|Institutional Source||Beutler Lab|
|Gene Name||myosin VIIB|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4616 (G1)|
|Chromosomal Location||31959234-32036961 bp(-) (GRCm38)|
|Type of Mutation||splice site (4 bp from exon)|
|DNA Base Change (assembly)||T to C at 32003487 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000118046 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000134663]|
|Meta Mutation Damage Score||0.9755|
|Coding Region Coverage||
|Validation Efficiency||100% (64/64)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Myo7b||
(F):5'- AGGCCCTGTGCTTTCATGTC -3'
(R):5'- TAAGGTCTTGAGCCATCTTGG -3'
(F):5'- CTCACCCTCAAACCTCTGGGG -3'
(R):5'- GTGGCTCTCTCTCAGCTGAAG -3'