Incidental Mutation 'R3162:Vmn2r86'
ID 349857
Institutional Source Beutler Lab
Gene Symbol Vmn2r86
Ensembl Gene ENSMUSG00000092162
Gene Name vomeronasal 2, receptor 86
Synonyms EG625109
MMRRC Submission 040613-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R3162 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 130282068-130291763 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 130291673 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glycine at position 31 (R31G)
Ref Sequence ENSEMBL: ENSMUSP00000126596 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170257]
AlphaFold G5E8Y4
Predicted Effect probably damaging
Transcript: ENSMUST00000170257
AA Change: R31G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: R31G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 77 425 1.1e-25 PFAM
Pfam:NCD3G 508 562 2.4e-19 PFAM
Pfam:7tm_3 595 829 6.4e-55 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.9%
Validation Efficiency 98% (62/63)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933412E24Rik T A 15: 59,888,134 (GRCm39) E102V probably damaging Het
9930014A18Rik A T 15: 60,695,296 (GRCm39) V150E probably damaging Het
Adcy9 A G 16: 4,129,452 (GRCm39) L715P probably damaging Het
Atad2b C A 12: 4,989,689 (GRCm39) N133K possibly damaging Het
AW551984 C A 9: 39,504,325 (GRCm39) R547L probably damaging Het
B3galt6 A G 4: 156,076,464 (GRCm39) Y204H probably benign Het
Camk1g T C 1: 193,042,115 (GRCm39) T45A possibly damaging Het
Caps2 C A 10: 112,018,391 (GRCm39) Y180* probably null Het
Cfap54 T A 10: 92,881,140 (GRCm39) K349N probably damaging Het
Copa T A 1: 171,918,800 (GRCm39) C127S probably damaging Het
Dapk2 T G 9: 66,161,893 (GRCm39) V267G probably damaging Het
Ddb1 T C 19: 10,603,335 (GRCm39) L881P probably damaging Het
Decr1 T A 4: 15,930,972 (GRCm39) D120V probably damaging Het
Dennd1c C T 17: 57,373,562 (GRCm39) G637D possibly damaging Het
Dhrs3 A G 4: 144,646,016 (GRCm39) D108G possibly damaging Het
Disp1 T C 1: 182,868,806 (GRCm39) K1205E probably benign Het
Dusp6 T C 10: 99,099,944 (GRCm39) Y131H probably damaging Het
Eif2b2 A T 12: 85,266,435 (GRCm39) M34L probably benign Het
Errfi1 G A 4: 150,951,816 (GRCm39) E415K probably damaging Het
Ext1 T C 15: 53,208,000 (GRCm39) N254D possibly damaging Het
Gm13141 GGTTTCTTGATGCC G 4: 147,612,561 (GRCm39) noncoding transcript Het
Hnrnpu T C 1: 178,158,690 (GRCm39) probably benign Het
Hpx C T 7: 105,248,847 (GRCm39) probably benign Het
Hyal3 T A 9: 107,464,005 (GRCm39) C407S probably damaging Het
Insr T G 8: 3,211,416 (GRCm39) N1141T possibly damaging Het
Ipo9 T C 1: 135,337,214 (GRCm39) T174A probably benign Het
Ivd T C 2: 118,692,650 (GRCm39) probably null Het
Leprot C T 4: 101,515,090 (GRCm39) T89I probably damaging Het
Msh6 T C 17: 88,292,909 (GRCm39) Y555H probably damaging Het
Nup155 G T 15: 8,177,867 (GRCm39) R1083S possibly damaging Het
Nusap1 A T 2: 119,460,885 (GRCm39) Q126L possibly damaging Het
Or13c7b T A 4: 43,820,544 (GRCm39) K272N probably benign Het
Or5al1 T C 2: 85,990,439 (GRCm39) I92V probably benign Het
Or6x1 G T 9: 40,098,901 (GRCm39) Q163H probably benign Het
Or7a35 C A 10: 78,853,438 (GRCm39) T94N probably benign Het
Pdik1l A G 4: 134,011,561 (GRCm39) L94S probably damaging Het
Pkdrej T A 15: 85,700,818 (GRCm39) D1706V probably damaging Het
Pkhd1l1 A G 15: 44,368,924 (GRCm39) I856M probably damaging Het
Prkcz A T 4: 155,374,981 (GRCm39) D114E probably benign Het
Psap T C 10: 60,113,575 (GRCm39) L4P possibly damaging Het
Ptprk T C 10: 28,468,822 (GRCm39) V1402A probably benign Het
Rai14 T C 15: 10,633,250 (GRCm39) T47A possibly damaging Het
Rlf A G 4: 121,006,044 (GRCm39) S979P probably damaging Het
Skic2 C T 17: 35,066,789 (GRCm39) W88* probably null Het
Skic8 T A 9: 54,631,473 (GRCm39) probably benign Het
Srbd1 A T 17: 86,437,643 (GRCm39) D233E probably benign Het
Tacr2 A G 10: 62,101,024 (GRCm39) D378G probably benign Het
Taok2 A G 7: 126,474,347 (GRCm39) I294T possibly damaging Het
Tert A G 13: 73,775,528 (GRCm39) E93G possibly damaging Het
Tns2 A G 15: 102,021,771 (GRCm39) E1118G possibly damaging Het
Ttc22 A T 4: 106,480,276 (GRCm39) I177F probably damaging Het
Wnt5a T C 14: 28,244,445 (GRCm39) Y231H probably benign Het
Zw10 T C 9: 48,988,860 (GRCm39) Y709H probably damaging Het
Other mutations in Vmn2r86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Vmn2r86 APN 10 130,288,895 (GRCm39) missense probably damaging 0.99
IGL01328:Vmn2r86 APN 10 130,288,365 (GRCm39) missense possibly damaging 0.78
IGL01377:Vmn2r86 APN 10 130,288,855 (GRCm39) missense probably damaging 0.99
IGL01548:Vmn2r86 APN 10 130,282,151 (GRCm39) missense probably benign 0.22
IGL01804:Vmn2r86 APN 10 130,288,858 (GRCm39) missense probably damaging 0.99
IGL01921:Vmn2r86 APN 10 130,291,610 (GRCm39) missense probably benign 0.00
IGL02406:Vmn2r86 APN 10 130,284,508 (GRCm39) missense possibly damaging 0.81
IGL02625:Vmn2r86 APN 10 130,288,781 (GRCm39) missense probably damaging 1.00
IGL02960:Vmn2r86 APN 10 130,289,636 (GRCm39) missense possibly damaging 0.74
IGL03104:Vmn2r86 APN 10 130,282,501 (GRCm39) missense probably damaging 1.00
R0408:Vmn2r86 UTSW 10 130,282,723 (GRCm39) missense probably damaging 1.00
R0437:Vmn2r86 UTSW 10 130,282,412 (GRCm39) missense probably damaging 1.00
R0577:Vmn2r86 UTSW 10 130,288,444 (GRCm39) missense probably benign 0.04
R0726:Vmn2r86 UTSW 10 130,282,265 (GRCm39) missense probably damaging 1.00
R0811:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R0812:Vmn2r86 UTSW 10 130,289,497 (GRCm39) missense probably benign 0.00
R1055:Vmn2r86 UTSW 10 130,282,226 (GRCm39) missense probably damaging 1.00
R1066:Vmn2r86 UTSW 10 130,282,145 (GRCm39) missense probably benign 0.01
R1199:Vmn2r86 UTSW 10 130,284,443 (GRCm39) splice site probably benign
R1332:Vmn2r86 UTSW 10 130,282,739 (GRCm39) missense probably damaging 1.00
R1568:Vmn2r86 UTSW 10 130,289,010 (GRCm39) missense probably benign 0.09
R1866:Vmn2r86 UTSW 10 130,282,255 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r86 UTSW 10 130,288,314 (GRCm39) missense probably damaging 1.00
R2017:Vmn2r86 UTSW 10 130,282,582 (GRCm39) missense probably benign 0.39
R3162:Vmn2r86 UTSW 10 130,291,673 (GRCm39) missense probably damaging 0.99
R3858:Vmn2r86 UTSW 10 130,291,594 (GRCm39) missense probably benign
R4049:Vmn2r86 UTSW 10 130,282,966 (GRCm39) missense probably damaging 0.98
R4378:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4411:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4413:Vmn2r86 UTSW 10 130,288,469 (GRCm39) missense possibly damaging 0.67
R4422:Vmn2r86 UTSW 10 130,288,845 (GRCm39) missense possibly damaging 0.87
R4738:Vmn2r86 UTSW 10 130,282,939 (GRCm39) missense probably damaging 0.99
R4767:Vmn2r86 UTSW 10 130,291,606 (GRCm39) missense probably benign 0.00
R4872:Vmn2r86 UTSW 10 130,289,460 (GRCm39) missense probably damaging 0.98
R4880:Vmn2r86 UTSW 10 130,289,484 (GRCm39) missense probably benign 0.33
R5092:Vmn2r86 UTSW 10 130,282,456 (GRCm39) missense probably damaging 1.00
R5421:Vmn2r86 UTSW 10 130,282,805 (GRCm39) missense probably benign 0.41
R6007:Vmn2r86 UTSW 10 130,289,535 (GRCm39) missense probably damaging 1.00
R6330:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R6355:Vmn2r86 UTSW 10 130,291,763 (GRCm39) start codon destroyed probably damaging 0.98
R6397:Vmn2r86 UTSW 10 130,282,131 (GRCm39) nonsense probably null
R6419:Vmn2r86 UTSW 10 130,282,795 (GRCm39) missense probably damaging 1.00
R6933:Vmn2r86 UTSW 10 130,282,126 (GRCm39) missense probably damaging 1.00
R6937:Vmn2r86 UTSW 10 130,284,523 (GRCm39) missense probably damaging 1.00
R6959:Vmn2r86 UTSW 10 130,282,400 (GRCm39) missense probably damaging 1.00
R7010:Vmn2r86 UTSW 10 130,291,726 (GRCm39) missense probably benign
R7549:Vmn2r86 UTSW 10 130,282,697 (GRCm39) missense probably damaging 1.00
R8179:Vmn2r86 UTSW 10 130,288,953 (GRCm39) missense probably benign 0.00
R8257:Vmn2r86 UTSW 10 130,288,279 (GRCm39) missense possibly damaging 0.87
R8286:Vmn2r86 UTSW 10 130,285,855 (GRCm39) missense probably benign 0.03
R8479:Vmn2r86 UTSW 10 130,282,735 (GRCm39) missense probably damaging 1.00
R8805:Vmn2r86 UTSW 10 130,282,396 (GRCm39) missense probably benign 0.05
R8960:Vmn2r86 UTSW 10 130,289,672 (GRCm39) missense probably benign 0.27
R9021:Vmn2r86 UTSW 10 130,282,934 (GRCm39) missense probably damaging 1.00
R9120:Vmn2r86 UTSW 10 130,289,677 (GRCm39) missense probably benign 0.00
R9137:Vmn2r86 UTSW 10 130,282,409 (GRCm39) missense probably damaging 1.00
R9311:Vmn2r86 UTSW 10 130,288,440 (GRCm39) missense probably damaging 1.00
R9312:Vmn2r86 UTSW 10 130,288,406 (GRCm39) missense probably benign 0.02
R9433:Vmn2r86 UTSW 10 130,282,567 (GRCm39) missense possibly damaging 0.88
R9696:Vmn2r86 UTSW 10 130,285,702 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- CAGGACAGAACACACAGTTTG -3'
(R):5'- GGATCTCCAGACAGCAGTATCC -3'

Sequencing Primer
(F):5'- CAGTTTGTGTACATGGCTAAA -3'
(R):5'- GTATCCTTAAAACAGACACATAGGTC -3'
Posted On 2015-10-08