Mutagenetix > Incidental Mutation

Incidental Mutation 'R4613:Vmn1r83'

350964

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r83

Ensembl Gene

ENSMUSG00000066804

Gene Name

vomeronasal 1 receptor 83

Synonyms

V1rg8

MMRRC Submission

041824-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.057) question?

Stock #

R4613 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12319707-12329481 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 12321768 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 121 (I121V)

Ref Sequence

ENSEMBL: ENSMUSP00000154521 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000086229] [ENSMUST00000226701]

AlphaFold

Q8R287

Predicted Effect

probably benign
Transcript: ENSMUST00000086229
AA Change: I121V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000083406
Gene: ENSMUSG00000066804
AA Change: I121V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	303	1.3e-8	PFAM
Pfam:V1R	26	299	1.7e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226701
AA Change: I121V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.4%
20x: 95.5%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
9830107B12Rik	A	T	17: 48,128,557 (GRCm38)	L130I	probably benign	Het
Abca9	A	G	11: 110,144,784 (GRCm38)	V670A	probably benign	Het
Adad1	A	G	3: 37,092,033 (GRCm38)	N517D	probably damaging	Het
Ankle2	T	C	5: 110,231,379 (GRCm38)	L48P	probably benign	Het
Aoc3	A	T	11: 101,337,659 (GRCm38)		probably benign	Het
Areg	A	G	5: 91,143,504 (GRCm38)	K102R	probably benign	Het
Bmp1	T	C	14: 70,508,523 (GRCm38)	T167A	probably damaging	Het
C4b	C	T	17: 34,734,551 (GRCm38)	G986D	probably benign	Het
Caml	G	T	13: 55,625,142 (GRCm38)	G200C	probably damaging	Het
Ccdc40	A	C	11: 119,231,532 (GRCm38)	R53S	probably benign	Het
Cdh22	T	A	2: 165,143,656 (GRCm38)	I337L	probably benign	Het
Col12a1	A	T	9: 79,647,601 (GRCm38)	V2065D	probably benign	Het
Copg2	A	G	6: 30,811,596 (GRCm38)	S591P	probably benign	Het
Cyp2d34	G	A	15: 82,616,325 (GRCm38)	P438S	probably damaging	Het
Dchs1	T	C	7: 105,772,724 (GRCm38)	D163G	probably damaging	Het
Depdc1b	T	C	13: 108,363,643 (GRCm38)	V230A	probably damaging	Het
Depdc5	T	A	5: 32,975,446 (GRCm38)	L1300H	probably damaging	Het
Dnah10	G	T	5: 124,762,869 (GRCm38)		probably null	Het
Dsc2	A	T	18: 20,041,819 (GRCm38)	D466E	probably damaging	Het
Dthd1	A	G	5: 62,827,068 (GRCm38)	D372G	probably damaging	Het
Eogt	G	T	6: 97,134,304 (GRCm38)	Q199K	probably benign	Het
Epha6	C	A	16: 59,666,597 (GRCm38)	R1029L	possibly damaging	Het
Eppin	C	A	2: 164,589,323 (GRCm38)	E128*	probably null	Het
Fam102b	A	T	3: 109,027,255 (GRCm38)	F23I	probably benign	Het
Fam160b1	C	A	19: 57,371,187 (GRCm38)	P53Q	probably damaging	Het
Fgf20	T	C	8: 40,286,611 (GRCm38)	R33G	probably benign	Het
Fgg	A	G	3: 83,010,090 (GRCm38)	N142S	probably damaging	Het
Gba	C	T	3: 89,208,644 (GRCm38)		probably null	Het
Gli2	A	G	1: 118,837,511 (GRCm38)	V970A	probably damaging	Het
Gramd1b	A	T	9: 40,307,993 (GRCm38)	V508D	probably damaging	Het
Gucy2c	T	A	6: 136,708,321 (GRCm38)	D898V	probably damaging	Het
Kcnj15	T	C	16: 95,295,794 (GRCm38)	Y92H	probably damaging	Het
L3mbtl3	A	T	10: 26,282,795 (GRCm38)	S652T	unknown	Het
Ldb2	G	T	5: 44,476,551 (GRCm38)	Q326K	probably benign	Het
Lipi	C	A	16: 75,560,801 (GRCm38)	R292L	probably benign	Het
Lrrc36	G	A	8: 105,449,614 (GRCm38)	V207I	possibly damaging	Het
Lyplal1	C	T	1: 186,088,752 (GRCm38)	G166D	probably benign	Het
Map1b	A	T	13: 99,430,302 (GRCm38)	Y1970*	probably null	Het
Map2	A	G	1: 66,425,469 (GRCm38)	N287D	probably damaging	Het
Map3k11	A	T	19: 5,697,470 (GRCm38)	Q578L	probably benign	Het
Map3k11	G	T	19: 5,697,471 (GRCm38)	Q578H	probably damaging	Het
Map4k4	G	A	1: 40,017,191 (GRCm38)	S1012N	probably benign	Het
Mapk13	A	T	17: 28,769,452 (GRCm38)	N15Y	probably damaging	Het
Mapk15	G	A	15: 75,995,910 (GRCm38)	A125T	probably damaging	Het
Mrgprb1	C	A	7: 48,447,708 (GRCm38)	R152L	possibly damaging	Het
Muc5ac	T	G	7: 141,791,103 (GRCm38)	Y104D	possibly damaging	Het
Myo1h	A	G	5: 114,348,379 (GRCm38)	N566S	possibly damaging	Het
Myo1h	C	A	5: 114,351,676 (GRCm38)	H647Q	probably benign	Het
Neo1	A	G	9: 58,889,041 (GRCm38)	I1201T	possibly damaging	Het
Nlgn1	T	C	3: 25,436,022 (GRCm38)	T514A	probably benign	Het
Olfr120	A	G	17: 37,726,696 (GRCm38)	Y224C	probably damaging	Het
Olfr533	A	T	7: 140,467,068 (GRCm38)	Y289F	probably damaging	Het
Olfr8	A	G	10: 78,956,065 (GRCm38)	N287D	probably damaging	Het
Olfr985	T	A	9: 40,127,722 (GRCm38)	K80*	probably null	Het
Orc2	A	T	1: 58,500,309 (GRCm38)	L57*	probably null	Het
Otoa	G	A	7: 121,145,568 (GRCm38)	V850M	probably damaging	Het
Pcnx3	T	C	19: 5,667,219 (GRCm38)	T1579A	possibly damaging	Het
Pde5a	A	T	3: 122,823,093 (GRCm38)	Y564F	probably damaging	Het
Pdxk	A	C	10: 78,447,919 (GRCm38)	I147S	probably damaging	Het
Pfdn5	A	G	15: 102,328,752 (GRCm38)	D108G	probably benign	Het
Pink1	T	C	4: 138,317,310 (GRCm38)	D342G	probably damaging	Het
Prkacb	A	T	3: 146,737,998 (GRCm38)	V336E	probably damaging	Het
Ptpro	C	A	6: 137,416,836 (GRCm38)	S13*	probably null	Het
Rfng	A	G	11: 120,782,650 (GRCm38)	L215P	probably damaging	Het
Rpn2	T	C	2: 157,302,425 (GRCm38)	F336L	possibly damaging	Het
Sacs	A	G	14: 61,211,797 (GRCm38)		probably null	Het
Sirpb1a	T	A	3: 15,417,037 (GRCm38)	Y77F	probably benign	Het
Skiv2l2	C	A	13: 112,921,739 (GRCm38)	E53*	probably null	Het
Slc30a8	A	G	15: 52,333,575 (GRCm38)	D294G	probably benign	Het
Sox13	T	C	1: 133,388,934 (GRCm38)	I212V	probably benign	Het
Srebf2	T	A	15: 82,185,348 (GRCm38)	I657N	possibly damaging	Het
Srsf6	C	A	2: 162,933,709 (GRCm38)	T146K	probably benign	Het
Strn4	T	C	7: 16,824,163 (GRCm38)	V162A	possibly damaging	Het
Sulf2	T	C	2: 166,132,605 (GRCm38)	D53G	probably damaging	Het
Tbc1d8	T	A	1: 39,372,708 (GRCm38)	I1016F	probably damaging	Het
Tfrc	G	T	16: 32,618,657 (GRCm38)	A278S	probably damaging	Het
Tnrc6a	T	G	7: 123,184,289 (GRCm38)		probably null	Het
Vps13d	T	C	4: 145,131,655 (GRCm38)	S2200G	possibly damaging	Het
Washc2	T	A	6: 116,229,269 (GRCm38)	D397E	probably damaging	Het
Wipf3	T	C	6: 54,485,555 (GRCm38)	L250P	probably damaging	Het
Xirp1	A	G	9: 120,019,682 (GRCm38)	F45S	probably damaging	Het
Xpo5	A	G	17: 46,236,963 (GRCm38)	T910A	probably benign	Het
Zfp235	T	C	7: 24,141,676 (GRCm38)	Y507H	probably damaging	Het

Other mutations in Vmn1r83

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01371:Vmn1r83	APN	7	12,321,233 (GRCm38)	missense	probably benign	0.10
IGL01447:Vmn1r83	APN	7	12,321,497 (GRCm38)	missense	probably benign
IGL01793:Vmn1r83	APN	7	12,321,577 (GRCm38)	missense	probably benign	0.02
IGL02137:Vmn1r83	APN	7	12,321,834 (GRCm38)	missense	probably damaging	1.00
IGL03155:Vmn1r83	APN	7	12,321,690 (GRCm38)	missense	probably benign
IGL03182:Vmn1r83	APN	7	12,321,690 (GRCm38)	missense	probably benign
R0627:Vmn1r83	UTSW	7	12,321,992 (GRCm38)	missense	probably damaging	0.99
R1511:Vmn1r83	UTSW	7	12,321,270 (GRCm38)	missense	possibly damaging	0.87
R3882:Vmn1r83	UTSW	7	12,321,402 (GRCm38)	missense	probably damaging	1.00
R4678:Vmn1r83	UTSW	7	12,321,770 (GRCm38)	missense	possibly damaging	0.67
R5580:Vmn1r83	UTSW	7	12,321,873 (GRCm38)	missense	probably benign	0.01
R6982:Vmn1r83	UTSW	7	12,321,836 (GRCm38)	missense	probably damaging	1.00
R7440:Vmn1r83	UTSW	7	12,321,629 (GRCm38)	missense	probably damaging	1.00
R7476:Vmn1r83	UTSW	7	12,321,615 (GRCm38)	missense	possibly damaging	0.93
R7522:Vmn1r83	UTSW	7	12,321,578 (GRCm38)	missense	possibly damaging	0.61
R7759:Vmn1r83	UTSW	7	12,321,433 (GRCm38)	missense	probably benign	0.06
R8886:Vmn1r83	UTSW	7	12,321,916 (GRCm38)	missense	probably benign	0.10
R9077:Vmn1r83	UTSW	7	12,321,644 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GCTGGAAGTGAACCATGAGC -3'
(R):5'- CACCGAAAGACCTGATTATAGAGC -3'

Sequencing Primer
(F):5'- GTGAACCATGAGCAGTACCC -3'
(R):5'- GAGCACTTGACATTTGCCAACTG -3'

Posted On

2015-10-08