Incidental Mutation 'R4638:Tmem198'
ID 350776
Institutional Source Beutler Lab
Gene Symbol Tmem198
Ensembl Gene ENSMUSG00000051703
Gene Name transmembrane protein 198
Synonyms A230078I05Rik, Tmem198-1, Tmem198a
MMRRC Submission 041900-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.439) question?
Stock # R4638 (G1)
Quality Score 175
Status Validated
Chromosome 1
Chromosomal Location 75456176-75462349 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 75456351 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 2 (G2*)
Ref Sequence ENSEMBL: ENSMUSP00000140795 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050899] [ENSMUST00000079205] [ENSMUST00000094818] [ENSMUST00000113575] [ENSMUST00000124042] [ENSMUST00000138683] [ENSMUST00000187411] [ENSMUST00000148980]
AlphaFold Q8BG75
Predicted Effect probably benign
Transcript: ENSMUST00000050899
SMART Domains Protein: ENSMUSP00000057865
Gene: ENSMUSG00000051703

DomainStartEndE-ValueType
Pfam:DUF4203 40 236 7.2e-51 PFAM
low complexity region 252 302 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000079205
SMART Domains Protein: ENSMUSP00000078199
Gene: ENSMUSG00000032997

DomainStartEndE-ValueType
low complexity region 37 46 N/A INTRINSIC
Pfam:CHGN 262 761 5e-150 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000094818
SMART Domains Protein: ENSMUSP00000092412
Gene: ENSMUSG00000032997

DomainStartEndE-ValueType
Pfam:CHGN 100 599 3.3e-174 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113575
SMART Domains Protein: ENSMUSP00000109205
Gene: ENSMUSG00000051703

DomainStartEndE-ValueType
Pfam:DUF4203 39 237 2.2e-59 PFAM
low complexity region 252 302 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124042
SMART Domains Protein: ENSMUSP00000122057
Gene: ENSMUSG00000032997

DomainStartEndE-ValueType
low complexity region 37 46 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000138683
SMART Domains Protein: ENSMUSP00000117253
Gene: ENSMUSG00000032997

DomainStartEndE-ValueType
low complexity region 37 46 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000187411
AA Change: G2*
SMART Domains Protein: ENSMUSP00000140795
Gene: ENSMUSG00000051703
AA Change: G2*

DomainStartEndE-ValueType
low complexity region 38 50 N/A INTRINSIC
Pfam:DUF4203 101 142 6.9e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148980
AA Change: R32L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000116977
Gene: ENSMUSG00000051703
AA Change: R32L

DomainStartEndE-ValueType
low complexity region 8 19 N/A INTRINSIC
Pfam:DUF4203 119 150 6.6e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143496
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156499
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency 91% (40/44)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg8 A G 17: 84,999,369 (GRCm39) D155G probably damaging Het
Ano4 C T 10: 88,790,559 (GRCm39) A847T probably damaging Het
B4galt7 T C 13: 55,747,959 (GRCm39) probably benign Het
Camk1g T A 1: 193,038,667 (GRCm39) D85V probably damaging Het
Caskin1 G A 17: 24,725,602 (GRCm39) S1296N probably benign Het
Cebpa A G 7: 34,819,687 (GRCm39) N282D probably damaging Het
Cngb1 G A 8: 95,992,647 (GRCm39) T196M probably damaging Het
Cobll1 T C 2: 64,929,581 (GRCm39) M619V probably benign Het
Coro7 A T 16: 4,450,151 (GRCm39) I566N probably damaging Het
Dpyd A T 3: 119,059,726 (GRCm39) S808C probably benign Het
Fbn2 A G 18: 58,143,376 (GRCm39) V2893A probably benign Het
Gm10801 G C 2: 98,494,352 (GRCm39) R143T possibly damaging Het
Krba1 T A 6: 48,386,685 (GRCm39) L441* probably null Het
Lama5 T C 2: 179,832,206 (GRCm39) T1712A possibly damaging Het
Lnpep G A 17: 17,795,569 (GRCm39) T314I probably damaging Het
Lyst T C 13: 13,871,379 (GRCm39) probably null Het
Naa16 C A 14: 79,577,473 (GRCm39) probably null Het
Nek7 A T 1: 138,472,038 (GRCm39) F34Y probably benign Het
Or12e7 T C 2: 87,288,327 (GRCm39) S273P possibly damaging Het
Or2ag17 A T 7: 106,390,205 (GRCm39) M1K probably null Het
Park7 G A 4: 150,991,556 (GRCm39) Q45* probably null Het
Pclo C A 5: 14,730,447 (GRCm39) S2983* probably null Het
Pth1r A G 9: 110,556,141 (GRCm39) L244P possibly damaging Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Slc11a1 G A 1: 74,414,437 (GRCm39) probably benign Het
Slc12a8 T G 16: 33,410,693 (GRCm39) S200A possibly damaging Het
Slc7a10 A G 7: 34,897,355 (GRCm39) E262G probably damaging Het
Smg1 T C 7: 117,795,149 (GRCm39) probably benign Het
Snapc4 A G 2: 26,255,314 (GRCm39) L1070P probably damaging Het
Sp2 A G 11: 96,848,300 (GRCm39) I435T possibly damaging Het
Srp72 A G 5: 77,138,142 (GRCm39) E309G probably benign Het
Sympk G T 7: 18,777,385 (GRCm39) R545L possibly damaging Het
Tie1 C T 4: 118,341,039 (GRCm39) R314H probably benign Het
Tmem81 A G 1: 132,435,943 (GRCm39) probably benign Het
Ttn A T 2: 76,652,821 (GRCm39) V10938E possibly damaging Het
Zfp773 T A 7: 7,138,335 (GRCm39) Y100F probably damaging Het
Other mutations in Tmem198
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01451:Tmem198 APN 1 75,461,014 (GRCm39) unclassified probably benign
IGL03033:Tmem198 APN 1 75,459,612 (GRCm39) missense possibly damaging 0.92
R1165:Tmem198 UTSW 1 75,456,576 (GRCm39) intron probably benign
R1876:Tmem198 UTSW 1 75,461,567 (GRCm39) missense probably damaging 1.00
R5320:Tmem198 UTSW 1 75,456,500 (GRCm39) missense probably benign
R6369:Tmem198 UTSW 1 75,456,387 (GRCm39) missense probably benign 0.00
R6601:Tmem198 UTSW 1 75,457,017 (GRCm39) missense possibly damaging 0.71
R7455:Tmem198 UTSW 1 75,456,430 (GRCm39) missense unknown
R8027:Tmem198 UTSW 1 75,456,706 (GRCm39) intron probably benign
R8163:Tmem198 UTSW 1 75,459,671 (GRCm39) missense possibly damaging 0.63
R8502:Tmem198 UTSW 1 75,459,353 (GRCm39) missense probably damaging 1.00
R9191:Tmem198 UTSW 1 75,456,426 (GRCm39) missense unknown
R9329:Tmem198 UTSW 1 75,456,522 (GRCm39) missense probably damaging 0.99
R9664:Tmem198 UTSW 1 75,459,272 (GRCm39) missense possibly damaging 0.71
Z1088:Tmem198 UTSW 1 75,456,906 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- GATGACGTCAGAAGCAGCC -3'
(R):5'- AATTGTCCAAGATCTACCTGGG -3'

Sequencing Primer
(F):5'- CCTGCCAGGATGGTGCAC -3'
(R):5'- AAGATCTACCTGGGCCGGAG -3'
Posted On 2015-10-08