Incidental Mutation 'R0267:Ccdc63'
ID 34989
Institutional Source Beutler Lab
Gene Symbol Ccdc63
Ensembl Gene ENSMUSG00000043036
Gene Name coiled-coil domain containing 63
Synonyms 4921511C16Rik
MMRRC Submission 038493-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R0267 (G1)
Quality Score 183
Status Validated
Chromosome 5
Chromosomal Location 122246115-122276143 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 122255107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000114143 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058960] [ENSMUST00000111751] [ENSMUST00000152389]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000058960
SMART Domains Protein: ENSMUSP00000050582
Gene: ENSMUSG00000043036

DomainStartEndE-ValueType
coiled coil region 140 158 N/A INTRINSIC
coiled coil region 209 285 N/A INTRINSIC
low complexity region 308 318 N/A INTRINSIC
coiled coil region 393 438 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111751
SMART Domains Protein: ENSMUSP00000107380
Gene: ENSMUSG00000013936

DomainStartEndE-ValueType
EFh 28 56 2.81e-5 SMART
EFh 98 126 4.53e0 SMART
EFh 134 162 3.97e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152389
Coding Region Coverage
  • 1x: 98.6%
  • 3x: 97.7%
  • 10x: 96.2%
  • 20x: 94.0%
Validation Efficiency 97% (64/66)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A G 4: 53,046,105 (GRCm39) F1721S probably damaging Het
Adgrb1 G A 15: 74,401,238 (GRCm39) R78H probably damaging Het
Adgrd1 G A 5: 129,216,658 (GRCm39) A342T probably benign Het
Adrb1 A T 19: 56,711,923 (GRCm39) K374* probably null Het
Aldh18a1 C A 19: 40,562,233 (GRCm39) V264F probably benign Het
Aldh1l2 C T 10: 83,358,551 (GRCm39) probably benign Het
Alox15 T A 11: 70,236,979 (GRCm39) H393L probably damaging Het
Aox1 A G 1: 58,378,605 (GRCm39) probably benign Het
Appbp2 T C 11: 85,092,288 (GRCm39) Y297C probably damaging Het
Atxn2l T G 7: 126,092,379 (GRCm39) Q950P probably damaging Het
Bicd1 A T 6: 149,418,540 (GRCm39) D737V probably damaging Het
C9 T C 15: 6,496,939 (GRCm39) I212T probably benign Het
Chst1 C A 2: 92,443,951 (GRCm39) P141Q probably damaging Het
Cped1 T A 6: 22,119,475 (GRCm39) F311L probably damaging Het
D6Wsu163e T A 6: 126,923,454 (GRCm39) H113Q probably benign Het
Dcn A T 10: 97,342,345 (GRCm39) probably benign Het
Dmbx1 C T 4: 115,775,309 (GRCm39) A324T probably benign Het
Dock10 G T 1: 80,490,171 (GRCm39) Q1618K probably damaging Het
Dpyd A G 3: 118,710,921 (GRCm39) E443G probably benign Het
Espl1 T C 15: 102,221,452 (GRCm39) V953A possibly damaging Het
Exosc10 T C 4: 148,647,213 (GRCm39) L174P probably damaging Het
Foxg1 A G 12: 49,432,365 (GRCm39) Y366C probably damaging Het
Fxyd3 T C 7: 30,770,159 (GRCm39) probably benign Het
Gbp2 T C 3: 142,335,867 (GRCm39) V189A probably benign Het
Gins4 T C 8: 23,719,426 (GRCm39) probably benign Het
Gm12789 A G 4: 101,845,319 (GRCm39) T3A probably benign Het
Gnb1l T C 16: 18,366,839 (GRCm39) probably benign Het
Gtpbp3 T C 8: 71,944,141 (GRCm39) L295S probably damaging Het
Hrh4 C A 18: 13,155,455 (GRCm39) Y331* probably null Het
Hsd11b1 A T 1: 192,923,705 (GRCm39) Y52N probably damaging Het
Jam3 A G 9: 27,017,701 (GRCm39) I29T probably benign Het
Kctd16 T A 18: 40,663,930 (GRCm39) I353N probably benign Het
Lama4 G T 10: 38,904,635 (GRCm39) G246C probably damaging Het
Lhx3 T A 2: 26,093,040 (GRCm39) M137L probably benign Het
Morc2a T C 11: 3,628,567 (GRCm39) I340T probably benign Het
Myo7a A C 7: 97,703,831 (GRCm39) I1969S probably benign Het
Or14a258 T C 7: 86,035,475 (GRCm39) E131G possibly damaging Het
Or5b116 T A 19: 13,422,792 (GRCm39) C139S probably damaging Het
Or6n1 A G 1: 173,916,732 (GRCm39) N42S probably damaging Het
Pclo T C 5: 14,731,194 (GRCm39) L3232P unknown Het
Polr1a T G 6: 71,951,123 (GRCm39) I1407M probably damaging Het
Ppip5k2 A G 1: 97,656,722 (GRCm39) V817A probably damaging Het
Rbfox3 T C 11: 118,386,066 (GRCm39) T280A probably benign Het
Rfx3 T C 19: 27,771,188 (GRCm39) D521G probably benign Het
Scn5a C T 9: 119,372,201 (GRCm39) V223I probably damaging Het
Sgsm3 T G 15: 80,890,803 (GRCm39) M119R probably damaging Het
Slc6a7 T A 18: 61,129,783 (GRCm39) M608L probably benign Het
Slit2 A G 5: 48,339,673 (GRCm39) probably benign Het
Steap2 T A 5: 5,723,561 (GRCm39) I440F probably benign Het
Syn2 T G 6: 115,231,111 (GRCm39) probably benign Het
Taar2 G A 10: 23,817,393 (GRCm39) R311H probably benign Het
Tfb2m G A 1: 179,361,203 (GRCm39) H262Y probably benign Het
Trmt1l A G 1: 151,333,426 (GRCm39) probably benign Het
Trpm6 C A 19: 18,800,742 (GRCm39) P819T probably benign Het
Ttn G A 2: 76,574,033 (GRCm39) A25620V probably damaging Het
Ubn2 T C 6: 38,459,553 (GRCm39) probably null Het
Vars1 T C 17: 35,230,572 (GRCm39) probably benign Het
Vip A T 10: 5,594,004 (GRCm39) D119V possibly damaging Het
Vmn2r92 C T 17: 18,388,219 (GRCm39) A408V probably damaging Het
Vps33b T C 7: 79,935,802 (GRCm39) I405T possibly damaging Het
Zbtb21 T A 16: 97,753,300 (GRCm39) S356C probably damaging Het
Zdhhc6 A T 19: 55,297,362 (GRCm39) S237T probably benign Het
Zfp142 G A 1: 74,615,223 (GRCm39) A427V probably benign Het
Zfp692 T A 11: 58,205,140 (GRCm39) V463E possibly damaging Het
Zmynd8 A T 2: 165,670,322 (GRCm39) I384N probably damaging Het
Other mutations in Ccdc63
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00919:Ccdc63 APN 5 122,262,982 (GRCm39) splice site probably benign
IGL01660:Ccdc63 APN 5 122,249,027 (GRCm39) missense possibly damaging 0.81
IGL01773:Ccdc63 APN 5 122,251,208 (GRCm39) missense possibly damaging 0.93
IGL02341:Ccdc63 APN 5 122,251,261 (GRCm39) missense probably benign 0.00
IGL03030:Ccdc63 APN 5 122,260,876 (GRCm39) missense probably benign 0.00
IGL02991:Ccdc63 UTSW 5 122,246,275 (GRCm39) missense probably benign 0.10
R0961:Ccdc63 UTSW 5 122,249,009 (GRCm39) missense possibly damaging 0.75
R1333:Ccdc63 UTSW 5 122,246,224 (GRCm39) missense probably benign 0.04
R1802:Ccdc63 UTSW 5 122,267,940 (GRCm39) missense probably damaging 1.00
R1999:Ccdc63 UTSW 5 122,265,628 (GRCm39) missense possibly damaging 0.72
R2048:Ccdc63 UTSW 5 122,268,350 (GRCm39) critical splice donor site probably null
R2150:Ccdc63 UTSW 5 122,265,628 (GRCm39) missense possibly damaging 0.72
R2350:Ccdc63 UTSW 5 122,260,948 (GRCm39) missense probably benign 0.04
R4049:Ccdc63 UTSW 5 122,260,813 (GRCm39) missense probably damaging 0.99
R5072:Ccdc63 UTSW 5 122,259,118 (GRCm39) missense probably benign 0.28
R5847:Ccdc63 UTSW 5 122,254,908 (GRCm39) missense possibly damaging 0.78
R6031:Ccdc63 UTSW 5 122,267,799 (GRCm39) missense possibly damaging 0.74
R6031:Ccdc63 UTSW 5 122,267,799 (GRCm39) missense possibly damaging 0.74
R6249:Ccdc63 UTSW 5 122,263,062 (GRCm39) missense probably benign 0.17
R6782:Ccdc63 UTSW 5 122,249,077 (GRCm39) nonsense probably null
R7073:Ccdc63 UTSW 5 122,249,073 (GRCm39) missense probably benign 0.00
R7250:Ccdc63 UTSW 5 122,260,906 (GRCm39) missense probably damaging 1.00
R7448:Ccdc63 UTSW 5 122,246,245 (GRCm39) missense probably benign 0.00
R7584:Ccdc63 UTSW 5 122,251,267 (GRCm39) missense possibly damaging 0.73
R7773:Ccdc63 UTSW 5 122,247,335 (GRCm39) missense probably damaging 1.00
R7856:Ccdc63 UTSW 5 122,268,006 (GRCm39) missense probably benign 0.00
R8114:Ccdc63 UTSW 5 122,251,244 (GRCm39) missense possibly damaging 0.87
R8933:Ccdc63 UTSW 5 122,251,265 (GRCm39) missense probably damaging 1.00
R9036:Ccdc63 UTSW 5 122,247,346 (GRCm39) missense probably benign 0.08
R9136:Ccdc63 UTSW 5 122,259,146 (GRCm39) missense probably damaging 1.00
X0028:Ccdc63 UTSW 5 122,247,238 (GRCm39) missense possibly damaging 0.50
Predicted Primers PCR Primer
(F):5'- TCGGGGAAAACCCTTGAAAGCC -3'
(R):5'- tcttcgtgtctgTGCGTCATCG -3'

Sequencing Primer
(F):5'- GCATGGTCTCCATGTCATTG -3'
(R):5'- TTCCTCCCCAAGACAGTATGGA -3'
Posted On 2013-05-09