Incidental Mutation 'R0268:Cdcp3'
ID 35071
Institutional Source Beutler Lab
Gene Symbol Cdcp3
Ensembl Gene ENSMUSG00000006204
Gene Name CUB domain containing protein 3
Synonyms 5430419D17Rik
MMRRC Submission 038494-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0268 (G1)
Quality Score 218
Status Validated
Chromosome 7
Chromosomal Location 130776131-130908180 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 130839905 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 609 (D609G)
Ref Sequence ENSEMBL: ENSMUSP00000150784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050586] [ENSMUST00000124096] [ENSMUST00000208921]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000050586
AA Change: D493G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061529
Gene: ENSMUSG00000006204
AA Change: D493G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 85 105 N/A INTRINSIC
SR 144 244 3.3e-57 SMART
CUB 272 378 1.2e-16 SMART
SR 428 528 3.9e-56 SMART
low complexity region 533 548 N/A INTRINSIC
CUB 556 667 5.1e-38 SMART
SR 680 780 1.5e-57 SMART
Pfam:CUB 795 840 3.1e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

DomainStartEndE-ValueType
Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000128522
Predicted Effect probably damaging
Transcript: ENSMUST00000208921
AA Change: D609G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 98.7%
  • 3x: 97.7%
  • 10x: 95.9%
  • 20x: 93.0%
Validation Efficiency 98% (93/95)
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik T A 7: 29,274,027 (GRCm39) noncoding transcript Het
Aadacl4 A T 4: 144,349,565 (GRCm39) H274L probably benign Het
Aldh1a7 T A 19: 20,686,866 (GRCm39) probably null Het
Ap3m1 A C 14: 21,087,170 (GRCm39) probably benign Het
Atp5f1a C A 18: 77,867,895 (GRCm39) N356K probably damaging Het
AU021092 A T 16: 5,040,031 (GRCm39) M31K possibly damaging Het
Avpr1a T C 10: 122,285,614 (GRCm39) V302A probably damaging Het
Bicral A G 17: 47,124,978 (GRCm39) probably benign Het
Btbd9 C T 17: 30,493,916 (GRCm39) D492N possibly damaging Het
Casp8ap2 A T 4: 32,644,079 (GRCm39) I1051F probably damaging Het
Cd209e T C 8: 3,899,125 (GRCm39) I196V probably benign Het
Cdc42bpa G T 1: 179,983,347 (GRCm39) probably benign Het
Clec16a T A 16: 10,462,692 (GRCm39) L670* probably null Het
Cmtm2b A G 8: 105,049,066 (GRCm39) E27G probably damaging Het
Col4a1 T A 8: 11,317,588 (GRCm39) probably benign Het
Cyp26b1 A T 6: 84,551,554 (GRCm39) F221I probably damaging Het
D430041D05Rik G C 2: 103,998,295 (GRCm39) P1836R probably damaging Het
Dennd6b T C 15: 89,080,432 (GRCm39) Q56R probably benign Het
Dip2c G A 13: 9,687,186 (GRCm39) R1270H probably damaging Het
Dlg1 T C 16: 31,503,011 (GRCm39) C73R probably benign Het
Dnah8 A G 17: 30,988,681 (GRCm39) D3217G probably damaging Het
Dtx1 T C 5: 120,819,356 (GRCm39) E614G probably damaging Het
Dut C A 2: 125,099,011 (GRCm39) A166E probably damaging Het
Ebf1 C A 11: 44,534,240 (GRCm39) D166E probably damaging Het
Egln2 A T 7: 26,864,672 (GRCm39) D84E possibly damaging Het
Exosc7 T A 9: 122,948,025 (GRCm39) S65T probably benign Het
Fam83e G A 7: 45,376,334 (GRCm39) R349Q probably benign Het
Fbxl17 G A 17: 63,692,062 (GRCm39) probably benign Het
Fras1 A G 5: 96,884,868 (GRCm39) N2582S probably damaging Het
Fubp1 T C 3: 151,925,350 (GRCm39) V164A probably damaging Het
Gfral A T 9: 76,104,383 (GRCm39) C210S probably damaging Het
Gls GGCTGCTGCTGCTGCTGCTGCTGCTGCTG GGCTGCTGCTGCTGCTGCTGCTGCTG 1: 52,271,853 (GRCm39) probably benign Het
Hcn4 A C 9: 58,767,445 (GRCm39) E1002A unknown Het
Hcrtr2 A G 9: 76,135,470 (GRCm39) V449A probably benign Het
Hectd1 T C 12: 51,815,891 (GRCm39) S1394G possibly damaging Het
Hectd1 C A 12: 51,815,890 (GRCm39) S1394I probably damaging Het
Hecw2 A G 1: 53,965,857 (GRCm39) probably benign Het
Herc3 A G 6: 58,845,613 (GRCm39) probably benign Het
Ipo4 T C 14: 55,863,399 (GRCm39) Q1073R possibly damaging Het
Itsn2 G A 12: 4,750,333 (GRCm39) R1199Q probably benign Het
Kcnj3 C A 2: 55,484,971 (GRCm39) Y356* probably null Het
Klb T A 5: 65,506,180 (GRCm39) D142E probably benign Het
Klhl35 T A 7: 99,120,958 (GRCm39) S409T probably benign Het
Krt16 T A 11: 100,137,351 (GRCm39) probably benign Het
Krt82 C A 15: 101,450,148 (GRCm39) R516L probably benign Het
Lce3a A T 3: 92,833,038 (GRCm39) C21S unknown Het
Lims2 A G 18: 32,077,573 (GRCm39) E103G probably benign Het
Map2 A T 1: 66,419,881 (GRCm39) K71* probably null Het
Mthfr C G 4: 148,139,885 (GRCm39) S618W probably damaging Het
Mycbp2 T A 14: 103,551,761 (GRCm39) R157* probably null Het
Nat10 C A 2: 103,558,262 (GRCm39) probably benign Het
Obscn G A 11: 58,958,098 (GRCm39) T3810M possibly damaging Het
Or13a19 G A 7: 139,903,068 (GRCm39) S152N possibly damaging Het
Or1x6 T A 11: 50,939,768 (GRCm39) M278K probably damaging Het
Or5d35 A T 2: 87,855,812 (GRCm39) I249F probably damaging Het
Or5g29 A G 2: 85,421,645 (GRCm39) T254A possibly damaging Het
Or6c209 A T 10: 129,483,045 (GRCm39) D16V possibly damaging Het
Or7a38 C T 10: 78,753,439 (GRCm39) T255I probably damaging Het
Park7 A G 4: 150,992,806 (GRCm39) V20A possibly damaging Het
Pgm2 T A 5: 64,263,151 (GRCm39) V266E probably damaging Het
Phip G A 9: 82,753,341 (GRCm39) T1801I probably damaging Het
Pkhd1l1 C A 15: 44,460,407 (GRCm39) H4205Q probably benign Het
Ppp1r12a T A 10: 108,109,242 (GRCm39) probably benign Het
Pramel26 A T 4: 143,537,338 (GRCm39) I331N probably damaging Het
Ptprq A T 10: 107,541,409 (GRCm39) D372E probably benign Het
Ptprr G A 10: 116,088,868 (GRCm39) V340I possibly damaging Het
Qki A G 17: 10,428,575 (GRCm39) probably benign Het
Qpct T A 17: 79,385,081 (GRCm39) D240E probably benign Het
Ren1 A G 1: 133,283,349 (GRCm39) T162A possibly damaging Het
Rif1 T C 2: 51,980,298 (GRCm39) probably null Het
Sart3 A G 5: 113,890,460 (GRCm39) V461A probably damaging Het
Saxo4 A G 19: 10,454,449 (GRCm39) V329A possibly damaging Het
Scgb1b24 G A 7: 33,443,278 (GRCm39) G19R probably null Het
Spen A T 4: 141,204,868 (GRCm39) I1253N unknown Het
Sspo C A 6: 48,442,489 (GRCm39) H1995N probably benign Het
Tfap2c A G 2: 172,393,423 (GRCm39) T113A probably benign Het
Togaram2 T C 17: 72,004,993 (GRCm39) probably null Het
Trim65 T A 11: 116,017,470 (GRCm39) probably benign Het
Trpm3 T A 19: 22,874,885 (GRCm39) probably null Het
Ubxn7 T C 16: 32,178,864 (GRCm39) I87T probably benign Het
Vav1 T C 17: 57,603,090 (GRCm39) F81L probably damaging Het
Vmn2r102 A G 17: 19,898,112 (GRCm39) T376A probably benign Het
Vmn2r105 A T 17: 20,428,938 (GRCm39) C713S probably benign Het
Zbtb45 C T 7: 12,742,254 (GRCm39) M1I probably null Het
Zfp229 A T 17: 21,964,822 (GRCm39) M351L probably benign Het
Zfp932 T C 5: 110,156,929 (GRCm39) I176T probably benign Het
Zswim1 G A 2: 164,668,046 (GRCm39) E433K probably damaging Het
Other mutations in Cdcp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Cdcp3 APN 7 130,839,823 (GRCm39) splice site probably null
IGL00848:Cdcp3 APN 7 130,848,453 (GRCm39) missense probably damaging 1.00
IGL00966:Cdcp3 APN 7 130,844,836 (GRCm39) nonsense probably null
IGL01286:Cdcp3 APN 7 130,848,432 (GRCm39) missense probably damaging 1.00
IGL01303:Cdcp3 APN 7 130,796,060 (GRCm39) missense possibly damaging 0.53
IGL01585:Cdcp3 APN 7 130,846,487 (GRCm39) missense probably damaging 0.97
IGL01665:Cdcp3 APN 7 130,848,386 (GRCm39) nonsense probably null
IGL01953:Cdcp3 APN 7 130,826,709 (GRCm39) missense probably benign 0.04
IGL02427:Cdcp3 APN 7 130,846,517 (GRCm39) missense probably damaging 0.99
IGL02508:Cdcp3 APN 7 130,824,559 (GRCm39) missense probably damaging 1.00
IGL02678:Cdcp3 APN 7 130,830,646 (GRCm39) missense probably damaging 1.00
IGL03092:Cdcp3 APN 7 130,803,527 (GRCm39) critical splice donor site probably null
IGL03122:Cdcp3 APN 7 130,798,243 (GRCm39) missense possibly damaging 0.68
IGL03343:Cdcp3 APN 7 130,848,420 (GRCm39) missense probably damaging 1.00
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0011:Cdcp3 UTSW 7 130,831,722 (GRCm39) missense probably damaging 0.99
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0234:Cdcp3 UTSW 7 130,796,032 (GRCm39) splice site probably null
R0383:Cdcp3 UTSW 7 130,841,268 (GRCm39) missense probably benign 0.05
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0973:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R0974:Cdcp3 UTSW 7 130,839,911 (GRCm39) missense probably damaging 1.00
R1572:Cdcp3 UTSW 7 130,846,560 (GRCm39) nonsense probably null
R1911:Cdcp3 UTSW 7 130,839,818 (GRCm39) missense probably damaging 1.00
R2032:Cdcp3 UTSW 7 130,844,781 (GRCm39) missense probably damaging 1.00
R2097:Cdcp3 UTSW 7 130,783,693 (GRCm39) nonsense probably null
R2221:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2223:Cdcp3 UTSW 7 130,849,186 (GRCm39) critical splice acceptor site probably null
R2254:Cdcp3 UTSW 7 130,824,634 (GRCm39) missense probably damaging 1.00
R2913:Cdcp3 UTSW 7 130,783,753 (GRCm39) missense possibly damaging 0.90
R2991:Cdcp3 UTSW 7 130,848,429 (GRCm39) missense probably damaging 1.00
R3439:Cdcp3 UTSW 7 130,790,508 (GRCm39) critical splice donor site probably null
R4418:Cdcp3 UTSW 7 130,849,194 (GRCm39) missense possibly damaging 0.86
R4916:Cdcp3 UTSW 7 130,776,206 (GRCm39) splice site probably null
R5488:Cdcp3 UTSW 7 130,848,324 (GRCm39) missense probably damaging 1.00
R5594:Cdcp3 UTSW 7 130,841,252 (GRCm39) missense probably benign 0.12
R5897:Cdcp3 UTSW 7 130,798,280 (GRCm39) splice site probably null
R5898:Cdcp3 UTSW 7 130,843,696 (GRCm39) splice site probably null
R5940:Cdcp3 UTSW 7 130,839,992 (GRCm39) missense probably damaging 1.00
R6170:Cdcp3 UTSW 7 130,776,216 (GRCm39) splice site probably null
R6187:Cdcp3 UTSW 7 130,872,328 (GRCm39) intron probably benign
R6321:Cdcp3 UTSW 7 130,858,735 (GRCm39) critical splice donor site probably null
R6409:Cdcp3 UTSW 7 130,863,800 (GRCm39) intron probably benign
R6432:Cdcp3 UTSW 7 130,846,601 (GRCm39) critical splice donor site probably null
R6481:Cdcp3 UTSW 7 130,858,530 (GRCm39) missense probably benign 0.05
R6750:Cdcp3 UTSW 7 130,889,974 (GRCm39) intron probably benign
R6783:Cdcp3 UTSW 7 130,828,493 (GRCm39) missense probably damaging 0.99
R6836:Cdcp3 UTSW 7 130,798,233 (GRCm39) missense possibly damaging 0.84
R6925:Cdcp3 UTSW 7 130,824,436 (GRCm39) missense possibly damaging 0.92
R6995:Cdcp3 UTSW 7 130,824,400 (GRCm39) missense probably damaging 1.00
R7199:Cdcp3 UTSW 7 130,837,641 (GRCm39) nonsense probably null
R7205:Cdcp3 UTSW 7 130,879,352 (GRCm39) critical splice donor site probably null
R7340:Cdcp3 UTSW 7 130,879,344 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,873,762 (GRCm39) missense unknown
R7354:Cdcp3 UTSW 7 130,858,458 (GRCm39) missense possibly damaging 0.84
R7434:Cdcp3 UTSW 7 130,881,212 (GRCm39) missense unknown
R7485:Cdcp3 UTSW 7 130,830,562 (GRCm39) missense probably damaging 0.99
R7513:Cdcp3 UTSW 7 130,873,800 (GRCm39) missense unknown
R7562:Cdcp3 UTSW 7 130,904,426 (GRCm39) missense unknown
R7623:Cdcp3 UTSW 7 130,879,295 (GRCm39) splice site probably null
R7782:Cdcp3 UTSW 7 130,904,466 (GRCm39) splice site probably null
R7879:Cdcp3 UTSW 7 130,844,871 (GRCm39) missense probably damaging 0.98
R7935:Cdcp3 UTSW 7 130,852,205 (GRCm39) missense probably damaging 0.96
R7949:Cdcp3 UTSW 7 130,895,324 (GRCm39) splice site probably null
R7964:Cdcp3 UTSW 7 130,899,963 (GRCm39) missense unknown
R7980:Cdcp3 UTSW 7 130,836,506 (GRCm39) missense probably damaging 0.98
R8145:Cdcp3 UTSW 7 130,898,045 (GRCm39) missense unknown
R8673:Cdcp3 UTSW 7 130,844,846 (GRCm39) missense probably damaging 0.99
R8684:Cdcp3 UTSW 7 130,837,688 (GRCm39) nonsense probably null
R8721:Cdcp3 UTSW 7 130,879,335 (GRCm39) missense unknown
R8725:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8727:Cdcp3 UTSW 7 130,875,485 (GRCm39) missense unknown
R8742:Cdcp3 UTSW 7 130,783,741 (GRCm39) missense unknown
R8807:Cdcp3 UTSW 7 130,846,507 (GRCm39) missense probably damaging 0.97
R8822:Cdcp3 UTSW 7 130,843,706 (GRCm39) critical splice acceptor site probably null
R8861:Cdcp3 UTSW 7 130,861,690 (GRCm39) nonsense probably null
R8897:Cdcp3 UTSW 7 130,867,566 (GRCm39) missense unknown
R8900:Cdcp3 UTSW 7 130,904,197 (GRCm39) intron probably benign
R9214:Cdcp3 UTSW 7 130,824,481 (GRCm39) missense possibly damaging 0.89
R9218:Cdcp3 UTSW 7 130,863,728 (GRCm39) missense unknown
R9311:Cdcp3 UTSW 7 130,859,490 (GRCm39) missense unknown
R9323:Cdcp3 UTSW 7 130,828,401 (GRCm39) missense probably damaging 0.96
R9384:Cdcp3 UTSW 7 130,904,404 (GRCm39) missense unknown
R9387:Cdcp3 UTSW 7 130,863,620 (GRCm39) missense unknown
R9417:Cdcp3 UTSW 7 130,852,218 (GRCm39) missense possibly damaging 0.60
R9502:Cdcp3 UTSW 7 130,836,815 (GRCm39) missense possibly damaging 0.61
R9603:Cdcp3 UTSW 7 130,830,643 (GRCm39) missense probably damaging 0.98
R9642:Cdcp3 UTSW 7 130,848,257 (GRCm39) missense probably benign 0.01
Z1088:Cdcp3 UTSW 7 130,848,362 (GRCm39) missense probably damaging 1.00
Z1177:Cdcp3 UTSW 7 130,867,595 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCAGGACGAGTGGAAATCCTCTACC -3'
(R):5'- TGGAATCCTTACTGCAATGCCCC -3'

Sequencing Primer
(F):5'- TGGAAATCCTCTACCAGGGAGTC -3'
(R):5'- TTACTGCAATGCCCCAGAGTG -3'
Posted On 2013-05-09