	510	564	2.5e-19	PFAM
Pfam:7tm_3	597	832	1.1e-52	PFAM
low complexity region	843	855	N/A	INTRINSIC

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 98.3%
3x: 97.2%
10x: 94.9%
20x: 89.8%

Validation Efficiency

100% (79/79)

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700001K19Rik	A	G	12: 110,668,754	S117P	possibly damaging	Het
Aars2	T	C	17: 45,507,510		probably benign	Het
Acot11	T	C	4: 106,749,988	D466G	probably damaging	Het
Adgrd1	G	A	5: 129,139,594	A342T	probably benign	Het
Apbb2	A	T	5: 66,302,611	N714K	probably benign	Het
Aqp12	C	A	1: 93,006,850	H150N	possibly damaging	Het
Brinp3	T	A	1: 146,682,680	L114*	probably null	Het
Ccng2	T	C	5: 93,271,289		probably benign	Het
Cd36	T	A	5: 17,798,252	R265S	probably benign	Het
Ces4a	T	C	8: 105,141,966	L104S	probably benign	Het
Clca4b	T	C	3: 144,922,786	I387V	probably damaging	Het
Cul7	T	A	17: 46,654,595	H566Q	probably benign	Het
Ddx60	A	T	8: 62,033,493	H1646L	possibly damaging	Het
Dntt	T	C	19: 41,059,127	I503T	probably damaging	Het
Dynlt1a	T	G	17: 6,317,395	E2D	probably benign	Het
Efemp2	G	T	19: 5,477,999	C78F	probably damaging	Het
Esco1	T	C	18: 10,594,605	E227G	probably benign	Het
Fezf2	T	A	14: 12,342,607	K419N	probably damaging	Het
Gm17541	A	T	12: 4,689,487		probably benign	Het
Gm2381	G	A	7: 42,819,948	Q251*	probably null	Het
Gm4782	T	G	6: 50,610,694	S686R	probably damaging	Het
Grin3a	G	A	4: 49,665,501	R1045*	probably null	Het
Grm8	T	C	6: 27,285,896	Y839C	probably damaging	Het
Gtf3c1	G	A	7: 125,644,134	P1766L	possibly damaging	Het
Herc2	T	A	7: 56,206,578	H3921Q	probably damaging	Het
Hes6	A	T	1: 91,412,304	D143E	possibly damaging	Het
Hmcn2	A	G	2: 31,394,827	E2055G	probably benign	Het
Hmcn2	G	A	2: 31,445,353		probably benign	Het
Ikzf3	A	G	11: 98,467,317	L398P	probably benign	Het
Il10ra	A	T	9: 45,265,652	I125N	probably benign	Het
Kcnb2	G	A	1: 15,712,913		probably benign	Het
Krt77	T	C	15: 101,869,378	R81G	possibly damaging	Het
Lrrc40	T	A	3: 158,041,661		probably null	Het
Man1a2	C	T	3: 100,582,034	R543Q	probably damaging	Het
Mansc1	T	C	6: 134,610,707	D169G	probably benign	Het
Mdn1	T	A	4: 32,741,835	S3869T	probably damaging	Het
Mettl14	A	T	3: 123,382,826	S58T	probably benign	Het
Mrpl4	T	C	9: 21,003,314	V62A	probably benign	Het
Myh3	A	G	11: 67,093,672	D1085G	possibly damaging	Het
Myo5c	C	A	9: 75,284,216		probably benign	Het
Naalad2	G	T	9: 18,350,943		probably benign	Het
Nat3	A	G	8: 67,547,780	T104A	probably benign	Het
Nek4	A	G	14: 30,957,296	E198G	probably damaging	Het
Olfm1	A	G	2: 28,229,607	Y403C	probably damaging	Het
Olfr1131	C	A	2: 87,629,282	T273K	possibly damaging	Het
Olfr873	A	T	9: 20,301,158	R320S	probably benign	Het
Osbpl1a	T	A	18: 12,871,163		probably null	Het
Pax7	G	A	4: 139,779,736	S330L	possibly damaging	Het
Pcdhb15	C	A	18: 37,475,276	D520E	probably damaging	Het
Pgm3	T	C	9: 86,567,533	T145A	probably benign	Het
Phox2b	G	A	5: 67,096,625		probably null	Het
Pik3r6	A	T	11: 68,526,408	R59*	probably null	Het
Pold1	A	G	7: 44,541,025		probably benign	Het
Ppp1r21	T	C	17: 88,569,072		probably benign	Het
Prl5a1	A	G	13: 28,149,987	K158E	possibly damaging	Het
Rag2	T	G	2: 101,630,603	C419W	probably damaging	Het
Reln	A	G	5: 21,988,776	S1395P	probably damaging	Het
Retnlb	T	G	16: 48,818,659	Y74*	probably null	Het
Robo3	A	G	9: 37,422,640	S633P	probably damaging	Het
Ryr1	A	G	7: 29,040,679	S3941P	probably damaging	Het
Scnn1b	A	G	7: 121,912,475	N370S	probably damaging	Het
Slc6a5	C	A	7: 49,938,408		probably benign	Het
Sort1	T	A	3: 108,344,931	N481K	probably benign	Het
Sptlc3	T	A	2: 139,596,037	I417K	possibly damaging	Het
Svil	T	A	18: 5,099,063		probably benign	Het
Taf4b	T	C	18: 14,813,077		probably benign	Het
Tchp	T	C	5: 114,709,333	M71T	possibly damaging	Het
Thsd4	T	A	9: 59,997,134	H233L	probably benign	Het
Tmem217	G	T	17: 29,526,599	N52K	possibly damaging	Het
Tmem38b	T	C	4: 53,840,765	L60S	probably damaging	Het
Uqcrfs1	A	C	13: 30,541,163	N131K	probably benign	Het
Vars	T	A	17: 35,013,869	S896R	probably benign	Het
Vmn1r170	A	T	7: 23,606,481	M103L	probably benign	Het
Vmn2r22	T	C	6: 123,637,404	Y409C	probably damaging	Het
Wdr49	A	T	3: 75,451,796	I8N	possibly damaging	Het
Zfp648	T	A	1: 154,204,886	Y264N	probably damaging	Het
Zmym1	A	C	4: 127,048,025	F857V	possibly damaging	Het

Other mutations in Vmn2r92

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01591:Vmn2r92	APN	17	18185161	missense	unknown
IGL01758:Vmn2r92	APN	17	18152013	nonsense	probably null
IGL02614:Vmn2r92	APN	17	18167241	splice site	probably benign
IGL03095:Vmn2r92	APN	17	18166710	missense	possibly damaging	0.55
IGL03403:Vmn2r92	APN	17	18166852	missense	probably damaging	0.98
R0133:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0225:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0227:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0265:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0267:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0420:Vmn2r92	UTSW	17	18168921	missense	probably benign	0.01
R0426:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R0494:Vmn2r92	UTSW	17	18167957	missense	probably damaging	1.00
R1253:Vmn2r92	UTSW	17	18166766	missense	probably benign	0.08
R1497:Vmn2r92	UTSW	17	18167363	missense	probably benign	0.02
R1571:Vmn2r92	UTSW	17	18152090	missense	probably damaging	0.96
R1656:Vmn2r92	UTSW	17	18151936	missense	probably benign
R1816:Vmn2r92	UTSW	17	18166677	missense	probably damaging	0.98
R2229:Vmn2r92	UTSW	17	18167392	missense	probably benign	0.01
R2909:Vmn2r92	UTSW	17	18185115	missense	possibly damaging	0.89
R3694:Vmn2r92	UTSW	17	18151943	nonsense	probably null
R4207:Vmn2r92	UTSW	17	18184261	missense	possibly damaging	0.62
R4548:Vmn2r92	UTSW	17	18171316	missense	probably benign
R4612:Vmn2r92	UTSW	17	18166870	missense	probably benign	0.25
R4742:Vmn2r92	UTSW	17	18166857	missense	probably benign	0.06
R4824:Vmn2r92	UTSW	17	18151921	utr 5 prime	probably benign
R4865:Vmn2r92	UTSW	17	18167372	missense	probably benign	0.16
R4900:Vmn2r92	UTSW	17	18184343	missense	probably benign	0.27
R5084:Vmn2r92	UTSW	17	18185177	makesense	probably null
R5140:Vmn2r92	UTSW	17	18152050	missense	probably benign	0.07
R5995:Vmn2r92	UTSW	17	18168951	critical splice donor site	probably null
R6045:Vmn2r92	UTSW	17	18168043	critical splice donor site	probably null
R6269:Vmn2r92	UTSW	17	18166774	missense	probably benign	0.01
R6877:Vmn2r92	UTSW	17	18168822	missense	probably damaging	1.00
R7151:Vmn2r92	UTSW	17	18166743	missense	probably benign	0.01
R7260:Vmn2r92	UTSW	17	18166876	missense	probably damaging	1.00
R7344:Vmn2r92	UTSW	17	18167251	missense	probably benign	0.01
R7514:Vmn2r92	UTSW	17	18171271	missense	probably damaging	1.00
R7576:Vmn2r92	UTSW	17	18167359	missense	probably benign	0.01
R7584:Vmn2r92	UTSW	17	18166766	missense	probably benign	0.08
R7912:Vmn2r92	UTSW	17	18184708	missense	possibly damaging	0.91
R7941:Vmn2r92	UTSW	17	18184837	missense	possibly damaging	0.89
R8178:Vmn2r92	UTSW	17	18166726	missense	possibly damaging	0.69
R8238:Vmn2r92	UTSW	17	18185016	missense	probably benign	0.00
R8239:Vmn2r92	UTSW	17	18185016	missense	probably benign	0.00
R8252:Vmn2r92	UTSW	17	18166872	missense	probably damaging	1.00
R8322:Vmn2r92	UTSW	17	18166624	missense	probably damaging	0.99
R8355:Vmn2r92	UTSW	17	18184799	missense	probably damaging	0.99
X0066:Vmn2r92	UTSW	17	18184895	missense	probably damaging	1.00
Z1177:Vmn2r92	UTSW	17	18184533	missense	probably damaging	0.96

Predicted Primers

PCR Primer
(F):5'- AGCTGTGGTATTTCTTCTTCAAGTGCTC -3'
(R):5'- GCTCCGGTGTTGAAAATGAGGGT -3'

Sequencing Primer
(F):5'- CTTCAAGTGCTCATTTGCTGG -3'
(R):5'- TGTACAGCTAGATACTGATGACAAG -3'

Posted On

2013-05-09