|Institutional Source||Beutler Lab|
|Gene Name||histamine receptor H4|
|Is this an essential gene?||Probably non essential (E-score: 0.073)|
|Stock #||R0267 (G1)|
|Chromosomal Location||13006990-13022882 bp(+) (GRCm38)|
|Type of Mutation||nonsense|
|DNA Base Change (assembly)||C to A at 13022398 bp|
|Amino Acid Change||Tyrosine to Stop codon at position 331 (Y331*)|
|Ref Sequence||ENSEMBL: ENSMUSP00000041061 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000041676]|
|Predicted Effect||probably null
AA Change: Y331*
AA Change: Y331*
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||97% (64/66)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a histamine receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit decreased allergic response to airway inflammation and decreased Th2 responses. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hrh4||
(F):5'- GTCCTCGAAGAAAGAGCAGCATCC -3'
(R):5'- GATACTGACTGGTTCTGTGACAGCG -3'
(F):5'- TGAACAGCAGTATCACTGCCTTC -3'
(R):5'- GCTGGTTGCTTTGTCACAC -3'