Incidental Mutation 'R4637:Zfp3'
| ID |
350766 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp3
|
| Ensembl Gene |
ENSMUSG00000043602 |
| Gene Name |
zinc finger protein 3 |
| Synonyms |
Zfp-3, Fnp-1 |
| MMRRC Submission |
042010-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.235)
|
| Stock # |
R4637 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
70655273-70663754 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 70662181 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 47
(S47P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000054020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060444]
|
| AlphaFold |
Q8BLB0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060444
AA Change: S47P
PolyPhen 2
Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000054020
Gene: ENSMUSG00000043602
AA Change: S47P
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
136 |
158 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
164 |
186 |
4.01e-5 |
SMART |
|
ZnF_C2H2
|
192 |
214 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
220 |
242 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
248 |
270 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
276 |
298 |
7.9e-4 |
SMART |
|
ZnF_C2H2
|
304 |
326 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
332 |
354 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
360 |
382 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
388 |
410 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
416 |
438 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
444 |
466 |
5.59e-4 |
SMART |
|
ZnF_C2H2
|
472 |
494 |
1.82e-3 |
SMART |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
96% (27/28) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Art1 |
T |
A |
7: 101,755,544 (GRCm39) |
V12E |
probably damaging |
Het |
| Ccdc121 |
G |
A |
5: 31,645,435 (GRCm39) |
R396Q |
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,914,443 (GRCm39) |
S653G |
probably benign |
Het |
| Clic6 |
T |
C |
16: 92,293,949 (GRCm39) |
|
probably benign |
Het |
| Fras1 |
T |
A |
5: 96,925,947 (GRCm39) |
L3717Q |
probably damaging |
Het |
| Gpat3 |
C |
T |
5: 101,005,039 (GRCm39) |
P58L |
probably benign |
Het |
| Gtf2f1 |
G |
T |
17: 57,311,534 (GRCm39) |
P292H |
probably benign |
Het |
| Hcn1 |
A |
T |
13: 118,112,249 (GRCm39) |
T738S |
unknown |
Het |
| Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
| Hmbs |
A |
G |
9: 44,250,834 (GRCm39) |
S130P |
probably damaging |
Het |
| Kif1b |
A |
T |
4: 149,283,768 (GRCm39) |
I1299N |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Muc17 |
A |
T |
5: 137,175,502 (GRCm39) |
L56Q |
probably damaging |
Het |
| Myd88 |
G |
A |
9: 119,167,175 (GRCm39) |
|
probably null |
Het |
| Nol6 |
G |
A |
4: 41,121,788 (GRCm39) |
R249W |
probably damaging |
Het |
| Or4g17 |
C |
T |
2: 111,209,927 (GRCm39) |
T194I |
probably benign |
Het |
| Pcdhb1 |
T |
C |
18: 37,398,802 (GRCm39) |
V251A |
possibly damaging |
Het |
| Prkcd |
A |
G |
14: 30,320,722 (GRCm39) |
S633P |
probably benign |
Het |
| Rarb |
T |
C |
14: 16,574,875 (GRCm38) |
H47R |
possibly damaging |
Het |
| Slc16a14 |
A |
G |
1: 84,885,003 (GRCm39) |
V512A |
possibly damaging |
Het |
| Slc34a3 |
C |
T |
2: 25,119,473 (GRCm39) |
V466M |
possibly damaging |
Het |
| Stat3 |
A |
G |
11: 100,784,056 (GRCm39) |
S623P |
probably damaging |
Het |
| Vmn2r16 |
T |
G |
5: 109,478,280 (GRCm39) |
S12A |
probably benign |
Het |
| Zfhx4 |
C |
G |
3: 5,468,464 (GRCm39) |
P2874R |
probably damaging |
Het |
| Zfp791 |
T |
C |
8: 85,836,514 (GRCm39) |
E450G |
possibly damaging |
Het |
|
| Other mutations in Zfp3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0684:Zfp3
|
UTSW |
11 |
70,662,395 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1067:Zfp3
|
UTSW |
11 |
70,663,411 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1389:Zfp3
|
UTSW |
11 |
70,663,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1940:Zfp3
|
UTSW |
11 |
70,662,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1962:Zfp3
|
UTSW |
11 |
70,662,954 (GRCm39) |
nonsense |
probably null |
|
|
R4112:Zfp3
|
UTSW |
11 |
70,662,333 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6006:Zfp3
|
UTSW |
11 |
70,662,590 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6333:Zfp3
|
UTSW |
11 |
70,662,266 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7213:Zfp3
|
UTSW |
11 |
70,663,351 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7378:Zfp3
|
UTSW |
11 |
70,662,899 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8434:Zfp3
|
UTSW |
11 |
70,663,384 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9094:Zfp3
|
UTSW |
11 |
70,663,241 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9095:Zfp3
|
UTSW |
11 |
70,662,405 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9404:Zfp3
|
UTSW |
11 |
70,663,366 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9622:Zfp3
|
UTSW |
11 |
70,662,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1176:Zfp3
|
UTSW |
11 |
70,662,152 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Zfp3
|
UTSW |
11 |
70,662,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGCAGCCTCACATGAGTAC -3'
(R):5'- ATACTCCCCAGGCAGTTGTG -3'
Sequencing Primer
(F):5'- AGCCTCACATGAGTACCCTCTC -3'
(R):5'- GGCAGTTGTGGCCAGAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation