Incidental Mutation 'R4652:Setd2'
| ID |
351406 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Setd2
|
| Ensembl Gene |
ENSMUSG00000044791 |
| Gene Name |
SET domain containing 2 |
| Synonyms |
KMT3A, 4921524K10Rik |
| MMRRC Submission |
041912-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.925)
|
| Stock # |
R4652 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
9 |
| Chromosomal Location |
110361665-110447701 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 110423200 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 2085
(D2085G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000116313
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000153838]
|
| AlphaFold |
E9Q5F9 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000153838
AA Change: D2085G
PolyPhen 2
Score 0.533 (Sensitivity: 0.88; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000116313
Gene: ENSMUSG00000044791
AA Change: D2085G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
156 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
185 |
207 |
N/A |
INTRINSIC |
|
low complexity region
|
297 |
313 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
419 |
N/A |
INTRINSIC |
|
low complexity region
|
795 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
867 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1039 |
N/A |
INTRINSIC |
|
low complexity region
|
1066 |
1077 |
N/A |
INTRINSIC |
|
low complexity region
|
1384 |
1395 |
N/A |
INTRINSIC |
|
AWS
|
1468 |
1523 |
8.39e-30 |
SMART |
|
SET
|
1524 |
1647 |
3.07e-41 |
SMART |
|
PostSET
|
1648 |
1664 |
1.27e-5 |
SMART |
|
Blast:SET
|
1689 |
1714 |
2e-6 |
BLAST |
|
low complexity region
|
1884 |
1909 |
N/A |
INTRINSIC |
|
low complexity region
|
1956 |
1967 |
N/A |
INTRINSIC |
|
coiled coil region
|
2090 |
2113 |
N/A |
INTRINSIC |
|
low complexity region
|
2189 |
2211 |
N/A |
INTRINSIC |
|
low complexity region
|
2248 |
2265 |
N/A |
INTRINSIC |
|
WW
|
2363 |
2395 |
2.1e-11 |
SMART |
|
Pfam:SRI
|
2440 |
2530 |
6e-30 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196814
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197655
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198697
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000200460
AA Change: D307G
|
| Meta Mutation Damage Score |
0.1056 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
95% (111/117) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. [provided by RefSeq, Aug 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired embryonic vascular remodeling in the embryo proper, yolk sac, and placenta that leads to death around E10.5. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022B05Rik |
T |
A |
8: 125,366,350 (GRCm39) |
Q131L |
probably damaging |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 4933409G03Rik |
G |
A |
2: 68,436,559 (GRCm39) |
E168K |
unknown |
Het |
| A830018L16Rik |
C |
A |
1: 11,607,566 (GRCm39) |
|
probably benign |
Het |
| Adam26b |
A |
G |
8: 43,974,375 (GRCm39) |
V209A |
possibly damaging |
Het |
| Adh6a |
T |
A |
3: 138,031,876 (GRCm39) |
M256K |
probably benign |
Het |
| Ahnak2 |
T |
G |
12: 112,741,271 (GRCm39) |
S128R |
possibly damaging |
Het |
| Angptl2 |
G |
T |
2: 33,133,895 (GRCm39) |
D406Y |
probably damaging |
Het |
| Ano10 |
A |
T |
9: 122,090,181 (GRCm39) |
Y377* |
probably null |
Het |
| Arfgef1 |
C |
T |
1: 10,243,487 (GRCm39) |
D1021N |
probably damaging |
Het |
| Arhgap17 |
G |
A |
7: 122,885,841 (GRCm39) |
|
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atp10b |
G |
A |
11: 43,085,472 (GRCm39) |
G284S |
probably damaging |
Het |
| Atp13a4 |
A |
T |
16: 29,271,421 (GRCm39) |
D498E |
probably damaging |
Het |
| C4a |
T |
A |
17: 35,029,108 (GRCm39) |
|
noncoding transcript |
Het |
| Cacna1d |
C |
T |
14: 29,817,365 (GRCm39) |
M1232I |
probably benign |
Het |
| Camsap3 |
A |
C |
8: 3,650,689 (GRCm39) |
K223T |
possibly damaging |
Het |
| Cast |
A |
G |
13: 74,894,133 (GRCm39) |
S171P |
probably benign |
Het |
| Cdh8 |
T |
A |
8: 99,751,491 (GRCm39) |
D742V |
probably benign |
Het |
| Ceacam12 |
A |
G |
7: 17,801,359 (GRCm39) |
T113A |
probably damaging |
Het |
| Cers3 |
G |
A |
7: 66,431,604 (GRCm39) |
|
probably null |
Het |
| Cipc |
T |
C |
12: 87,008,864 (GRCm39) |
V241A |
probably benign |
Het |
| Cntn5 |
C |
A |
9: 9,704,917 (GRCm39) |
K832N |
possibly damaging |
Het |
| Col12a1 |
A |
T |
9: 79,520,228 (GRCm39) |
D2815E |
probably damaging |
Het |
| Ctf2 |
T |
C |
7: 127,318,556 (GRCm39) |
T148A |
probably benign |
Het |
| Cttnbp2 |
A |
G |
6: 18,434,037 (GRCm39) |
I607T |
possibly damaging |
Het |
| Cux1 |
A |
T |
5: 136,596,083 (GRCm39) |
N4K |
probably damaging |
Het |
| Dhx36 |
A |
T |
3: 62,408,419 (GRCm39) |
L140M |
probably benign |
Het |
| Dhx58 |
T |
A |
11: 100,592,185 (GRCm39) |
N288Y |
probably damaging |
Het |
| Dlgap1 |
T |
A |
17: 71,068,090 (GRCm39) |
Y554N |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,806,207 (GRCm39) |
Y127H |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,047,580 (GRCm39) |
M3140V |
probably benign |
Het |
| Dnd1 |
G |
A |
18: 36,898,114 (GRCm39) |
|
probably benign |
Het |
| Dpy19l1 |
A |
C |
9: 24,393,350 (GRCm39) |
S140A |
possibly damaging |
Het |
| Dyrk1a |
C |
T |
16: 94,492,924 (GRCm39) |
T719I |
probably benign |
Het |
| Erlin1 |
T |
A |
19: 44,029,231 (GRCm39) |
K234* |
probably null |
Het |
| Fndc7 |
T |
C |
3: 108,770,135 (GRCm39) |
N597S |
probably benign |
Het |
| Folh1 |
C |
A |
7: 86,393,633 (GRCm39) |
G360* |
probably null |
Het |
| Frmd4b |
T |
C |
6: 97,272,716 (GRCm39) |
H846R |
probably benign |
Het |
| Gm10375 |
C |
A |
14: 43,844,326 (GRCm39) |
|
probably null |
Het |
| Gm27047 |
T |
C |
6: 130,607,479 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7168 |
A |
G |
17: 14,170,069 (GRCm39) |
R479G |
possibly damaging |
Het |
| Gm9996 |
T |
A |
10: 29,019,754 (GRCm39) |
|
probably benign |
Het |
| Gnat3 |
T |
A |
5: 18,220,568 (GRCm39) |
L247H |
probably damaging |
Het |
| H2-D1 |
T |
G |
17: 35,485,492 (GRCm39) |
|
probably null |
Het |
| Hpf1 |
T |
G |
8: 61,346,764 (GRCm39) |
S26R |
possibly damaging |
Het |
| Ift80 |
T |
A |
3: 68,822,273 (GRCm39) |
N627I |
probably benign |
Het |
| Inpp5d |
A |
G |
1: 87,593,173 (GRCm39) |
K91R |
probably benign |
Het |
| Irgc |
C |
A |
7: 24,132,238 (GRCm39) |
R193L |
probably damaging |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Lamc1 |
T |
G |
1: 153,104,523 (GRCm39) |
S59R |
probably damaging |
Het |
| Lrrc9 |
T |
C |
12: 72,524,160 (GRCm39) |
W790R |
probably damaging |
Het |
| Man1a2 |
A |
G |
3: 100,539,877 (GRCm39) |
L188P |
probably damaging |
Het |
| Med8 |
A |
T |
4: 118,268,089 (GRCm39) |
E5V |
probably damaging |
Het |
| Mefv |
A |
G |
16: 3,535,682 (GRCm39) |
L82P |
probably damaging |
Het |
| Mettl25 |
A |
T |
10: 105,615,509 (GRCm39) |
C498* |
probably null |
Het |
| Mettl3 |
T |
A |
14: 52,532,549 (GRCm39) |
I545F |
probably damaging |
Het |
| Mvp |
T |
A |
7: 126,592,721 (GRCm39) |
I397F |
probably damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,781,024 (GRCm39) |
I74F |
probably benign |
Het |
| Nudt5 |
G |
A |
2: 5,860,876 (GRCm39) |
|
probably benign |
Het |
| Nyap2 |
T |
A |
1: 81,314,444 (GRCm39) |
D713E |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,929,703 (GRCm39) |
R5824C |
probably damaging |
Het |
| Or4f6 |
G |
T |
2: 111,838,595 (GRCm39) |
S312Y |
probably damaging |
Het |
| Or6c214 |
T |
C |
10: 129,591,287 (GRCm39) |
I11V |
probably benign |
Het |
| Orc4 |
A |
T |
2: 48,826,762 (GRCm39) |
|
probably benign |
Het |
| Pde10a |
T |
A |
17: 8,975,885 (GRCm39) |
N3K |
possibly damaging |
Het |
| Pgm3 |
T |
A |
9: 86,440,523 (GRCm39) |
R389S |
probably benign |
Het |
| Piwil4 |
G |
A |
9: 14,623,604 (GRCm39) |
R529* |
probably null |
Het |
| Pkd2l2 |
A |
T |
18: 34,542,889 (GRCm39) |
R20* |
probably null |
Het |
| Ppp4r3a |
T |
A |
12: 101,049,170 (GRCm39) |
|
probably benign |
Het |
| Prkcq |
T |
C |
2: 11,284,333 (GRCm39) |
V501A |
possibly damaging |
Het |
| Prkg1 |
T |
C |
19: 30,572,412 (GRCm39) |
T400A |
probably damaging |
Het |
| Prps2 |
T |
C |
X: 166,135,288 (GRCm39) |
D183G |
probably damaging |
Het |
| Prrc2c |
A |
T |
1: 162,550,843 (GRCm39) |
H40Q |
probably damaging |
Het |
| Ptcd1 |
A |
T |
5: 145,091,985 (GRCm39) |
H371Q |
probably benign |
Het |
| Ptprk |
T |
C |
10: 28,139,686 (GRCm39) |
I137T |
probably damaging |
Het |
| R3hdm1 |
T |
C |
1: 128,112,181 (GRCm39) |
S422P |
probably damaging |
Het |
| Rapgef5 |
G |
A |
12: 117,677,863 (GRCm39) |
G366E |
probably damaging |
Het |
| Rsf1 |
GCGGCGGCG |
GCGGCGGCGTCGGCGGCG |
7: 97,229,126 (GRCm39) |
|
probably benign |
Het |
| Sfxn3 |
A |
G |
19: 45,039,313 (GRCm39) |
|
probably null |
Het |
| Sgce |
T |
C |
6: 4,689,560 (GRCm39) |
|
probably benign |
Het |
| Sipa1l1 |
T |
A |
12: 82,469,245 (GRCm39) |
L1248* |
probably null |
Het |
| Skint7 |
T |
G |
4: 111,839,309 (GRCm39) |
M201R |
probably damaging |
Het |
| Slc18a1 |
A |
G |
8: 69,496,583 (GRCm39) |
M360T |
possibly damaging |
Het |
| Srp68 |
A |
T |
11: 116,164,840 (GRCm39) |
S31R |
probably benign |
Het |
| Stag1 |
T |
A |
9: 100,678,769 (GRCm39) |
M230K |
probably damaging |
Het |
| Strc |
A |
T |
2: 121,204,829 (GRCm39) |
D985E |
possibly damaging |
Het |
| Tars3 |
T |
A |
7: 65,339,717 (GRCm39) |
V704E |
probably damaging |
Het |
| Tbc1d2b |
A |
G |
9: 90,089,940 (GRCm39) |
F863S |
probably damaging |
Het |
| Tek |
T |
C |
4: 94,669,121 (GRCm39) |
S41P |
probably damaging |
Het |
| Top1 |
T |
C |
2: 160,554,637 (GRCm39) |
Y463H |
probably damaging |
Het |
| Trim24 |
T |
G |
6: 37,934,774 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,576,979 (GRCm39) |
V24638A |
possibly damaging |
Het |
| Ttn |
A |
G |
2: 76,701,213 (GRCm39) |
|
probably benign |
Het |
| Txndc11 |
A |
G |
16: 10,892,986 (GRCm39) |
S915P |
probably benign |
Het |
| Tyro3 |
G |
C |
2: 119,647,349 (GRCm39) |
G826A |
probably benign |
Het |
| Ubxn4 |
T |
A |
1: 128,202,587 (GRCm39) |
W410R |
probably benign |
Het |
| Vmn1r193 |
C |
T |
13: 22,403,695 (GRCm39) |
G99D |
probably damaging |
Het |
| Vmn2r109 |
T |
A |
17: 20,761,656 (GRCm39) |
K567M |
probably damaging |
Het |
| Vmn2r23 |
T |
C |
6: 123,718,689 (GRCm39) |
F681L |
probably damaging |
Het |
| Vrk2 |
T |
C |
11: 26,439,803 (GRCm39) |
D256G |
probably damaging |
Het |
| Vwa3a |
T |
A |
7: 120,378,138 (GRCm39) |
I476N |
probably damaging |
Het |
| Wdr81 |
A |
G |
11: 75,342,066 (GRCm39) |
V1067A |
probably damaging |
Het |
| Zcwpw2 |
A |
G |
9: 117,843,119 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Setd2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00722:Setd2
|
APN |
9 |
110,380,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01023:Setd2
|
APN |
9 |
110,376,581 (GRCm39) |
nonsense |
probably null |
|
|
IGL01063:Setd2
|
APN |
9 |
110,402,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01745:Setd2
|
APN |
9 |
110,423,779 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01911:Setd2
|
APN |
9 |
110,446,499 (GRCm39) |
splice site |
probably null |
|
|
IGL01955:Setd2
|
APN |
9 |
110,378,386 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02023:Setd2
|
APN |
9 |
110,423,704 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02080:Setd2
|
APN |
9 |
110,376,518 (GRCm39) |
splice site |
probably null |
|
|
IGL02412:Setd2
|
APN |
9 |
110,379,842 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02519:Setd2
|
APN |
9 |
110,382,184 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02631:Setd2
|
APN |
9 |
110,379,644 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02754:Setd2
|
APN |
9 |
110,379,124 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02828:Setd2
|
APN |
9 |
110,390,282 (GRCm39) |
missense |
probably benign |
0.31 |
|
IGL03033:Setd2
|
APN |
9 |
110,380,343 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
IGL03140:Setd2
|
APN |
9 |
110,444,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03378:Setd2
|
APN |
9 |
110,382,220 (GRCm39) |
missense |
unknown |
|
|
American_samoa
|
UTSW |
9 |
110,396,826 (GRCm39) |
nonsense |
probably null |
|
|
slingshot
|
UTSW |
9 |
110,378,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0028:Setd2
|
UTSW |
9 |
110,403,022 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4544001:Setd2
|
UTSW |
9 |
110,380,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0058:Setd2
|
UTSW |
9 |
110,423,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0058:Setd2
|
UTSW |
9 |
110,423,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0167:Setd2
|
UTSW |
9 |
110,402,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0408:Setd2
|
UTSW |
9 |
110,423,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0452:Setd2
|
UTSW |
9 |
110,382,168 (GRCm39) |
splice site |
probably null |
|
|
R0541:Setd2
|
UTSW |
9 |
110,402,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0947:Setd2
|
UTSW |
9 |
110,377,579 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1249:Setd2
|
UTSW |
9 |
110,402,948 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1294:Setd2
|
UTSW |
9 |
110,378,575 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1518:Setd2
|
UTSW |
9 |
110,431,306 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1585:Setd2
|
UTSW |
9 |
110,380,464 (GRCm39) |
missense |
unknown |
|
|
R1647:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1649:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1651:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1652:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1673:Setd2
|
UTSW |
9 |
110,433,248 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1703:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1706:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1709:Setd2
|
UTSW |
9 |
110,378,925 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1752:Setd2
|
UTSW |
9 |
110,423,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1796:Setd2
|
UTSW |
9 |
110,446,884 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1796:Setd2
|
UTSW |
9 |
110,379,413 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1812:Setd2
|
UTSW |
9 |
110,379,170 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1884:Setd2
|
UTSW |
9 |
110,385,486 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2024:Setd2
|
UTSW |
9 |
110,378,201 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2051:Setd2
|
UTSW |
9 |
110,379,958 (GRCm39) |
missense |
probably benign |
|
|
R2117:Setd2
|
UTSW |
9 |
110,433,212 (GRCm39) |
frame shift |
probably null |
|
|
R2120:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2124:Setd2
|
UTSW |
9 |
110,378,932 (GRCm39) |
missense |
probably benign |
0.12 |
|
R2172:Setd2
|
UTSW |
9 |
110,378,912 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2179:Setd2
|
UTSW |
9 |
110,423,756 (GRCm39) |
nonsense |
probably null |
|
|
R2262:Setd2
|
UTSW |
9 |
110,390,311 (GRCm39) |
intron |
probably benign |
|
|
R2411:Setd2
|
UTSW |
9 |
110,379,497 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R2413:Setd2
|
UTSW |
9 |
110,376,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2419:Setd2
|
UTSW |
9 |
110,378,065 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2424:Setd2
|
UTSW |
9 |
110,446,590 (GRCm39) |
missense |
probably benign |
0.37 |
|
R3757:Setd2
|
UTSW |
9 |
110,402,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3765:Setd2
|
UTSW |
9 |
110,423,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3796:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3797:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3799:Setd2
|
UTSW |
9 |
110,378,639 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3899:Setd2
|
UTSW |
9 |
110,421,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3900:Setd2
|
UTSW |
9 |
110,421,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Setd2
|
UTSW |
9 |
110,380,114 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4010:Setd2
|
UTSW |
9 |
110,428,263 (GRCm39) |
missense |
probably null |
1.00 |
|
R4580:Setd2
|
UTSW |
9 |
110,403,311 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4614:Setd2
|
UTSW |
9 |
110,398,881 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4651:Setd2
|
UTSW |
9 |
110,423,200 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4855:Setd2
|
UTSW |
9 |
110,401,022 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4970:Setd2
|
UTSW |
9 |
110,377,226 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5112:Setd2
|
UTSW |
9 |
110,377,226 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5123:Setd2
|
UTSW |
9 |
110,446,595 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5140:Setd2
|
UTSW |
9 |
110,380,197 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5202:Setd2
|
UTSW |
9 |
110,380,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Setd2
|
UTSW |
9 |
110,446,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5560:Setd2
|
UTSW |
9 |
110,378,907 (GRCm39) |
nonsense |
probably null |
|
|
R5604:Setd2
|
UTSW |
9 |
110,433,284 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5678:Setd2
|
UTSW |
9 |
110,431,254 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5708:Setd2
|
UTSW |
9 |
110,377,891 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R5763:Setd2
|
UTSW |
9 |
110,385,343 (GRCm39) |
splice site |
probably null |
|
|
R5814:Setd2
|
UTSW |
9 |
110,396,826 (GRCm39) |
nonsense |
probably null |
|
|
R5924:Setd2
|
UTSW |
9 |
110,403,112 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6244:Setd2
|
UTSW |
9 |
110,377,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6313:Setd2
|
UTSW |
9 |
110,385,434 (GRCm39) |
missense |
unknown |
|
|
R6431:Setd2
|
UTSW |
9 |
110,379,453 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6526:Setd2
|
UTSW |
9 |
110,361,785 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6579:Setd2
|
UTSW |
9 |
110,378,846 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6996:Setd2
|
UTSW |
9 |
110,379,640 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7012:Setd2
|
UTSW |
9 |
110,376,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7105:Setd2
|
UTSW |
9 |
110,377,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7134:Setd2
|
UTSW |
9 |
110,377,865 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7222:Setd2
|
UTSW |
9 |
110,380,530 (GRCm39) |
missense |
|
|
|
R7359:Setd2
|
UTSW |
9 |
110,392,012 (GRCm39) |
missense |
|
|
|
R7492:Setd2
|
UTSW |
9 |
110,423,700 (GRCm39) |
missense |
|
|
|
R7643:Setd2
|
UTSW |
9 |
110,396,908 (GRCm39) |
splice site |
probably null |
|
|
R7869:Setd2
|
UTSW |
9 |
110,379,082 (GRCm39) |
nonsense |
probably null |
|
|
R7903:Setd2
|
UTSW |
9 |
110,446,905 (GRCm39) |
missense |
|
|
|
R8004:Setd2
|
UTSW |
9 |
110,421,613 (GRCm39) |
missense |
|
|
|
R8017:Setd2
|
UTSW |
9 |
110,431,255 (GRCm39) |
missense |
|
|
|
R8019:Setd2
|
UTSW |
9 |
110,431,255 (GRCm39) |
missense |
|
|
|
R8366:Setd2
|
UTSW |
9 |
110,377,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8460:Setd2
|
UTSW |
9 |
110,423,338 (GRCm39) |
missense |
|
|
|
R8498:Setd2
|
UTSW |
9 |
110,378,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8725:Setd2
|
UTSW |
9 |
110,402,912 (GRCm39) |
missense |
|
|
|
R8870:Setd2
|
UTSW |
9 |
110,423,321 (GRCm39) |
missense |
|
|
|
R8878:Setd2
|
UTSW |
9 |
110,421,467 (GRCm39) |
missense |
probably benign |
|
|
R9132:Setd2
|
UTSW |
9 |
110,374,385 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9159:Setd2
|
UTSW |
9 |
110,374,385 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9198:Setd2
|
UTSW |
9 |
110,378,168 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9277:Setd2
|
UTSW |
9 |
110,379,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9326:Setd2
|
UTSW |
9 |
110,378,671 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9558:Setd2
|
UTSW |
9 |
110,376,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9664:Setd2
|
UTSW |
9 |
110,377,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9673:Setd2
|
UTSW |
9 |
110,378,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF009:Setd2
|
UTSW |
9 |
110,379,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Setd2
|
UTSW |
9 |
110,376,647 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1176:Setd2
|
UTSW |
9 |
110,376,343 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Setd2
|
UTSW |
9 |
110,361,794 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
Z1177:Setd2
|
UTSW |
9 |
110,376,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGGCATCTTTCCAGCTCC -3'
(R):5'- ACATAGGCTTGCATGGGGTAAC -3'
Sequencing Primer
(F):5'- GTGCTGGATGTTGAATTTAAGCAATC -3'
(R):5'- ATCCCCAAGTTCTGCATC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation