Incidental Mutation 'R4678:Pde4dip'
| ID |
349736 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pde4dip
|
| Ensembl Gene |
ENSMUSG00000038170 |
| Gene Name |
phosphodiesterase 4D interacting protein (myomegalin) |
| Synonyms |
Usmg4, D3Bwg1078e, D130016K21Rik, 9430063L05Rik, 4732458A06Rik |
| MMRRC Submission |
041931-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4678 (G1)
|
| Quality Score |
220 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
97597144-97796023 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 97602321 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Tyrosine
at position 2252
(D2252Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131170
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000090750]
[ENSMUST00000168438]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000090750
AA Change: D2303Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000088254
Gene: ENSMUSG00000038170
AA Change: D2303Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Cnn_1N
|
124 |
196 |
3.2e-26 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
4.03e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
6.59e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
4.03e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
6.59e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1780 |
N/A |
INTRINSIC |
|
low complexity region
|
1836 |
1851 |
N/A |
INTRINSIC |
|
low complexity region
|
1860 |
1874 |
N/A |
INTRINSIC |
|
low complexity region
|
1940 |
1951 |
N/A |
INTRINSIC |
|
coiled coil region
|
1962 |
2138 |
N/A |
INTRINSIC |
|
coiled coil region
|
2162 |
2197 |
N/A |
INTRINSIC |
|
coiled coil region
|
2387 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000168438
AA Change: D2252Y
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000131170
Gene: ENSMUSG00000038170
AA Change: D2252Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
45 |
57 |
N/A |
INTRINSIC |
|
Pfam:Microtub_assoc
|
124 |
198 |
1.4e-31 |
PFAM |
|
low complexity region
|
204 |
219 |
N/A |
INTRINSIC |
|
coiled coil region
|
282 |
325 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
438 |
3.56e-5 |
PROSPERO |
|
low complexity region
|
567 |
578 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
617 |
667 |
5.83e-5 |
PROSPERO |
|
internal_repeat_1
|
620 |
661 |
3.56e-5 |
PROSPERO |
|
coiled coil region
|
866 |
942 |
N/A |
INTRINSIC |
|
low complexity region
|
1038 |
1056 |
N/A |
INTRINSIC |
|
low complexity region
|
1067 |
1082 |
N/A |
INTRINSIC |
|
coiled coil region
|
1118 |
1163 |
N/A |
INTRINSIC |
|
coiled coil region
|
1336 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1403 |
1420 |
N/A |
INTRINSIC |
|
coiled coil region
|
1470 |
1508 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1597 |
1644 |
5.83e-5 |
PROSPERO |
|
DUF1220
|
1680 |
1747 |
1.17e-17 |
SMART |
|
low complexity region
|
1758 |
1769 |
N/A |
INTRINSIC |
|
low complexity region
|
1785 |
1800 |
N/A |
INTRINSIC |
|
low complexity region
|
1809 |
1823 |
N/A |
INTRINSIC |
|
low complexity region
|
1889 |
1900 |
N/A |
INTRINSIC |
|
coiled coil region
|
1911 |
2087 |
N/A |
INTRINSIC |
|
coiled coil region
|
2111 |
2146 |
N/A |
INTRINSIC |
|
coiled coil region
|
2336 |
2380 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000184178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000197791
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000200063
|
| Meta Mutation Damage Score |
0.5494 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 96.9%
- 20x: 94.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110025L11Rik |
T |
C |
16: 88,860,873 (GRCm39) |
|
probably benign |
Het |
| Abcc4 |
A |
G |
14: 118,865,103 (GRCm39) |
S308P |
probably damaging |
Het |
| Agr3 |
G |
T |
12: 35,997,832 (GRCm39) |
V115L |
probably damaging |
Het |
| Ahr |
A |
T |
12: 35,557,463 (GRCm39) |
I319N |
probably damaging |
Het |
| Alpk1 |
A |
T |
3: 127,473,507 (GRCm39) |
V832D |
probably damaging |
Het |
| Ano1 |
T |
C |
7: 144,223,289 (GRCm39) |
T78A |
probably benign |
Het |
| Apob |
G |
A |
12: 8,045,585 (GRCm39) |
G897D |
probably damaging |
Het |
| Arfgef1 |
A |
G |
1: 10,212,891 (GRCm39) |
F1677L |
probably benign |
Het |
| Arhgap40 |
G |
T |
2: 158,374,226 (GRCm39) |
G217W |
probably benign |
Het |
| Arhgef4 |
A |
G |
1: 34,761,749 (GRCm39) |
E335G |
unknown |
Het |
| Calcoco2 |
T |
C |
11: 95,994,374 (GRCm39) |
T60A |
probably damaging |
Het |
| Catsperg1 |
A |
T |
7: 28,889,721 (GRCm39) |
S741T |
probably benign |
Het |
| Ccdc181 |
T |
G |
1: 164,105,846 (GRCm39) |
I27S |
probably damaging |
Het |
| Ceacam9 |
A |
T |
7: 16,459,334 (GRCm39) |
Y211F |
probably damaging |
Het |
| Cep41 |
T |
C |
6: 30,671,318 (GRCm39) |
|
probably null |
Het |
| Cercam |
T |
A |
2: 29,759,689 (GRCm39) |
L45Q |
probably damaging |
Het |
| Cnnm2 |
G |
A |
19: 46,751,685 (GRCm39) |
V492M |
possibly damaging |
Het |
| Cntn3 |
A |
G |
6: 102,180,981 (GRCm39) |
V738A |
probably damaging |
Het |
| Coq8a |
T |
C |
1: 179,997,646 (GRCm39) |
E351G |
probably damaging |
Het |
| Cyp3a57 |
T |
C |
5: 145,307,538 (GRCm39) |
|
probably null |
Het |
| Dbn1 |
T |
C |
13: 55,623,071 (GRCm39) |
I471V |
probably benign |
Het |
| Ddx21 |
G |
T |
10: 62,429,782 (GRCm39) |
Q321K |
probably benign |
Het |
| Dhx8 |
T |
C |
11: 101,630,634 (GRCm39) |
V347A |
probably damaging |
Het |
| Dkc1 |
A |
G |
X: 74,144,598 (GRCm39) |
I215V |
probably benign |
Homo |
| Dlg2 |
A |
G |
7: 92,077,788 (GRCm39) |
I685V |
possibly damaging |
Het |
| Dusp11 |
A |
C |
6: 85,930,363 (GRCm39) |
N140K |
probably damaging |
Het |
| Ece2 |
A |
G |
16: 20,459,468 (GRCm39) |
K454R |
probably damaging |
Het |
| Eno4 |
T |
A |
19: 58,935,181 (GRCm39) |
V131E |
probably damaging |
Het |
| Enpep |
A |
G |
3: 129,097,362 (GRCm39) |
|
probably null |
Het |
| Etv1 |
T |
C |
12: 38,885,219 (GRCm39) |
Y236H |
probably damaging |
Het |
| F2rl2 |
A |
G |
13: 95,837,140 (GRCm39) |
T62A |
probably benign |
Het |
| Fbxl21 |
T |
C |
13: 56,684,862 (GRCm39) |
V296A |
probably damaging |
Het |
| Fig4 |
T |
C |
10: 41,148,994 (GRCm39) |
I153V |
probably benign |
Het |
| Fis1 |
T |
A |
5: 136,991,951 (GRCm39) |
N41K |
possibly damaging |
Het |
| Fras1 |
T |
A |
5: 96,848,427 (GRCm39) |
M1814K |
probably benign |
Het |
| Frem2 |
T |
A |
3: 53,451,792 (GRCm39) |
I2266F |
probably benign |
Het |
| Gm10330 |
A |
T |
12: 23,829,843 (GRCm39) |
*113R |
probably null |
Het |
| Gm12185 |
T |
A |
11: 48,806,367 (GRCm39) |
I275F |
probably benign |
Het |
| Gsdme |
A |
T |
6: 50,206,304 (GRCm39) |
C180S |
possibly damaging |
Het |
| Herc1 |
A |
G |
9: 66,323,551 (GRCm39) |
E1355G |
probably benign |
Het |
| Hnrnpm |
A |
T |
17: 33,869,185 (GRCm39) |
I453N |
possibly damaging |
Het |
| Hspb9 |
T |
C |
11: 100,604,896 (GRCm39) |
L74P |
probably damaging |
Het |
| Ift46 |
C |
A |
9: 44,695,260 (GRCm39) |
Y85* |
probably null |
Het |
| Insyn2b |
T |
G |
11: 34,353,227 (GRCm39) |
L423R |
probably damaging |
Het |
| Ints3 |
T |
C |
3: 90,315,817 (GRCm39) |
T316A |
possibly damaging |
Het |
| Isg20 |
C |
T |
7: 78,564,076 (GRCm39) |
|
probably benign |
Het |
| Itga11 |
T |
A |
9: 62,642,639 (GRCm39) |
N187K |
probably damaging |
Het |
| Klhl9 |
G |
A |
4: 88,639,161 (GRCm39) |
T360I |
probably damaging |
Het |
| Krt39 |
T |
A |
11: 99,411,826 (GRCm39) |
I87F |
probably benign |
Het |
| Krtap19-4 |
G |
A |
16: 88,681,734 (GRCm39) |
S74F |
unknown |
Het |
| Lgi1 |
G |
A |
19: 38,289,737 (GRCm39) |
V268I |
probably damaging |
Het |
| Lrrc46 |
G |
A |
11: 96,925,719 (GRCm39) |
P248S |
probably benign |
Het |
| Lrrn4 |
C |
T |
2: 132,721,488 (GRCm39) |
V110I |
probably benign |
Het |
| Mamstr |
C |
A |
7: 45,294,116 (GRCm39) |
|
probably benign |
Het |
| Micu3 |
T |
A |
8: 40,833,718 (GRCm39) |
F451I |
probably damaging |
Het |
| Mid1 |
C |
A |
X: 168,768,044 (GRCm39) |
D130E |
possibly damaging |
Het |
| Mkks |
T |
C |
2: 136,722,201 (GRCm39) |
T319A |
probably benign |
Het |
| Mob3c |
A |
G |
4: 115,690,968 (GRCm39) |
|
probably null |
Het |
| Muc6 |
T |
C |
7: 141,230,554 (GRCm39) |
E1192G |
probably benign |
Het |
| Ndc80 |
A |
G |
17: 71,827,753 (GRCm39) |
|
probably null |
Het |
| Nfx1 |
A |
G |
4: 41,012,070 (GRCm39) |
K807E |
probably benign |
Het |
| Nrxn1 |
A |
T |
17: 90,930,850 (GRCm39) |
L181Q |
probably damaging |
Het |
| Nsun7 |
A |
G |
5: 66,418,407 (GRCm39) |
S46G |
probably benign |
Het |
| Nup98 |
A |
T |
7: 101,834,038 (GRCm39) |
L308H |
probably damaging |
Het |
| Or4c115 |
C |
A |
2: 88,927,860 (GRCm39) |
W137L |
probably benign |
Het |
| Or52j3 |
T |
C |
7: 102,836,098 (GRCm39) |
F97L |
probably damaging |
Het |
| Or6f2 |
T |
C |
7: 139,756,141 (GRCm39) |
V36A |
probably benign |
Het |
| Or8k32 |
T |
C |
2: 86,369,077 (GRCm39) |
M61V |
possibly damaging |
Het |
| Palb2 |
T |
C |
7: 121,726,589 (GRCm39) |
K427R |
probably damaging |
Het |
| Pcdha1 |
C |
A |
18: 37,063,965 (GRCm39) |
Q210K |
probably benign |
Het |
| Pcdhb2 |
T |
C |
18: 37,429,260 (GRCm39) |
L411P |
probably damaging |
Het |
| Plekhg4 |
T |
A |
8: 106,107,003 (GRCm39) |
Y899* |
probably null |
Het |
| Plxnb2 |
G |
T |
15: 89,045,131 (GRCm39) |
T1105K |
probably benign |
Het |
| Psmd2 |
T |
C |
16: 20,478,719 (GRCm39) |
V606A |
probably damaging |
Het |
| Ptprq |
A |
T |
10: 107,521,043 (GRCm39) |
F710I |
probably benign |
Het |
| Rad51ap2 |
A |
G |
12: 11,506,552 (GRCm39) |
E158G |
probably damaging |
Het |
| Rasip1 |
T |
A |
7: 45,277,247 (GRCm39) |
H18Q |
possibly damaging |
Het |
| Rassf8 |
A |
G |
6: 145,760,808 (GRCm39) |
K45E |
probably damaging |
Het |
| Rrn3 |
T |
A |
16: 13,613,940 (GRCm39) |
M284K |
probably damaging |
Het |
| Rsf1 |
GGCG |
GGCGACGGCTGCG |
7: 97,229,113 (GRCm39) |
|
probably benign |
Het |
| Rtn2 |
C |
A |
7: 19,027,820 (GRCm39) |
N403K |
probably damaging |
Het |
| Rusc1 |
A |
G |
3: 88,997,027 (GRCm39) |
W462R |
probably damaging |
Het |
| Sdc3 |
T |
A |
4: 130,545,907 (GRCm39) |
|
probably benign |
Het |
| Secisbp2l |
C |
T |
2: 125,582,657 (GRCm39) |
G933D |
possibly damaging |
Het |
| Slc12a2 |
T |
A |
18: 58,039,032 (GRCm39) |
C537* |
probably null |
Het |
| Slc4a2 |
G |
A |
5: 24,639,238 (GRCm39) |
|
probably null |
Het |
| Spsb4 |
T |
A |
9: 96,877,744 (GRCm39) |
D193V |
probably damaging |
Het |
| Strn |
A |
C |
17: 78,984,780 (GRCm39) |
F288V |
probably damaging |
Het |
| Stx18 |
G |
A |
5: 38,293,712 (GRCm39) |
|
probably benign |
Het |
| Tfcp2l1 |
T |
A |
1: 118,596,378 (GRCm39) |
M371K |
probably benign |
Het |
| Thnsl1 |
A |
G |
2: 21,216,352 (GRCm39) |
|
probably null |
Het |
| Tlr11 |
C |
T |
14: 50,598,439 (GRCm39) |
H142Y |
possibly damaging |
Het |
| Tor1aip2 |
T |
A |
1: 155,940,780 (GRCm39) |
I362K |
probably damaging |
Het |
| Trmt13 |
T |
C |
3: 116,383,404 (GRCm39) |
K125E |
probably damaging |
Het |
| Trpm8 |
T |
C |
1: 88,264,851 (GRCm39) |
V320A |
probably benign |
Het |
| Ubr3 |
A |
T |
2: 69,766,263 (GRCm39) |
H377L |
probably damaging |
Het |
| Usp8 |
A |
G |
2: 126,567,349 (GRCm39) |
R123G |
probably null |
Het |
| Vim |
T |
A |
2: 13,579,775 (GRCm39) |
L178Q |
probably damaging |
Het |
| Vmn1r231 |
A |
C |
17: 21,110,489 (GRCm39) |
V142G |
possibly damaging |
Het |
| Vmn1r83 |
A |
G |
7: 12,055,697 (GRCm39) |
M120T |
possibly damaging |
Het |
| Vwce |
G |
T |
19: 10,642,012 (GRCm39) |
V913F |
possibly damaging |
Het |
| Zbtb18 |
C |
A |
1: 177,275,285 (GRCm39) |
T215K |
probably benign |
Het |
| Zeb2 |
A |
T |
2: 44,886,353 (GRCm39) |
D857E |
probably damaging |
Het |
| Zfp106 |
G |
A |
2: 120,364,221 (GRCm39) |
H729Y |
probably damaging |
Het |
| Zfp977 |
C |
A |
7: 42,229,437 (GRCm39) |
A363S |
probably benign |
Het |
|
| Other mutations in Pde4dip |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00332:Pde4dip
|
APN |
3 |
97,674,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00543:Pde4dip
|
APN |
3 |
97,664,940 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL00979:Pde4dip
|
APN |
3 |
97,655,074 (GRCm39) |
splice site |
probably benign |
|
|
IGL01483:Pde4dip
|
APN |
3 |
97,661,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02122:Pde4dip
|
APN |
3 |
97,674,737 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02398:Pde4dip
|
APN |
3 |
97,674,097 (GRCm39) |
missense |
probably benign |
|
|
IGL02814:Pde4dip
|
APN |
3 |
97,674,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02826:Pde4dip
|
APN |
3 |
97,674,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D3080:Pde4dip
|
UTSW |
3 |
97,674,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0077:Pde4dip
|
UTSW |
3 |
97,660,442 (GRCm39) |
nonsense |
probably null |
|
|
R0096:Pde4dip
|
UTSW |
3 |
97,674,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0277:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0304:Pde4dip
|
UTSW |
3 |
97,751,028 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0616:Pde4dip
|
UTSW |
3 |
97,654,849 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0676:Pde4dip
|
UTSW |
3 |
97,624,413 (GRCm39) |
splice site |
probably benign |
|
|
R1166:Pde4dip
|
UTSW |
3 |
97,620,512 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1376:Pde4dip
|
UTSW |
3 |
97,650,533 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1452:Pde4dip
|
UTSW |
3 |
97,631,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1550:Pde4dip
|
UTSW |
3 |
97,627,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1700:Pde4dip
|
UTSW |
3 |
97,610,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1704:Pde4dip
|
UTSW |
3 |
97,661,576 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1769:Pde4dip
|
UTSW |
3 |
97,603,246 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1934:Pde4dip
|
UTSW |
3 |
97,600,007 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1980:Pde4dip
|
UTSW |
3 |
97,664,312 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2088:Pde4dip
|
UTSW |
3 |
97,661,749 (GRCm39) |
missense |
probably null |
1.00 |
|
R2143:Pde4dip
|
UTSW |
3 |
97,795,835 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2149:Pde4dip
|
UTSW |
3 |
97,700,152 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2156:Pde4dip
|
UTSW |
3 |
97,631,534 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2158:Pde4dip
|
UTSW |
3 |
97,664,937 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2240:Pde4dip
|
UTSW |
3 |
97,631,480 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2249:Pde4dip
|
UTSW |
3 |
97,700,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2256:Pde4dip
|
UTSW |
3 |
97,625,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2680:Pde4dip
|
UTSW |
3 |
97,608,933 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2921:Pde4dip
|
UTSW |
3 |
97,626,885 (GRCm39) |
missense |
probably benign |
|
|
R3407:Pde4dip
|
UTSW |
3 |
97,661,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3736:Pde4dip
|
UTSW |
3 |
97,631,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3787:Pde4dip
|
UTSW |
3 |
97,622,868 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3883:Pde4dip
|
UTSW |
3 |
97,620,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4437:Pde4dip
|
UTSW |
3 |
97,673,885 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R4528:Pde4dip
|
UTSW |
3 |
97,624,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4576:Pde4dip
|
UTSW |
3 |
97,661,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4600:Pde4dip
|
UTSW |
3 |
97,603,260 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4653:Pde4dip
|
UTSW |
3 |
97,674,654 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4679:Pde4dip
|
UTSW |
3 |
97,602,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4688:Pde4dip
|
UTSW |
3 |
97,750,993 (GRCm39) |
nonsense |
probably null |
|
|
R4770:Pde4dip
|
UTSW |
3 |
97,674,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4841:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4842:Pde4dip
|
UTSW |
3 |
97,700,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4899:Pde4dip
|
UTSW |
3 |
97,616,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Pde4dip
|
UTSW |
3 |
97,622,644 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4943:Pde4dip
|
UTSW |
3 |
97,662,827 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5131:Pde4dip
|
UTSW |
3 |
97,616,830 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5408:Pde4dip
|
UTSW |
3 |
97,704,052 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5583:Pde4dip
|
UTSW |
3 |
97,654,892 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R5677:Pde4dip
|
UTSW |
3 |
97,748,964 (GRCm39) |
nonsense |
probably null |
|
|
R5689:Pde4dip
|
UTSW |
3 |
97,599,683 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Pde4dip
|
UTSW |
3 |
97,616,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5860:Pde4dip
|
UTSW |
3 |
97,631,504 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6279:Pde4dip
|
UTSW |
3 |
97,606,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6341:Pde4dip
|
UTSW |
3 |
97,602,227 (GRCm39) |
missense |
probably benign |
|
|
R6440:Pde4dip
|
UTSW |
3 |
97,674,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Pde4dip
|
UTSW |
3 |
97,617,660 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6489:Pde4dip
|
UTSW |
3 |
97,662,907 (GRCm39) |
nonsense |
probably null |
|
|
R6706:Pde4dip
|
UTSW |
3 |
97,648,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6722:Pde4dip
|
UTSW |
3 |
97,625,555 (GRCm39) |
nonsense |
probably null |
|
|
R6798:Pde4dip
|
UTSW |
3 |
97,795,850 (GRCm39) |
missense |
probably benign |
|
|
R6804:Pde4dip
|
UTSW |
3 |
97,700,564 (GRCm39) |
nonsense |
probably null |
|
|
R6862:Pde4dip
|
UTSW |
3 |
97,674,340 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6957:Pde4dip
|
UTSW |
3 |
97,731,649 (GRCm39) |
splice site |
probably null |
|
|
R6983:Pde4dip
|
UTSW |
3 |
97,625,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7014:Pde4dip
|
UTSW |
3 |
97,622,738 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7025:Pde4dip
|
UTSW |
3 |
97,631,499 (GRCm39) |
nonsense |
probably null |
|
|
R7136:Pde4dip
|
UTSW |
3 |
97,601,379 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7178:Pde4dip
|
UTSW |
3 |
97,622,946 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7269:Pde4dip
|
UTSW |
3 |
97,674,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Pde4dip
|
UTSW |
3 |
97,666,198 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7354:Pde4dip
|
UTSW |
3 |
97,626,646 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7357:Pde4dip
|
UTSW |
3 |
97,622,857 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7360:Pde4dip
|
UTSW |
3 |
97,625,632 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7371:Pde4dip
|
UTSW |
3 |
97,664,587 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7432:Pde4dip
|
UTSW |
3 |
97,602,408 (GRCm39) |
missense |
probably benign |
|
|
R7536:Pde4dip
|
UTSW |
3 |
97,664,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7542:Pde4dip
|
UTSW |
3 |
97,673,971 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7609:Pde4dip
|
UTSW |
3 |
97,622,881 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7650:Pde4dip
|
UTSW |
3 |
97,606,423 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7800:Pde4dip
|
UTSW |
3 |
97,622,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Pde4dip
|
UTSW |
3 |
97,622,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Pde4dip
|
UTSW |
3 |
97,622,539 (GRCm39) |
nonsense |
probably null |
|
|
R8120:Pde4dip
|
UTSW |
3 |
97,614,254 (GRCm39) |
missense |
probably null |
0.94 |
|
R8139:Pde4dip
|
UTSW |
3 |
97,604,309 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8144:Pde4dip
|
UTSW |
3 |
97,622,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8177:Pde4dip
|
UTSW |
3 |
97,674,848 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8294:Pde4dip
|
UTSW |
3 |
97,674,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8406:Pde4dip
|
UTSW |
3 |
97,606,428 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8911:Pde4dip
|
UTSW |
3 |
97,650,917 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8912:Pde4dip
|
UTSW |
3 |
97,617,633 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8960:Pde4dip
|
UTSW |
3 |
97,700,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8993:Pde4dip
|
UTSW |
3 |
97,673,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9031:Pde4dip
|
UTSW |
3 |
97,599,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9032:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9085:Pde4dip
|
UTSW |
3 |
97,601,385 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9103:Pde4dip
|
UTSW |
3 |
97,749,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9163:Pde4dip
|
UTSW |
3 |
97,659,123 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9182:Pde4dip
|
UTSW |
3 |
97,602,314 (GRCm39) |
missense |
probably benign |
0.13 |
|
R9185:Pde4dip
|
UTSW |
3 |
97,666,132 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9286:Pde4dip
|
UTSW |
3 |
97,607,183 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9357:Pde4dip
|
UTSW |
3 |
97,625,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9415:Pde4dip
|
UTSW |
3 |
97,660,468 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9500:Pde4dip
|
UTSW |
3 |
97,795,896 (GRCm39) |
missense |
unknown |
|
|
R9595:Pde4dip
|
UTSW |
3 |
97,602,207 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9689:Pde4dip
|
UTSW |
3 |
97,649,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9720:Pde4dip
|
UTSW |
3 |
97,603,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCGCAAAGAAGGTGCAGC -3'
(R):5'- TGCCATCCTATAGTTTTGAAGGC -3'
Sequencing Primer
(F):5'- TGCAGCCAGAGTACGAGC -3'
(R):5'- ATCCCCTTGGAGTTCGAACTGAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation